Microtubules decorated with monomeric kinesin motor domain proteins in the presence of AMP-PNP, no nucleotide, or ADP. The figure shows a montage of reconstructions made from separate negative stain images. The differences in density of the motor:microtubule complex reflect the conformational changes associated with different nucleotide occupancy of the active site. For further information, see Hirose, K., Lockhart, A., Cross, R.A. & Amos, L.A. (1995) Nucleotide-dependent angular change in kinesin motor domain bound to tubulin. Nature 376, 277-279. Contributed by Keiko Hirose, Linda Amos & Rob Cross.
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Created 21 January 1997 12:00 GMT
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