A preliminary (pairwise) alignment of all of the full length sequences was made with a modified version of the method of Feng and Doolittle in ClustalW [1]. The sequences were then trimmed to produce a core motor domain. This core motor domain corresponds to residues 88 to 780 of chicken pectoralis muscle myosin II from which the first crystal structure of a myosin head was solved[5]. A second guide alignment with these core motor domain sequences was produced, followed by a final multiple alignment, with correction for multiple substitutions[6]. Optimally, when producing a phylogenetic tree from such an alignment, any positions in the alignment with gaps are excluded. Such a strategy would have excluded half of the data because of the large number of sequences, thus positions with gaps were included. An unrooted phylogenetic tree was constructed and tested for branching order confidence by bootstrapping[7]. Bootstrapping redraws 1000 trees with random samples from the multiple alignment. If the same branches were found at a certain node in >900 out of those 1000 random trees, then that node was accepted as being significant and therefore the branching order at that point in the tree was well supported. (Bootstrapping data).
A colour alignment in HTML is also available (NB 2.2 Mb)
See key below for expansion of organism names and other abbreviations. Where no formal name has been given in prior literature we have used the format: Nn XXA where Nn is the organism's genus and species, XX is the myosin class and A is an identifier given in date order of the gene/protien discovery and publication in the database. To avoid confusion in the plant myosin XI class a hyphen has been added to distinguish the myosin class from the 9th example discovered: At XI-I.
The residue number for Gg FSk (chicken fast skeletal) and the secondary structure assignments as derived from the chicken myosin S1 crystal structure are shown along the top. HC corresponds to Helix C, S1B to strand one of beta-sheet B. Since there are mnore than 26 helices identified the 27th and 28th helices are labelled HA' and HB'.
Tony
Hodge MRC-LMB Cambridge
& Jamie Cope
UC Berkeley
May 2000.
HC S1B S2B HD HE S4B HF HG HH S1C S6B S7B HI HJ HK HL S1D S2D HM HN S4D S3D HO S5B switch II HP HQ HR HS S1E S2E S3E HT HU HV HW S3B HX HY S1F HZ HA' S2F S3F (Long Helix to V826
<-----------> <-> <---> <-----> <---------> <----> <-------------> 25-50 Junction 25-50 Junction 25-50 Junction 25-50 Junction <-----> <-----------> <-> <----> <-------> <----> <-----> <------------> <-------------------> <> <-> <------> <-------> <> <> <--------------------------------------------------------> <----> <--------------------------------> <-------> <-----> <--------------> <--> <--> <--> <-----> <-------> <---> <------------------------------------> <------> <---------> <-----------> <> <------> <------> <---> <---------> Light Chain Binding)
Gg FSk residue # 90 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 600 620 640 660 680 700 720 740 760 780
Dm NinaC III -PEDLAA-LENPV-DENIIESLRHRILM-GESYSFIGDILLSLNSNEIKQ-EFP-QE---------------FHAKYRFKSRSE-----------NQ---PHIFSVADIAYQDMLH---------HKEPQHIVLSGESYSGKSTNARLLIKHLCYLGDGNR--------------------------------------------------------------------------------------------------------------------------------------------------------------------GATGRVESSIK-----------AILMLVNAGTPVNNDSTRCVLQYCLTFGKTG------KMSGAVFNMYM-LEKLRVAT-TDGTQHNFHIFYYFYDFINQQN----------------------------------------QLKEYN---LKADR----------NYRYLRV-----------------------------PPEVPPSKLKYRRDDPEGNVERYREFENILRDID-----FNHKQLETVRKVLAAILNIG-NIRFRQNG------KYA--------EVENT-----DIVSRIAELLRVDEKKFMWSLTNFIMVKGG--------IAERRQYTTEEARDARDAVASTLYSRLVDFI---------------------------INRINMNMSFP---------RAVFG------DTNAIIIHDMFGFECFN------RNGLEQLMINTLNEQMQYH-YNQRIFISEMLEMEAEDIDT-INLN--FYDNKTALDNLLTK-----------------------------------P---DGLFYIIDDASRSCQD-----------------QNLIMDRVSE--------K--HSQFVKKHTAT--------------EISVAHYT--GRIIYDTRAFTD-INRDFVPPEMIETFRSS-----------------LDESIMLMFTNQLTKAGNLTM---PFEAVQHKDESERKSYALNTLSAGC----------------------------------------------------------------------------------------------------------------------------------------------------------ISQVNNLRTLAANFR--------------------FTCLTLLKMLSQNA--NLGVHFVRCIRADLEYKPR-----------------------------SFHSDVVQQQMKALGVLDTV----IARQKGFSSRLPFDEFLRRYQF--LAFDFD-----EPVEM--------------------TKDNCRLLFLRLKMEG--------------WALGKTKVFLR------YYNDEFLARLYE-----*
Lp III -VDDLAF-LDSPT-EEVVLENLEQRYRK-GEIYTFAGDVLLTLNPGKVLP-LYG-DQ---------------TAVKYCERGRSD-----------NP---PHVFAVADRAYQQMLH---------HKSPQAVILSGVSGSGKSFCTHQVIRHLAFLGAQNKE-------------------------------------------------------------------------------------------------------------------------------------------------------------------GMREKLEYLCP-----------LLDTLGNAYTSTNPNSSHFVKILEVTFTKTG------KITGAILFTFL-LEARRLTD-IPKGERNFHVFYYFYEGLRSEG----------------------------------------RLKEFG---LEEK-----------NYRYL--------------------------------PELKSS-------NSPEYVKGYQQFLRALTSLA-----FTEEEIFAIQKVLAAILLLG-ETEIQN---------------------S-----------AAFKLLGAESSELENTLT--------------------------QDVNARDVYARAMYLRLFSWI---------------------------VAVVNRQLSFS---------RLVFG------DVYSVTVIDSPGFENGL------HNSLHQLCANVISDNLQNY-IQQIIFFKELEEYGEEGVNVPFNLEG-GVDHRTLVNKLMDS-----------------------------------G---QGLLTAISKATQYQRKGES------------GWMESLQEADSE--------E--LVEFSNVNGKP--------------IVSVKHIF--RKVSYDATDLVK-KNVEDKTRALTSTMQRS-----------------CDPRIRAIFSSENPSP--------------FLSSPRRSSIQENMLLP------------------------------------------------------------------------------------------------------------------------------------------------------------------ERTVTDSLH--------------------SALSSVLNLASTED--PP--HLILCMRPQKKELIN-----------------------------DYDSKSVQIQLHALNVLETI----LIRQFGFARRISFVDFLNRYQY--LAFDFN-----ENVEL--------------------TKENCRLLLLRLKMDG--------------WTLGKNKVFLK------YYSEEYLSRIYETHIKK*
Rn XVI -SDDLAT-LSELN-DSSLLYEIQKRFGN-DQIHTFIGDIFLLVNPFKELP-IYS-TV---------------VSQMYLSPTGQR-----------SPSLPPHLFSCAERAFHRLFQ---------ERRPQNIILSGERGSGKTQASKQIMKHLTSRASSSCT-------------------------------------------------------------------------------------------------------------------------------------------------------------------MFDSRFKHAIC-----------ILEAFGHAKTTLNNVSSCLIQYWELQFCQRRK-----HVTGARISTYM-LEKPRLVA-QPPGQGSFLIFSWLMDGLSAEE----------------------------------------KCGLH----LSNFC----------AHRYVSQ-----------------------------GMREDVS-----TAERSLNKERLADLKHALNVIG-----FSALEVENLFAILSAILHIG-DIQFTALT------EADS------AFVSDL-----QLLEQVADMLQVSTDELASALTTDIQYFKG--------DVIIRRHTTQIAAFYRDLLAKSLYSRLFGFL---------------------------INTVNCCLQSQD--------EYKSL------QTLDIGILDIFGFEEFQ------KNEFEQLCVNLTNEKMHHY-IQEVLFLQEQTECVQEGVAMETACS--PGNQAGVLDFFFQK-----------------------------------P---SGFFSLLDEESQAIWSVEPNLPRKLQGLLESSNTNAVYSPMKD--------G--NGNVAFKGQGA--------------AFTVMHYA--GRVTYEIRGAVE-RNKDSLSQNLLFVMKTS-----------------ENVVISHLFQSKLSPTGSLISSYPSFKFGGHKSSLLSKRIASSMVGVNKNYLELSK-------------------------------------------------------------------------------------------------------------------------LLK-----------------KKGTCTFLQRLERGDPATTAS--------------------QLTKSLADITAKLQ--KGSPHFILCVKPNTSQLPG-----------------------------VFDHFYVSAQLQYLGVLGLV----RLFRYGYPVRPSFEDFLSRYEP--LASVLLG---EKKGQP--------------------AEERCRLVLQRCKLQG--------------WQMGVHKVFLK------YWQVDQLGDLWLQMQR-*
Tg myoA XIV -YGDIGM-LPHTN-IPCVLDFLKVRFMK-NQIYTTADPLVVAINPFRDLGNTTL-----------------DWIVRYR--DTFD-----------LSKLAPHVFYTARRALDNLHA---------VNKSQTIIVSGESGAGKTEATKQIMRYFAAAKTG----------------------------------------------------------------------------------------------------------------------------------------------------------------------SMDLRIQNAIMA--AN-----PVLEAFGNAKTIRNNNSSRFGRFMQLDVGRE------GGIKFGSVVAFL-LEKSRVLT-QDEQERSYHIFYQMCKGADAAM-----------------------------------------KERFHI---LPLS----------EYKYIN-------------PL---------------CLDAPG----------IDDVAEFHEVCESFRSMN----LTEDEV-ASVWSIVSGVLLLG-NVEVTATK------DGG--I-DDAAAIEG---KNLEVFKKACGLLFLDAERIREELTVKVSYAGN--------QEIRGRWKQEDGDMLKSSLAKAMYDKLFMWI---------------------------IAVLNRSIKPPGG-------FKI-----------FMGMLDIFGFEVFK------NNSLEQFFINITNEMLQKN-FVDIVFDRESKLYRDEGVS--SKELI-FTSN-AEVIKILTAK---------------------------------NN----SVLAALEDQCLAP----------------GGSDEKFLSTCKNALKGTT-------KFKPAKVSPNI------------NFLISHTV--GDIQYNAEGFLF-KNKDVLRAEIMEIVQQSK-----------------NPVVAQLFAGI------------------VMEKGK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAKGQLIGSQFL-----------------------SQLQSLMELIN--STEPHFIRCIKPNDTKKPL-----------------------------DWVPSKMLIQLHALSVLEAL----QLRQLGYSYRRPFKEFLFQFKF--IDLSASENPNLD------------------------PKEAALRLLKSS------------KLPSEEYQLGKTMVF--------LKQTGAKELTQIQRE--*
Pf PfMA -FGDIGL-LNHTN-IPCVLDFLKHRYLK-NQIYTTAVPLIVAINPYKDLGNTTN-----------------EWIRRYR--DTAD-----------HTKLPPHVFTCAREALSNLHG---------VNKSQTIIVSGESGAGKTEATKQIMRYFASSKSG----------------------------------------------------------------------------------------------------------------------------------------------------------------------NMDLRIQTAIMA--AN-----PVLEAFGNAKTIRNNNSSRFGRFMQLVISHE------GGIRYGSVVAFL-LEKSRIIT-QDDNERSYHIFYQFLKGANSTM-----------------------------------------KSKFGL---KGVT----------EYKLLN-------------PN---------------STEVSG----------VDDVKDFEEVIESLKNME----LSESDI-EVIFSIVAGILTLG-NVRLIEKQ------EAG--L-SDAAAIMD---EDMGVFNKACELMYLDPELIKREILIKVTVAGG--------TKIEGRWNKNDAEVLKSSLCKAMYEKLFLWI---------------------------IRHLNSRIEPEGG-------FKT-----------FMGMLDIFGFEVFK------NNSLEQLFINITNEMLQKN-FVDIVFERESKLYKDEGIS--TAELK-YTSN-KEVINVLCEK---------------------------------GK----SVLSYLEDQCLAP----------------GGTDEKFVSSCATNLKENN-------KFTPAKVASNK------------NFIIQHTI--GPIQYCAESFLL-KNKDVLRGDLVEVIKDSP-----------------NPIVQQLFEGQ------------------VIEKGK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------IAKGSLIGSQFL-----------------------NQLTSLMNLIN--STEPHFIRCIKPNENKKPL-----------------------------EWCEPKILIQLHALSILEAL----VLRQLGYSYRRTFEEFLYQYKF--VDIAAAEDSSVE------------------------NQNKCVNILKLS------------GLSESMYKIGKSMVF--------LKQEGAKILTKIQREK-*
Tg myoD -YGDIGG-LPHTN-EPCVLDFLARRYQS-KVIYTTAEPLIVAVNPFQDLKNAGP-----------------DTIALYR--DAPD-----------VDKLPPHVFYASRRAMTNMHQ---------LKKPQTIIVSGESGAGKTETTKMLMKYLATSAGG----------------------------------------------------------------------------------------------------------------------------------------------------------------------NLDLKIQTAIMA--AN-----PVLEAFGNAKTVRNNNSSRFGRFMLLDVARE------GGIQHGKVVAFL-LEKSRIVC-QDKDERNYHIFYQFLKGAPGHM-----------------------------------------RQRYML---QPLE----------AYTFIN-------------PH---------------CLDAPG----------IVDTEDFEQTVKSLESMN----MTETET-CTIWSIVSGVLLMG-NAKPTGKT------EAG--V-ENAACFVG---ESEAALRNACSLLFLDYPSILHELTVKTTYAGS--------NKIESRWTVPDSEMLRASLAKGMFEQLFLWI---------------------------IRKLNADIEPKGGS------FDV-----------FMGLLDIFGFEVFQ------NNSLEQLFINITNEVLQRN-FTDIVFEKELQLYSKEGIS--SKKIE-YTTN-EKLIETLLGK---------------------------------GT----SVLAALEDQCISP----------------SGTDEKFVSSLASKLAGNK-------CFIPSKNTKSL------------EFTVVHTI--GKVIYNADGFAF-KNKDVLRPEIIEITRAST-----------------NDVVRGLFEGV------------------KVEKGK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAKGMLIGSQFM-----------------------TQLKGLMEVIQ--KTESHFIRCIKPNDDKVPL-----------------------------KWVNSKVLIQLHALSILEAL----HLRQLAFSYRRTFEEFAAQFRF--INLGVSNKPGAD------------------------AKTICVELLKST------------SISADEYALGKTMVF--------LKPQAAKMLVRLQREA-*
