Colour Alignment [U.S. Mirror]

Myosin Motor Domain Sequence
Colour Alignment
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A preliminary (pairwise) alignment of all of the full length sequences was made with a modified version of the method of Feng and Doolittle in ClustalW [1]. The sequences were then trimmed to produce a core motor domain. This core motor domain corresponds to residues 88 to 780 of chicken pectoralis muscle myosin II from which the first crystal structure of a myosin head was solved[5]. A second guide alignment with these core motor domain sequences was produced, followed by a final multiple alignment, with correction for multiple substitutions[6]. Optimally, when producing a phylogenetic tree from such an alignment, any positions in the alignment with gaps are excluded. Such a strategy would have excluded half of the data because of the large number of sequences, thus positions with gaps were included. An unrooted phylogenetic tree was constructed and tested for branching order confidence by bootstrapping[7]. Bootstrapping redraws 1000 trees with random samples from the multiple alignment. If the same branches were found at a certain node in >900 out of those 1000 random trees, then that node was accepted as being significant and therefore the branching order at that point in the tree was well supported. (Bootstrapping data)
See key below for expansion of organism names and other abbreviations. Where no formal name has been given in prior literature we have used the format: Nn XXA where Nn is the organism's genus and species, XX is the myosin class and A is an identifier given in date order of the gene/protien discovery and publication in the database. To avoid confusion in the plant myosin XI class a hyphen has been added to distinguish the myosin class from the 9th example discovered: At XI-I.
The residue number for Gg FSk (chicken fast skeletal) and the secondary structure assignments as derived from the chicken myosin S1 crystal structure are shown along the top. HC corresponds to Helix C, S1B to strand one of beta-sheet B. Since there are mnore than 26 helices identified the 27th and 28th helices are labelled HA' and HB'.
Colour scheme:
AILVPTWM - 'Non Polar'
GSTYCNQ - 'Uncharged Polar' and Glycine
DE - 'Acidic'
HKR - 'Basic'
Tony Hodge MRC-LMB Cambridge
& Jamie Cope UC Berkeley
May 2000.
                                      HC         S1B     S2B                             HD                                  HE                     S4B              HF                                                                                                                                                                                       HG           HH              S1C   S6B                 S7B                         HI         HJ                                                                                                                         HK                        HL           S1D                   S2D            HM           HN     S4D             S3D                              HO                                                         S5B switch II                       HP                                   HQ                                                HR                                HS                 S1E                     S2E     S3E        HT          HU                         HV                                                                                                                                                                                                                                   HW                        S3B                                                HX           HY          S1F   HZ                                              HA'                         S2F        S3F    (Long Helix to V826
                                <----------->    <->    <--->                          <----->                          <--------->               <---->       <------------->                     25-50 Junction              25-50 Junction              25-50 Junction              25-50 Junction                                                      <----->   <----------->         <-> <---->             <------->                    <---->     <----->                                                                                                                <------------>        <------------------->  <>                    <->         <------>    <------->  <>              <>    <-------------------------------------------------------->                          <---->                <-------------------------------->                <------->                                         <----->                       <-------------->         <-->                    <-->    <-->     <----->    <------->                    <--->                                                                                                                                                                                                              <------------------------------------>     <------>                                         <---------> <----------->     <> <------>                                        <------>                      <--->  <---------> Light Chain Binding)
Gg FSk residue #   90        100                  120                                   140                               160                          180                 200                                                                                                                                                                             220                        240                       260                   280                  300                                                                                                 320                           340                      360                              380                      400                         420                 440                                                              460                       480                  500                     520                                                      540                                  560                               580                    600                                  620                                                                                                                                                                                                   640                                        660                   680                                              700                     720                                          740                             760                          780
Dm NinaC III     -PEDLAA-LENPV-DENIIESLRHRILM-GESYSFIGDILLSLNSNEIKQ-EFP-QE---------------FHAKYRFKSRSE-----------NQ---PHIFSVADIAYQDMLH---------HKEPQHIVLSGESYSGKSTNARLLIKHLCYLGDGNR--------------------------------------------------------------------------------------------------------------------------------------------------------------------GATGRVESSIK-----------AILMLVNAGTPVNNDSTRCVLQYCLTFGKTG------KMSGAVFNMYM-LEKLRVAT-TDGTQHNFHIFYYFYDFINQQN----------------------------------------QLKEYN---LKADR----------NYRYLRV-----------------------------PPEVPPSKLKYRRDDPEGNVERYREFENILRDID-----FNHKQLETVRKVLAAILNIG-NIRFRQNG------KYA--------EVENT-----DIVSRIAELLRVDEKKFMWSLTNFIMVKGG--------IAERRQYTTEEARDARDAVASTLYSRLVDFI---------------------------INRINMNMSFP---------RAVFG------DTNAIIIHDMFGFECFN------RNGLEQLMINTLNEQMQYH-YNQRIFISEMLEMEAEDIDT-INLN--FYDNKTALDNLLTK-----------------------------------P---DGLFYIIDDASRSCQD-----------------QNLIMDRVSE--------K--HSQFVKKHTAT--------------EISVAHYT--GRIIYDTRAFTD-INRDFVPPEMIETFRSS-----------------LDESIMLMFTNQLTKAGNLTM---PFEAVQHKDESERKSYALNTLSAGC----------------------------------------------------------------------------------------------------------------------------------------------------------ISQVNNLRTLAANFR--------------------FTCLTLLKMLSQNA--NLGVHFVRCIRADLEYKPR-----------------------------SFHSDVVQQQMKALGVLDTV----IARQKGFSSRLPFDEFLRRYQF--LAFDFD-----EPVEM--------------------TKDNCRLLFLRLKMEG--------------WALGKTKVFLR------YYNDEFLARLYE-----*
Lp III           -VDDLAF-LDSPT-EEVVLENLEQRYRK-GEIYTFAGDVLLTLNPGKVLP-LYG-DQ---------------TAVKYCERGRSD-----------NP---PHVFAVADRAYQQMLH---------HKSPQAVILSGVSGSGKSFCTHQVIRHLAFLGAQNKE-------------------------------------------------------------------------------------------------------------------------------------------------------------------GMREKLEYLCP-----------LLDTLGNAYTSTNPNSSHFVKILEVTFTKTG------KITGAILFTFL-LEARRLTD-IPKGERNFHVFYYFYEGLRSEG----------------------------------------RLKEFG---LEEK-----------NYRYL--------------------------------PELKSS-------NSPEYVKGYQQFLRALTSLA-----FTEEEIFAIQKVLAAILLLG-ETEIQN---------------------S-----------AAFKLLGAESSELENTLT--------------------------QDVNARDVYARAMYLRLFSWI---------------------------VAVVNRQLSFS---------RLVFG------DVYSVTVIDSPGFENGL------HNSLHQLCANVISDNLQNY-IQQIIFFKELEEYGEEGVNVPFNLEG-GVDHRTLVNKLMDS-----------------------------------G---QGLLTAISKATQYQRKGES------------GWMESLQEADSE--------E--LVEFSNVNGKP--------------IVSVKHIF--RKVSYDATDLVK-KNVEDKTRALTSTMQRS-----------------CDPRIRAIFSSENPSP--------------FLSSPRRSSIQENMLLP------------------------------------------------------------------------------------------------------------------------------------------------------------------ERTVTDSLH--------------------SALSSVLNLASTED--PP--HLILCMRPQKKELIN-----------------------------DYDSKSVQIQLHALNVLETI----LIRQFGFARRISFVDFLNRYQY--LAFDFN-----ENVEL--------------------TKENCRLLLLRLKMDG--------------WTLGKNKVFLK------YYSEEYLSRIYETHIKK*
