Conserved motifs on 3-D kinesin motor

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Conserved Motifs Positioned on the Kinesin Motor Domain

Jon Kull has made available the coordinates for structure of the human kinesin motor domain (HsKHC residues 3-323) with ADP (the smaller ball and stick molecule in the display). This structure is still undergoing refinement.

As described on the Kinesin Crystal Structure page, most conserved residues in the kinesin family are positioned near the nucleotide or the proposed microtubule-binding site. The kinesin nucleotide binding pocket is similar in architecture to the nucleotide pocket of G proteins and the motifs that contribute to the pocket, N-4 (in motif X), P-loop (in motif A), N-2 (in motif C) and N-3 (in motif D), are named for corresponding motifs in G proteins (more on these conserved motifs in the kinesin motor domain). The individual conserved residues can also be positioned on the 3D structure.

Tips for using Chime: To stop the molecule from spining, hold down the (left) mouse button in the display and select Rotate:Stop from the menu. To rotate the molecule in 3-D, hold down the (right) mouse button and drag the mouse. To zoom in or out, hold down the Shift key and drag the mouse (right button) in the display. Use the buttons on the right to color selected motifs in the protein. To reset to the original image, reload this page in your browser. For more options visit Eric Martz's Chime: How To Use It.

On Off color all conserved motifs

On Off color motif X only (9-22)
On Off color motif A only (70-97)
On Off color motif B only (128-146)
On Off color motif C only (190-210)
On Off color motif D only (225-237)
On Off color motif E only (250-268)
On Off color motif F only (274-290)
On Off color motif Y only (295-304)

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