Tg myoE -FPDIGL-LPHKN-CAAVLDFLKQRYLL-DLIYTTADPLLIAINPFKDLNNTTP-----------------EWLQLYR--DAPD-----------AEILAPHVFRLARTVLERLSA---------FMASQTIIVSGESGAGKTEATKQIMSYFAAGKRGE---------------------------------------------------------------------------------------------------------------------------------------------------------------------VSHQRIQNAVIA--AN-----PVLEAFGNAKTVRNNNSSRFGRFMQLQLGEK------GGIEYGSIRNFL-LEKVRVTS-QEQHERSYHIFYQLVKGADDAK-----------------------------------------RRQLHL---LNLE----------DYTYLS-------------KNG-------------GCYDCPG----------IDDVKDFKEMNKSLRSIG----LNLDDV-ESLWSIIAGVLLLG-NVHLESRE------TDG--Q-PNAAALTP---DGEATLQKCCALLFVDEEAVKKEILYKVKTIGD--------QQIESPNSLSDALMNRDSLAKAVYEKLFDWV---------------------------VRRVNATIEPPQG-------FGI-----------FMGMLDIFGFEMFE------NNSLEQLLINITNEQLQKN-FIQIVFARETKLYYEEGIG--NVKIT-WTDN-ENVIKALCGK---------------------------------SS----SVLAILEDKSLAP----------------GGTDEAIVTSMNQALKSSD-------VWKPGQKNPRI------------CFCICHTI--ADIQYDATGFIE-KNKDLLKPELCSIVQASS-----------------NNVAKELFEGV------------------VMQKGK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------IAKGQLIASQFM-----------------------RSLDALLTLIS--STESHFIRCLKPNETKNPH-----------------------------DWSNGKVLAQLFSLSILEAL----QLKNLSFSYRRPYADFLKQFEQ--LDLEVTRKSGN-------------------------AKEKTKQLLTRA------------NVPQAKWALGNTMVF--------MKPDAVRELTQKMRL--*
Tg myoB XIV --LPLRR-VRDTV-PRAEFGTRKSRFLR-SIIYTTAEPLLVAINPFKDLGNTTD-----------------AWISTYR--NASK-----------PEMLPPHVFKTARAALEDLEG---------YKKNQSIIVSGESGAGKTEATKQIMRFFASASS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------EVRTTIQDTIMA--GN-----PILEAFGNAKTIRNNNSSRFGRFMMLDVSSH------RGIQHGSISNFL-LEKVRVVS-QEANERSYHIFYQLLKGATSEM-----------------------------------------RAKYHL---RSLK----------EYAYLNG------------KNG-------------GCYDVPG----------IDDKADFEEVLQSLDAMQ----ITGSKR-HSVFSILSGLLLIG-NVSIEGKD------AQG--V-PDAAYISP---QSEEILEEACQLLSVDDAALKKEILVKSTKVGP--------QVIEGVRTKDEAKTSVLSLSKNVYDKLFDWL---------------------------VRQLNSLIDAPDG-------MPN-----------FIGILDIFGFEVLE------VNSLEQVLINITNEYLQKH-FIDVVFDMETKLYQAEGVP--TEALE-YTDN-LALVGALCGK---------------------------------ND----SFFALLEDACLGI----------------RSTDEGFCGTILRRLEPSG-------FFLESRRDKRL------------KFIIRHTI--ADIEYTCEGMLE-KNKDFLRKEVMDVMKAST-----------------DPVTKALFEGI------------------EIEAGK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------IGKGTLIASRFL-----------------------KNLEEMIGIVA--QTEAHFIRCLKPNEEKKPL-----------------------------GWNGSKVLNQLFSLSILEAL----QLRQVGYAYRRNFSEFCSHFRW--LDLGLVN-SDRD------------------------RKEVAHVLLEQS------------GIPESSWVIGKTMVF--------VKPDAAKELSILQRE--*
Tg myoC -VDDIGY-LPHTN-VACVLDVLKSRFLR-SIIYTTAEPLLVAINPFKDLGNTTD-----------------AWISTYR--NASK-----------PEMLPPHVFKTARAALEDLEG---------YKKNQSIIVSGESGAGKTEATKQIMRFFASASS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------EVRTTIQDTIMA--GN-----PILEAFGNAKTIRNNNSSRFGRFMMLDVSSH------RGIQHGSISNFL-LEKVRVVS-QEANERSYHIFYQLLKGATSEM-----------------------------------------RAKYHL---RSLK----------EYAYLNG------------KNG-------------GCYDVPG----------IDDKADFEEVLQSLDAMQ----ITGSKR-HSVFSILSGLLLIG-NVSIEGKD------AQG--V-PDAAYISP---QSEEILEEACQLLSVDDAALKKEILVKSTKVGP--------QVIEGVRTKDEAKTSVLSLSKNVYDKLFDWL---------------------------VRQLNSLIDAPDG-------MPN-----------FIGILDIFGFEVLE------VNSLEQVLINITNEYLQKH-FIDVVFDMETKLYQAEGVP--TEALE-YTDN-LALVGALCGK---------------------------------ND----SFFALLEDACLGI----------------RSTDEGFCGTILRRLEPSG-------FFLESRRDKRL------------KFIIRHTI--ADIEYTCEGMLE-KNKDFLRKEVMDVMKAST-----------------DPVTKALFEGI------------------EIEAGK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------IGKGTLIASRFL-----------------------KNLEEMIGIVA--QTEAHFIRCLKPNEEKKPL-----------------------------GWNGSKVLNQLFSLSILEAL----QLRQVGYAYRRNFSEFCSHFRW--LDLGLVN-SDRD------------------------RKEVAHVLLEQS------------GIPESSWVIGKTMVF--------VKPDAAKELSILQRE--*
Pf PfMB -SHRLND-MVHQN-SAEVLNTLALRYEK-NYIYTIAEPMLISVNPYQVIDTD---------------------MNEYK--NKS------------TDLLPPHVYTYAKDAMLDFIN---------TKNSQSIIISGESGSGKTEASKLVIKFYLSGVR-----------------------------------------------------------------------------------------------------------------------------------------------------------------------E-DNDISKTLWD--SN-----FILEAFGNAKTVKNNNSSRYGKYIKIQLDEN------QNIVSSSIEIFL-LEKIRVVS-QEPDERCYHIFYEILKGMNDEM-----------------------------------------KKKYKI---KSEE----------DYKYISN------------KS----------------INIPE----------IDDAKDFENLMISFDKMK----MS-DLK-DDLFLTLSGLLLLG-NIQFNGIE------KGG--K-SNCSELDD---ENLEVVNEASELLGIDYESLKNSLVITEKSIAN--------QKIEIPLSIEESLSICRSISKDIYNKIFEYI---------------------------TKRINNFLNNNKE-------LEN-----------FIGILDIFGFEIFV------KNSLEQLLINIANEEIHNI-YLFVVYEKESYLYKKEGPL--IESVK-YTNN-ESIIDLLRG----------------------------------NT----SIISILEDNCLAP----------------GKKDESIVSVYTNKFSKNE-------HYSVCKKNITE------------SFVIKHTV--SDVTYSISNFIS-KNKDILSPNILKLLKVSN-----------------NKLIQNLYDDA------------------EVTDS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------LGRKNLITYKYL-----------------------ENLKQICSYLK--STNIYFIKCIKPNETKEKN-----------------------------NFNPKKVYPQLFSLSIVETL----NIKYF-FQYKYTFASFLSYYQY--LDIAVSNDSSLD------------------------EKTKVTMLLER-------------NFDKDSYKVGHTMVF--------LKKEAVHKIRDIINSN-*
Tt MYO1 -YSDMVH-MKYLN-EAEIINNLRKRYQN-NMIFTYIGPTLVVMNPYKEIEGVQDNQVIDKIKSDLGIKFEEDFKMNNL--STNQ-----------NIINTPHTYTVSGLAYKQMFS---------NKKNQAIVISGESGAGKTENAKLSMQFLTSLKEF-----------------------------------------------------------------------------------------------------------------------------------------------------------------------NQFAIEVKILA--CN-----PILEAFGNAKTVRNNNSSRFGKYVKIYIDKTS-----QKINGASIDSYL-LEKSRIPC-PGKGERNYHIFYHMLKGNQELSN----------------------------------------LRLSQF---KNLS----------DFDYLKK------------SD---------------CFEVEN----------IQDAKLYLEVKKSFRQMN----FSNQEQ-EAIFSLISAILLLG-NANLDSSK------VSD--T-QAPTFLNMSLPTHHKEFKNASELLQVNPKDLEESLVFKVRKVGT--------TVIKSPQTAEECLSMRDSLSKNLYDSLFNFL---------------------------VWKLNQNLLPPQDL------LNKS---------LSIGLLDIFGFESFD------INSFEQLCINFTNEKFQQL-YVQYVFKSEEEDYKQEGILDVFSDLQ-YQEN-QLIIDTIEKK---------------------------------PN----GIMVLLDENCSLG----------------SGTDDSFLNQITKNHSKNQ-------LVSFPKKD-KY------------SFSLSHTA--KRVVYDVRGFRD-KNKDEVSTEVEKSLQSSK-----------------CPVIANLLSYQ------------------GSQTQQNKETQNLQNFGNNLNFKKAE----------------------------------------------------------------------------------------------------------------------------------------------ISNQMNSSKKNVKFLGQKFR-----------------------QSLQELMIELN--NSDVHFIRCIKPNEEKKKN-----------------------------FFKYDYVYQQVQYLGILDSI----KIRKVGYSYRMTYENFFLEYQE--LGQKTKGLTLQK------------------------VQQQKPIYLQNK------------QLPQKCVAFGKTKIF--------LKNEVMKILHEK-----*
Dd myoM -FSDMVE-IQDLS-EAIILNNLGLRYKS-DQIYTYIGNVLISINPYKEIKDIYS----------------LNILNKYK--DINT-----------IKSNPPHIYAVALRAYQSMVS---------EKKNQSIIISGESGSGKTEASKTILQYLINTSNSNSN----------------------------------------------------------------------------------------------------------------------------------------NNTNIN---------------------NNNNSIEKDILN--SN-----PILEAFGNSRTTKNHNSSRFGKFLKIEFRSSD-----MKIDGASIETYL-LEKSRISHRPDVNNLSYHIFYYLVMGASKEER----------------------------------------ERLGLD---NDPS----------KYRYLDASTSVIESFKKQSNGG-------------SGGGSGN----------NDLSESLQLVKQSLESMS----IAKEQC-DDIFLTLAAILHLG-NIEFEVDQ------TENEQT-SGFSKISEQKASVKKSLSMVSKLLGYPEQVFKQTLLNRNLKGGGRG------SVYCRPMEVYQSEQTRDALSKALYVRLFASI---------------------------VEKINVKFIQNTGS------KDLQGGYSSKRNNLFIGVLDIFGFENLS------SNSLDQLLINFTNEKLQQQ-FNLNVFENEQKDYLQEGIP--WSTSN-FIDN-KECIELFEKK---------------------------------SY----GLLSLLDDECMMP----------------KGSEVTLLEKYNKQYHNTN-------QYYQRTLAKG-------------TLGIKHFA--GDVTYQTDGWLE-KNRDSIPTEVEQLLSASS-----------------NNLIKSLFNLK------------------ELNKSNDNNSNNNNSNNNSSSSSSSQSTASITAKASPPRERFNSGSGSGTTSPLNLSGSSSP----------------------LSGSGS-----------------------------------------------------------------YSIIGGNSNSNSNNNNSSNNKKSQSVSVAGQFI-----------------------EQLNKLISTIN--STSVHYIRCIKPNVTMDCN-----------------------------NFNNSHVLSQLRNVGVLNTV----KVRKMGYSYRRDFIQFYSRYNC--ILNSLNIKINLTNINHSNLCKEILENVNSQYKNNNNNKNNNNQIVKIT------------TNSKPTFQIGKTKIF--------ISDELYIYLEKKRY---*
Gg FSk -IEDMAM-MTHLH-EPAVLYNLKERYAA-WMIYTYSGLFCVTVNPYKWLP-VYNPK----------------VVLAYR--GKK------------RQEAPPHIFSISDNAYQFMLTDR---------ENQSILITGESGAGKTVNTKRVIQYFATIAASGEK----------------------------------------------------------------------------------------------------------------------------------------KKEEQ-SG-------------------KMQGTLEDQIIS--AN-----PLLEAFGNAKTVRNDNSSRFGKFIRIHFGAT------GKLASADIETYL-LEKSRVTF-QLPAERSYHIFYQIMSNKKPEL-----------------------------------------IDMLLI--TTNPY----------DYHYVSEG----------------------------EITVPS----------IDDQEELMATDSAIDILG----FSADEK-TAIYKLTGAVMHYG-NLKFKQK-------QRE-----EQAEPDGT--E--VADKAAYLMG-LNSAELLKALCYPRVGVGN--------EAVTKGETVSEVHNSVGALAKAVYEKMFLWM---------------------------VIRINQQLDTK---------QPR---------QYFIGVLDIAGFEIFD------FNSFEQLCINFTNEKLQQF-FNHHMFVLEQEEYKKEGIE--WEFID-FGMDLAACIELIE-----------------------------------KPM---GIFSILEEECMFP----------------KATDTSFKNKLYDEHL-GK-----SNNFQKP-KPAK--------GKAEAHFSLVHYA--GTVDYNISGWLE-KNKDPLNETVIGLYQKSS-----------------VKTLALLFATYGG------------------EAE-G------G-GGKKG--------------------------------------------------------------------------------------------------------------------------------------------------------GKKKGSSFQTVSALFR-----------------------ENLNKLMANLR--STHPHFVRCIIPNETKTPG-----------------------------AMEHELVLHQLRCNGVLEGI----RICRKGFPSRVLYADFKQRYR---VLNAS----AIPEGQ--F----------------MDSKKASEKLLGGG----------DVDH--TQYAFGHTKVF--------FKAGL-LGLLEEMRD--*
Gg FSkE -IEDMAM-MTHLH-EPAVLYNLKERYAA-WMIYTYSGLFCVTVNPYKWLP-VYNPE----------------VVLAYR--GKK------------RQEAPPHIFSISDNAYQFMLTDR---------ENQSILITGESGAGKTVNTKRVIQYFATIAATGDK----------------------------------------------------------------------------------------------------------------------------------------KKEEQPAG-------------------KMQGTLEDQIIS--AN-----PLLEAFGNAKTVRNDNSSRFGKFIRIHFGAT------GKLASADIETYL-LEKSRVTF-QLKAERSYHIFYQIMSNKKPEL-----------------------------------------IEMLLI--TTNPY----------DYQYVSQG----------------------------EITVPS----------INDQEELMATDSAIDILG----FTPDEK-TAIYKLTGAVMHYG-NLKFKQK-------QRE-----EQAEPGGT--E--VADKAAYLMG-LNSADLLKALCYPRVKVGN--------EYVTKGQTVQQVYNSVGALAKSVFEKMFLWM---------------------------VVRINQQLDTK---------QPR---------QYFIGVLDIAGFEIFD------FNSLEQLCINFTNEKLQQF-FNHHMFVLEQEEYKKEGIE--WEFID-FGMDLAACIELIE-----------------------------------KPM---GIFSILEEECMFP----------------KATDTSFKNKLYDQHL-GK-----SNNFQKP-KPGK--------GKLEAHFSLVHYA--GTVDYNITGWLE-KNKDPLNETVVGLYQKSS-----------------LKTLALLFASVGG----------------A-EAESG------A-GGKKG--------------------------------------------------------------------------------------------------------------------------------------------------------GKKKGSSFQTVSALFR-----------------------ENLNKLMSNLR--STHPHFVRCLIPNETKTPG-----------------------------AMEHELVLHQLRCNGVLEGI----RICRKGFPIRILYADFKQRYK---VLNAS----AIPEGQ--F----------------IDSKKASEKLLGSI----------DVDH--TQYKFGHTKVF--------FKAGL-LGLLEEMRD--*
Hs Peri -IEDMAM-MTHLH-EPGVLYNLKERYAA-WMIYTYSGLFCVTVNPYKWLP-VYKPE----------------VVAAYR--GKK------------RQEAPPHIFSISDNAYQFMLTDR---------ENQSILITGESGAGKTVNTKRVIQYFATIAVTGEK----------------------------------------------------------------------------------------------------------------------------------------KKDES--G-------------------KMQGTLEDQIIS--AN-----PLLEAFGNAKTVRNDNSSRFGKFIRIHFGTT------GKLASADIETYL-LEKSRVTF-QLKAERSYHIFYQITSNKKPDL-----------------------------------------IEMLLI--TTNPY----------DYAFVSQG----------------------------EITVPS----------IDDQEELMATDSAIDILG----FTPEEK-VSIYKLTGAVMHYG-NMKFKQK-------QRE-----EQAEPDGT--E--VADKAAYLQS-LNSADLLKALCYPRVKVGN--------EYVTKGQTVQQVYNAVGALAKAVYEKMFLWM---------------------------VTRINQQLDTK---------QPR---------QYFIGVLDIAGFEIFD------FNSLEQLCINFTNEKLQQF-FNHHMFVLEQEEYKKEGIE--WTFID-FGMDLAACIELIE-----------------------------------KPL---GIFSILEEECMFP----------------KATDTSFKNKLYDQHL-GK-----SANFQKP-KVVK--------GKAEAHFSLIHYA--GTVDYNITGWLD-KNKDPLNDTVVGLYQKSA-----------------MKTLASLFSTYAS----------------A-EAD--------S-SAKKG--------------------------------------------------------------------------------------------------------------------------------------------------------AKKKGSSFQTVSALFR-----------------------ENLNKLMTNLR--STHPHFVRCIIPNETKTPG-----------------------------AMEHELVLHQLRCNGVLEGI----RICRKGFPSRILYGDFKQRYK---VLNAS----AIPEGQ--F----------------IDSKKASEKLLASI----------DIDH--TQYKFGHTKVF--------FKAGL-LGLLEEMRD--*