Rn XVI           -SDDLAT-LSELN-DSSLLYEIQKRFGN-DQIHTFIGDIFLLVNPFKELP-IYS-TV---------------VSQMYLSPTGQR-----------SPSLPPHLFSCAERAFHRLFQ---------ERRPQNIILSGERGSGKTQASKQIMKHLTSRASSSCT-------------------------------------------------------------------------------------------------------------------------------------------------------------------MFDSRFKHAIC-----------ILEAFGHAKTTLNNVSSCLIQYWELQFCQRRK-----HVTGARISTYM-LEKPRLVA-QPPGQGSFLIFSWLMDGLSAEE----------------------------------------KCGLH----LSNFC----------AHRYVSQ-----------------------------GMREDVS-----TAERSLNKERLADLKHALNVIG-----FSALEVENLFAILSAILHIG-DIQFTALT------EADS------AFVSDL-----QLLEQVADMLQVSTDELASALTTDIQYFKG--------DVIIRRHTTQIAAFYRDLLAKSLYSRLFGFL---------------------------INTVNCCLQSQD--------EYKSL------QTLDIGILDIFGFEEFQ------KNEFEQLCVNLTNEKMHHY-IQEVLFLQEQTECVQEGVAMETACS--PGNQAGVLDFFFQK-----------------------------------P---SGFFSLLDEESQAIWSVEPNLPRKLQGLLESSNTNAVYSPMKD--------G--NGNVAFKGQGA--------------AFTVMHYA--GRVTYEIRGAVE-RNKDSLSQNLLFVMKTS-----------------ENVVISHLFQSKLSPTGSLISSYPSFKFGGHKSSLLSKRIASSMVGVNKNYLELSK-------------------------------------------------------------------------------------------------------------------------LLK-----------------KKGTCTFLQRLERGDPATTAS--------------------QLTKSLADITAKLQ--KGSPHFILCVKPNTSQLPG-----------------------------VFDHFYVSAQLQYLGVLGLV----RLFRYGYPVRPSFEDFLSRYEP--LASVLLG---EKKGQP--------------------AEERCRLVLQRCKLQG--------------WQMGVHKVFLK------YWQVDQLGDLWLQMQR-*
Tg myoA XIV      -YGDIGM-LPHTN-IPCVLDFLKVRFMK-NQIYTTADPLVVAINPFRDLGNTTL-----------------DWIVRYR--DTFD-----------LSKLAPHVFYTARRALDNLHA---------VNKSQTIIVSGESGAGKTEATKQIMRYFAAAKTG----------------------------------------------------------------------------------------------------------------------------------------------------------------------SMDLRIQNAIMA--AN-----PVLEAFGNAKTIRNNNSSRFGRFMQLDVGRE------GGIKFGSVVAFL-LEKSRVLT-QDEQERSYHIFYQMCKGADAAM-----------------------------------------KERFHI---LPLS----------EYKYIN-------------PL---------------CLDAPG----------IDDVAEFHEVCESFRSMN----LTEDEV-ASVWSIVSGVLLLG-NVEVTATK------DGG--I-DDAAAIEG---KNLEVFKKACGLLFLDAERIREELTVKVSYAGN--------QEIRGRWKQEDGDMLKSSLAKAMYDKLFMWI---------------------------IAVLNRSIKPPGG-------FKI-----------FMGMLDIFGFEVFK------NNSLEQFFINITNEMLQKN-FVDIVFDRESKLYRDEGVS--SKELI-FTSN-AEVIKILTAK---------------------------------NN----SVLAALEDQCLAP----------------GGSDEKFLSTCKNALKGTT-------KFKPAKVSPNI------------NFLISHTV--GDIQYNAEGFLF-KNKDVLRAEIMEIVQQSK-----------------NPVVAQLFAGI------------------VMEKGK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAKGQLIGSQFL-----------------------SQLQSLMELIN--STEPHFIRCIKPNDTKKPL-----------------------------DWVPSKMLIQLHALSVLEAL----QLRQLGYSYRRPFKEFLFQFKF--IDLSASENPNLD------------------------PKEAALRLLKSS------------KLPSEEYQLGKTMVF--------LKQTGAKELTQIQRE--*
Pf PfMA          -FGDIGL-LNHTN-IPCVLDFLKHRYLK-NQIYTTAVPLIVAINPYKDLGNTTN-----------------EWIRRYR--DTAD-----------HTKLPPHVFTCAREALSNLHG---------VNKSQTIIVSGESGAGKTEATKQIMRYFASSKSG----------------------------------------------------------------------------------------------------------------------------------------------------------------------NMDLRIQTAIMA--AN-----PVLEAFGNAKTIRNNNSSRFGRFMQLVISHE------GGIRYGSVVAFL-LEKSRIIT-QDDNERSYHIFYQFLKGANSTM-----------------------------------------KSKFGL---KGVT----------EYKLLN-------------PN---------------STEVSG----------VDDVKDFEEVIESLKNME----LSESDI-EVIFSIVAGILTLG-NVRLIEKQ------EAG--L-SDAAAIMD---EDMGVFNKACELMYLDPELIKREILIKVTVAGG--------TKIEGRWNKNDAEVLKSSLCKAMYEKLFLWI---------------------------IRHLNSRIEPEGG-------FKT-----------FMGMLDIFGFEVFK------NNSLEQLFINITNEMLQKN-FVDIVFERESKLYKDEGIS--TAELK-YTSN-KEVINVLCEK---------------------------------GK----SVLSYLEDQCLAP----------------GGTDEKFVSSCATNLKENN-------KFTPAKVASNK------------NFIIQHTI--GPIQYCAESFLL-KNKDVLRGDLVEVIKDSP-----------------NPIVQQLFEGQ------------------VIEKGK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------IAKGSLIGSQFL-----------------------NQLTSLMNLIN--STEPHFIRCIKPNENKKPL-----------------------------EWCEPKILIQLHALSILEAL----VLRQLGYSYRRTFEEFLYQYKF--VDIAAAEDSSVE------------------------NQNKCVNILKLS------------GLSESMYKIGKSMVF--------LKQEGAKILTKIQREK-*
Tg myoD          -YGDIGG-LPHTN-EPCVLDFLARRYQS-KVIYTTAEPLIVAVNPFQDLKNAGP-----------------DTIALYR--DAPD-----------VDKLPPHVFYASRRAMTNMHQ---------LKKPQTIIVSGESGAGKTETTKMLMKYLATSAGG----------------------------------------------------------------------------------------------------------------------------------------------------------------------NLDLKIQTAIMA--AN-----PVLEAFGNAKTVRNNNSSRFGRFMLLDVARE------GGIQHGKVVAFL-LEKSRIVC-QDKDERNYHIFYQFLKGAPGHM-----------------------------------------RQRYML---QPLE----------AYTFIN-------------PH---------------CLDAPG----------IVDTEDFEQTVKSLESMN----MTETET-CTIWSIVSGVLLMG-NAKPTGKT------EAG--V-ENAACFVG---ESEAALRNACSLLFLDYPSILHELTVKTTYAGS--------NKIESRWTVPDSEMLRASLAKGMFEQLFLWI---------------------------IRKLNADIEPKGGS------FDV-----------FMGLLDIFGFEVFQ------NNSLEQLFINITNEVLQRN-FTDIVFEKELQLYSKEGIS--SKKIE-YTTN-EKLIETLLGK---------------------------------GT----SVLAALEDQCISP----------------SGTDEKFVSSLASKLAGNK-------CFIPSKNTKSL------------EFTVVHTI--GKVIYNADGFAF-KNKDVLRPEIIEITRAST-----------------NDVVRGLFEGV------------------KVEKGK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAKGMLIGSQFM-----------------------TQLKGLMEVIQ--KTESHFIRCIKPNDDKVPL-----------------------------KWVNSKVLIQLHALSILEAL----HLRQLAFSYRRTFEEFAAQFRF--INLGVSNKPGAD------------------------AKTICVELLKST------------SISADEYALGKTMVF--------LKPQAAKMLVRLQREA-*
Tg myoE          -FPDIGL-LPHKN-CAAVLDFLKQRYLL-DLIYTTADPLLIAINPFKDLNNTTP-----------------EWLQLYR--DAPD-----------AEILAPHVFRLARTVLERLSA---------FMASQTIIVSGESGAGKTEATKQIMSYFAAGKRGE---------------------------------------------------------------------------------------------------------------------------------------------------------------------VSHQRIQNAVIA--AN-----PVLEAFGNAKTVRNNNSSRFGRFMQLQLGEK------GGIEYGSIRNFL-LEKVRVTS-QEQHERSYHIFYQLVKGADDAK-----------------------------------------RRQLHL---LNLE----------DYTYLS-------------KNG-------------GCYDCPG----------IDDVKDFKEMNKSLRSIG----LNLDDV-ESLWSIIAGVLLLG-NVHLESRE------TDG--Q-PNAAALTP---DGEATLQKCCALLFVDEEAVKKEILYKVKTIGD--------QQIESPNSLSDALMNRDSLAKAVYEKLFDWV---------------------------VRRVNATIEPPQG-------FGI-----------FMGMLDIFGFEMFE------NNSLEQLLINITNEQLQKN-FIQIVFARETKLYYEEGIG--NVKIT-WTDN-ENVIKALCGK---------------------------------SS----SVLAILEDKSLAP----------------GGTDEAIVTSMNQALKSSD-------VWKPGQKNPRI------------CFCICHTI--ADIQYDATGFIE-KNKDLLKPELCSIVQASS-----------------NNVAKELFEGV------------------VMQKGK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------IAKGQLIASQFM-----------------------RSLDALLTLIS--STESHFIRCLKPNETKNPH-----------------------------DWSNGKVLAQLFSLSILEAL----QLKNLSFSYRRPYADFLKQFEQ--LDLEVTRKSGN-------------------------AKEKTKQLLTRA------------NVPQAKWALGNTMVF--------MKPDAVRELTQKMRL--*
Tg myoB XIV      --LPLRR-VRDTV-PRAEFGTRKSRFLR-SIIYTTAEPLLVAINPFKDLGNTTD-----------------AWISTYR--NASK-----------PEMLPPHVFKTARAALEDLEG---------YKKNQSIIVSGESGAGKTEATKQIMRFFASASS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------EVRTTIQDTIMA--GN-----PILEAFGNAKTIRNNNSSRFGRFMMLDVSSH------RGIQHGSISNFL-LEKVRVVS-QEANERSYHIFYQLLKGATSEM-----------------------------------------RAKYHL---RSLK----------EYAYLNG------------KNG-------------GCYDVPG----------IDDKADFEEVLQSLDAMQ----ITGSKR-HSVFSILSGLLLIG-NVSIEGKD------AQG--V-PDAAYISP---QSEEILEEACQLLSVDDAALKKEILVKSTKVGP--------QVIEGVRTKDEAKTSVLSLSKNVYDKLFDWL---------------------------VRQLNSLIDAPDG-------MPN-----------FIGILDIFGFEVLE------VNSLEQVLINITNEYLQKH-FIDVVFDMETKLYQAEGVP--TEALE-YTDN-LALVGALCGK---------------------------------ND----SFFALLEDACLGI----------------RSTDEGFCGTILRRLEPSG-------FFLESRRDKRL------------KFIIRHTI--ADIEYTCEGMLE-KNKDFLRKEVMDVMKAST-----------------DPVTKALFEGI------------------EIEAGK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------IGKGTLIASRFL-----------------------KNLEEMIGIVA--QTEAHFIRCLKPNEEKKPL-----------------------------GWNGSKVLNQLFSLSILEAL----QLRQVGYAYRRNFSEFCSHFRW--LDLGLVN-SDRD------------------------RKEVAHVLLEQS------------GIPESSWVIGKTMVF--------VKPDAAKELSILQRE--*
Tg myoC          -VDDIGY-LPHTN-VACVLDVLKSRFLR-SIIYTTAEPLLVAINPFKDLGNTTD-----------------AWISTYR--NASK-----------PEMLPPHVFKTARAALEDLEG---------YKKNQSIIVSGESGAGKTEATKQIMRFFASASS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------EVRTTIQDTIMA--GN-----PILEAFGNAKTIRNNNSSRFGRFMMLDVSSH------RGIQHGSISNFL-LEKVRVVS-QEANERSYHIFYQLLKGATSEM-----------------------------------------RAKYHL---RSLK----------EYAYLNG------------KNG-------------GCYDVPG----------IDDKADFEEVLQSLDAMQ----ITGSKR-HSVFSILSGLLLIG-NVSIEGKD------AQG--V-PDAAYISP---QSEEILEEACQLLSVDDAALKKEILVKSTKVGP--------QVIEGVRTKDEAKTSVLSLSKNVYDKLFDWL---------------------------VRQLNSLIDAPDG-------MPN-----------FIGILDIFGFEVLE------VNSLEQVLINITNEYLQKH-FIDVVFDMETKLYQAEGVP--TEALE-YTDN-LALVGALCGK---------------------------------ND----SFFALLEDACLGI----------------RSTDEGFCGTILRRLEPSG-------FFLESRRDKRL------------KFIIRHTI--ADIEYTCEGMLE-KNKDFLRKEVMDVMKAST-----------------DPVTKALFEGI------------------EIEAGK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------IGKGTLIASRFL-----------------------KNLEEMIGIVA--QTEAHFIRCLKPNEEKKPL-----------------------------GWNGSKVLNQLFSLSILEAL----QLRQVGYAYRRNFSEFCSHFRW--LDLGLVN-SDRD------------------------RKEVAHVLLEQS------------GIPESSWVIGKTMVF--------VKPDAAKELSILQRE--*
