Conserved residues on 3-D kinesin motor

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Conserved Residues Positioned on the Kinesin Motor Domain

Jon Kull has made available the coordinates for structure of the human kinesin motor domain (HsKHC residues 3-323) with ADP (the smaller ball and stick molecule in the display). This structure is still undergoing refinement.

As described on the Kinesin Crystal Structure page, most conserved residues in the kinesin family are positioned near the nucleotide or the proposed microtubule-binding site. The kinesin nucleotide binding pocket is similar in architecture to the nucleotide pocket of G proteins and the motifs that contribute to the pocket, N-4, P-loop, N-2 and N-3, are named for corresponding motifs in G proteins. View the conserved motifs positioned on the 3D structure.

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On Off color all conserved residues
On Off color residues of the nucleotide pocket

On Off color motif X/N-4 - R14, R16, P17

On Off color motif A/P-loop - Y84, G85, T87, G90, K91

On Off color motif B - E136, Y138, D144, L145

On Off color motif C/N-2 - N198, S201, S202, R203, S204, H205

On Off color motif D/N-3 - D231, G234, E236

On Off color motif E - L258, L261

On Off color motif F - R278A*, T283
* The conserved arginine (R) is modeled as alanine (A) in the 3-D structure.

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