Hs FSkE -IEDMAM-LTHLN-EPAVLYNLKDRYTS-WMIYTYSGLFCVTVNPYKWLP-VYNPE----------------VVEGYR--GKK------------RQEAPPHIFSISDNAYQFMLTDR---------ENQSILITGESGAGKTVNTKRVIQYFATIAATGDL----------------------------------------------------------------------------------------------------------------------------------------AKKKD--S-------------------KMKGTLEDQIIS--AN-----PLLEAFGNAKTVRNDNSSRFGKFIRIHFGTT------GKLASADIETYL-LEKSRVTF-QLKAERSYHIFYQILSNKKPEL-----------------------------------------IELLLI--TTNPY----------DYPFISQG----------------------------EILVAS----------IDDREELLATDSAIDILG----FTPEEK-SGLYKLTGAVMHYG-NMKFKQK-------QRE-----EQAEPDGT--E--VADKTAYLMG-LNSSDLLKALCFPRVKVGN--------EYVTKGQTVDQVHHAVNALSKSVYEKLFLWM---------------------------VTRINQQLDTK---------LPR---------QHFIGVLDIAGFEIFE------YNSLEQLCINFTNEKLQQF-FNHHMFVLEQEEYKKEGIE--WTFID-FGMDLAACIELIE-----------------------------------KPM---GIFSILEEECMFP----------------KATDTSFKNKLYDQHL-GK-----SNNFQKP-KVVK--------GRAEAHFSLIHYA--GTVDYSVSGWLE-KNKDPLNETVVGLYQKSS-----------------NRLLAHLYATFAT----------------A-DAD--------S-GKKKV--------------------------------------------------------------------------------------------------------------------------------------------------------AKKKGSSFQTVSALFR-----------------------ENLNKLMSNLR--TTHPHFVRCIIPNETKTPG-----------------------------AMEHSLVLHQLRCNGVLEGI----RICRKGFPNRILYGDFKQRYR---VLNAS----AILEGQ--F----------------IDSKKACEKLLASI----------DIDH--TQYKFGHTKVF--------FKAGL-LGTLEEMRD--*
Rn FSkE -IEDMAM-LTHLN-EPAVLYNLKDRYTS-WMIYTYSGLFCVTVNPYKWLP-VYTPE----------------VVDGYR--GKK------------RQEAPPHIFSISDNAYQFMLTDR---------ENQSILITGESGAGKTVNTKRVIQYFATIAATGDL----------------------------------------------------------------------------------------------------------------------------------------AKKKD--S-------------------KMKGTLEDQIIS--AN-----PLLEAFGNAKTVRNDNSSRFGKFIRIHFGTT------GKLASADIETYL-LEKSRVTF-QLKAERSYHIFYQILSNKKPEL-----------------------------------------IELLLI--TTNPY----------DYPFISQG----------------------------EILVAS----------IDDREELLATDSAIDILG----FTPEEK-SGLYKLTGAVMHYG-NMKFKQK-------QRE-----EQAEPDGT--E--VADKTAYLMG-LNSSDLLKALCFPRVKVGN--------EYVTKGQTVDQVHHAVNALSKSVYEKLFLWM---------------------------VTRINQQLDTK---------LPR---------QHFIGVLDIAGFEIFE------YNSLEQLCINFTNEKLQQF-FNHHMFVLEQEEYKKEGIE--WTFID-FGMDLAACIELIE-----------------------------------KPM---GIFSILEEECMFP----------------KATDTSFKNKLYDQHL-GK-----SNNFQKP-KVVK--------GKAEAHFSLIHYA--GTVDYSVSGWLE-KNKDPLNETVVGLYQKSS-----------------NRLLAHLYATFAT----------------T-DAD--------G-GKKKV--------------------------------------------------------------------------------------------------------------------------------------------------------AKKKGSSFQTVSALFR-----------------------ENLNKLMSNLR--TTHPHFVRCIIPNETKTPG-----------------------------AMEHSLVLHQLRCNGVLEGI----RICRKGFPNRILYGDFKQRYR---VLNAS----AIPEGQ--F----------------IDSKKACEKLLASI----------DIDH--TQYKFGHTKVF--------FKAGL-LGTLEEMRD--*
Rn CaA -IEDMAM-LTFLH-EPAVLYNLKERYAA-WMIYTYSGLFCVTVNPYKWLP-VYNAE----------------VVAAYR--GKK------------RSEAPPHIFSISDNAYQYMLTDR---------ENQSILITGESGAGKTVNTKRVIQYFASIAAIGDR----------------------------------------------------------------------------------------------------------------------------------------SKKDNP-N-------------------ANKGTLEDQIIQ--AN-----PALEAFGNAKTVRNDNSSRFGKFIRIHFGAT------GKLASADIETYL-LEKSRVIF-QLKAERNYHIFYQILSNKKPEL-----------------------------------------LDMLLV--TNNPY----------DYAFVSQG----------------------------EVSVAS----------IDDSEELLATDSAFDVLG----FTAEEK-AGVYKLTGAIMHYG-NMKFKQK-------QRE-----EQAEPDGT--E--DADKSAYLMG-LNSADLLKGLCHPRVKVGN--------EYVTKGQSVQQVYYSIGALAKSVYEKMFNWM---------------------------VTRINATLETK---------QPR---------QYFIGVLDIAGFEIFD------FNSFEQLCINFTNEKLQQF-FNHHMFVLEQEEYKKEGIE--WEFID-FGMDLQACIDLIE-----------------------------------KPM---GIMSILEEECMFP----------------KATDMTFKAKLYDNHL-GK-----SNNFQKP-RNVK--------GKQEAHFSLVHYA--GTVDYNILGWLE-KNKDPLNETVVGLYQKSS-----------------LKLMATLFSTYAS----------------A-DTGD-------S-GKGKG--------------------------------------------------------------------------------------------------------------------------------------------------------GKKKGSSFQTVSALHR-----------------------ENLNKLMTNLR--TTHPHFVRCIIPNERKAPG-----------------------------VMDNPLVMHQLRCNGVLEGI----RICRKGFPNRILYGDFRQRYR---ILNPA----AIPEGQ--F----------------IDSGKGAEKLLGSL----------DIDH--NQYKFGHTKVF--------FKAGL-LGLLEEMRD--*
Ma CaA -IEDMAM-LTFLH-EPAVLYNLKERYAA-WMIYTYSGLFCVTVNPYKWLP-VYNAE----------------VVAAYR--GKK------------RSEAPAHIFSISDNAYQYMLTDR---------ENQSILITGESGAGKTVNTKRVIQYFASIAAIGDR----------------------------------------------------------------------------------------------------------------------------------------SKKDNP-N-------------------ANKGTLEDQIIQ--AN-----PALEAFGNAKTVRNDNSSRFGKFIRIHFGAT------GKLASADIETYL-LEKSRVIF-QLKAERNYHIFYQILSNKKPEL-----------------------------------------LDMLLV--TNNPY----------DYAFVSQG----------------------------EVSVAS----------IDDSEELLATDSAFDVLG----FTAEEK-AGVYKLTGAIMHYG-NMKFKQK-------QRE-----EQAEPDGT--E--DADKSAYLMG-LNSADLLKGLCHPRVKVGN--------EYVTKGQSVQQVYYSIGALGKSVYEKMFNWM---------------------------VTRINATLETK---------QPR---------QYFIGVLDIAGFEIFD------FNSFEQLCINFTNEKLQQF-FNHHMFVLEQEEYKKEGIE--WEFID-FGMDLQACIDLIE-----------------------------------KPM---GIMSILEEECMFP----------------KATDMTFKAKLYDNHL-GK-----SNNFQKP-RNVK--------GKQEAHFSLVHYA--GTVDYNILGWLE-KNKDPLNETVVGLYQKSS-----------------LKLMATLFSTYAS----------------A-DAGD-------S-GKGKG--------------------------------------------------------------------------------------------------------------------------------------------------------GKKKGSSFQTVSALHR-----------------------ENLNKLMTNLR--TTHPHFVRCIIPNERKAPG-----------------------------VMDNPLVMHQLRCNGVLEGI----RICRKGFPNRILYGDFRQRYR---ILNPA----AIPEGQ--F----------------IDSRKGAEKLLSSL----------DIDH--NQYKFGHTKVF--------FKAGL-LGLLEEMRD--*
Mm CaA -IEDMAM-LTFLH-EPAVLYNLKERYAA-WMIYTYSGLFCVTVNPYKWLP-VYNAE----------------VVAAYR--GKK------------RSEAPPHIFSISDNAYQYMLTDR---------ENQSILITGESGAGKTVNTKRVIQYFASIAAIGDR----------------------------------------------------------------------------------------------------------------------------------------SKKENP-N-------------------ANKGTLEDQIIQ--AN-----PALEAFGNAKTVRNDNSSRFGKFIRIHFGAT------GKLASADIETYL-LEKSRVIF-QLKAERNYHIFYQILSNKKPEL-----------------------------------------LDMLLV--TNNPY----------DYAFVSQG----------------------------EVSVAS----------IDDSEELLATDSAFDVLS----FTAEEK-AGVYKLTGAIMHYG-NMKFKQK-------QRE-----EQAEPDGT--E--DADKSAYLMG-LNSADLLKGLCHPRVKVGN--------EYVTKGQSVQQVYYSIGALAKSVYEKMFNWM---------------------------VTRINATLETK---------QPR---------QYFIGVLDIAGFEIFD------FNSFEQLCINFTNEKLQQF-FNHHMFVLEQEEYKKEGIE--WEFID-FGMDLQACIDLIE-----------------------------------KPM---GIMSILEEECMFP----------------KAADMTFKAKLYDNHL-GK-----SNNFQKP-RNVK--------GKQEAHFSLVHYA--GTVDYNIMGWLE-KNKDPLNETVVGLYQKSS-----------------LKLMATLFSTYAS----------------A-DTGD-------S-GKGKG--------------------------------------------------------------------------------------------------------------------------------------------------------GKKKGSSFQTVSALHR-----------------------ENLNKLMTNLK--TTHPHFVRCIIPNERKAPG-----------------------------VMDNPLVMHQLRCNGVLEGI----RICRKGFPNRILYGDFRQRYR---ILNPA----AIPEGQ--F----------------IDSRKGAEKLLGSL----------DIDH--NQYKFGHTKVF--------FKAGL-LGLLEEMRD--*
Hs CaA -IEDMAM-LTFLH-EPAVLFNLKERYAA-WMIYTYSGLFCVTVNPYKWLP-VYNAE----------------VVAAYR--GKK------------RSEAPPHIFSISDNAYQYMLTDR---------ENQSILITGESGAGKTVNTKRVIQYFASIAAIGDR----------------------------------------------------------------------------------------------------------------------------------------GKKDNA-N-------------------ANKGTLEDQIIQ--AN-----PALEAFGNAKTVRNDNSSRFGKFIRIHFGAT------GKLASADIETYL-LEKSRVIF-QLKAERNYHIFYQILSNKKPEL-----------------------------------------LDMLLV--TNNPY----------DYAFVSQG----------------------------EVSVAS----------IDDSEELMATDSAFDVLG----FTSEEK-AGVYKLTGAIMHYG-NMKFKQK-------QRE-----EQAEPDGT--E--DADKSAYLMG-LNSADLLKGLCHPRVKVGN--------EYVTKGQSVQQVYYSIGALAKAVYEKMFNWM---------------------------VTRINATLETK---------QPR---------QYFIGVLDIAGFEIFD------FNSFEQLCINFTNEKLQQF-FNHHMFVLEQEEYKKEGIE--WTFID-FGMDLQACIDLIE-----------------------------------KPM---GIMSILEEECMFP----------------KATDMTFKAKLYDNHL-GK-----SNNFQKP-RNIK--------GKPEAHFSLIHYA--GTVDYNILGWLE-KNKDPLNETVVGLYQKSS-----------------LKLMATLFSSYAT----------------A-DTGD-------S-GKSKG--------------------------------------------------------------------------------------------------------------------------------------------------------GKKKGSSFQTVSALHR-----------------------ENLNKLMTNLR--TTHPHFVRCIIPNERKAPG-----------------------------VMDNPLVMHQLRCNGVLEGI----RICRKGFPNRILYGDFRQRYR---ILNPV----AIPEGQ--F----------------IDSRKGAEKLLSSL----------DIDH--NQYKFGHTKVF--------FKAGL-LGLLEEMRD--*
Rn CaB -IEDMAM-LTFLH-EPAVLYNLKERYAS-WMIYTYSGLFCVTVNPYKWLP-VYNAQ----------------VVAAYR--GKK------------RSEAPPHIFSISDNAYQYMLTDR---------ENQSILITGESGAGKTVNTKRVIQYFAVIAAIGDR----------------------------------------------------------------------------------------------------------------------------------------SKKDQ--T-------------------PGKGTLEDQIIQ--AN-----PALEAFGNAKTVRNDNSSRFGKFIRIHFGAT------GKLASADIETYL-LEKSRVIF-QLKAERDYHIFYQILSNKKPEL-----------------------------------------LDMLLI--TNNPY----------DYAFFSQG----------------------------ETTVAS----------IDDSEEHMATDSAFDVLG----FTPEEK-NSIYKLTGAIMHFG-NMKFKQK-------QRE-----EQAEPDGT--E--EADKSAYLMG-LNSADLLKGLCHPRVKVGN--------EYVTKGQNVQQVAYAIGALAKSVYEKMFNWM---------------------------VTRINATLETK---------QPR---------QYFIGVLDIAGFEIFD------FNSFEQLCINFTNEKLQQF-FNHHMFVLEQEEYKKEGIE--WTFID-FGMDLQACIDLIE-----------------------------------KPM---GIMSILEEECMFP----------------KATDMTFKAKLYDNHL-GK-----SNNFQKP-RNIK--------GKQEAHFSLIHYA--GTVDYNILGWLQ-KNKDPLNETVVGLYQKSS-----------------LKLLSNLFANYAG----------------A-DAP--------V-DKGKG--------------------------------------------------------------------------------------------------------------------------------------------------------KAKKGSSFQTVSALHR-----------------------ENLNKLMTNLR--STHPHFVRCIIPNETKSPG-----------------------------VMDNPLVMHQLRCNGVLEGI----RICRKGFPNRILYGDFRQRYR---ILNPA----AIPEGQ--F----------------IDSRKGAEKLLGSL----------DIDH--NQYKFGHTKVF--------FKAGL-LGLLEEMRD--*
Ma CaB -IEDMAM-LTFLH-EPAVLYNLKDGYAS-WMIYTYSGLFCVTVNPYKWLP-VYNAE----------------VVAAYR--GKK------------RSEAPAHIFSISDNAYQYMLTDR---------ENQSILITGESGAGKTVNTKRVIQYFAVIAAIGDR----------------------------------------------------------------------------------------------------------------------------------------SKKDQ--T-------------------PGKGTLEDQIIQ--AN-----PALEAFGNAKTVRNDNSSRFGKFIRIHFGAT------GKLASADIETYL-LEKSRVIF-QLKAERDYHIFYQILSNKKPEL-----------------------------------------LDMLLI--TNNPY----------DYAFIPQG----------------------------ETTVAS----------IDDSEELMATDSAFDVLG----FTSEEK-NSIYKLTGAIMHFG-NMKFKQK-------QRE-----EQADRDGT--E--EEDKSAYLMG-LNSADLLKGMCHPRVKVGN--------EYVTKGQNVQQVSYAIGALAKSVYEKMFNWM---------------------------VTRINATLETK---------QPR---------QYFIGVLDIAGFEIFD------FNSFEQLCINFTNEKLQQF-FNHHMFVLEQEEYKKEGIE--WTFID-FGMDLQACIDLIE-----------------------------------KPM---RIMSILEEECMFP----------------KATDMTFKAKLYDNHL-GK-----SNNFQKP-RNVK--------GKQEAHFSLVHYA--GTVDYNILGWLQ-KNKDPLNETVVGLYQKSS-----------------LKLLSNLFANYAG----------------A-DAP--------V-DKGKG--------------------------------------------------------------------------------------------------------------------------------------------------------KAKKGSSFQTVSVLHR-----------------------ENLNKLMTNLR--STHPHFVRCIIPNETKSPG-----------------------------VMDNPLVMHQLRCNGVLEGI----RICRKGFPNRILYGDFRQRYR---ILNPA----AIPEGQ--F----------------IDSRKGAEKLLSSL----------DIDH--NQYKFGHTKVF--------FKAGL-LGLLEEMRD--*