Pf PfMB          -SHRLND-MVHQN-SAEVLNTLALRYEK-NYIYTIAEPMLISVNPYQVIDTD---------------------MNEYK--NKS------------TDLLPPHVYTYAKDAMLDFIN---------TKNSQSIIISGESGSGKTEASKLVIKFYLSGVR-----------------------------------------------------------------------------------------------------------------------------------------------------------------------E-DNDISKTLWD--SN-----FILEAFGNAKTVKNNNSSRYGKYIKIQLDEN------QNIVSSSIEIFL-LEKIRVVS-QEPDERCYHIFYEILKGMNDEM-----------------------------------------KKKYKI---KSEE----------DYKYISN------------KS----------------INIPE----------IDDAKDFENLMISFDKMK----MS-DLK-DDLFLTLSGLLLLG-NIQFNGIE------KGG--K-SNCSELDD---ENLEVVNEASELLGIDYESLKNSLVITEKSIAN--------QKIEIPLSIEESLSICRSISKDIYNKIFEYI---------------------------TKRINNFLNNNKE-------LEN-----------FIGILDIFGFEIFV------KNSLEQLLINIANEEIHNI-YLFVVYEKESYLYKKEGPL--IESVK-YTNN-ESIIDLLRG----------------------------------NT----SIISILEDNCLAP----------------GKKDESIVSVYTNKFSKNE-------HYSVCKKNITE------------SFVIKHTV--SDVTYSISNFIS-KNKDILSPNILKLLKVSN-----------------NKLIQNLYDDA------------------EVTDS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------LGRKNLITYKYL-----------------------ENLKQICSYLK--STNIYFIKCIKPNETKEKN-----------------------------NFNPKKVYPQLFSLSIVETL----NIKYF-FQYKYTFASFLSYYQY--LDIAVSNDSSLD------------------------EKTKVTMLLER-------------NFDKDSYKVGHTMVF--------LKKEAVHKIRDIINSN-*
Tt MYO1          -YSDMVH-MKYLN-EAEIINNLRKRYQN-NMIFTYIGPTLVVMNPYKEIEGVQDNQVIDKIKSDLGIKFEEDFKMNNL--STNQ-----------NIINTPHTYTVSGLAYKQMFS---------NKKNQAIVISGESGAGKTENAKLSMQFLTSLKEF-----------------------------------------------------------------------------------------------------------------------------------------------------------------------NQFAIEVKILA--CN-----PILEAFGNAKTVRNNNSSRFGKYVKIYIDKTS-----QKINGASIDSYL-LEKSRIPC-PGKGERNYHIFYHMLKGNQELSN----------------------------------------LRLSQF---KNLS----------DFDYLKK------------SD---------------CFEVEN----------IQDAKLYLEVKKSFRQMN----FSNQEQ-EAIFSLISAILLLG-NANLDSSK------VSD--T-QAPTFLNMSLPTHHKEFKNASELLQVNPKDLEESLVFKVRKVGT--------TVIKSPQTAEECLSMRDSLSKNLYDSLFNFL---------------------------VWKLNQNLLPPQDL------LNKS---------LSIGLLDIFGFESFD------INSFEQLCINFTNEKFQQL-YVQYVFKSEEEDYKQEGILDVFSDLQ-YQEN-QLIIDTIEKK---------------------------------PN----GIMVLLDENCSLG----------------SGTDDSFLNQITKNHSKNQ-------LVSFPKKD-KY------------SFSLSHTA--KRVVYDVRGFRD-KNKDEVSTEVEKSLQSSK-----------------CPVIANLLSYQ------------------GSQTQQNKETQNLQNFGNNLNFKKAE----------------------------------------------------------------------------------------------------------------------------------------------ISNQMNSSKKNVKFLGQKFR-----------------------QSLQELMIELN--NSDVHFIRCIKPNEEKKKN-----------------------------FFKYDYVYQQVQYLGILDSI----KIRKVGYSYRMTYENFFLEYQE--LGQKTKGLTLQK------------------------VQQQKPIYLQNK------------QLPQKCVAFGKTKIF--------LKNEVMKILHEK-----*
Dd myoM          -FSDMVE-IQDLS-EAIILNNLGLRYKS-DQIYTYIGNVLISINPYKEIKDIYS----------------LNILNKYK--DINT-----------IKSNPPHIYAVALRAYQSMVS---------EKKNQSIIISGESGSGKTEASKTILQYLINTSNSNSN----------------------------------------------------------------------------------------------------------------------------------------NNTNIN---------------------NNNNSIEKDILN--SN-----PILEAFGNSRTTKNHNSSRFGKFLKIEFRSSD-----MKIDGASIETYL-LEKSRISHRPDVNNLSYHIFYYLVMGASKEER----------------------------------------ERLGLD---NDPS----------KYRYLDASTSVIESFKKQSNGG-------------SGGGSGN----------NDLSESLQLVKQSLESMS----IAKEQC-DDIFLTLAAILHLG-NIEFEVDQ------TENEQT-SGFSKISEQKASVKKSLSMVSKLLGYPEQVFKQTLLNRNLKGGGRG------SVYCRPMEVYQSEQTRDALSKALYVRLFASI---------------------------VEKINVKFIQNTGS------KDLQGGYSSKRNNLFIGVLDIFGFENLS------SNSLDQLLINFTNEKLQQQ-FNLNVFENEQKDYLQEGIP--WSTSN-FIDN-KECIELFEKK---------------------------------SY----GLLSLLDDECMMP----------------KGSEVTLLEKYNKQYHNTN-------QYYQRTLAKG-------------TLGIKHFA--GDVTYQTDGWLE-KNRDSIPTEVEQLLSASS-----------------NNLIKSLFNLK------------------ELNKSNDNNSNNNNSNNNSSSSSSSQSTASITAKASPPRERFNSGSGSGTTSPLNLSGSSSP----------------------LSGSGS-----------------------------------------------------------------YSIIGGNSNSNSNNNNSSNNKKSQSVSVAGQFI-----------------------EQLNKLISTIN--STSVHYIRCIKPNVTMDCN-----------------------------NFNNSHVLSQLRNVGVLNTV----KVRKMGYSYRRDFIQFYSRYNC--ILNSLNIKINLTNINHSNLCKEILENVNSQYKNNNNNKNNNNQIVKIT------------TNSKPTFQIGKTKIF--------ISDELYIYLEKKRY---*
Gg FSk           -IEDMAM-MTHLH-EPAVLYNLKERYAA-WMIYTYSGLFCVTVNPYKWLP-VYNPK----------------VVLAYR--GKK------------RQEAPPHIFSISDNAYQFMLTDR---------ENQSILITGESGAGKTVNTKRVIQYFATIAASGEK----------------------------------------------------------------------------------------------------------------------------------------KKEEQ-SG-------------------KMQGTLEDQIIS--AN-----PLLEAFGNAKTVRNDNSSRFGKFIRIHFGAT------GKLASADIETYL-LEKSRVTF-QLPAERSYHIFYQIMSNKKPEL-----------------------------------------IDMLLI--TTNPY----------DYHYVSEG----------------------------EITVPS----------IDDQEELMATDSAIDILG----FSADEK-TAIYKLTGAVMHYG-NLKFKQK-------QRE-----EQAEPDGT--E--VADKAAYLMG-LNSAELLKALCYPRVGVGN--------EAVTKGETVSEVHNSVGALAKAVYEKMFLWM---------------------------VIRINQQLDTK---------QPR---------QYFIGVLDIAGFEIFD------FNSFEQLCINFTNEKLQQF-FNHHMFVLEQEEYKKEGIE--WEFID-FGMDLAACIELIE-----------------------------------KPM---GIFSILEEECMFP----------------KATDTSFKNKLYDEHL-GK-----SNNFQKP-KPAK--------GKAEAHFSLVHYA--GTVDYNISGWLE-KNKDPLNETVIGLYQKSS-----------------VKTLALLFATYGG------------------EAE-G------G-GGKKG--------------------------------------------------------------------------------------------------------------------------------------------------------GKKKGSSFQTVSALFR-----------------------ENLNKLMANLR--STHPHFVRCIIPNETKTPG-----------------------------AMEHELVLHQLRCNGVLEGI----RICRKGFPSRVLYADFKQRYR---VLNAS----AIPEGQ--F----------------MDSKKASEKLLGGG----------DVDH--TQYAFGHTKVF--------FKAGL-LGLLEEMRD--*
Gg FSkE          -IEDMAM-MTHLH-EPAVLYNLKERYAA-WMIYTYSGLFCVTVNPYKWLP-VYNPE----------------VVLAYR--GKK------------RQEAPPHIFSISDNAYQFMLTDR---------ENQSILITGESGAGKTVNTKRVIQYFATIAATGDK----------------------------------------------------------------------------------------------------------------------------------------KKEEQPAG-------------------KMQGTLEDQIIS--AN-----PLLEAFGNAKTVRNDNSSRFGKFIRIHFGAT------GKLASADIETYL-LEKSRVTF-QLKAERSYHIFYQIMSNKKPEL-----------------------------------------IEMLLI--TTNPY----------DYQYVSQG----------------------------EITVPS----------INDQEELMATDSAIDILG----FTPDEK-TAIYKLTGAVMHYG-NLKFKQK-------QRE-----EQAEPGGT--E--VADKAAYLMG-LNSADLLKALCYPRVKVGN--------EYVTKGQTVQQVYNSVGALAKSVFEKMFLWM---------------------------VVRINQQLDTK---------QPR---------QYFIGVLDIAGFEIFD------FNSLEQLCINFTNEKLQQF-FNHHMFVLEQEEYKKEGIE--WEFID-FGMDLAACIELIE-----------------------------------KPM---GIFSILEEECMFP----------------KATDTSFKNKLYDQHL-GK-----SNNFQKP-KPGK--------GKLEAHFSLVHYA--GTVDYNITGWLE-KNKDPLNETVVGLYQKSS-----------------LKTLALLFASVGG----------------A-EAESG------A-GGKKG--------------------------------------------------------------------------------------------------------------------------------------------------------GKKKGSSFQTVSALFR-----------------------ENLNKLMSNLR--STHPHFVRCLIPNETKTPG-----------------------------AMEHELVLHQLRCNGVLEGI----RICRKGFPIRILYADFKQRYK---VLNAS----AIPEGQ--F----------------IDSKKASEKLLGSI----------DVDH--TQYKFGHTKVF--------FKAGL-LGLLEEMRD--*
Hs Peri          -IEDMAM-MTHLH-EPGVLYNLKERYAA-WMIYTYSGLFCVTVNPYKWLP-VYKPE----------------VVAAYR--GKK------------RQEAPPHIFSISDNAYQFMLTDR---------ENQSILITGESGAGKTVNTKRVIQYFATIAVTGEK----------------------------------------------------------------------------------------------------------------------------------------KKDES--G-------------------KMQGTLEDQIIS--AN-----PLLEAFGNAKTVRNDNSSRFGKFIRIHFGTT------GKLASADIETYL-LEKSRVTF-QLKAERSYHIFYQITSNKKPDL-----------------------------------------IEMLLI--TTNPY----------DYAFVSQG----------------------------EITVPS----------IDDQEELMATDSAIDILG----FTPEEK-VSIYKLTGAVMHYG-NMKFKQK-------QRE-----EQAEPDGT--E--VADKAAYLQS-LNSADLLKALCYPRVKVGN--------EYVTKGQTVQQVYNAVGALAKAVYEKMFLWM---------------------------VTRINQQLDTK---------QPR---------QYFIGVLDIAGFEIFD------FNSLEQLCINFTNEKLQQF-FNHHMFVLEQEEYKKEGIE--WTFID-FGMDLAACIELIE-----------------------------------KPL---GIFSILEEECMFP----------------KATDTSFKNKLYDQHL-GK-----SANFQKP-KVVK--------GKAEAHFSLIHYA--GTVDYNITGWLD-KNKDPLNDTVVGLYQKSA-----------------MKTLASLFSTYAS----------------A-EAD--------S-SAKKG--------------------------------------------------------------------------------------------------------------------------------------------------------AKKKGSSFQTVSALFR-----------------------ENLNKLMTNLR--STHPHFVRCIIPNETKTPG-----------------------------AMEHELVLHQLRCNGVLEGI----RICRKGFPSRILYGDFKQRYK---VLNAS----AIPEGQ--F----------------IDSKKASEKLLASI----------DIDH--TQYKFGHTKVF--------FKAGL-LGLLEEMRD--*