Hs CaB -IEDMAM-LTFLH-EPAVLYNLKERYGS-WMIYTYSGLFCVTVNPYKWLP-VYTPE----------------VVAAYR--GKK------------RSEAPPHIFSISDNAYQYMLTDR---------ENQSILITGESGAGKTVNTKRVIQYFAVIAAIGDR----------------------------------------------------------------------------------------------------------------------------------------SKKDQ--S-------------------PGKGTLEDQIIQ--AN-----PALEAFGNAKTVRNDNSSRFGKFIRIHFGAT------GKLASADIETYL-LEKSRVIF-QLKAERDYHIFYQILSNKKPEL-----------------------------------------LDMLLI--TNNPY----------DYAFISQG----------------------------ETTVAS----------IDDAEELMATDNAFDVLG----FTSEEK-NSMYKLTGAIMHFG-NMKFKLK-------QRE-----EQAEPDGT--E--EADKSAYLMG-LNSADLLKGLCHPRVKVGN--------EYVTKGQNVQQVIYATGALAKAVYERMFNWM---------------------------VTRINATLETK---------QPR---------QYFIGVLDIAGFEIFD------FNSFEQLCINFTNEKLQQF-FNHHMFVLEQEEYKKEGIE--WTFID-FGMDLQACIDLIE-----------------------------------KPM---GIMSILEEECMFP----------------KATDMTFKAKLFDNHL-GK-----SANFQKP-RNIK--------GKPEAHFSLIHYA--GIVDYNIIGWLQ-KNKDPLNETVVGLYQKSS-----------------LKLLSTLFANYAG----------------A-DAP--------I-EKGKG--------------------------------------------------------------------------------------------------------------------------------------------------------KAKKGSSFQTVSALHR-----------------------ENLNKLMTNLR--STHPHFVRLYHPNETKSPG-----------------------------VMDNPLVMHQLRCNGVLEGI----RICRKGFPNRILYGDFRQRYR---ILNPA----AIPEGQ--F----------------IDSRKGAEKLLSSL----------DIDH--NQYKFGHTKVF--------FKAGL-LGLLEEMRD--*
Ai II -LEDMAN-MTYLN-EASVLYNLRSRYTS-GLIYTYSGLFCIAVNPYRRLP-IYTDS----------------VIAKYR--GKR------------KTEIPPHLFSVADNAYQNMVTDR---------ENQSCLITGESGAGKTENTKKVIMYLAKVACAVKK----------------------------------------------------------------------------------------------------------------------------------------KDEEAS-D-------------------KKEGSLEDQIIQ--AN-----PVLEAYGNAKTTRNNNSSRFGKFIRIHFGPT------GKIAGADIETYL-LEKSRVTY-QQSAERNYHIFYQICSNAIPEL-----------------------------------------NDVMLV--TPDSG----------LYSFINQG----------------------------CLTVDN----------IDDVEEFKLCDEAFDILG----FTKEEK-QSMFKCTASILHMG-EMKFKQR-------PRE-----EQAESDGT--A--EAEKVAFLCG-INAGDLLKALLKPKVKVGT--------EMVTKGQNMNQVVNSVGALAKSLYDRMFNWL---------------------------VRRVNKTLDTK---------AKR---------NYYIGVLDIAGFEIFD------FNSFEQLCINYTNERLQQF-FNHHMFILEQEEYKKEGIA--WEFID-FGMDLQMCIDLIE-----------------------------------KPM---GILSILEEECMFP----------------KADDKSFQDKLYQNHM-GK-----NRMFTKPGKPTRP-------NQGPAHFELHHYA--GNVPYSITGWLE-KNKDPINENVVALLGASK-----------------EPLVAELFKAPEE----------------P-AGG------------GKK--------------------------------------------------------------------------------------------------------------------------------------------------------KKGKSSAFQTISAVHR-----------------------ESLNKLMKNLY--STHPHFVRCIIPNELKQPG-----------------------------LVDAELVLHQLQCNGVLEGI----RICRKGFPSRLIYSEFKQRYS---ILAPN----AIPQG---F----------------VDGKTVSEKILAGL----------QMDP--AEYRLGTTKVF--------FKAGV-LGNLEEMRD--*
Sm II -IEDMAN-LTHLN-DASVLENLRARYYR-QLIYTYSGLFCVAVNPYKRFP-IYTEQ----------------VALKYK--GKR------------RGEMPPHIFSISDNAYHNMLQDR---------ENQSILITGESGAGKTENTKKVISYFAVVAAASKK----------------------------------------------------------------------------------------------------------------------------------------EDDDSS----------------------KKGTLEDQIVQ--AN-----PVLEAYGNAKTTRNNNSSRFGKFIRIHFGTT------GKIAGADIEHYL-LEKSRVVS-QMKGERNYHIFYQLLSTYGSKY-----------------------------------------HDKLLV--QTDPA----------LYSFINQG----------------------------ELTIDG----------VDDSEEMKLCDEAFEVLG----FNDDEK-LSLFKCTTSICNMG-EMKFKQR-------PRE-----EQAEADGT--A--EAEKVAFLLG-VNAKDLLTSFLKPKVKVGT--------EFVTKGQNLNQVTYAVSALAKSLYNRMFGWL---------------------------VARVNKTLDTK---------VKR---------QFFIGVLDIAGFEIFT------ENGFEQICINYTNERLQQF-FNHHMFVLEQEEYKREKIQ--WTFID-FGMDLQACIDLIE-----------------------------------KPM---GILSILEEECIVP----------------KASDQTFLSKLYDNHL-GK-----SPNFTKP-KPPKP-------GHVEAHFELHHYA--GSVPYTITGWLE-KNKDPLNDSVVALLGDSK-----------------DPLVSNLFTPVVG----------------E-PG------------------------------------------------------------------------------------------------------------------------------------------------------------------------KKTKGGSFLTVTYMHR-----------------------ESLNKLMKNLQ--STSPSFIRCIVPNEFKQPG-----------------------------VIDAHLVLHQLHCNGVLEGI----RICRKGFPNRMIYSEFKQRYS---ILAPN----VIPDG---F----------------VDGRQVTEKILEAT----------QLDK--NLYQCGNTKVF--------FKAGT-LAHLEDLRD--*
Dm II -AEDMSN-LTYLN-DASVLHNLRQRYYN-KLIYTYSGLFCVAINPYKRYP-VYTNR----------------CAKMYR--GKR------------RNEVPPHIFAISDGAYVDMLTNH---------VNQSMLITGESGAGKTENTKKVIAYFATVGASKKT----------------------------------------------------------------------------------------------------------------------------------------DEAAK-----------------------SKGSLEDQVVQ--TN-----PVLEAFGNAKTVRNDNSSRFGKFIRIHFGPT------GKLAGADIETYL-LEKARVIS-QQSLERCYHIFYQIMSGSVPGV-----------------------------------------KEMCFL--SDNIY----------DYYNVSQG----------------------------KVTVPN----------MDDGEEFQLADQAFDILG----FTKQEK-EDVYRITAAVMHMG-GMKFKQR-------GRE-----EQAEQDGE--E--EGGRVSKLFG-CDTAELYKNLLKPRIKVGN--------EFVTQGRNVQQVTNSIGALCKGVFDRLFKWL---------------------------VKKCNETLDTQ---------QKR---------QHFIGVLDIAGFEIFE------YNGFEQLCINFTNEKLQQF-FNHHMFVLEQEEYKREGID--WAFID-FGMDLLACIDLIE-----------------------------------KPM---GILSILEEESMFP----------------KATDQTFSEKLTNTHL-GK-----SAPFQKP-KPPKP-------GQQAAHFAIAHYA--GCVSYNITGWLE-KNKDPLNDTVVDQFKKSQ-----------------NKLLIEIFADHAG----------------Q-SGGG-------E-QAKGG--------------------------------------------------------------------------------------------------------------------------------------------------------RGKKGGGFATVSSAYK-----------------------EQLNSLMTTLR--STQPHFVRCIIPNEMKQPG-----------------------------VVDAHLVMHQLTCNGVLEGI----RICRKGFPNRMMYPDFKMRYQ---ILNPA----GIVG----V----------------DDPKKCGSIILEST----------ALDP--DMYRIGHTKVF--------FRAGV-LGQMEEFRD--*
Ce IIB -TEDMSN-LSFLN-DASVLHNLRSRYAA-MLIYTYSGLFCVVINPYKRLP-IYTDS----------------CARMFM--GKR------------KTEMPPHLFAVSDEAYRNMLQDH---------ENQSMLITGESGAGKTENTKKVICYFAAVGASQQEGG--------------------------------------------------------------------------------------------------------------------------------------AEVDP--N-------------------KKKVTLEDQIVQ--TN-----PVLEAFGNAKTVRNNNSSRFGKFIRIHFNKH------GRLASCDIEHYL-LEKSRVIR-QAPGERCYHIFYQIYSDFRPEL-----------------------------------------KKELLL--DLPIK----------DYWFVAQA----------------------------ELIIDG----------IDDVEEFQLTDEAFDILN----FSAVEK-QDCYRLMSAHMHMG-NMKFKQR-------PRE-----EQAEPDGT--V--EAEKASNMYG-IGCEEFLKALTKPRVKVGT--------EWVSKGQNCEQVNWAVGAMAKGLYSRVFNWL---------------------------VKKCNLTLDQKG--------IDR---------DYFIGVLDIAGFEIFD------FNSFEQLWINFVNEKLQQF-FNHHMFVLEQEEYAREGIQ--WVFID-FGLDLQACIELIE-----------------------------------KPL---GIISMLDEECIVP----------------KATDLTLASKLVDQHL-GK-----HPNFEKP-KPPKG-------KQGEAHFAMRHYA--GTVRYNCLNWLE-KNKDPLNDTVVSAMKQSKG----------------NDLLVEIWQDYTT----------------QEEAAAK------A-KEGGGGG-----------------------------------------------------------------------------------------------------------------------------------------------------KKKGKSGSFMTVSMLYR-----------------------ESLNNLMTMLN--KTHPHFIRCIIPNEKKQSG-----------------------------MIDAALVLNQLTCNGVLEGI----RICRKGFPNRTLHPDFVQRYA---ILAAK----EAKS----D----------------DDKKKCAEAIMSKLVNDG------SLSE--EMFRIGLTKVF--------FKAGV-LAHLEDIRD--*
Ce IID -TEDMSN-LTFLN-DASVLWNLRSRYAA-MLIYTYSGLFCVVINPYKRLP-IYTDS----------------VARMFM--GKR------------RTEMPPHLFAVSDQAYRYMLQDH---------ENQSMLITGESGAGKTENTKKVICYFATVGASQK-----------------------------------------------------------------------------------------------------------------------------------------AALKE--G-------------------EKEVTLEDQIVQ--TN-----PVLEAFGNAKTVRNNNSSRFGKFIRIHFNKH------GTLASCDIEHYL-LEKSRVIR-QAPGERCYHIFYQIYSDFKPQL-----------------------------------------RDELLL--NHPIS----------NYWFVAQA----------------------------ELLIDG----------IDDTEEFQLTDEAFDVLK----FSPTEK-MDCYRLMSAHMHMG-NMKFKQR-------PRE-----EQAEPDGQ--V--EAERACNMYG-IDVVQFLKALVSPRVKVGT--------EWVSKGQNVDQVHWAIGAMAKGLYARVFHWL---------------------------VKKCNLTLDQKG--------IDR---------DYFIGVLDIAGFEIFD------FNSFEQLWINFVNEKLQQF-FNHHMFVLEQEEYAREGIQ--WTFID-FGLDLQACIELIE-----------------------------------KPL---GIISMLDEECIVP----------------KATDMTLAQKLTDQHL-GK-----HPNFEKP-KPPKG-------KQGEAHLAMRHYA--GTVRYNVLNWLE-KNKDPLNDTVVSVMKASKK----------------NDLLVEIWQDYTT----------------QEEAAAA------A-KAGGG-------------------------------------------------------------------------------------------------------------------------------------------------------RKGGKSGSFMTVSMMYR-----------------------ESLNKLMTMLH--KTHPHFIRCIIPIEKKQSG-----------------------------MIDAALVLNQLTCNGVLEGI----RICRKGFPNRTQHPDFVQRYA---ILAAK----EAKS----S----------------DDMKTCAGAILQALINQK------QLND--EQFRIGHTKVF--------FKAGV-VAHIEDLRD--*
Ov II -TEDMSN-LTFLN-DASVLYNLRSRYSA-MLIYTYSGLFCVVINPYKRLP-IYTNS----------------VATMYM--GKR------------RTEMPPHLFAVSDEAYRNMLVDH---------ENQSMLITGESGAGKTENTKKVIAYFAVVGASQN-----------------------------------------------------------------------------------------------------------------------------------------KGQDQ--G-------------------EKKVTLEDQIVQ--TN-----PVLEAFGNAKTVRNNNSSRFGKFIRIHFSKQ------GKVASCDIEHYL-LEKSRVIR-QAPGERCYHIFYQVFSDFNPTL-----------------------------------------KKDLLL--DQPLK----------NYYFVAQA----------------------------ELTIDG----------VNDKEEHQLTDEAFDILN----FSPEEK-MNCYRLVAAIMHMG-CMKFKQR-------PRE-----EQAEPDGT--D--EADKASNMYG-IDTEEFLKALTKPRVKVGT--------EWVSKGQNVDQVTWDVGAMANLLYDRIFKWL---------------------------VTKCNKTLDQKG--------LTR---------DYFIGVLDIAGFEIFD------FNSFEQLWINFVNEKLQQF-FNHHMFVLEQEEYEREGIQ--WTFID-FGLDLQACIELIE-----------------------------------KPM---GIISMLDEECIVP----------------KATDLTLAQKLVDTHL-GK-----HPNFEKP-KPPKG-------KQSEAHFAMKHYA--GTVRYNVMNWLE-KNKDPLNDTVVSVMKQSKA----------------NDLLVEIWKDYTT----------------QEESAAA------K-DGGGG-------------------------------------------------------------------------------------------------------------------------------------------------------KKKGKSGSFLTVSMMYR-----------------------ESLNSLMSMLN--MTHPHFIRCIIPNHNKTSG-----------------------------LLHRRMVLNQLTCNGVLEGI----RICRKGFPNRNLHADFKQRYA---VLAAK----EAKS----E----------------DDPKKCAEVMLSKLVNDG------ALTE--ENFRLGKTKVF--------FKAGV-LAHLEDQRD--*
Bm II -TEDMSN-LTFLN-DASVLYNLRSRYSS-MLIYTYSGLFCVVINPYKRLP-IYTDS----------------VATMYM--GKR------------RTEMPPHLFAVSDEAYRNMLVDH---------ENQSMLITGESGAGKTENTKKVIAYFAVVGASQN-----------------------------------------------------------------------------------------------------------------------------------------K--NQ--G-------------------EKKVTLEDQIVQ--TN-----PVLEAFGNAKTVRNNNSSRFGKFIRIHFSRQ------GKVASCDIEHYL-LEKSRVIR-QAPGERCYHIFYQIFSEFNPTL-----------------------------------------KKELQL--DQPLK----------NYYFVAQA----------------------------ELTIDG----------VNDKEEHQLTDEAFDILN----FSPEEK-MNCYRLVAAIMHMG-CMKFKQR-------PRE-----EQAEPDGT--D--EAEKASAMYG-IDTEEFLKALTKPRVKVGT--------EWVSKGQNVDQVTWAVGAMAKGLYARIFKWL---------------------------VNKCNKTLDQKG--------ISR---------DYFIGVLDIAGFEIFD------FNSFEQLWINFVNEKLQQF-FNHHMFVLEQEEYEREGIQ--WTFID-FGLDLQACIELIE-----------------------------------KPM---GIISMLDEECIVP----------------KATDLTLAQKLVDNHL-GK-----HPNFEKP-KPPKG-------KQSERHFAMKHYA--GTVRYNVMNWLE-KNKDPLNDTVVSTMKASKT----------------NDLLVEIWQDYTT----------------QEERAAA------K-DGGGG-------------------------------------------------------------------------------------------------------------------------------------------------------KKKGKSGSFLTVSMMYR-----------------------ESLNSLMSMLN--MTHPHFIRCIIPNEKKTSG-----------------------------LLDAALVLNQLTCNGALEGI----RICRKGFPNRNLHADFKQRYA---VLAAK----EAKS----E----------------DDPKKSAEVMLSKLVNDG------ALTE--ENFRLGKTKVF--------FKAGV-LAHLEDLRD--*
Ce IIC -TEDMSN-LTFLN-DASVLYNLKARYAA-MLIYTYSGLFCVVINPYKRLP-IYTES----------------VARMFM--GKR------------RTEMPPHLFAVSDEAYRNMLQNH---------ENQSMLITGESGAGKTENTKKVISYFAAVGAAQQETFGAK-------KAA-------------------------------------------------------------------------------------------------------------------------TEEDK--N-------------------KKKVTLEDQIVQ--TN-----PVLEAFGNAKTVRNNNSSRFGKFIRIHFSKQ------GRVASCDIEHYL-LEKSRVIR-QAPGERSYHIFYQVFSDYLPNL-----------------------------------------KKDLLL--NKPVK----------DYWFIAQA----------------------------ELIIDG----------INDKEEHQLTDEAFDILK----FTPTEK-MECYRLVAAMMHMG-NMKFKQR-------PRE-----EQAEPDGT--D--DAERAAKCFG-IDSEEFLKALTRPRVKVGN--------EWVNKGQKIEQVNWAVGAMAKGLYSRIFNWL---------------------------VKKCNQTLDQKG--------ISR---------DHFIGVLDIAGFEIFD------FNSFEQLWINFVNEKLQQF-FNHHMFVLEQEEYAREGIQ--WTFID-FGLDLQACIELIE-----------------------------------KPL---GIIAMLDEECIVP----------------KATDLTLAQKLIDQHL-GK-----HPNFEKP-KPPKG-------KQAEAHFAMRHYA--GTVRYNCLNWLE-KNKDPLNDTVVTVMKASKE----------------HALIVEVWQDYTT----------------QEEAAAA------A-AKGTAGA-----------------------------------------------------------------------------------------------------------------------------------------------------KKKGKSGSFMTVSMLYR-----------------------ESLNKLMTMLH--STHPHFIRCIIPNEKKASG-----------------------------VIDAGLVLNQLTCNGVLEGI----RICRKGFPNRTLHPDFVQRYA---LLAAD----ESIIG---K----------------TDAKKGSALMLARLVKEK------KLEE--ENFRVGLTKVF--------FKAGI-VAHLEDLRD--*