Hs FSkE          -IEDMAM-LTHLN-EPAVLYNLKDRYTS-WMIYTYSGLFCVTVNPYKWLP-VYNPE----------------VVEGYR--GKK------------RQEAPPHIFSISDNAYQFMLTDR---------ENQSILITGESGAGKTVNTKRVIQYFATIAATGDL----------------------------------------------------------------------------------------------------------------------------------------AKKKD--S-------------------KMKGTLEDQIIS--AN-----PLLEAFGNAKTVRNDNSSRFGKFIRIHFGTT------GKLASADIETYL-LEKSRVTF-QLKAERSYHIFYQILSNKKPEL-----------------------------------------IELLLI--TTNPY----------DYPFISQG----------------------------EILVAS----------IDDREELLATDSAIDILG----FTPEEK-SGLYKLTGAVMHYG-NMKFKQK-------QRE-----EQAEPDGT--E--VADKTAYLMG-LNSSDLLKALCFPRVKVGN--------EYVTKGQTVDQVHHAVNALSKSVYEKLFLWM---------------------------VTRINQQLDTK---------LPR---------QHFIGVLDIAGFEIFE------YNSLEQLCINFTNEKLQQF-FNHHMFVLEQEEYKKEGIE--WTFID-FGMDLAACIELIE-----------------------------------KPM---GIFSILEEECMFP----------------KATDTSFKNKLYDQHL-GK-----SNNFQKP-KVVK--------GRAEAHFSLIHYA--GTVDYSVSGWLE-KNKDPLNETVVGLYQKSS-----------------NRLLAHLYATFAT----------------A-DAD--------S-GKKKV--------------------------------------------------------------------------------------------------------------------------------------------------------AKKKGSSFQTVSALFR-----------------------ENLNKLMSNLR--TTHPHFVRCIIPNETKTPG-----------------------------AMEHSLVLHQLRCNGVLEGI----RICRKGFPNRILYGDFKQRYR---VLNAS----AILEGQ--F----------------IDSKKACEKLLASI----------DIDH--TQYKFGHTKVF--------FKAGL-LGTLEEMRD--*
Rn FSkE          -IEDMAM-LTHLN-EPAVLYNLKDRYTS-WMIYTYSGLFCVTVNPYKWLP-VYTPE----------------VVDGYR--GKK------------RQEAPPHIFSISDNAYQFMLTDR---------ENQSILITGESGAGKTVNTKRVIQYFATIAATGDL----------------------------------------------------------------------------------------------------------------------------------------AKKKD--S-------------------KMKGTLEDQIIS--AN-----PLLEAFGNAKTVRNDNSSRFGKFIRIHFGTT------GKLASADIETYL-LEKSRVTF-QLKAERSYHIFYQILSNKKPEL-----------------------------------------IELLLI--TTNPY----------DYPFISQG----------------------------EILVAS----------IDDREELLATDSAIDILG----FTPEEK-SGLYKLTGAVMHYG-NMKFKQK-------QRE-----EQAEPDGT--E--VADKTAYLMG-LNSSDLLKALCFPRVKVGN--------EYVTKGQTVDQVHHAVNALSKSVYEKLFLWM---------------------------VTRINQQLDTK---------LPR---------QHFIGVLDIAGFEIFE------YNSLEQLCINFTNEKLQQF-FNHHMFVLEQEEYKKEGIE--WTFID-FGMDLAACIELIE-----------------------------------KPM---GIFSILEEECMFP----------------KATDTSFKNKLYDQHL-GK-----SNNFQKP-KVVK--------GKAEAHFSLIHYA--GTVDYSVSGWLE-KNKDPLNETVVGLYQKSS-----------------NRLLAHLYATFAT----------------T-DAD--------G-GKKKV--------------------------------------------------------------------------------------------------------------------------------------------------------AKKKGSSFQTVSALFR-----------------------ENLNKLMSNLR--TTHPHFVRCIIPNETKTPG-----------------------------AMEHSLVLHQLRCNGVLEGI----RICRKGFPNRILYGDFKQRYR---VLNAS----AIPEGQ--F----------------IDSKKACEKLLASI----------DIDH--TQYKFGHTKVF--------FKAGL-LGTLEEMRD--*
Rn CaA           -IEDMAM-LTFLH-EPAVLYNLKERYAA-WMIYTYSGLFCVTVNPYKWLP-VYNAE----------------VVAAYR--GKK------------RSEAPPHIFSISDNAYQYMLTDR---------ENQSILITGESGAGKTVNTKRVIQYFASIAAIGDR----------------------------------------------------------------------------------------------------------------------------------------SKKDNP-N-------------------ANKGTLEDQIIQ--AN-----PALEAFGNAKTVRNDNSSRFGKFIRIHFGAT------GKLASADIETYL-LEKSRVIF-QLKAERNYHIFYQILSNKKPEL-----------------------------------------LDMLLV--TNNPY----------DYAFVSQG----------------------------EVSVAS----------IDDSEELLATDSAFDVLG----FTAEEK-AGVYKLTGAIMHYG-NMKFKQK-------QRE-----EQAEPDGT--E--DADKSAYLMG-LNSADLLKGLCHPRVKVGN--------EYVTKGQSVQQVYYSIGALAKSVYEKMFNWM---------------------------VTRINATLETK---------QPR---------QYFIGVLDIAGFEIFD------FNSFEQLCINFTNEKLQQF-FNHHMFVLEQEEYKKEGIE--WEFID-FGMDLQACIDLIE-----------------------------------KPM---GIMSILEEECMFP----------------KATDMTFKAKLYDNHL-GK-----SNNFQKP-RNVK--------GKQEAHFSLVHYA--GTVDYNILGWLE-KNKDPLNETVVGLYQKSS-----------------LKLMATLFSTYAS----------------A-DTGD-------S-GKGKG--------------------------------------------------------------------------------------------------------------------------------------------------------GKKKGSSFQTVSALHR-----------------------ENLNKLMTNLR--TTHPHFVRCIIPNERKAPG-----------------------------VMDNPLVMHQLRCNGVLEGI----RICRKGFPNRILYGDFRQRYR---ILNPA----AIPEGQ--F----------------IDSGKGAEKLLGSL----------DIDH--NQYKFGHTKVF--------FKAGL-LGLLEEMRD--*
Ma CaA           -IEDMAM-LTFLH-EPAVLYNLKERYAA-WMIYTYSGLFCVTVNPYKWLP-VYNAE----------------VVAAYR--GKK------------RSEAPAHIFSISDNAYQYMLTDR---------ENQSILITGESGAGKTVNTKRVIQYFASIAAIGDR----------------------------------------------------------------------------------------------------------------------------------------SKKDNP-N-------------------ANKGTLEDQIIQ--AN-----PALEAFGNAKTVRNDNSSRFGKFIRIHFGAT------GKLASADIETYL-LEKSRVIF-QLKAERNYHIFYQILSNKKPEL-----------------------------------------LDMLLV--TNNPY----------DYAFVSQG----------------------------EVSVAS----------IDDSEELLATDSAFDVLG----FTAEEK-AGVYKLTGAIMHYG-NMKFKQK-------QRE-----EQAEPDGT--E--DADKSAYLMG-LNSADLLKGLCHPRVKVGN--------EYVTKGQSVQQVYYSIGALGKSVYEKMFNWM---------------------------VTRINATLETK---------QPR---------QYFIGVLDIAGFEIFD------FNSFEQLCINFTNEKLQQF-FNHHMFVLEQEEYKKEGIE--WEFID-FGMDLQACIDLIE-----------------------------------KPM---GIMSILEEECMFP----------------KATDMTFKAKLYDNHL-GK-----SNNFQKP-RNVK--------GKQEAHFSLVHYA--GTVDYNILGWLE-KNKDPLNETVVGLYQKSS-----------------LKLMATLFSTYAS----------------A-DAGD-------S-GKGKG--------------------------------------------------------------------------------------------------------------------------------------------------------GKKKGSSFQTVSALHR-----------------------ENLNKLMTNLR--TTHPHFVRCIIPNERKAPG-----------------------------VMDNPLVMHQLRCNGVLEGI----RICRKGFPNRILYGDFRQRYR---ILNPA----AIPEGQ--F----------------IDSRKGAEKLLSSL----------DIDH--NQYKFGHTKVF--------FKAGL-LGLLEEMRD--*
Mm CaA           -IEDMAM-LTFLH-EPAVLYNLKERYAA-WMIYTYSGLFCVTVNPYKWLP-VYNAE----------------VVAAYR--GKK------------RSEAPPHIFSISDNAYQYMLTDR---------ENQSILITGESGAGKTVNTKRVIQYFASIAAIGDR----------------------------------------------------------------------------------------------------------------------------------------SKKENP-N-------------------ANKGTLEDQIIQ--AN-----PALEAFGNAKTVRNDNSSRFGKFIRIHFGAT------GKLASADIETYL-LEKSRVIF-QLKAERNYHIFYQILSNKKPEL-----------------------------------------LDMLLV--TNNPY----------DYAFVSQG----------------------------EVSVAS----------IDDSEELLATDSAFDVLS----FTAEEK-AGVYKLTGAIMHYG-NMKFKQK-------QRE-----EQAEPDGT--E--DADKSAYLMG-LNSADLLKGLCHPRVKVGN--------EYVTKGQSVQQVYYSIGALAKSVYEKMFNWM---------------------------VTRINATLETK---------QPR---------QYFIGVLDIAGFEIFD------FNSFEQLCINFTNEKLQQF-FNHHMFVLEQEEYKKEGIE--WEFID-FGMDLQACIDLIE-----------------------------------KPM---GIMSILEEECMFP----------------KAADMTFKAKLYDNHL-GK-----SNNFQKP-RNVK--------GKQEAHFSLVHYA--GTVDYNIMGWLE-KNKDPLNETVVGLYQKSS-----------------LKLMATLFSTYAS----------------A-DTGD-------S-GKGKG--------------------------------------------------------------------------------------------------------------------------------------------------------GKKKGSSFQTVSALHR-----------------------ENLNKLMTNLK--TTHPHFVRCIIPNERKAPG-----------------------------VMDNPLVMHQLRCNGVLEGI----RICRKGFPNRILYGDFRQRYR---ILNPA----AIPEGQ--F----------------IDSRKGAEKLLGSL----------DIDH--NQYKFGHTKVF--------FKAGL-LGLLEEMRD--*
Hs CaA           -IEDMAM-LTFLH-EPAVLFNLKERYAA-WMIYTYSGLFCVTVNPYKWLP-VYNAE----------------VVAAYR--GKK------------RSEAPPHIFSISDNAYQYMLTDR---------ENQSILITGESGAGKTVNTKRVIQYFASIAAIGDR----------------------------------------------------------------------------------------------------------------------------------------GKKDNA-N-------------------ANKGTLEDQIIQ--AN-----PALEAFGNAKTVRNDNSSRFGKFIRIHFGAT------GKLASADIETYL-LEKSRVIF-QLKAERNYHIFYQILSNKKPEL-----------------------------------------LDMLLV--TNNPY----------DYAFVSQG----------------------------EVSVAS----------IDDSEELMATDSAFDVLG----FTSEEK-AGVYKLTGAIMHYG-NMKFKQK-------QRE-----EQAEPDGT--E--DADKSAYLMG-LNSADLLKGLCHPRVKVGN--------EYVTKGQSVQQVYYSIGALAKAVYEKMFNWM---------------------------VTRINATLETK---------QPR---------QYFIGVLDIAGFEIFD------FNSFEQLCINFTNEKLQQF-FNHHMFVLEQEEYKKEGIE--WTFID-FGMDLQACIDLIE-----------------------------------KPM---GIMSILEEECMFP----------------KATDMTFKAKLYDNHL-GK-----SNNFQKP-RNIK--------GKPEAHFSLIHYA--GTVDYNILGWLE-KNKDPLNETVVGLYQKSS-----------------LKLMATLFSSYAT----------------A-DTGD-------S-GKSKG--------------------------------------------------------------------------------------------------------------------------------------------------------GKKKGSSFQTVSALHR-----------------------ENLNKLMTNLR--TTHPHFVRCIIPNERKAPG-----------------------------VMDNPLVMHQLRCNGVLEGI----RICRKGFPNRILYGDFRQRYR---ILNPV----AIPEGQ--F----------------IDSRKGAEKLLSSL----------DIDH--NQYKFGHTKVF--------FKAGL-LGLLEEMRD--*