Ce F58G4.1 -TEDMAN-LTFLN-DASVLHNLRQRYYS-MMIYTYSGLFCVVINPYKRLP-IYSES----------------VCQMYL--GKR------------RNEMPPHLFAVSDEAYRNMTNDR---------ENQSMLITGESGAGKTENTKKVISYFAMVGASQQSNK--------------------------------------------------------------------------------------------------------------------------------------KKSKK--D-------------------KAQVSLEDQIVQ--TN-----PVLEAFGNAKTVRNNNSSRFGKFIRIHFNTG------GKVAGADIEHYL-LEKSRVIK-QAPGERSYHIFYQIYSDAVKGL-----------------------------------------REKLFL--TRPIK----------EYTFVSQA----------------------------EVTIDG----------VDDKEEMLITDEAFDIMK----FTATEK-SELFAITAGIMHMG-ELKFKQR-------PRE-----EQAELEEG--K--EGELACKLYC-VESEKFINALLKPRVKVGT--------EWVNKGQNLDQVNWAVGALAKALFARMFSWL---------------------------IRRCNKTLDAQD--------LSR---------DFFIGVLDIAGFEIFD------LNSFEQLWINFVNEKLQQF-FNHHMFVLEQEEYKREGIQ--WEFID-FGLDLQACIELIE-----------------------------------KPL---GIVSMLDEECIVP----------------KASDLTLASKLNDQHL-GK-----HPNFQKP-RPPKG-------KQAEAHLAIVHYA--GTVRYNVKGWLE-KNKDPLNDTAVTVLKANKG----------------NQLMADLWADYAT----------------QEDVAAA------A-KDGKKAVG----------------------------------------------------------------------------------------------------------------------------------------------------KKKGKSASFMTVSMMYR-----------------------ESLNKLMHMLH--QTHPHFIRCIIPNELKKAG-----------------------------MIDANLVLNQLTCNGVLEGI----RICRKGFPNRMPFLDFKQRYA---VLAAD----AAKA----G----------------KDPKDAGEKISAALIKDG------SLKQ--EEFQCGLTKVF--------FKAGV-LAHLEELRD--*
Ce IIA -TEDMAN-LTFLN-EASVLGNLKDRYKD-LMIYTYSGLFCVVINPYKRLP-IYSES----------------VIKHFM--GKR------------RNEMPPHLFAVSDEAYRNMVQDK---------ENQSMLITGESGAGKTENTKKVISYFAIVGATQAASG--------------------------------------------------------------------------------------------------------------------------------------KEAKD--G-------------------KKGGTLEEQIVQ--TN-----PVLEAFGNAKTVRNNNSSRFGKFIRTHFSGS------GKLAGGDIEHYL-LEKSRVVR-QAPGERCYHIFYQIMSGNDPSL-----------------------------------------RGKLKL--SNDIT----------YYHFCSQA----------------------------ELTIEG----------MDDKEEMRLTQEAFDIMG----FEDNET-MDLYRSTAGIMHMG-EMKFKQR-------PRE-----EQAEPDGE--E--DALNAAAMLG-IQAEEFLKALTKPRVRVGT--------EWVNKGQNLEQVNWAVSGLAKAIYARMFKWI---------------------------ITRCNKTLDAKE--------IER---------KHFIGVLDIAGFEIFD------LNSFEQLWINFVNERLQQF-FNHHMFVLEQEEYKREGIA--WTFID-FGLDLQACIELIE-----------------------------------KPL---GIISILDEECIVP----------------KATDMTYAQKLLDQHL-GK-----HPNFQKP-KPPKG-------KQGDAHFAIVHYA--GTVRYNATNFLE-KNKDPLNDTAVALLKHSTD----------------NSLMLDIWQDYQT----------------QEEAAEA------A-KAGQTAG-----------------------------------------------------------------------------------------------------------------------------------------------------GKRGKSSSFATVSMIYR-----------------------ESLNNLMNMLY--QTHPHFIRCIIPNEKKASG-----------------------------VIDSALVLNQLTCNGVLEGI----RICRKGFPNRMLYPDFKHRYA---ILAAD----AAKE---------------------SDPKKASVGILDKISVDG------NLTD--EEFKVGETKIF--------FKAGV-LAKLEDLRD--*
Ce F45G2.2 -TEDMSN-LTFLN-EASVLHNLRQRYYS-MMIYTYSGLFCVFINPYKMLP-IYTDS----------------VASMYV--NKR------------RAEMPPHLFAVSDEAFRNMMSDK---------ENQSMLITGESGAGKTENTKKVIAYFAMIGSGNK--------------------------------------------------------------------------------------------------------------------------------------------D---Q-------------------KSESSLENQVVQ--AN-----PAIEAFGNGATTRNYNSSRYGKFIRIHFDRK------GKLVGGDIEHYL-LEKSRVIK-QAPGERSYHIFYQIMT--QKAL-----------------------------------------RERYGL--SDNIR----------DYKFVSQA----------------------------EITVPG----------MNDTEEWQITDGAFNVMG----FSEREK-DDLYKLCSAIMHIG-NSTFKQK-------PRD-----EQAEVDDM--T--SPTAACKLFG-INTDQFLNALTRPRIKVGM--------EWVNKGQNVQQVDWAVGALSKAIYARMFNWL---------------------------IKRVNKTLQANS--------DEM---------VYYIGVLDIAGFEIFD------RNSFEQLWINFVNEKLQQF-FNHHMFVLEQEEYQREGIE--WTFID-FGLDLQSCIELIE-----------------------------------KPL---GIVSMLDEECIVP----------------KASDMTYVDKLLTQHL-GK-----HPNFQKA-KPPKG-------KQAEAHFSIMHYA--GTVRYNAEQWLD-KNKDPLNDSAVAILKTSDK----------------EGVLYQLWEEYQT----------------DVDREES------E-KRGKAQA-----------------------------------------------------------------------------------------------------------------------------------------------------KKKGKSASFLTVSTMYR-----------------------ESLTSLMTMLH--TTHPHFIRCIIPNEKKTSG-----------------------------LIDAPLVLNQLTCNGVLEGI----RICRKGFPNRMMFADFRFRYA---ILAAD----EASD---------------------KDAAKASKAMLRKLSKNN------QLNV--DTFKVGTTKFR--------LDIPM-REHSVN-----*
Gg smII -VEDMAE-LTCLN-EASVLHNLRERYFS-GLIYTYSGLFCVVINPYKQLP-IYSEK----------------IIDMYK--GKK------------RHEMPPHIYAIADTAYRSMLQDR---------EDQSILCTGESGAGKTENTKKVIQYLAVVASSHKG----------------------------------------------------------------------------------------------------------------------------------------KRTPASL----------------KVHLFPYGELEKQLLQ--AN-----PILEAFGNAKTVKNDNSSRFGKFIRINFDVT------GYIVGANIETYL-LEKSRAIR-QAKDERTFHIFYYLIAGASEQM-----------------------------------------RNDLLL--EG-FN----------NYTFLSNG----------------------------HVPIPA----------QQDDEMFQETLEAMTIMG----FTEEEQ-TSILRVVSSVLQLG-NIVFKKE-------RNT-----DQASMPDN--T--AAQKVCHLMG-INVTDFTRSILTPRIKVGR--------DVVQKAQTKEQADFAIEALAKAKFERLFRWI---------------------------LTRVNKALDKTK--------RQG---------ASFLGILDIAGFEIFE------INSFEQLCINYTNEKLQQL-FNHTMFILEQEEYQREGIE--WNFID-FGLDLQPCIELIE-----------------------------------RPTNPPGVLALLDEECWFP----------------KATDTSFVEKLIQEQ--GN-----HAKFQKS-KQLK----------DKTEFCILHYA--GKVTYNASAWLT-KNMDPLNDNVTSLLNQSS-----------------DKFVADLWKDVDR----------------IVGLDQM------AKMTESSLPS----------------------------------------------------------------------------------------------------------------------------------------------------ASKTKKGMFRTVGQLYK-----------------------EQLTKLMTTLR--NTNPNFVRCIIPNHEKRAG-----------------------------KLDAHLVLEQLRCNGVLEGI----RICRQGFPNRIVFQEFRQRYE---ILAAN----AIPKG---F----------------MDGKQACILMIKAL----------ELDP--NLYRIGQSKIF--------FRTGV-LAHLEEERD--*
Oc smII -VEDMAE-LTCLN-EASVLHNLRERYFS-GLIYTYSGLFCVVVNPYKQLP-IYSEK----------------IVDMYK--GKK------------RHEMPPHIYAIADTAYRSMLQDR---------EDQSILCTGESGAGKTENTKKVIQYLAVVASSHKG----------------------------------------------------------------------------------------------------------------------------------------KKDTS-----------------------ITGELEKQLLQ--AN-----PILEAFGNAKTVKNDNSSRFGKFIRINFDVT------GYIVGANIETYL-LEKSRAIR-QAREERTFHIFYYLIAGAKEKM-----------------------------------------RNDLLL--EG-FN----------NYTFLSNG----------------------------FVPIPA----------AQDDEMFQEKVEAMSIMG----FSEEEQ-LSVLKVVSSVLQLG-NIVFKKE-------RNT-----DQASMPDN--T--AAQKVCHLMG-INVTDFTRSILTPRIKVGR--------DVVQKAQTKEQADFAVEALAKATYERLFRWI---------------------------LSRVNKALDKTH--------RQG---------ASFLGILDIAGFEIFE------VNSFEQLCINYTNEKLQQL-FNHTMFILEQEEYQREGIE--WNFID-FGLDLQPCIELIE-----------------------------------RPNNPPGVLALLDEECWFP----------------KATDKSFVEKLCTEQ--GN-----HPKFQKP-KQLK----------DKTEFSIIHYA--GKVDYNASAWLT-KNMDPLNDNVTSLLNASS-----------------DKFVADLWKDVDR----------------IVGLDQM------AKMTESSLPS----------------------------------------------------------------------------------------------------------------------------------------------------ASKTKKGMFRTVGQLYK-----------------------EQLGKLMTTLR--NTTPNFVRCIIPNHEKRSG-----------------------------KLDAFLVLEQLRCNGVLEGI----RICRQGFPNRIVFQEFRQRYE---ILAAN----AIPKG---F----------------MDGKQACILMIKAL----------ELDP--NLYRIGQSKIF--------FRTGV-LAHLEEERD--*
Gg nmII -VEDMAE-LTCLN-EASVLHNLKERYYS-GLIYTYSGLFCVVINPYKNLP-IYSEE----------------IVEMYK--GKK------------RHEMPPHIYAITDTAYRSMMQDR---------EDQSILCTGESGAGKTENTKKVIQYLAHVASSHKS----------------------------------------------------------------------------------------------------------------------------------------KKDQ--------------------------GELERQLLQ--AN-----PILEAFGNAKTVKNDNSSRFGKFIRINFDVN------GYIVGANIETYL-LEKSRAIR-QAKEERTFHIFYYLLSGAGEHL-----------------------------------------KTDLLL--EP-YN----------KYRFLSNG----------------------------HVTIPG----------QQDKDMFQETMEAMRIMG----IPDEEQ-IGLLKVISGVLQLG-NIVFKKE-------RNT-----DQASMPDN--T--AAQKVSHLLG-INVTDFTRGILTPRIKVGR--------DYVQKAQTKEQADFAIEALAKATYEQMFRWL---------------------------VMRINKALDKTK--------RQG---------ASFIGILDIAGFEIFE------LNSFEQLCINYTNEKLQQL-FNHTMFILEQEEYQNEGIE--WNFID-FGLDLQPCIDLIE-----------------------------------KPAGPPGILALLDEECWFP----------------KATDKSFVEKVVQEQ--GT-----HPKFQKP-KQLK----------DKADFCIIHYA--GKVDYKADEWLM-KNMDPLNDNIATLLHQSS-----------------DKFVSELWKDVDR----------------IVGLDQV------AGMSETALPG----------------------------------------------------------------------------------------------------------------------------------------------------AFKTRKGMFRTVGQLYK-----------------------EQLAKLMATLR--NTNPNFVRCIIPNHEKKAG-----------------------------KLDPHLVLDQLRCNGVLEGI----RICRQGFPNRVVFQEFRQRYE---ILTPN----AIPKG---F----------------MDGKQACVLMIKAL----------ELDS--NLYRIGQSKVF--------FRAGV-LAHLEEERD--*
Hs nmIIA -VEDMAE-LTCLN-EASVLHNLKERYYS-GLIYTYSGLFCVVINPYKNLP-IYSEE----------------IVEMYK--GKK------------RHEMPPHIYAITDTAYRSMMQDR---------EDQSILCTGESGAGKTENTKKVIQYLAYVASSHKS----------------------------------------------------------------------------------------------------------------------------------------KKDQ--------------------------GELERQLLQ--AN-----PILEAFGNAKTVKNDNSSRFGKFIRINFDVN------GYIVGANIETYL-LEKSRAIR-QAKEERTFHIFYYLLSGAGEHL-----------------------------------------KTDLLL--EP-YN----------KYRFLSNG----------------------------HVTIPG----------QQDKDMFQETMEAMRIMG----IPEEEQ-MGLLRVISGVLQLG-NIVFKKE-------RNT-----DQASMPDN--T--AAQKVSHLLG-INVTDFTRGILTPRIKVGR--------DYVQKAQTKEQADFAIEALAKATYERMFRWL---------------------------VLRINKALDKTK--------RQG---------ASFIGILDIAGFEIFD------LNSFEQLCINYTNEKLQQL-FNHTMFILEQEEYQREGIE--WNFID-FGLDLQPCIDLIE-----------------------------------KPAGPPGILALLDEECWFP----------------KATDKSFVEKVMQEQ--GT-----HPKFQKP-KQLK----------DKADFCIIHYA--GKVDYKADEWLM-KNMDPLNDNIATLLHQSS-----------------DKFVSELWKDVDR----------------IIGLDQV------AGMSETALPG----------------------------------------------------------------------------------------------------------------------------------------------------AFKTRKGMFRTVGQLYK-----------------------EQLAKLMATLR--NTNPNFVRCIIPNHEKKAG-----------------------------KLDPHLVLDQLRCNGVLEGI----RICRQGFPNRVVFQEFRQRYE---ILTPN----SIPKG---F----------------MDGKQACVLMIKAL----------ELDS--NLYRIGQSKVF--------FRAGV-LAHLEEERD--*
Rn neurII -VEDMAE-LTCLN-EASVLHNLKERYYS-GLIYTYSGLFCVVINPYKNLP-IYSEE----------------IVEMYK--GKK------------RHEMPPHIYAITDTAYRSMMQDR---------EDQSILCTGESGAGKTENTKKVIQYLAHVASSHKS----------------------------------------------------------------------------------------------------------------------------------------KKDQ--------------------------GELERQLLQ--AN-----PILEAFGNAKTVKNDNSSRFGKFIRINFDVN------GYIVGANIETYL-LEKSRAIR-QAKEERTFHIFYYLLSGAGEHL-----------------------------------------KTDLLL--EP-YG----------KYRFLSNG----------------------------HVTIPG----------QQDKDMFQETMEAMRIMG----IPDEEQ-IGLLKVISGVLQLG-NIVFKKE-------RNT-----DQASMPDN--T--AAQKVSHLLG-INVTDFTRGILTPRIKVGR--------DYVQKAQTKEQADFAIEALAKATYEQMFRWL---------------------------VMRINKALDKTK--------RQG---------ASFIGILDIAGFEIFE------LNSFEQLCINYTNEKLQQL-FNHTMFIE-QEEYQREGIE--WNFID-FGLDLQPCIDLIE-----------------------------------RPANPPGVLALLDEECWFP----------------KATDKTFVEKLVQEQ--GT-----HSKFQKP-RQLK----------DKADFCIIHYA--GKVDYKGDEWLM-KNMDPLNDNVATLLHQSS-----------------DKFVAELWKDVDR----------------IVGLDQV------TGITETAFGS----------------------------------------------------------------------------------------------------------------------------------------------------AYKTKKGMFRTVGQLYK-----------------------ESLTKLMATLR--NTNPNFVRCIIPNHEKRAG-----------------------------KLDPHLVLDQLRCNGVLEGI----RICRQGFPNRIVFQEFRQRYE---ILTPN----AIPKG---F----------------MDGKQACERMIRAL----------ELDP--NLYRIGQSKIF--------FRAGV-LAHLEEERD--*
Hs nmIIB -VEDMAE-LTCLN-EASVLHNLKDRYYS-GLIYTYSGLFCVVINPYKNLP-IYSEN----------------IIEMYR--GKK------------RHEMPPHIYAISESAYRCMLQDR---------EDQSILCTGESGAGKTENTKKVIQYLAHVASSHKG----------------------------------------------------------------------------------------------------------------------------------------RKDHNIP-----------------------GELERQLLQ--AN-----PILESFGNAKTVKNDNSSRFGKFIRINFDVT------GYIVGANIETYL-LEKSRAVR-QAKDERTFHIFYQLLSGAGEHL-----------------------------------------KSDLLL--EG-FN----------NYRFLSNG----------------------------YIPIPG----------QQDKDNFQETMEAMHIMG----FSHEEI-LSMLKVVSSVLQFG-NISFKKE-------RNT-----DQASMPEN--T--VAQKLCHLLG-MNVMEFTRAILTPRIKVGR--------DYVQKAQTKEQADFAVEALAKATYERLFRWL---------------------------VHRINKALDRTK--------RQG---------ASFIGILDIAGFEIFE------LNSFEQLCINYTNEKLQQL-FNHTMFILEQEEYQREGIE--WNFID-FGLDLQPCIDLIE-----------------------------------RPANPPGVLALLDEECWFP----------------KATDKTFVEKLVQEQ--GS-----HSKFQKP-RQLK----------DKADFCIIHYA--GKVDYKADEWLM-KNMDPLNDNVATLLHQSS-----------------DRFVAELWKDVDR----------------IVGLDQV------TGMTETAFGS----------------------------------------------------------------------------------------------------------------------------------------------------AYKTKKGMFRTVGQLYK-----------------------ESLTKLMATLR--NTNPNFVRCIIPNHEKRAG-----------------------------KLDPHLVLDQLRCNGVLEGI----RICRQGFPNRIVFQEFRQRYE---ILTPN----AIPKG---F----------------MDGKQACERMIRAL----------ELDP--NLYRIGQSKIF--------FRAGV-LAHLEEERD--*
Xl nmII -VEDMAE-LTCLN-EASVLHNLKDRYYS-GLIYTYSGLFCVVINPYKNLP-IYSEN----------------IIEMYR--GKK------------RHEMPPHIYAISESAYRCMLQDR---------EDQSILCTGESGAGKTENTKKVIQYLAHVASSHKG----------------------------------------------------------------------------------------------------------------------------------------KKDHTIPTESPKAIKH-------QSGSLLYGELERQLLQ--AN-----PILESFGNAKTVKNDNSSRFGKFIRINFDVT------GYIVGANIETYL-LEKSRAVR-QAKDERTFHIFYQLLAGSGEHL-----------------------------------------KSDLLL--DG-FN----------NYRFVSNG----------------------------YIPIPG----------QQDKDNFQETMEAMHIMG----FSHEEI-LSMLKVVSSVLQFG-NIVFKKE-------RNT-----DQASMPEN--T--AAQKLCHLLG-LNIMEFTRAILTPRIKVGR--------DYVQKAQTKEQADFAVEALRKATYERLFRWL---------------------------VYRINKALDRTK--------RQG---------ASFIGILDIAGFEIFE------LNSFEQLCINYTNEKLQQL-FNHTMFILEQEEYQREGIE--WNFID-FGLDLQPCIDLIE-----------------------------------RPANSPGVLALLDEECWFP----------------KATDKTFVDKLVQEQ--GT-----HSKFQKP-RQLK----------DKADFCIIHYA--GRVDYKADEWLL-KNMDPLNDNVATLLHQSS-----------------DKFVSELWKDVDR----------------IVGLDQV------AGMAETAFGA----------------------------------------------------------------------------------------------------------------------------------------------------AYKTKKGMFRTVGQLYK-----------------------ESLAKLMATLR--NTNPNFVRCIIPNHEKRAG-----------------------------KLDPHLVLDQLRCNGVLEGI----RICRQGFPNRIVFQEFRQRYE---ILTPN----SIPRG---F----------------MDGKQACERMIRSL----------ELDP--NLYRIGQSKIF--------FRAGV-LAHLEEERD--*
Dm nmII -VEDMAE-LTCLN-EASVLHNIKDRYYS-GLIYTYSGLFCVVVNPYKKLP-IYTEK----------------IMERYK--GIK------------RHEVPPHVFAITDSAYRNMLGDR---------EDQSILCTGESGAGKTENTKKVIQFLAYVAASKPK----------------------------------------------------------------------------------------------------------------------------------------GSGAVPHP------------------AVLIGELEQQLLQ--AN-----PILEAFGNAKTVKNDNSSRFGKFIRINFDAS------GFISGANIETYL-LEKSRAIR-QAKDERTFHIFYQLLAGATPEQ-----------------------------------------REKFIL--DD-VK----------SYAFLSNG----------------------------SLPVPG----------VDDYAEFQATVKSMNIMG----MTSEDF-NSIFRIVSAVLLFG-SMKFRQE-------RNN-----DQATLPDN--T--VAQKIAHLLG-LSVTDMTRAFLTPRIKVGR--------DFVTKAQTKEQVEFAVEAIAKACYERMFKWL---------------------------VNRINRSLDRTK--------RQG---------ASFIGILDMAGFEIFE------LNSFEQLCINYTNEKLQQL-FNHTMFILEQEEYQREGIE--WKFID-FGLDLQPTIDLID-----------------------------------KPG---GIMALLDEECWFP----------------KATDKTFVDKLVSAH--SM-----HPKFMKT--DFR----------GVADFAIVHYA--GRVDYSAAKWLM-KNMDPLNENIVSLLQGSQ-----------------DPFVVNIWKDAE-----------------IVGMAQQ------A-LTDTQFG------------------------------------------------------------------------------------------------------------------------------------------------------ARTRKGMFRTVSHLYK-----------------------EQLAKLMDTLR--NTNPNFVRCIIPNHEKRAG-----------------------------KIDAPLVLDQLRCNGVLEGI----RICRQGFPNRIPFQEFRQRYE---LLTPN----VIPKG---F----------------MDGKKACEKMIQAL----------ELDS--NLYRVGQSKIF--------FRAGV-LAHLEEERD--*
Ce NMY1 -IEDMSE-LTYLN-EASVLHNLKDRYYS-SLIYTYSGLFCVVINPYKKLP-IYSED----------------LIEEFK--GKK------------RHEMPPHIFAIADTAYRSMLQER---------EDQSILCTGESGAGKTENTKKVIQYLAHVAGATRN----------------------------------------------------------------------------------------------------------------------------------------KSLNAAAQQN----------------IVQKGELEHQLLQ--AN-----PILEAFGNSKTVKNDNSSRFGKFIRINFDMS------GYISGANIEFYL-LEKSRVLR-QAQDERSFHIFYQILRGCSAKE-----------------------------------------KSEYLL--EG-VD----------NYRFLVNR----------------------------GITLPN----------VDDVQEFHSTINSMRIMG----FADDEI-SSIMRVVSAVLLLG-NLEFTQE-------KKS-----DQAMLQDD--R--VIQKVCHLLG-LPVIELQKAFLRPRIKVGR--------EFVNKAQNQEQAEFAVEAIAKASYERLFKWL---------------------------VTRINKSLDRTH--------RQG---------ASFIGILDIAGFEIFD------INSFEQICINYTNEKLQQL-FNNTMFILEQEEYQREGIE--WDFID-FGLDLQPTIDLIE-----------------------------------KPM---GVLALLDEECLFP----------------KANDKSFVEKLQKTH--NK-----HPKFIVP--DMR----------SKSHFAVVHYA--GRVDYSADQWLM-KNMDPLNENVVGLMQNST-----------------DPFVAGIWKDAE-----------------FAGICAA------E-MNETAFG------------------------------------------------------------------------------------------------------------------------------------------------------MRSRKGMFRTVSQLHK-----------------------EQLTKLMTTLR--NTSPHFVRCIIPNHEKKSG-----------------------------KINSNLVLEQLRCNGVLEGI----RICRQGFPNRVPFQEFRHRYE---ILTPD----VIPKN---F----------------IDGKESVRKMITAL----------DIDT--NLYRIGQSKVF--------FRTGV-LAHLEEERD--*
Ce NMY2 -CEDMSM-LTCLN-EASVLHNLKQRYFS-NLYYTYSGLFCVVINPYKRIP-IYTDT----------------IAEQFK--CKK------------RKEMPPHIFAVADEAYRSMLQER---------DDQSILCTGESGAGKTENTKKVIQYLAYVANRSMV----------------------------------------------------------------------------------------------------------------------------------------KNRKTSVDLDTSTN-------------RIMGQLEEQLLQ--AN-----PILEAFGNSKTVKNDNSSRFGKFIRVHFDST------GCISGANIEFYL-LEKSRVLK-QAPNERSFHIFYQLLKGLSKVQ-----------------------------------------REHYLL--EDSLS----------KYKFVSNG----------------------------DSKLAG----------VDDGAEMKETLNAMSIMG----LNDEEI-GGILRVVSAVMLFG-NLEFSHEN------KNN-----DQAVLLND--A--VAQKIASLLG-VNVTELMRAFLKPKIKVQR--------DLVHRAQSVDQVNFSVGAIAKASYERLFRWL---------------------------VHRLNKSLDRTR--------QQS---------VSFIGILDIAGFEIFE------TNSFEQLCINYTNEKLQQL-FNNTMFVREQQEYLDEGLE--WKFLD-FGLNLQPTIDLID-----------------------------------KPM---GIMSTLDDVCLFP----------------QGNDQSFVQRLNNTH--SQ-----HPKYVVP--EIR----------SRSDFAVVHYA--GRVDYQSEGWRV-KNMDPLNENVIDVLKTSK-----------------ESLIVDMWKDIAD----------------VCSLSAA------DSTSDTGVFG----------------------------------------------------------------------------------------------------------------------------------------------------SRVPKKGMFRTVSQLYK-----------------------EQLARLMSTLN--NTNPHFVRCIIPNHEKKHG-----------------------------VLNAHLVLDQLRCNGVLEGI----RICRQGFPTRLPFQEFRQRYEK--LLAPD----VNPAG---F----------------MDGKNAVYRIVQYL----------EVDA--NLFRIGQSKIF--------FRSGV-IAEFEEMRD--*
Dd II -VEDMSE-LSYLN-EPAVFHNLRVRYNQ-DLIYTYSGLFLVAVNPFKRIP-IYTQE----------------MVDIFK--GRR------------RNEVAPHIFAISDVAYRSMLDDR---------QNQSLLITGESGAGKTENTKKVIQYLASVAGRNQAN-------------------------------------------------------------------------------------------------------------------------------------------------------------------GSGVLEQQILQ--AN-----PILEAFGNAKTTRNNNSSRFGKFIEIQFNNA------GFISGASIQSYL-LEKSRVVF-QSETERNYHIFYQLLAGATAEE-----------------------------------------KKALHL--AG-PE----------SFNYLNQS---------------------------GYVDIKG----------VSDSEEFKITRQAMDIVG----FSQEEQ-MSIFKIIAGILHLG-NIKFEKG--------AG-----EGAVLKDK--T--ALNAASTVFG-VNPSVLEKALMEPRILAGR--------DLVAQHLNVEKSSSSRDALVKALYGRLFLWL---------------------------VKKINNVLCQE---------RK----------AYFIGVLDISGFEIFK------VNSFEQLCINYTNEKLQQF-FNHHMFKLEQEEYLKEKIN--WTFID-FGLDSQATIDLIDG---------------------------------RQPP---GILALLDEQSVFP----------------NATDNTLITKLHSHFS-KK-----NAKYEEPRFSKT-------------EFGVTHYA--GQVMYEIQDWLE-KNKDPLQQDLELCFK-DSS----------------DNVVTKLFNDPN-----------------IAS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------RAKKGANFITVAAQYK-----------------------EQLASLMATLE--TTNPHFVRCIIPNNKQLPA-----------------------------KLEDKVVLDQLRCNGVLEGI----RITRKGFPNRIIYADFVKRYY---LLAPN----VPRD----A----------------EDSQKATDAVLKHLN----------IDP--EQYRFGITKIF--------FRAGQ-LARIEEARE--*
Ac II -VEDMGE-LGYLN-EPAVLHNLKKRYDA-DLFHTYSGLFLVVVNPYKRLP-VYTPE----------------IIDIYR--GRQ------------RDKVAPHIFAISDAAYRAMLNTR---------QNQSMLITGESGAGKTENTKKVIQYLTAIAGRAEG----------------------------------------------------------------------------------------------------------------------------------------------------------------------GLLEQQLLE--FN-----PILEAFGNAKTTKNNNSSRFGKFIELQFNAG------GQITGANTFIYL-LEKSRVTA-QGAGERNFHIFYQILSKAMPEEL----------------------------------------KQKLKL--TK-PE----------DYFFLNQN---------------------------ACYTVDD----------MDDAKEFDHMLKAFDILN----INEEER-LAIFQTISAILHLG-NLPFIDV--------NS-----ETAGLKDE--V--ELNIAAELLG-VSAAGLKAGLLSPRIKAGN--------EWVTRALNKPKAMASRDALCKALFGRLFLWI---------------------------VQKINRILSHK---------DKT---------ALWIGVLDISGFEIFQ------HNSFEQLCINYTNEKLQQF-FNHHMFTLEQQEYEREKID--WTFVD-YGMDSQDCIDLIE----------------------------------KKPM---GILPLLDEQTVFP----------------DADDTSFTKKLFQTHE-N------HRNFRRPRFDAN-------------NFKIVHYA--GEVEYQTSAWLE-KNRDPLEDDLSNLCK-KSS----------------VRFVTGLFDEDL-----------------MPSFKAAPAEEEKAAAGGSRNRST---------------------------------------------------------------------------------------------------------------------------------------------------GRGKGGAQFITVAFQYK-----------------------EQLAHLMSMLS--STAPHFIRCIIPNLGKKPG-----------------------------VVSDQLVLDQLKCNGVLEGI----RIARKGWPNRLKYDEFLKRYF---LLKPG----ATPT----S----------------PSTKDAVKDLIEHLIAKE----PTKVNK--DEVRFGVTKIF--------FRSGQ-LAAIEELRE--*
Eh II -VDDMSQ-LTHLS-EATVLYNLRIRYME-DIIHTYSGLFCVVINPYKFFP-IYTPF----------------IVSKYQ--GRR------------REDVAPHVYAIADGAYRAMLDPASKF------RNQSILITGESGAGKTENTKRVIQFLAMTAGQSKKAG------------------------------------------------------------------------------------------------------------------------------------------------------------------QLGELEEQLID--LN-----PMLEAFGNAKTVKNNNSSRFGKFIEIQFSNG------GKIVGCIMSSYL-LEKSRVVY-QAREDRNYHIFYQLLAGATAQQ-----------------------------------------KSEMHL--DR-PE----------SYKLIYQNK-----------------------KSPQELNVEY----------MDDAEEFKNTIKAMRTMN----ITDDEQ-NQIFKIVAGMLHLG-NVEYSQG--------R------DGAELANP--E--TFRKAAELFG-VDAESLRKAIIQPKIKAGL--------EIIERHLSKEEAEFNTTATLKAIYHRLFVFI---------------------------VNKVNEVMGKA---------G-----------AHSIGILDIAGFEIFR------ENSFEQLCINLTNEKLQQF-FNNHMFNLEQLEYQNEGIP--WTHQN-FGDDLQPVIDLIES---------------------------------KIPA---GILAMLDEQSFVA----------------SGSDENFHANICNTFG-RG-----HPRFRKPRIGGDG----------VYEFDILHYA--GTVTYNAKDWVK-KNRDPLERDIQQVFIGKDS----------------SSLISRLFRITEG----------------IAG------------SSGDDMGTG---------------------------------------------------------------------------------------------------------------------------------------------------KGSSKAAKFLTVGSNHK-----------------------AQLEELMRKLK--MTNPHFIRCILPNTQKKQR-----------------------------YFVDSTVLKQLRCNGVLEGI----RITRMGYPNRMIYSEFLKRYY---FLGDK----INRR----A----------------SDEKATASTLMRQIIEKYKKDGQPRAKE--GDYRFCKTKIF--------FRVGI-LAEIEEVRE--*