Rn CaB           -IEDMAM-LTFLH-EPAVLYNLKERYAS-WMIYTYSGLFCVTVNPYKWLP-VYNAQ----------------VVAAYR--GKK------------RSEAPPHIFSISDNAYQYMLTDR---------ENQSILITGESGAGKTVNTKRVIQYFAVIAAIGDR----------------------------------------------------------------------------------------------------------------------------------------SKKDQ--T-------------------PGKGTLEDQIIQ--AN-----PALEAFGNAKTVRNDNSSRFGKFIRIHFGAT------GKLASADIETYL-LEKSRVIF-QLKAERDYHIFYQILSNKKPEL-----------------------------------------LDMLLI--TNNPY----------DYAFFSQG----------------------------ETTVAS----------IDDSEEHMATDSAFDVLG----FTPEEK-NSIYKLTGAIMHFG-NMKFKQK-------QRE-----EQAEPDGT--E--EADKSAYLMG-LNSADLLKGLCHPRVKVGN--------EYVTKGQNVQQVAYAIGALAKSVYEKMFNWM---------------------------VTRINATLETK---------QPR---------QYFIGVLDIAGFEIFD------FNSFEQLCINFTNEKLQQF-FNHHMFVLEQEEYKKEGIE--WTFID-FGMDLQACIDLIE-----------------------------------KPM---GIMSILEEECMFP----------------KATDMTFKAKLYDNHL-GK-----SNNFQKP-RNIK--------GKQEAHFSLIHYA--GTVDYNILGWLQ-KNKDPLNETVVGLYQKSS-----------------LKLLSNLFANYAG----------------A-DAP--------V-DKGKG--------------------------------------------------------------------------------------------------------------------------------------------------------KAKKGSSFQTVSALHR-----------------------ENLNKLMTNLR--STHPHFVRCIIPNETKSPG-----------------------------VMDNPLVMHQLRCNGVLEGI----RICRKGFPNRILYGDFRQRYR---ILNPA----AIPEGQ--F----------------IDSRKGAEKLLGSL----------DIDH--NQYKFGHTKVF--------FKAGL-LGLLEEMRD--*
Ma CaB           -IEDMAM-LTFLH-EPAVLYNLKDGYAS-WMIYTYSGLFCVTVNPYKWLP-VYNAE----------------VVAAYR--GKK------------RSEAPAHIFSISDNAYQYMLTDR---------ENQSILITGESGAGKTVNTKRVIQYFAVIAAIGDR----------------------------------------------------------------------------------------------------------------------------------------SKKDQ--T-------------------PGKGTLEDQIIQ--AN-----PALEAFGNAKTVRNDNSSRFGKFIRIHFGAT------GKLASADIETYL-LEKSRVIF-QLKAERDYHIFYQILSNKKPEL-----------------------------------------LDMLLI--TNNPY----------DYAFIPQG----------------------------ETTVAS----------IDDSEELMATDSAFDVLG----FTSEEK-NSIYKLTGAIMHFG-NMKFKQK-------QRE-----EQADRDGT--E--EEDKSAYLMG-LNSADLLKGMCHPRVKVGN--------EYVTKGQNVQQVSYAIGALAKSVYEKMFNWM---------------------------VTRINATLETK---------QPR---------QYFIGVLDIAGFEIFD------FNSFEQLCINFTNEKLQQF-FNHHMFVLEQEEYKKEGIE--WTFID-FGMDLQACIDLIE-----------------------------------KPM---RIMSILEEECMFP----------------KATDMTFKAKLYDNHL-GK-----SNNFQKP-RNVK--------GKQEAHFSLVHYA--GTVDYNILGWLQ-KNKDPLNETVVGLYQKSS-----------------LKLLSNLFANYAG----------------A-DAP--------V-DKGKG--------------------------------------------------------------------------------------------------------------------------------------------------------KAKKGSSFQTVSVLHR-----------------------ENLNKLMTNLR--STHPHFVRCIIPNETKSPG-----------------------------VMDNPLVMHQLRCNGVLEGI----RICRKGFPNRILYGDFRQRYR---ILNPA----AIPEGQ--F----------------IDSRKGAEKLLSSL----------DIDH--NQYKFGHTKVF--------FKAGL-LGLLEEMRD--*
Hs CaB           -IEDMAM-LTFLH-EPAVLYNLKERYGS-WMIYTYSGLFCVTVNPYKWLP-VYTPE----------------VVAAYR--GKK------------RSEAPPHIFSISDNAYQYMLTDR---------ENQSILITGESGAGKTVNTKRVIQYFAVIAAIGDR----------------------------------------------------------------------------------------------------------------------------------------SKKDQ--S-------------------PGKGTLEDQIIQ--AN-----PALEAFGNAKTVRNDNSSRFGKFIRIHFGAT------GKLASADIETYL-LEKSRVIF-QLKAERDYHIFYQILSNKKPEL-----------------------------------------LDMLLI--TNNPY----------DYAFISQG----------------------------ETTVAS----------IDDAEELMATDNAFDVLG----FTSEEK-NSMYKLTGAIMHFG-NMKFKLK-------QRE-----EQAEPDGT--E--EADKSAYLMG-LNSADLLKGLCHPRVKVGN--------EYVTKGQNVQQVIYATGALAKAVYERMFNWM---------------------------VTRINATLETK---------QPR---------QYFIGVLDIAGFEIFD------FNSFEQLCINFTNEKLQQF-FNHHMFVLEQEEYKKEGIE--WTFID-FGMDLQACIDLIE-----------------------------------KPM---GIMSILEEECMFP----------------KATDMTFKAKLFDNHL-GK-----SANFQKP-RNIK--------GKPEAHFSLIHYA--GIVDYNIIGWLQ-KNKDPLNETVVGLYQKSS-----------------LKLLSTLFANYAG----------------A-DAP--------I-EKGKG--------------------------------------------------------------------------------------------------------------------------------------------------------KAKKGSSFQTVSALHR-----------------------ENLNKLMTNLR--STHPHFVRLYHPNETKSPG-----------------------------VMDNPLVMHQLRCNGVLEGI----RICRKGFPNRILYGDFRQRYR---ILNPA----AIPEGQ--F----------------IDSRKGAEKLLSSL----------DIDH--NQYKFGHTKVF--------FKAGL-LGLLEEMRD--*
Ai II            -LEDMAN-MTYLN-EASVLYNLRSRYTS-GLIYTYSGLFCIAVNPYRRLP-IYTDS----------------VIAKYR--GKR------------KTEIPPHLFSVADNAYQNMVTDR---------ENQSCLITGESGAGKTENTKKVIMYLAKVACAVKK----------------------------------------------------------------------------------------------------------------------------------------KDEEAS-D-------------------KKEGSLEDQIIQ--AN-----PVLEAYGNAKTTRNNNSSRFGKFIRIHFGPT------GKIAGADIETYL-LEKSRVTY-QQSAERNYHIFYQICSNAIPEL-----------------------------------------NDVMLV--TPDSG----------LYSFINQG----------------------------CLTVDN----------IDDVEEFKLCDEAFDILG----FTKEEK-QSMFKCTASILHMG-EMKFKQR-------PRE-----EQAESDGT--A--EAEKVAFLCG-INAGDLLKALLKPKVKVGT--------EMVTKGQNMNQVVNSVGALAKSLYDRMFNWL---------------------------VRRVNKTLDTK---------AKR---------NYYIGVLDIAGFEIFD------FNSFEQLCINYTNERLQQF-FNHHMFILEQEEYKKEGIA--WEFID-FGMDLQMCIDLIE-----------------------------------KPM---GILSILEEECMFP----------------KADDKSFQDKLYQNHM-GK-----NRMFTKPGKPTRP-------NQGPAHFELHHYA--GNVPYSITGWLE-KNKDPINENVVALLGASK-----------------EPLVAELFKAPEE----------------P-AGG------------GKK--------------------------------------------------------------------------------------------------------------------------------------------------------KKGKSSAFQTISAVHR-----------------------ESLNKLMKNLY--STHPHFVRCIIPNELKQPG-----------------------------LVDAELVLHQLQCNGVLEGI----RICRKGFPSRLIYSEFKQRYS---ILAPN----AIPQG---F----------------VDGKTVSEKILAGL----------QMDP--AEYRLGTTKVF--------FKAGV-LGNLEEMRD--*
Sm II            -IEDMAN-LTHLN-DASVLENLRARYYR-QLIYTYSGLFCVAVNPYKRFP-IYTEQ----------------VALKYK--GKR------------RGEMPPHIFSISDNAYHNMLQDR---------ENQSILITGESGAGKTENTKKVISYFAVVAAASKK----------------------------------------------------------------------------------------------------------------------------------------EDDDSS----------------------KKGTLEDQIVQ--AN-----PVLEAYGNAKTTRNNNSSRFGKFIRIHFGTT------GKIAGADIEHYL-LEKSRVVS-QMKGERNYHIFYQLLSTYGSKY-----------------------------------------HDKLLV--QTDPA----------LYSFINQG----------------------------ELTIDG----------VDDSEEMKLCDEAFEVLG----FNDDEK-LSLFKCTTSICNMG-EMKFKQR-------PRE-----EQAEADGT--A--EAEKVAFLLG-VNAKDLLTSFLKPKVKVGT--------EFVTKGQNLNQVTYAVSALAKSLYNRMFGWL---------------------------VARVNKTLDTK---------VKR---------QFFIGVLDIAGFEIFT------ENGFEQICINYTNERLQQF-FNHHMFVLEQEEYKREKIQ--WTFID-FGMDLQACIDLIE-----------------------------------KPM---GILSILEEECIVP----------------KASDQTFLSKLYDNHL-GK-----SPNFTKP-KPPKP-------GHVEAHFELHHYA--GSVPYTITGWLE-KNKDPLNDSVVALLGDSK-----------------DPLVSNLFTPVVG----------------E-PG------------------------------------------------------------------------------------------------------------------------------------------------------------------------KKTKGGSFLTVTYMHR-----------------------ESLNKLMKNLQ--STSPSFIRCIVPNEFKQPG-----------------------------VIDAHLVLHQLHCNGVLEGI----RICRKGFPNRMIYSEFKQRYS---ILAPN----VIPDG---F----------------VDGRQVTEKILEAT----------QLDK--NLYQCGNTKVF--------FKAGT-LAHLEDLRD--*
Dm II            -AEDMSN-LTYLN-DASVLHNLRQRYYN-KLIYTYSGLFCVAINPYKRYP-VYTNR----------------CAKMYR--GKR------------RNEVPPHIFAISDGAYVDMLTNH---------VNQSMLITGESGAGKTENTKKVIAYFATVGASKKT----------------------------------------------------------------------------------------------------------------------------------------DEAAK-----------------------SKGSLEDQVVQ--TN-----PVLEAFGNAKTVRNDNSSRFGKFIRIHFGPT------GKLAGADIETYL-LEKARVIS-QQSLERCYHIFYQIMSGSVPGV-----------------------------------------KEMCFL--SDNIY----------DYYNVSQG----------------------------KVTVPN----------MDDGEEFQLADQAFDILG----FTKQEK-EDVYRITAAVMHMG-GMKFKQR-------GRE-----EQAEQDGE--E--EGGRVSKLFG-CDTAELYKNLLKPRIKVGN--------EFVTQGRNVQQVTNSIGALCKGVFDRLFKWL---------------------------VKKCNETLDTQ---------QKR---------QHFIGVLDIAGFEIFE------YNGFEQLCINFTNEKLQQF-FNHHMFVLEQEEYKREGID--WAFID-FGMDLLACIDLIE-----------------------------------KPM---GILSILEEESMFP----------------KATDQTFSEKLTNTHL-GK-----SAPFQKP-KPPKP-------GQQAAHFAIAHYA--GCVSYNITGWLE-KNKDPLNDTVVDQFKKSQ-----------------NKLLIEIFADHAG----------------Q-SGGG-------E-QAKGG--------------------------------------------------------------------------------------------------------------------------------------------------------RGKKGGGFATVSSAYK-----------------------EQLNSLMTTLR--STQPHFVRCIIPNEMKQPG-----------------------------VVDAHLVMHQLTCNGVLEGI----RICRKGFPNRMMYPDFKMRYQ---ILNPA----GIVG----V----------------DDPKKCGSIILEST----------ALDP--DMYRIGHTKVF--------FRAGV-LGQMEEFRD--*
Ce IIB           -TEDMSN-LSFLN-DASVLHNLRSRYAA-MLIYTYSGLFCVVINPYKRLP-IYTDS----------------CARMFM--GKR------------KTEMPPHLFAVSDEAYRNMLQDH---------ENQSMLITGESGAGKTENTKKVICYFAAVGASQQEGG--------------------------------------------------------------------------------------------------------------------------------------AEVDP--N-------------------KKKVTLEDQIVQ--TN-----PVLEAFGNAKTVRNNNSSRFGKFIRIHFNKH------GRLASCDIEHYL-LEKSRVIR-QAPGERCYHIFYQIYSDFRPEL-----------------------------------------KKELLL--DLPIK----------DYWFVAQA----------------------------ELIIDG----------IDDVEEFQLTDEAFDILN----FSAVEK-QDCYRLMSAHMHMG-NMKFKQR-------PRE-----EQAEPDGT--V--EAEKASNMYG-IGCEEFLKALTKPRVKVGT--------EWVSKGQNCEQVNWAVGAMAKGLYSRVFNWL---------------------------VKKCNLTLDQKG--------IDR---------DYFIGVLDIAGFEIFD------FNSFEQLWINFVNEKLQQF-FNHHMFVLEQEEYAREGIQ--WVFID-FGLDLQACIELIE-----------------------------------KPL---GIISMLDEECIVP----------------KATDLTLASKLVDQHL-GK-----HPNFEKP-KPPKG-------KQGEAHFAMRHYA--GTVRYNCLNWLE-KNKDPLNDTVVSAMKQSKG----------------NDLLVEIWQDYTT----------------QEEAAAK------A-KEGGGGG-----------------------------------------------------------------------------------------------------------------------------------------------------KKKGKSGSFMTVSMLYR-----------------------ESLNNLMTMLN--KTHPHFIRCIIPNEKKQSG-----------------------------MIDAALVLNQLTCNGVLEGI----RICRKGFPNRTLHPDFVQRYA---ILAAK----EAKS----D----------------DDKKKCAEAIMSKLVNDG------SLSE--EMFRIGLTKVF--------FKAGV-LAHLEDIRD--*
Ce IID           -TEDMSN-LTFLN-DASVLWNLRSRYAA-MLIYTYSGLFCVVINPYKRLP-IYTDS----------------VARMFM--GKR------------RTEMPPHLFAVSDQAYRYMLQDH---------ENQSMLITGESGAGKTENTKKVICYFATVGASQK-----------------------------------------------------------------------------------------------------------------------------------------AALKE--G-------------------EKEVTLEDQIVQ--TN-----PVLEAFGNAKTVRNNNSSRFGKFIRIHFNKH------GTLASCDIEHYL-LEKSRVIR-QAPGERCYHIFYQIYSDFKPQL-----------------------------------------RDELLL--NHPIS----------NYWFVAQA----------------------------ELLIDG----------IDDTEEFQLTDEAFDVLK----FSPTEK-MDCYRLMSAHMHMG-NMKFKQR-------PRE-----EQAEPDGQ--V--EAERACNMYG-IDVVQFLKALVSPRVKVGT--------EWVSKGQNVDQVHWAIGAMAKGLYARVFHWL---------------------------VKKCNLTLDQKG--------IDR---------DYFIGVLDIAGFEIFD------FNSFEQLWINFVNEKLQQF-FNHHMFVLEQEEYAREGIQ--WTFID-FGLDLQACIELIE-----------------------------------KPL---GIISMLDEECIVP----------------KATDMTLAQKLTDQHL-GK-----HPNFEKP-KPPKG-------KQGEAHLAMRHYA--GTVRYNVLNWLE-KNKDPLNDTVVSVMKASKK----------------NDLLVEIWQDYTT----------------QEEAAAA------A-KAGGG-------------------------------------------------------------------------------------------------------------------------------------------------------RKGGKSGSFMTVSMMYR-----------------------ESLNKLMTMLH--KTHPHFIRCIIPIEKKQSG-----------------------------MIDAALVLNQLTCNGVLEGI----RICRKGFPNRTQHPDFVQRYA---ILAAK----EAKS----S----------------DDMKTCAGAILQALINQK------QLND--EQFRIGHTKVF--------FKAGV-VAHIEDLRD--*
Ov II            -TEDMSN-LTFLN-DASVLYNLRSRYSA-MLIYTYSGLFCVVINPYKRLP-IYTNS----------------VATMYM--GKR------------RTEMPPHLFAVSDEAYRNMLVDH---------ENQSMLITGESGAGKTENTKKVIAYFAVVGASQN-----------------------------------------------------------------------------------------------------------------------------------------KGQDQ--G-------------------EKKVTLEDQIVQ--TN-----PVLEAFGNAKTVRNNNSSRFGKFIRIHFSKQ------GKVASCDIEHYL-LEKSRVIR-QAPGERCYHIFYQVFSDFNPTL-----------------------------------------KKDLLL--DQPLK----------NYYFVAQA----------------------------ELTIDG----------VNDKEEHQLTDEAFDILN----FSPEEK-MNCYRLVAAIMHMG-CMKFKQR-------PRE-----EQAEPDGT--D--EADKASNMYG-IDTEEFLKALTKPRVKVGT--------EWVSKGQNVDQVTWDVGAMANLLYDRIFKWL---------------------------VTKCNKTLDQKG--------LTR---------DYFIGVLDIAGFEIFD------FNSFEQLWINFVNEKLQQF-FNHHMFVLEQEEYEREGIQ--WTFID-FGLDLQACIELIE-----------------------------------KPM---GIISMLDEECIVP----------------KATDLTLAQKLVDTHL-GK-----HPNFEKP-KPPKG-------KQSEAHFAMKHYA--GTVRYNVMNWLE-KNKDPLNDTVVSVMKQSKA----------------NDLLVEIWKDYTT----------------QEESAAA------K-DGGGG-------------------------------------------------------------------------------------------------------------------------------------------------------KKKGKSGSFLTVSMMYR-----------------------ESLNSLMSMLN--MTHPHFIRCIIPNHNKTSG-----------------------------LLHRRMVLNQLTCNGVLEGI----RICRKGFPNRNLHADFKQRYA---VLAAK----EAKS----E----------------DDPKKCAEVMLSKLVNDG------ALTE--ENFRLGKTKVF--------FKAGV-LAHLEDQRD--*
Bm II            -TEDMSN-LTFLN-DASVLYNLRSRYSS-MLIYTYSGLFCVVINPYKRLP-IYTDS----------------VATMYM--GKR------------RTEMPPHLFAVSDEAYRNMLVDH---------ENQSMLITGESGAGKTENTKKVIAYFAVVGASQN-----------------------------------------------------------------------------------------------------------------------------------------K--NQ--G-------------------EKKVTLEDQIVQ--TN-----PVLEAFGNAKTVRNNNSSRFGKFIRIHFSRQ------GKVASCDIEHYL-LEKSRVIR-QAPGERCYHIFYQIFSEFNPTL-----------------------------------------KKELQL--DQPLK----------NYYFVAQA----------------------------ELTIDG----------VNDKEEHQLTDEAFDILN----FSPEEK-MNCYRLVAAIMHMG-CMKFKQR-------PRE-----EQAEPDGT--D--EAEKASAMYG-IDTEEFLKALTKPRVKVGT--------EWVSKGQNVDQVTWAVGAMAKGLYARIFKWL---------------------------VNKCNKTLDQKG--------ISR---------DYFIGVLDIAGFEIFD------FNSFEQLWINFVNEKLQQF-FNHHMFVLEQEEYEREGIQ--WTFID-FGLDLQACIELIE-----------------------------------KPM---GIISMLDEECIVP----------------KATDLTLAQKLVDNHL-GK-----HPNFEKP-KPPKG-------KQSERHFAMKHYA--GTVRYNVMNWLE-KNKDPLNDTVVSTMKASKT----------------NDLLVEIWQDYTT----------------QEERAAA------K-DGGGG-------------------------------------------------------------------------------------------------------------------------------------------------------KKKGKSGSFLTVSMMYR-----------------------ESLNSLMSMLN--MTHPHFIRCIIPNEKKTSG-----------------------------LLDAALVLNQLTCNGALEGI----RICRKGFPNRNLHADFKQRYA---VLAAK----EAKS----E----------------DDPKKSAEVMLSKLVNDG------ALTE--ENFRLGKTKVF--------FKAGV-LAHLEDLRD--*
Ce IIC           -TEDMSN-LTFLN-DASVLYNLKARYAA-MLIYTYSGLFCVVINPYKRLP-IYTES----------------VARMFM--GKR------------RTEMPPHLFAVSDEAYRNMLQNH---------ENQSMLITGESGAGKTENTKKVISYFAAVGAAQQETFGAK-------KAA-------------------------------------------------------------------------------------------------------------------------TEEDK--N-------------------KKKVTLEDQIVQ--TN-----PVLEAFGNAKTVRNNNSSRFGKFIRIHFSKQ------GRVASCDIEHYL-LEKSRVIR-QAPGERSYHIFYQVFSDYLPNL-----------------------------------------KKDLLL--NKPVK----------DYWFIAQA----------------------------ELIIDG----------INDKEEHQLTDEAFDILK----FTPTEK-MECYRLVAAMMHMG-NMKFKQR-------PRE-----EQAEPDGT--D--DAERAAKCFG-IDSEEFLKALTRPRVKVGN--------EWVNKGQKIEQVNWAVGAMAKGLYSRIFNWL---------------------------VKKCNQTLDQKG--------ISR---------DHFIGVLDIAGFEIFD------FNSFEQLWINFVNEKLQQF-FNHHMFVLEQEEYAREGIQ--WTFID-FGLDLQACIELIE-----------------------------------KPL---GIIAMLDEECIVP----------------KATDLTLAQKLIDQHL-GK-----HPNFEKP-KPPKG-------KQAEAHFAMRHYA--GTVRYNCLNWLE-KNKDPLNDTVVTVMKASKE----------------HALIVEVWQDYTT----------------QEEAAAA------A-AKGTAGA-----------------------------------------------------------------------------------------------------------------------------------------------------KKKGKSGSFMTVSMLYR-----------------------ESLNKLMTMLH--STHPHFIRCIIPNEKKASG-----------------------------VIDAGLVLNQLTCNGVLEGI----RICRKGFPNRTLHPDFVQRYA---LLAAD----ESIIG---K----------------TDAKKGSALMLARLVKEK------KLEE--ENFRVGLTKVF--------FKAGI-VAHLEDLRD--*
Ce F58G4.1       -TEDMAN-LTFLN-DASVLHNLRQRYYS-MMIYTYSGLFCVVINPYKRLP-IYSES----------------VCQMYL--GKR------------RNEMPPHLFAVSDEAYRNMTNDR---------ENQSMLITGESGAGKTENTKKVISYFAMVGASQQSNK--------------------------------------------------------------------------------------------------------------------------------------KKSKK--D-------------------KAQVSLEDQIVQ--TN-----PVLEAFGNAKTVRNNNSSRFGKFIRIHFNTG------GKVAGADIEHYL-LEKSRVIK-QAPGERSYHIFYQIYSDAVKGL-----------------------------------------REKLFL--TRPIK----------EYTFVSQA----------------------------EVTIDG----------VDDKEEMLITDEAFDIMK----FTATEK-SELFAITAGIMHMG-ELKFKQR-------PRE-----EQAELEEG--K--EGELACKLYC-VESEKFINALLKPRVKVGT--------EWVNKGQNLDQVNWAVGALAKALFARMFSWL---------------------------IRRCNKTLDAQD--------LSR---------DFFIGVLDIAGFEIFD------LNSFEQLWINFVNEKLQQF-FNHHMFVLEQEEYKREGIQ--WEFID-FGLDLQACIELIE-----------------------------------KPL---GIVSMLDEECIVP----------------KASDLTLASKLNDQHL-GK-----HPNFQKP-RPPKG-------KQAEAHLAIVHYA--GTVRYNVKGWLE-KNKDPLNDTAVTVLKANKG----------------NQLMADLWADYAT----------------QEDVAAA------A-KDGKKAVG----------------------------------------------------------------------------------------------------------------------------------------------------KKKGKSASFMTVSMMYR-----------------------ESLNKLMHMLH--QTHPHFIRCIIPNELKKAG-----------------------------MIDANLVLNQLTCNGVLEGI----RICRKGFPNRMPFLDFKQRYA---VLAAD----AAKA----G----------------KDPKDAGEKISAALIKDG------SLKQ--EEFQCGLTKVF--------FKAGV-LAHLEELRD--*
Ce IIA           -TEDMAN-LTFLN-EASVLGNLKDRYKD-LMIYTYSGLFCVVINPYKRLP-IYSES----------------VIKHFM--GKR------------RNEMPPHLFAVSDEAYRNMVQDK---------ENQSMLITGESGAGKTENTKKVISYFAIVGATQAASG--------------------------------------------------------------------------------------------------------------------------------------KEAKD--G-------------------KKGGTLEEQIVQ--TN-----PVLEAFGNAKTVRNNNSSRFGKFIRTHFSGS------GKLAGGDIEHYL-LEKSRVVR-QAPGERCYHIFYQIMSGNDPSL-----------------------------------------RGKLKL--SNDIT----------YYHFCSQA----------------------------ELTIEG----------MDDKEEMRLTQEAFDIMG----FEDNET-MDLYRSTAGIMHMG-EMKFKQR-------PRE-----EQAEPDGE--E--DALNAAAMLG-IQAEEFLKALTKPRVRVGT--------EWVNKGQNLEQVNWAVSGLAKAIYARMFKWI---------------------------ITRCNKTLDAKE--------IER---------KHFIGVLDIAGFEIFD------LNSFEQLWINFVNERLQQF-FNHHMFVLEQEEYKREGIA--WTFID-FGLDLQACIELIE-----------------------------------KPL---GIISILDEECIVP----------------KATDMTYAQKLLDQHL-GK-----HPNFQKP-KPPKG-------KQGDAHFAIVHYA--GTVRYNATNFLE-KNKDPLNDTAVALLKHSTD----------------NSLMLDIWQDYQT----------------QEEAAEA------A-KAGQTAG-----------------------------------------------------------------------------------------------------------------------------------------------------GKRGKSSSFATVSMIYR-----------------------ESLNNLMNMLY--QTHPHFIRCIIPNEKKASG-----------------------------VIDSALVLNQLTCNGVLEGI----RICRKGFPNRMLYPDFKHRYA---ILAAD----AAKE---------------------SDPKKASVGILDKISVDG------NLTD--EEFKVGETKIF--------FKAGV-LAKLEDLRD--*