Sc MyoI IIA -VENMSE-LTHLN-EPSVLYNLEKRYDC-DLIYTYSGLFLVAINPYHNLN-LYSED----------------HINLYH--NKHNRLSKSRLDENSHEKLPPHIFAIAEEAYENLLSEG---------KDQSILVTGESGAGKTENTKKILQYLASITSGSPS----------------------------------------------------------------------------------------------------------------------------------------NIAPVSGS-------------------SIVESFEMKILQ--SN-----PILESFGNAQTVRNNNSSRFGKFIKIEFNEH------GMINGAHIEWYL-LEKSRIVH-QNSKERNYHIFYQLLSGLDDSEL----------------------------------------KNLRLK--SRNVK----------DYKILSNS---------------------------NQDIIPG----------INDVENFKELLSALNIIG----FSKDQI-RWIFQVVAIILLIG-NIEFVSD--------RA-----EQASFKN------DVSAICSNLG-VDEKDFQTAILRPRSKAGK--------EWVSQSKNSQQAKFILNALSRNLYERLFGYI---------------------------VDMINKNLDHG---------SAT---------LNYIGLLDIAGFEIFE------NNSFEQLCINYTNEKLQQF-FNNHMFVLEQSEYLKENIQ--WDYID-YGKDLQLTIDLIES---------------------------------KGPP--TGVLPLLDEEAVLP----------------KSTDESFYSKLISTWD-QN-----SSKFKRS--RLK------------NGFILKHYA--GDVEYTVEGWLS-KNKDPLNDNLLSLLSSSQ-----------------NDIISKLFQPEGE----------------KSSSAG------VEANISNQE--V---------------------------------------------------------------------------------------------------------------------------------------------------KKSARTSTFKTTSSRHR-----------------------EQQITLLNQLA--STHPHFVRCIIPNNVKKVK-----------------------------TFNRRLILDQLRCNGVLEGI----RLAREGYPNRIAFQEFFQRYR---ILYPE----NSTTTT--FSSKLK-----------ASTKQNCEFLLTSL----------QLDT--KVYKIGNTKLF--------FKAGV-LADLEKQKD--*
Ce Y11D7A.14 --EDLCT-LTQPN-AATVLNALKIRYTS-NVIHTFCGLFCVVINPWRNIP-IYSDE----------------VKQLYQ--LQN--------------DLPPHVYSVAQNAFHGILKGG---------RNQSILITGESGAGKTENTKKIIDFILSSSVSNN------------------------------------------------------------------------------------------------------------------------------------------------------------------------TIGDCVVT--SG-----VLLEAMGNARTTHNSNSSRFGKFIRIEFDEN------SKLIGAKIECYL-LEKSRVVF-QSDGDRNFHIFYQMLSNYFDNPH----------------------------------------KSFLKL--SKKVN----------EYKYLRND-------------------------------DSM----------IDDAETAKMTDEAFTRIG----LSEEEK-IWIFQILSAVLWIG-DIKFGER-------SGL-----DVSFVESM--Q--EVDNIAELLE-MKSSKLVDALTQPTIKVHD--------KLIRKNQNLAKTLSSASAMAKILYERLFGWI---------------------------VKRCNDAFSVDD--------TESTCRL-----SRFIAVLDIAGFEIIE------KNSFEQFCINYTNEKLQQF-FNHFMFAKEQSDYLEEGIK--WTQVN-FANHLQPTIDLIE-----------------------------------KPM---GILSFLEEECVVP----------------NGSEKSLLEKLCSNLS-N------DSSFKKS-KQTQK-------CSTIRHFYVQHYA--GEVHYNIDGWLD-KNRDNVETSVLDILSQST-----------------HPLLKLLFPPVPV----------------N-NLK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------TRRGTITNSTVSFLYK-----------------------NQLQCLLDTLN--SSSAHFIRCVVSNYEKLPG-----------------------------KIDAPLVLAQLKCNGVLEGI----RICREGYPSRLSHSEFIERYSL--LMKNK----EQSKG--------------------ASEKEKCTLICQDA----------QVRK--ERYAVGKTKLF--------CKVGV-ISELETKRN--*
Ss VI -VEDNCS-LMYLN-EATLLHNIKVRYSK-DRIYTYVANILIAVNPYFDIPKIYSSE----------------TIKSYQ--GKS------------LGTMPPHVFAIADKAFRDMKV---------LKLSQSIIVSGESGAGKTENTKFVLRYLTESYG------------------------------------------------------------------------------------------------------------------------------------------TGQ------------------------------DIDDRIVE--AN-----PLLEAFGNAKTVRNNNSSRFGKFVEIHFNEK------SSVVGGFVSHYL-LEKSRICV-QGKEERNYHIFYRLCAGASED-----------------------------------------IRERLH---LSSPD----------NFRYLNR-----------GCTRYFANKETDKQILQNRKSPEYLKAGSLKDPLLDDHGDFIRMCTAMKKIG----LDDEEK-LDLFRVVAGVLHLG-NIDFEEAG------STS-----GGCNLKNK--STQALEYCAEKLLGLDQDDLRVSLTTRVMLTTAGG---AKGTVIKVPLKVEQANNARDALAKTVYSHLFDHV---------------------------VNRVNQCFPFE---------TSS----------YFIGVLDIAGFEYF------EHNSFEQFCINYCNEKLQQF-FNERILKEEQELYQKEGLG--VNEVH-YVDN-QDCIDLIEA----------------------------------RL---VGILDILDEENRLP----------------QPSDQHFTSAGHQK--HKD-----HFRLSIPRKSKLA--IHR-NIAYDEGFIIRHFA--GAVCYETTQFVE-KNNDALHMSLESLICES-----------------RDKFIRELFESST--------------NNNKDTKQKAG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------KL-SFISVGNKFK-----------------------TQLNLLLDKLR--STGASFIRCIKPNLKMTSH-----------------------------HFEGAQILSQLQCSGMVSVL----DLMQGGFPSRASFHEVYNMYK---KSLPD----KL------AR--L-------------DPRLFCKALFKALG---------LNE---IDYKFGLTKVF--------FRPGK-FAEFDQIMK--*
Hs VI -VEDNCS-LMYLN-EATLLHNIKVRYSK-DRIYTYVANILIAVNPYFDIPKIYSSE----------------AIKSYQ--GKS------------LGTRPPHVFAIADKAFRDMKV---------LKMSQSIIVSGESGAGKTENTKFVLRYLTESYG------------------------------------------------------------------------------------------------------------------------------------------TGQ------------------------------DIDDRIVE--AN-----PLLEAFGNAKTVRNNNSSRFGKFVEIHFNEK------SSVVGGFVSHYL-LEKSRICV-QGKEERNYHIFYRLCAGASED-----------------------------------------IREKLH---LSSPD----------NFRYLNR-----------GCTRYFANKETDKQILQNRKSPEYLKAGSMKDPLLHDHGDFIKMCTALKKIG----LDDEEK-LDLFRVFPGVLHLG-NIDFEEAG------NTS-----GGCSLNNK--SAQSLEYCAE-LLGLDRYDLQVLLTTRVMLTTAGG---TRGTVIKVPLIVEQANHARDALAKTVYSHLFDHV---------------------------VNIVNQCFPFE---------PSS----------YFIGVLDIAGFEYF------EHNSFEQFCINYCNEKLQQF-FNERILKEEQELYQKEGLG--VNEVH-YVDN-QDCIDLIEA----------------------------------KL---VGILDILDEENRLP----------------QPSDQHFTSAVHQK--HKD-----HFRLTIPRKSKLA--VHR-NIRDDEGFIIRHFA--GAVCYETTQFVE-KNNDALHMSLESLICES-----------------RDKFIRELFESST--------------NNNKDTKQKAG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------KL-SFISVGNKFK-----------------------TQLNLLLDKLR--STGASFIRCIKPNLKMTSH-----------------------------HFEGAQILSQLQCSGMVSVL----DLMQGGYPSRASFHELYNMYK---KYMPD----KL------AR--L-------------DPRLFCKALFKALG---------LNE---NDYKFGLTKVF--------FRPGK-FAEFDQIMKS-*
Mm Waltzer VI -VEDNCS-LMYLN-EATLLHNVKVRYSK-DRIYTYVANILIAVNPYFDIPKIYSSD----------------TIKSYQ--GKS------------LGTMPPHVFGIADKAFRDMKV---------LKMSQSIIVSGESGAGKTENTKFGSKIPDRILW------------------------------------------------------------------------------------------------------------------------------------------TGQ------------------------------DIDDRIVE--AN-----PLLEAFGNAKTVRNNNSSRFGKFVEIHFNEK------SSVVGGFVSHYL-LEKSRICV-QGKEERNHHIFYRLCAGASED-----------------------------------------IREKLH---LSSPD----------NFRYLNR-----------GCTRFFANKETDKQILQNRKSPEYVKAGSLEGSSIRRPWRFYQDVHSHEKNW----FGMMKKNFDLFRVVAGVLHLG-NIDLEEAG------STS-----GGCNLKNK--SAPSLEYCAE-LLGLDQDDLRVSLTTRVMLTTAGG---TKGTVIKVPLKVEQANNARDALAKTVYSHLFDHV---------------------------VNRVNQCFPFE---------TSS----------YFIGVLDIAGFEYF------EHNSFEQFCINYCNEKLQQF-FNERILKEEQELYQKEGLG--VNEVH-YVDN-QDCIELIEV----------------------------------KL---VGILDILDEENRLP----------------QPSDQHFTSVVHQK--HKD-----HFRLTIPRKSKLA--VHR-NLRDDEGFIIRQLCR-GRVLRRQPQYGGGKNNDALHMSLESLICES-----------------RDKFIRALFESST--------------NNSKDTKQKAG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------KL-SFISVGNKFK-----------------------TQLNLLLDKLR--STGASFIRCIKPNLKMASH-----------------------------HFEGAQILSQLQCSGMVSVL----DLMQGGFPSRASFHELYNMYK---KYMPE----KL------PR--L-------------DPRLFCKPLFKALG---------LNE---VDYKFGLTQVF--------FRPGK-FAEFDQI----*
Ms VIB -VDDNCS-LMYLN-EATLLNNVRVRYSK-DHIYTYVANILIAVNPYYDIPKLYGPD----------------SIKSYR--GKS------------LGTLPPHVFAIADKAYRDMKV---------LKMSQSIIVSGESGAGKTENTKFVLRYLTTTYG------------------------------------------------------------------------------------------------------------------------------------------SGQ------------------------------DIDERIVE--AN-----PLLEAFGNAKTVRNNNSSRFGKFVEIHFDEK------NAVVGGFVSHYL-LEKSRICM-QSNDERNYHIFYRLCAGASED-----------------------------------------IKKKLH---LDSPD----------SFRYLNR-----------GCTRYFASKDSDKQIMQNRKSPEHLKVGALKDLLLDDQGDFNRMCVAMKKIG----LDDTEK-LDLFRVVAGVLHLG-NIDFEETG------SSS-----GGCVLKNQ--SGQTLEYCAD-LLGLDQDDLRVSLTTRIMLTTAGG---AKGTVIKVPLKVEQANNARDALAKAVYSRLFDHV---------------------------VKRVNQCFPFE---------TSS----------NFIGVLDIAGFEYF------EHNSFEQFCINYCNEKLQQF-FNERILKEEQELYQREGLG--VNEVH-YVDN-QDCIDLVEV----------------------------------KL---VGVLDILDEENRLP----------------QPSDQHFALAVHNK--HKD-----HFRLTVPRKSKLT--IHR-NLRDDEGFIIRHFA--GAVCYETCRFVE-KNNDALHMSLESLVCES-----------------KDKFVRELFENS---------------NTTKDSKQKAG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------KL-GFISVGNKFK-----------------------TQLNLLLEKLR--STGSSFIRCVKPNLKMVSH-----------------------------QFEGALILSQLQCSGMVSVL----DLMQGGFPSRASFHELYNMYK---QYMPD----KL------TR--L-------------NPRLFCKALFKALG---------LND---SDFKFGLTRVF--------FRPGK-FAEFDQIMRS*
Ms VIA -VEDNCS-LMYLN-EATLLNNVRVRYSK-DKIYTFVANILIAVNPYYDIPKLYSPE----------------TIKQYR--GRS------------LGTLPPHVYAIADKAYRDMKV---------LKMSQSIIVSGESGAGKTENTKFVLRYLTTSYG------------------------------------------------------------------------------------------------------------------------------------------TGQ------------------------------DIDERIVE--AN-----PLLEAFGNAKTVRNNNSSRFGKFVEIHFNEK------NAVVGGFVSHYL-LEKSRICR-QSSEERNYHIFYRLCAGATED-----------------------------------------IRQKFH---LSSPD----------TFRYLNR-----------GCTRFYASKDTDKQILQNRKSPEHMKSGPLKDPLLDDRGDFNRMSVAMKKIG----LDDTEK-LDLFRGVAGVLHLG-NIDFEEAG------STS-----GGCAIKNQ--SIQTLEHCAE-LLGLEEGDLRVSLTTRVMLTTAGG---AKGTLIKVPLKVEQANNSRDALAKAVYSRLFDHV---------------------------VTRVNQCFPFD---------SSA----------NFIGVLDIAGFEYF------EHNSFEQFCINYCNEKLQQF-FNERILKEEQELYQREGLG--VNEVH-YVDN-QDCIDLVEA----------------------------------KL---VGILDILDEENRLP----------------QPTDQHFTDTVHNK--HKN-----HFRLTIPRKSKLA--VHR-NVRDDEGFIIRHFA--GAVCYETTNFVE-KNNDALHMSLECLVSES-----------------KDRFVRELFENS---------------NNSKDVKQKPE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------KL-SFISVGNKFK-----------------------TQLNILLEQARC-STGSSFIRCIKPNLKMVSH-----------------------------QFEGAQILSQLQCSGMVSVL----DLMQGGFPSRAPFHELYNMYQ---KYMPP----KP------TR--L-------------DPCLFCKALFKALG---------LNE---NDYKFGLTIVF--------FRPGK-FAEFDHIMKS*
Dm 95F VI -HDDNCE-LMLLN-EATFLDNLKTRYYK-DKIYTYVANILIAVNPYREIKELYAPD----------------TIKKYN--GRS------------LGELPPHVFAIADKAIRDMRV---------YKLSQSIIVSGESGAGKTESTKYLLKYLCYSHD------------------------------------------------------------------------------------------------------------------------------------------SAG------------------------------PIETKILD--AN-----PVLEAFGNAKTTRNNNSSRFGKFIEVHYDAK------CQMVGGYISHYL-LEKSRICT-QSAEERNYHVFYMLLAGAPQQ-----------------------------------------LRDKLS---LGKPD----------DYRYLS------------GCTQYFANAKTEQLIPGSQKSKNHQQKGPLKDPIIDDYQHFHNLDKALGRLG----LSDTEK-LGIYSLVAAVLHLG-NIAFEEIP------DDVR----GGCQVSEA--SEQSLTITSG-LLGVDQTELRTALVSRVMQSKGGG---FKGTVIMVPLKIYEASNARDALAKAIYSRLFDRI---------------------------VGLINQSIPFQ---------ASN----------FYIGVLDIAGFEYF------TVNSFEQFCINYCNEKLQKF-FNDNILKNEQELYKREGLN--VPEIT-FTDN-QDIIELIEA----------------------------------KS---NGIFTLLDEESKLP----------------KPSYSHFTAEVHKS--WAN-----HYRLGLPRSSRLK--AHR-TLRDEEGFLVRHFA--GAVCYNTEQFIE-KNNDALHASLEGLVQEC-----------------DNPLLQTLFPSG-------------------SSTSVRG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------KL-NFISVGSKFK-----------------------TQLGELMEKLE--QNGTNFIRCIKPNSKMIDR-----------------------------QFEGSLALAQLKCSGTISVL----ELMEHGYPSRVLFADLYSMYK---SVLPP----EL------VS--L-------------PARTFCEAMFQSLN---------LSA---KDFKFGITKVF--------FRPGK-FVEFDRIMR--*
Ce hum3 -VEDNCA-LVHLN-EATLLNNCRLRYAN-GKIYTYVANILISINPYQLIDGLYSPE----------------TIKEYR--GKS------------LGQMEPHIFAIADKAYREMRR---------IKTSQSIIVSGESGAGKTESQKAVLKYLCENWG------------------------------------------------------------------------------------------------------------------------------------------TDAG-----------------------------PIQQRLLE--TN-----PILEAFGNAKTLRNNNSSRFGKFVQIHFSDN------GTVAGGFVSHYL-LETSRVCR-QAAGERNYHIFYQLIAGSSPD-----------------------------------------LYKKLR---LAPAS----------SFNYLKH-----------GATLFFVNSKSSLKTDASRFSETN---SSVSDSIISDIDDFAKLERALALSG----VSDDEK-MFIWSTVAGILHLG-NIEFEENA------SDSR----GGCMITSG--TENSLMAAAE-LLGLEPEEMKLGLCARIMQTTKGG---VKGTLIRVPLKAHEASAGRDALAKAIYSKLFDWL---------------------------VAQINKSIPFE---------KST----------GYIGVLDVAGFEYF------AVNSFEQFCINFCNEKLQHF-FNERILKQEQEMYEAEGLN--IQKIE-FTDN-LDCIELFEK----------------------------------KA---SGLFDLLDEEAKLP----------------RATFQHFTQRAHES--NKN-----HFRLDAPRKSKVK--SHR-EMRDDEGLLIRHYA--GTVCYETRYFVE-KNNDQLHNSLEMLIEQS-----------------SFPLVVSLFTSEA--------------TG---AVKTGG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------RL-KAVSVGAKFK-----------------------SQLSSLLDKLN--NTGTHFVRCVKPNSQMKAW-----------------------------HFDGSAILGQLQCAGMASVL----RLMQEGFPSRTSFADLYAMYE---KNLPP----SL------AR--L-------------DPRLFSKCLFHALG---------LDQ---NDFQFGNTKVF--------FTAGK-FAEFDQMMK--*