Ce F45G2.2       -TEDMSN-LTFLN-EASVLHNLRQRYYS-MMIYTYSGLFCVFINPYKMLP-IYTDS----------------VASMYV--NKR------------RAEMPPHLFAVSDEAFRNMMSDK---------ENQSMLITGESGAGKTENTKKVIAYFAMIGSGNK--------------------------------------------------------------------------------------------------------------------------------------------D---Q-------------------KSESSLENQVVQ--AN-----PAIEAFGNGATTRNYNSSRYGKFIRIHFDRK------GKLVGGDIEHYL-LEKSRVIK-QAPGERSYHIFYQIMT--QKAL-----------------------------------------RERYGL--SDNIR----------DYKFVSQA----------------------------EITVPG----------MNDTEEWQITDGAFNVMG----FSEREK-DDLYKLCSAIMHIG-NSTFKQK-------PRD-----EQAEVDDM--T--SPTAACKLFG-INTDQFLNALTRPRIKVGM--------EWVNKGQNVQQVDWAVGALSKAIYARMFNWL---------------------------IKRVNKTLQANS--------DEM---------VYYIGVLDIAGFEIFD------RNSFEQLWINFVNEKLQQF-FNHHMFVLEQEEYQREGIE--WTFID-FGLDLQSCIELIE-----------------------------------KPL---GIVSMLDEECIVP----------------KASDMTYVDKLLTQHL-GK-----HPNFQKA-KPPKG-------KQAEAHFSIMHYA--GTVRYNAEQWLD-KNKDPLNDSAVAILKTSDK----------------EGVLYQLWEEYQT----------------DVDREES------E-KRGKAQA-----------------------------------------------------------------------------------------------------------------------------------------------------KKKGKSASFLTVSTMYR-----------------------ESLTSLMTMLH--TTHPHFIRCIIPNEKKTSG-----------------------------LIDAPLVLNQLTCNGVLEGI----RICRKGFPNRMMFADFRFRYA---ILAAD----EASD---------------------KDAAKASKAMLRKLSKNN------QLNV--DTFKVGTTKFR--------LDIPM-REHSVN-----*
Gg smII          -VEDMAE-LTCLN-EASVLHNLRERYFS-GLIYTYSGLFCVVINPYKQLP-IYSEK----------------IIDMYK--GKK------------RHEMPPHIYAIADTAYRSMLQDR---------EDQSILCTGESGAGKTENTKKVIQYLAVVASSHKG----------------------------------------------------------------------------------------------------------------------------------------KRTPASL----------------KVHLFPYGELEKQLLQ--AN-----PILEAFGNAKTVKNDNSSRFGKFIRINFDVT------GYIVGANIETYL-LEKSRAIR-QAKDERTFHIFYYLIAGASEQM-----------------------------------------RNDLLL--EG-FN----------NYTFLSNG----------------------------HVPIPA----------QQDDEMFQETLEAMTIMG----FTEEEQ-TSILRVVSSVLQLG-NIVFKKE-------RNT-----DQASMPDN--T--AAQKVCHLMG-INVTDFTRSILTPRIKVGR--------DVVQKAQTKEQADFAIEALAKAKFERLFRWI---------------------------LTRVNKALDKTK--------RQG---------ASFLGILDIAGFEIFE------INSFEQLCINYTNEKLQQL-FNHTMFILEQEEYQREGIE--WNFID-FGLDLQPCIELIE-----------------------------------RPTNPPGVLALLDEECWFP----------------KATDTSFVEKLIQEQ--GN-----HAKFQKS-KQLK----------DKTEFCILHYA--GKVTYNASAWLT-KNMDPLNDNVTSLLNQSS-----------------DKFVADLWKDVDR----------------IVGLDQM------AKMTESSLPS----------------------------------------------------------------------------------------------------------------------------------------------------ASKTKKGMFRTVGQLYK-----------------------EQLTKLMTTLR--NTNPNFVRCIIPNHEKRAG-----------------------------KLDAHLVLEQLRCNGVLEGI----RICRQGFPNRIVFQEFRQRYE---ILAAN----AIPKG---F----------------MDGKQACILMIKAL----------ELDP--NLYRIGQSKIF--------FRTGV-LAHLEEERD--*
Oc smII          -VEDMAE-LTCLN-EASVLHNLRERYFS-GLIYTYSGLFCVVVNPYKQLP-IYSEK----------------IVDMYK--GKK------------RHEMPPHIYAIADTAYRSMLQDR---------EDQSILCTGESGAGKTENTKKVIQYLAVVASSHKG----------------------------------------------------------------------------------------------------------------------------------------KKDTS-----------------------ITGELEKQLLQ--AN-----PILEAFGNAKTVKNDNSSRFGKFIRINFDVT------GYIVGANIETYL-LEKSRAIR-QAREERTFHIFYYLIAGAKEKM-----------------------------------------RNDLLL--EG-FN----------NYTFLSNG----------------------------FVPIPA----------AQDDEMFQEKVEAMSIMG----FSEEEQ-LSVLKVVSSVLQLG-NIVFKKE-------RNT-----DQASMPDN--T--AAQKVCHLMG-INVTDFTRSILTPRIKVGR--------DVVQKAQTKEQADFAVEALAKATYERLFRWI---------------------------LSRVNKALDKTH--------RQG---------ASFLGILDIAGFEIFE------VNSFEQLCINYTNEKLQQL-FNHTMFILEQEEYQREGIE--WNFID-FGLDLQPCIELIE-----------------------------------RPNNPPGVLALLDEECWFP----------------KATDKSFVEKLCTEQ--GN-----HPKFQKP-KQLK----------DKTEFSIIHYA--GKVDYNASAWLT-KNMDPLNDNVTSLLNASS-----------------DKFVADLWKDVDR----------------IVGLDQM------AKMTESSLPS----------------------------------------------------------------------------------------------------------------------------------------------------ASKTKKGMFRTVGQLYK-----------------------EQLGKLMTTLR--NTTPNFVRCIIPNHEKRSG-----------------------------KLDAFLVLEQLRCNGVLEGI----RICRQGFPNRIVFQEFRQRYE---ILAAN----AIPKG---F----------------MDGKQACILMIKAL----------ELDP--NLYRIGQSKIF--------FRTGV-LAHLEEERD--*
Gg nmII          -VEDMAE-LTCLN-EASVLHNLKERYYS-GLIYTYSGLFCVVINPYKNLP-IYSEE----------------IVEMYK--GKK------------RHEMPPHIYAITDTAYRSMMQDR---------EDQSILCTGESGAGKTENTKKVIQYLAHVASSHKS----------------------------------------------------------------------------------------------------------------------------------------KKDQ--------------------------GELERQLLQ--AN-----PILEAFGNAKTVKNDNSSRFGKFIRINFDVN------GYIVGANIETYL-LEKSRAIR-QAKEERTFHIFYYLLSGAGEHL-----------------------------------------KTDLLL--EP-YN----------KYRFLSNG----------------------------HVTIPG----------QQDKDMFQETMEAMRIMG----IPDEEQ-IGLLKVISGVLQLG-NIVFKKE-------RNT-----DQASMPDN--T--AAQKVSHLLG-INVTDFTRGILTPRIKVGR--------DYVQKAQTKEQADFAIEALAKATYEQMFRWL---------------------------VMRINKALDKTK--------RQG---------ASFIGILDIAGFEIFE------LNSFEQLCINYTNEKLQQL-FNHTMFILEQEEYQNEGIE--WNFID-FGLDLQPCIDLIE-----------------------------------KPAGPPGILALLDEECWFP----------------KATDKSFVEKVVQEQ--GT-----HPKFQKP-KQLK----------DKADFCIIHYA--GKVDYKADEWLM-KNMDPLNDNIATLLHQSS-----------------DKFVSELWKDVDR----------------IVGLDQV------AGMSETALPG----------------------------------------------------------------------------------------------------------------------------------------------------AFKTRKGMFRTVGQLYK-----------------------EQLAKLMATLR--NTNPNFVRCIIPNHEKKAG-----------------------------KLDPHLVLDQLRCNGVLEGI----RICRQGFPNRVVFQEFRQRYE---ILTPN----AIPKG---F----------------MDGKQACVLMIKAL----------ELDS--NLYRIGQSKVF--------FRAGV-LAHLEEERD--*
Hs nmIIA         -VEDMAE-LTCLN-EASVLHNLKERYYS-GLIYTYSGLFCVVINPYKNLP-IYSEE----------------IVEMYK--GKK------------RHEMPPHIYAITDTAYRSMMQDR---------EDQSILCTGESGAGKTENTKKVIQYLAYVASSHKS----------------------------------------------------------------------------------------------------------------------------------------KKDQ--------------------------GELERQLLQ--AN-----PILEAFGNAKTVKNDNSSRFGKFIRINFDVN------GYIVGANIETYL-LEKSRAIR-QAKEERTFHIFYYLLSGAGEHL-----------------------------------------KTDLLL--EP-YN----------KYRFLSNG----------------------------HVTIPG----------QQDKDMFQETMEAMRIMG----IPEEEQ-MGLLRVISGVLQLG-NIVFKKE-------RNT-----DQASMPDN--T--AAQKVSHLLG-INVTDFTRGILTPRIKVGR--------DYVQKAQTKEQADFAIEALAKATYERMFRWL---------------------------VLRINKALDKTK--------RQG---------ASFIGILDIAGFEIFD------LNSFEQLCINYTNEKLQQL-FNHTMFILEQEEYQREGIE--WNFID-FGLDLQPCIDLIE-----------------------------------KPAGPPGILALLDEECWFP----------------KATDKSFVEKVMQEQ--GT-----HPKFQKP-KQLK----------DKADFCIIHYA--GKVDYKADEWLM-KNMDPLNDNIATLLHQSS-----------------DKFVSELWKDVDR----------------IIGLDQV------AGMSETALPG----------------------------------------------------------------------------------------------------------------------------------------------------AFKTRKGMFRTVGQLYK-----------------------EQLAKLMATLR--NTNPNFVRCIIPNHEKKAG-----------------------------KLDPHLVLDQLRCNGVLEGI----RICRQGFPNRVVFQEFRQRYE---ILTPN----SIPKG---F----------------MDGKQACVLMIKAL----------ELDS--NLYRIGQSKVF--------FRAGV-LAHLEEERD--*
Rn neurII        -VEDMAE-LTCLN-EASVLHNLKERYYS-GLIYTYSGLFCVVINPYKNLP-IYSEE----------------IVEMYK--GKK------------RHEMPPHIYAITDTAYRSMMQDR---------EDQSILCTGESGAGKTENTKKVIQYLAHVASSHKS----------------------------------------------------------------------------------------------------------------------------------------KKDQ--------------------------GELERQLLQ--AN-----PILEAFGNAKTVKNDNSSRFGKFIRINFDVN------GYIVGANIETYL-LEKSRAIR-QAKEERTFHIFYYLLSGAGEHL-----------------------------------------KTDLLL--EP-YG----------KYRFLSNG----------------------------HVTIPG----------QQDKDMFQETMEAMRIMG----IPDEEQ-IGLLKVISGVLQLG-NIVFKKE-------RNT-----DQASMPDN--T--AAQKVSHLLG-INVTDFTRGILTPRIKVGR--------DYVQKAQTKEQADFAIEALAKATYEQMFRWL---------------------------VMRINKALDKTK--------RQG---------ASFIGILDIAGFEIFE------LNSFEQLCINYTNEKLQQL-FNHTMFIE-QEEYQREGIE--WNFID-FGLDLQPCIDLIE-----------------------------------RPANPPGVLALLDEECWFP----------------KATDKTFVEKLVQEQ--GT-----HSKFQKP-RQLK----------DKADFCIIHYA--GKVDYKGDEWLM-KNMDPLNDNVATLLHQSS-----------------DKFVAELWKDVDR----------------IVGLDQV------TGITETAFGS----------------------------------------------------------------------------------------------------------------------------------------------------AYKTKKGMFRTVGQLYK-----------------------ESLTKLMATLR--NTNPNFVRCIIPNHEKRAG-----------------------------KLDPHLVLDQLRCNGVLEGI----RICRQGFPNRIVFQEFRQRYE---ILTPN----AIPKG---F----------------MDGKQACERMIRAL----------ELDP--NLYRIGQSKIF--------FRAGV-LAHLEEERD--*
Hs nmIIB         -VEDMAE-LTCLN-EASVLHNLKDRYYS-GLIYTYSGLFCVVINPYKNLP-IYSEN----------------IIEMYR--GKK------------RHEMPPHIYAISESAYRCMLQDR---------EDQSILCTGESGAGKTENTKKVIQYLAHVASSHKG----------------------------------------------------------------------------------------------------------------------------------------RKDHNIP-----------------------GELERQLLQ--AN-----PILESFGNAKTVKNDNSSRFGKFIRINFDVT------GYIVGANIETYL-LEKSRAVR-QAKDERTFHIFYQLLSGAGEHL-----------------------------------------KSDLLL--EG-FN----------NYRFLSNG----------------------------YIPIPG----------QQDKDNFQETMEAMHIMG----FSHEEI-LSMLKVVSSVLQFG-NISFKKE-------RNT-----DQASMPEN--T--VAQKLCHLLG-MNVMEFTRAILTPRIKVGR--------DYVQKAQTKEQADFAVEALAKATYERLFRWL---------------------------VHRINKALDRTK--------RQG---------ASFIGILDIAGFEIFE------LNSFEQLCINYTNEKLQQL-FNHTMFILEQEEYQREGIE--WNFID-FGLDLQPCIDLIE-----------------------------------RPANPPGVLALLDEECWFP----------------KATDKTFVEKLVQEQ--GS-----HSKFQKP-RQLK----------DKADFCIIHYA--GKVDYKADEWLM-KNMDPLNDNVATLLHQSS-----------------DRFVAELWKDVDR----------------IVGLDQV------TGMTETAFGS----------------------------------------------------------------------------------------------------------------------------------------------------AYKTKKGMFRTVGQLYK-----------------------ESLTKLMATLR--NTNPNFVRCIIPNHEKRAG-----------------------------KLDPHLVLDQLRCNGVLEGI----RICRQGFPNRIVFQEFRQRYE---ILTPN----AIPKG---F----------------MDGKQACERMIRAL----------ELDP--NLYRIGQSKIF--------FRAGV-LAHLEEERD--*
Xl nmII          -VEDMAE-LTCLN-EASVLHNLKDRYYS-GLIYTYSGLFCVVINPYKNLP-IYSEN----------------IIEMYR--GKK------------RHEMPPHIYAISESAYRCMLQDR---------EDQSILCTGESGAGKTENTKKVIQYLAHVASSHKG----------------------------------------------------------------------------------------------------------------------------------------KKDHTIPTESPKAIKH-------QSGSLLYGELERQLLQ--AN-----PILESFGNAKTVKNDNSSRFGKFIRINFDVT------GYIVGANIETYL-LEKSRAVR-QAKDERTFHIFYQLLAGSGEHL-----------------------------------------KSDLLL--DG-FN----------NYRFVSNG----------------------------YIPIPG----------QQDKDNFQETMEAMHIMG----FSHEEI-LSMLKVVSSVLQFG-NIVFKKE-------RNT-----DQASMPEN--T--AAQKLCHLLG-LNIMEFTRAILTPRIKVGR--------DYVQKAQTKEQADFAVEALRKATYERLFRWL---------------------------VYRINKALDRTK--------RQG---------ASFIGILDIAGFEIFE------LNSFEQLCINYTNEKLQQL-FNHTMFILEQEEYQREGIE--WNFID-FGLDLQPCIDLIE-----------------------------------RPANSPGVLALLDEECWFP----------------KATDKTFVDKLVQEQ--GT-----HSKFQKP-RQLK----------DKADFCIIHYA--GRVDYKADEWLL-KNMDPLNDNVATLLHQSS-----------------DKFVSELWKDVDR----------------IVGLDQV------AGMAETAFGA----------------------------------------------------------------------------------------------------------------------------------------------------AYKTKKGMFRTVGQLYK-----------------------ESLAKLMATLR--NTNPNFVRCIIPNHEKRAG-----------------------------KLDPHLVLDQLRCNGVLEGI----RICRQGFPNRIVFQEFRQRYE---ILTPN----SIPRG---F----------------MDGKQACERMIRSL----------ELDP--NLYRIGQSKIF--------FRAGV-LAHLEEERD--*
Dm nmII          -VEDMAE-LTCLN-EASVLHNIKDRYYS-GLIYTYSGLFCVVVNPYKKLP-IYTEK----------------IMERYK--GIK------------RHEVPPHVFAITDSAYRNMLGDR---------EDQSILCTGESGAGKTENTKKVIQFLAYVAASKPK----------------------------------------------------------------------------------------------------------------------------------------GSGAVPHP------------------AVLIGELEQQLLQ--AN-----PILEAFGNAKTVKNDNSSRFGKFIRINFDAS------GFISGANIETYL-LEKSRAIR-QAKDERTFHIFYQLLAGATPEQ-----------------------------------------REKFIL--DD-VK----------SYAFLSNG----------------------------SLPVPG----------VDDYAEFQATVKSMNIMG----MTSEDF-NSIFRIVSAVLLFG-SMKFRQE-------RNN-----DQATLPDN--T--VAQKIAHLLG-LSVTDMTRAFLTPRIKVGR--------DFVTKAQTKEQVEFAVEAIAKACYERMFKWL---------------------------VNRINRSLDRTK--------RQG---------ASFIGILDMAGFEIFE------LNSFEQLCINYTNEKLQQL-FNHTMFILEQEEYQREGIE--WKFID-FGLDLQPTIDLID-----------------------------------KPG---GIMALLDEECWFP----------------KATDKTFVDKLVSAH--SM-----HPKFMKT--DFR----------GVADFAIVHYA--GRVDYSAAKWLM-KNMDPLNENIVSLLQGSQ-----------------DPFVVNIWKDAE-----------------IVGMAQQ------A-LTDTQFG------------------------------------------------------------------------------------------------------------------------------------------------------ARTRKGMFRTVSHLYK-----------------------EQLAKLMDTLR--NTNPNFVRCIIPNHEKRAG-----------------------------KIDAPLVLDQLRCNGVLEGI----RICRQGFPNRIPFQEFRQRYE---LLTPN----VIPKG---F----------------MDGKKACEKMIQAL----------ELDS--NLYRVGQSKIF--------FRAGV-LAHLEEERD--*
Ce NMY1          -IEDMSE-LTYLN-EASVLHNLKDRYYS-SLIYTYSGLFCVVINPYKKLP-IYSED----------------LIEEFK--GKK------------RHEMPPHIFAIADTAYRSMLQER---------EDQSILCTGESGAGKTENTKKVIQYLAHVAGATRN----------------------------------------------------------------------------------------------------------------------------------------KSLNAAAQQN----------------IVQKGELEHQLLQ--AN-----PILEAFGNSKTVKNDNSSRFGKFIRINFDMS------GYISGANIEFYL-LEKSRVLR-QAQDERSFHIFYQILRGCSAKE-----------------------------------------KSEYLL--EG-VD----------NYRFLVNR----------------------------GITLPN----------VDDVQEFHSTINSMRIMG----FADDEI-SSIMRVVSAVLLLG-NLEFTQE-------KKS-----DQAMLQDD--R--VIQKVCHLLG-LPVIELQKAFLRPRIKVGR--------EFVNKAQNQEQAEFAVEAIAKASYERLFKWL---------------------------VTRINKSLDRTH--------RQG---------ASFIGILDIAGFEIFD------INSFEQICINYTNEKLQQL-FNNTMFILEQEEYQREGIE--WDFID-FGLDLQPTIDLIE-----------------------------------KPM---GVLALLDEECLFP----------------KANDKSFVEKLQKTH--NK-----HPKFIVP--DMR----------SKSHFAVVHYA--GRVDYSADQWLM-KNMDPLNENVVGLMQNST-----------------DPFVAGIWKDAE-----------------FAGICAA------E-MNETAFG------------------------------------------------------------------------------------------------------------------------------------------------------MRSRKGMFRTVSQLHK-----------------------EQLTKLMTTLR--NTSPHFVRCIIPNHEKKSG-----------------------------KINSNLVLEQLRCNGVLEGI----RICRQGFPNRVPFQEFRHRYE---ILTPD----VIPKN---F----------------IDGKESVRKMITAL----------DIDT--NLYRIGQSKVF--------FRTGV-LAHLEEERD--*
Ce NMY2          -CEDMSM-LTCLN-EASVLHNLKQRYFS-NLYYTYSGLFCVVINPYKRIP-IYTDT----------------IAEQFK--CKK------------RKEMPPHIFAVADEAYRSMLQER---------DDQSILCTGESGAGKTENTKKVIQYLAYVANRSMV----------------------------------------------------------------------------------------------------------------------------------------KNRKTSVDLDTSTN-------------RIMGQLEEQLLQ--AN-----PILEAFGNSKTVKNDNSSRFGKFIRVHFDST------GCISGANIEFYL-LEKSRVLK-QAPNERSFHIFYQLLKGLSKVQ-----------------------------------------REHYLL--EDSLS----------KYKFVSNG----------------------------DSKLAG----------VDDGAEMKETLNAMSIMG----LNDEEI-GGILRVVSAVMLFG-NLEFSHEN------KNN-----DQAVLLND--A--VAQKIASLLG-VNVTELMRAFLKPKIKVQR--------DLVHRAQSVDQVNFSVGAIAKASYERLFRWL---------------------------VHRLNKSLDRTR--------QQS---------VSFIGILDIAGFEIFE------TNSFEQLCINYTNEKLQQL-FNNTMFVREQQEYLDEGLE--WKFLD-FGLNLQPTIDLID-----------------------------------KPM---GIMSTLDDVCLFP----------------QGNDQSFVQRLNNTH--SQ-----HPKYVVP--EIR----------SRSDFAVVHYA--GRVDYQSEGWRV-KNMDPLNENVIDVLKTSK-----------------ESLIVDMWKDIAD----------------VCSLSAA------DSTSDTGVFG----------------------------------------------------------------------------------------------------------------------------------------------------SRVPKKGMFRTVSQLYK-----------------------EQLARLMSTLN--NTNPHFVRCIIPNHEKKHG-----------------------------VLNAHLVLDQLRCNGVLEGI----RICRQGFPTRLPFQEFRQRYEK--LLAPD----VNPAG---F----------------MDGKNAVYRIVQYL----------EVDA--NLFRIGQSKIF--------FRSGV-IAEFEEMRD--*
Dd II            -VEDMSE-LSYLN-EPAVFHNLRVRYNQ-DLIYTYSGLFLVAVNPFKRIP-IYTQE----------------MVDIFK--GRR------------RNEVAPHIFAISDVAYRSMLDDR---------QNQSLLITGESGAGKTENTKKVIQYLASVAGRNQAN-------------------------------------------------------------------------------------------------------------------------------------------------------------------GSGVLEQQILQ--AN-----PILEAFGNAKTTRNNNSSRFGKFIEIQFNNA------GFISGASIQSYL-LEKSRVVF-QSETERNYHIFYQLLAGATAEE-----------------------------------------KKALHL--AG-PE----------SFNYLNQS---------------------------GYVDIKG----------VSDSEEFKITRQAMDIVG----FSQEEQ-MSIFKIIAGILHLG-NIKFEKG--------AG-----EGAVLKDK--T--ALNAASTVFG-VNPSVLEKALMEPRILAGR--------DLVAQHLNVEKSSSSRDALVKALYGRLFLWL---------------------------VKKINNVLCQE---------RK----------AYFIGVLDISGFEIFK------VNSFEQLCINYTNEKLQQF-FNHHMFKLEQEEYLKEKIN--WTFID-FGLDSQATIDLIDG---------------------------------RQPP---GILALLDEQSVFP----------------NATDNTLITKLHSHFS-KK-----NAKYEEPRFSKT-------------EFGVTHYA--GQVMYEIQDWLE-KNKDPLQQDLELCFK-DSS----------------DNVVTKLFNDPN-----------------IAS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------RAKKGANFITVAAQYK-----------------------EQLASLMATLE--TTNPHFVRCIIPNNKQLPA-----------------------------KLEDKVVLDQLRCNGVLEGI----RITRKGFPNRIIYADFVKRYY---LLAPN----VPRD----A----------------EDSQKATDAVLKHLN----------IDP--EQYRFGITKIF--------FRAGQ-LARIEEARE--*
Ac II            -VEDMGE-LGYLN-EPAVLHNLKKRYDA-DLFHTYSGLFLVVVNPYKRLP-VYTPE----------------IIDIYR--GRQ------------RDKVAPHIFAISDAAYRAMLNTR---------QNQSMLITGESGAGKTENTKKVIQYLTAIAGRAEG----------------------------------------------------------------------------------------------------------------------------------------------------------------------GLLEQQLLE--FN-----PILEAFGNAKTTKNNNSSRFGKFIELQFNAG------GQITGANTFIYL-LEKSRVTA-QGAGERNFHIFYQILSKAMPEEL----------------------------------------KQKLKL--TK-PE----------DYFFLNQN---------------------------ACYTVDD----------MDDAKEFDHMLKAFDILN----INEEER-LAIFQTISAILHLG-NLPFIDV--------NS-----ETAGLKDE--V--ELNIAAELLG-VSAAGLKAGLLSPRIKAGN--------EWVTRALNKPKAMASRDALCKALFGRLFLWI---------------------------VQKINRILSHK---------DKT---------ALWIGVLDISGFEIFQ------HNSFEQLCINYTNEKLQQF-FNHHMFTLEQQEYEREKID--WTFVD-YGMDSQDCIDLIE----------------------------------KKPM---GILPLLDEQTVFP----------------DADDTSFTKKLFQTHE-N------HRNFRRPRFDAN-------------NFKIVHYA--GEVEYQTSAWLE