Mm shaker VII ---------------------------------TYTGSILVAVNPYQ-LLSIYSPE----------------HIRQYT--NKK------------IGEMPPHIFAIADNCYFNMKR---------NNRDQCCIIRGESGAGKTESTKLILQFLAAIS---------------------------------------------------------------------------------------------------------------------------------------------GQ---------------------------HSWIEQQVLE--AT-----PILEAFGNAKTIRNDNSSRFGKYIDIHFNKR------GAIEGAKIEQYL-LEKSRVCR-QAPDERNYHVFYCMLEGMNEE-----------------------------------------EKKKLG---LGQAA----------DYNYLAMG-----------N----------------CITCEG----------RVDSQEYANIRSAMKVLM----FTDTEN-WEISKLLAAILHMG-NLQYEAR-------TFEN---LDACEVLFS--P--SLATAASLL-EVNPPDLMSCLTSRTLITRG--------ETVSTPLSREQALDVRDAFVKGIYGRLFVWI---------------------------VEKINAAIYKP---------PPLEVKN----SRRSIGLLDIFGFENF------TVNSFEQLCINFANEHLQQF-FVRHVFKLEQEEYDLESID--WLHIE-FTDN-QEALDMIAN----------------------------------RR---MNVISLIDEESKFP----------------KGTDATMLHKLNSQ--HKL-----NANYVPPKNSHET------------QFGINHFA--GVVYYESQGFLE-KNRDTLHGDIIQLVHSS-----------------RNKFVKQIFQAD----------------VAMGAET--------------------------------------------------------------------------------------------------------------------------------------------------------------------------RK-RSPTLSSQFK-----------------------RSLELLMRTLG--ACQPFFVRCIKPNEFKKPM-----------------------------LFDRHLCVRQLRYSGMMETI----RIRHAGYPIRYSFVEFVERYR---VLLPG----VKP-----AYKQ--------------GDLRGTCQRMAEAVL--------GTH---DDWQIGKTKIF--------LKDHH-DMLLEVERD--*
Hs UsherIb VIIa -VEDMIR-LGDLN-EAGILRNLLIRYRD-HLIYTYTGSILVAVNPYQ-LLSIYSPE----------------HIRQYT--NKK------------IGEMPPHIFAIADNCYFNMKR---------NSRDQCCIISGESGAGKTESTKLILQFLAAIS---------------------------------------------------------------------------------------------------------------------------------------------GQ---------------------------HSWIEQQVLE--AT-----PILEAFGNAKTIRNDNSSRFGKYIDIHFNKR------GAIEGAKIEQYL-LEKSRVCR-QALDERNYHVFYCMLEGMSED-----------------------------------------QKKKLG---LGQAS----------DYNYLAMG-----------N----------------CITCEG----------RVDSQEYANIRSAMKVLM----FTDTEN-WEISKLLAAILHLG-NLQYEAR-------TFEN---LDACEVLFS--P--SLATAASLL-EVNPPDLMSCLTSRTLITRG--------ETVSTPLSREQALDVRDAFVKGIYGRLFVWI---------------------------VDKINAAIYKP---------PSQDVKN----SRRSIGLLDIFGFENF------AVNSFEQLCINFANEHLQQF-FVRHVFKLEQEEYDLESID--WLHIE-FTDN-QDALDMIAN----------------------------------KP---MNIISLIDEESKFP----------------KGTDTTMLHKLNSQ--HKL-----NANYIPPKNNHET------------QFGINHFA--GIVYYETQGFLE-KNRDTLHGDIIQLVHSS-----------------RNKFIKQIFQAD----------------VAMGAET--------------------------------------------------------------------------------------------------------------------------------------------------------------------------RK-RSPTLSSQFK-----------------------RSLELLMRTLG--ACQPFFVRCIKPNEFKKPM-----------------------------LFDRHLCVRQLRYSGMMETI----RIRRAGYPIRYSFVEFVERYR---VLLPG----VKP-----AYKQ--------------GDLRGTCQRMAEAVL--------GTH---DDWQIGKTKIF--------LKDHH-DMLLEVERD--*
Ss VIIa -MEDMIQHLGDLN-EAGILRNLLIRYRD-HLIYTYTGSILVAVNPYQ-LLSIYSPE----------------HIRQYT--NKK------------IGEMPPHIFAIADNCYFNMKR---------NSRDQCCIISGESGAGKTESTKLILQFLAAIS---------------------------------------------------------------------------------------------------------------------------------------------GQ---------------------------HSWIEQQVLE--AT-----PILEAFGNAKTIRNDNSSRFGKYIDIHFNKR------GAIEGARIEQYL-LEKSRVCR-QAPDERNYHVFYCMLEGMSEE-----------------------------------------QKKKLG---LGQAT----------DYNYLAMG-----------N----------------CITCEG----------REDSQEYANIRSAMKVLM----FTDTEN-WEISKLLAAILHLG-NLQYKDR-------TFEN---LDACEVLFS--T--ALATAASLL-EVNPPDLMNCLTSRTLITRG--------ETVSTPLSREQALDVRDAFVKGIYGRLFVWI---------------------------VDKINAAIYKP---------PSQEVKN----PRRSIGLLDIFGFENF------AVNSFEQLCINFANEHLQQF-FVRHVFKLEQEEYDLESID--WLHIE-FTDN-QDALDMIAN----------------------------------KP---MNIISLIDEESKFP----------------KGTDTTMLHKLNSQ--HRL-----NSNYIPPKYNHET------------QFGINHFA--GVVYYESQG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------*
Dm 35B VII -VEDMIS-LGDLH-EAGILRNLLIRYKE-NLIYTYTGSILVAVNPYQ-ILPIYTGD----------------QIKLYK--ERK------------IGELPPHIFAIGDNAYAHMKR---------YRQDQCIVISGESGAGKTESTKLILQYLAAIS---------------------------------------------------------------------------------------------------------------------------------------------GK---------------------------HSWIEQQILE--AN-----PILEAFGNAKTIRNDNSSRFGKYIDIHFSAN------GVIEGAKIEQYL-LEKSRIVS-QNHSERNYHVFYCILAGLSAD-----------------------------------------EKSRLD---LGMAA----------DYKYLTGG-----------N----------------SITCEG----------RDDAAEFSDIRSAMKVLL----FSDQEI-WEIIKLLAALLHCG-NIKYKAT-------VVDN---LDATEIPEH--I--NVERVAGLL-GLPIQPLIDALTRRTLFAHG--------ETVVSTLSRDQSVDVRDAFVKGIYGRMFVHI---------------------------VRKINTAIFKP---------RG--T------SRNAIGVLDIFGFENF------DQNSFEQFCINYANENLQQF-FVQHIFKLEQEEYNHEAIN--WQHIE-FVDN-QDALDLIAI----------------------------------KQ---LNIMALIDEEARFP----------------KGTDQTMLAKLHKT--HGS-----HKNYLKPKSDINT------------SFGLNHFA--GVVFYDTRGFLD-KNRDTFSPDLLHLVSQS-----------------TNKFLRQIFAQD----------------IEMGAET--------------------------------------------------------------------------------------------------------------------------------------------------------------------------RK-RTPTLSTQFR-----------------------KSLDALMKTLS--SCQPFFIRCIKPNELKKPM-----------------------------MFDRGLCCRQLRYSGMMETI----RIRRAGYPIRHGFREFVERYR---FLIPG----VPP-----AHR---------------TDCQAATSRICAVVL--------G-K---SDYQLGHTKVF--------LKDAH-DLFLEQERD--*
Ce HUM6 -VEDMCQ-LGDFH-ESAILRNLFIRYRE-KLIYAYTGSILIAVNPYM-DIAIYTAD----------------EIRMYK--RKR------------IGELPPHIFAIADNAYTNMRR---------EKKNQSVIISGESGAGKTESTKLVLQFLATIS---------------------------------------------------------------------------------------------------------------------------------------------GQ---------------------------HSWIEQQVLE--AN-----PVLEAFGNAKTIRNDNSSRFGKYIDVHFNES------GSIEGAKIEQYL-LEKSRIVT-QSENERNYHIFYCLLAGLSRE-----------------------------------------EKSELE---LGTAA----------DYYYLIQG-----------K----------------TLTAEG----------RDDAADLAEIRSAMRVLM----INEQEI-GSIFKLLASLLHIG-NIRFRQN-------TNDN---MESVDVADP--S--TLVRIAKLL-QLHEQNLLDAITTKSLVTRE--------ERVISRLNGQQAVDARDALAKAIYGKLFIHI---------------------------VRRVNDAIYKP---------SQ--S------RRTSIGILDIFGFENF------ESNSFEQLCINFANETLQQF-FVHHVFKMEQKEYDEEHIN--WRHIK-FVDN-QATVDLIAQ----------------------------------RP---LNILSLIDEESIFP----------------KGTDKTMLLKLHST--HGR-----NELYLQPKSELQR------------AFGVTHFA--GNVFYNTRGFLE-KNRDSFSADLSVLISSS-----------------KMPFLARLFD-D----------------IEYDTSS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------RK-K-VTVGNQFR-----------------------RSLEQLMSQLT--QTHPFFIRCIKPNEMKRAL-----------------------------VMDRDLVLRQLRYSGMMETI----KIRRSGYPIRHDYYPFVFRYR---VLVSS----IQG-----PVNR--------------IDLHDAAKKICHMIL--------GTN---ADYQLGKTKVF--------LKDKH-DLVLEQ-----*
Dd myoI -VEDMIT-LPILT-EESLLLNLKMRYKK-KEIYTYTGSILVAVNPYE-ILPIYTAD----------------IVKSYF--AKS------------RNLMLPHIFAVSDAAFTNMIE---------EGKNQSIIISGESGAGKTESTKLIIQYLAART---------------------------------------------------------------------------------------------------------------------------------------------NR---------------------------HSQVEQMIVE--SS-----PILEAFGNAKTIRNNNSSRFGKFIEIQFNRE------GHISGARIINYL-LEKSRISH-QASSERNYHIFYQLLAGASDE-----------------------------------------LKEKLK---LGEPE----------DYHYLSQS-----------G----------------CIRIEN----------INDVEDFEHVKYAMNVLG----LPEDKQ-FTIFSIVSAVLHIG-NLKFEKSE------KTQG---AEGSEVSNK--D--TLKIIAQLL-SVDPVKLETCLTIRHVLIRG--------QNFVIPLKVNEAEDTRDSLAKALYGNVFNWL---------------------------VVFINSKIHKP---------QK--N-------STFIGVLDIFGFENF------KKNSFEQFCINFANEKLQQH-FNQHIFKLEQEEYEKEKIN--WSKIV-YNDN-QECLDLIEK----------------------------------RP---LGILSLLDEESRFP----------------QATDLTYLDKLHTN--HEK-----HPYYEKPRRSKN-------------TFVVKHYA--GEVHYDTQGFLD-KNKDTVSDDLSSLLQGS-----------------KSKFIIELFTPP----------------REEGDDSDKG----------R------------------------------------------------------------------------------------------------------------------------------------------------------------EK-KKTTAGQTFK-----------------------TQLQSLINILS--STQPHYVRCIKPNTTKEPA-----------------------------VYDRELIQAQLRYAGMMETI----RIRKLGYPIRHTHKEFRDRYL---ILDYR----ARS-----TDHK--------------QTCAGLINLLSGTGG--------LER---DEWQLGNTKVF--------IRDHQ-YLKLEELRK--*
Bt X -VDDMAT-LTELH-GGAIMHNLYQRYKR-NQIYTYIGSIIASVNPYKTITGLYSRD----------------AVDRYS--RCH------------LGELPPHVFAIANECYRCLWK---------RHDNQCVLISGESGAGKTESTKLILKFLSAIS---------------------------------------------------------------------------------------------------------------------------------------------QQSVDLSS------------------KEKTSSVEQAILE--SS-----PIMEAFGNAKTVYNNNSSRFGKFVQLNIGQK------GNIQGGRIVDYL-LEKNRVVR-QNPGERNYHIFYALLAGLGHE-----------------------------------------EREEFY---LSVPE----------NYHYLNQS-----------G----------------CVTDRT----------ISDQESFREVIMAMEVMQ----FSKEEV-REVLRLLAGILHLG-NIEFITAG------G---------AQVSFK--T--ALGRSAELL-GLDPAQLTDALTQRSMFLRG--------EEILTPLNVQQAADSRDSLAMALYARCFEWV---------------------------IKKINSRIKGK---------DDFKS----------IGILDIFGFENF------EVNHFEQFNINYANEKLQEY-FNKHIFSLEQLEYSREGLV--WEDID-WIDN-GECLDLIEK----------------------------------K----LGLLALINEESHFP----------------QATDSTLLEKLHNQ--HAN-----NHFYVKPRVAVN-------------NFGVKHYA--GEVQYDVRGILE-KNRDTFRDDLLNLLRES-----------------RFDFIYDLFEHV----------------SSRNNQDTLK-------CGS-------------------------------------------------------------------------------------------------------------------------------------------------------------KH-RRPTVSSQFK-----------------------DSLHSLMATLS--ASNPFFVRCIKPNMQKMPD-----------------------------QFDQAVVVNQLRYSGMLETV----RIRKAGYAVRRPFQDFYKRYK---VLMR-----NVA-----LPE----------------DIRGKCTALLQLYD--------ASN---SEWQLGKTKVF--------LRESL-EQKLEKRQE--*
Mm X -VDDMAS-LAELH-GVAIMYNLFQRYKR-NQIYTYIGSIIASVNPYQPIAGLYERA----------------TMEEYS--RCH------------LGELPPHIFAIANECYRCLWK---------RHDNQCVLISGESGAGKTESTKLILKFLSVIS---------------------------------------------------------------------------------------------------------------------------------------------QQTLDLGL------------------QEKTSSVEQAILQ--SS-----PIMEAFGNAKTVYNNNSSRFGKFVQLNICQQ------GNIQGGRIVDYL-LEKNRVVR-RIPGERNYHIFYALLAGLDQE-----------------------------------------EREEFY---LSLPE----------NYHYLNQS-----------G----------------CTEDKT----------ISDQESFRQVITAMEVMQ----FSKEEV-REVLRLLAGILHLG-NIEFITAG------G---------AQIPFK--T--ALGRSADLL-GLDPTQLTDALTQRSMILRG--------EEILTPLSVQQAVDSRDSLAMALYARCFEWV---------------------------IKKINSRIKGK---------DDFKS----------IGILDIFGFENF------EVNHFEQFNINYANEKLQEY-FNKHIFSLEQLEYSREGLV--WEDID-WIDN-GECLDLIEK----------------------------------K----LRLLALINEESHFP----------------QATDSTLLEKLHSQ--HAN-----NHFYVKPRVAVN-------------NFGVKHYA--GEVQYDVRGILE-KNRDTFRDDLLNLLRES-----------------RFDFIYDLFEHV----------------SSRNNQDTLK-------CGS-------------------------------------------------------------------------------------------------------------------------------------------------------------KH-RRPTVSSQFK-----------------------DSLHSLMATLS--SSNPFFVRCIKPNTQKMPD-----------------------------QFDQVVVLNQLRYSGMLETV----RIRKAGYAVRRPFQDFYKRYK---VLMR-----NLA-----LPD----------------DIRGKCTVLLQVYD--------ASN---SEWQLGKTKVF--------LRESL-EQKLEKRRE--*
Mm XV -VEDMTQ-LEDLQ-ETTVLANLKTRFER-NLIYTYIGSILVSVNPYR-MFAIYGPE----------------QVQQYS--GRA------------LGENPPHLFAIANLAFAKMLD---------AKQNQCVIISGESGSGKTEATKLILRCLAAMN---------------------------------------------------------------------------------------------------------------------------------------------QR------------------------RDVMQQI----LE--AT-----PLLEAFGNAKTVRNDNSSRFGKFVEIFLEG-------GVICGAITSQYL-LEKSRIVF-QAKNERNYHIFYELLAGLPAQ-----------------------------------------LRQAFS---LQEAE----------TYYYLNQG-----------G----------------NCEIAG----------KSDADDFRRLLAAMEVLG----FTSEDQ-DSIFRILASILHLG-NVYFEKHE------TD-A---QEVASVVSA--R--EIQAVAELL-QVSPEGLQKAITFKVTETIR--------EKIFTPLTVESAVDARDAIAKVLYALLFGWL---------------------------ITRVNALVSPK---------QDTLS----------IAILDIYGFEDL------SFNSFEQLCINYANENLQYL-FNKIVFQEEQEEYIREQMD--WREIA-FADN-QPCINLISL----------------------------------KP---YGILRILDDQCCFP----------------QATDHTFLQKCHYH--HGA-----NPLYSKPKMPLP-------------EFTIKHYA--GKVTYQVHKFLD-KNHDQVRQDVLDLFVHS-----------------RTRVVAHLFSSH----------------AAQTAPPRLG-------KSSS--------------------------------------------------------------------------------------------------------------------------------IT------------------R-------LY-KAHTVAAKFQ-----------------------QSLLDLVEKME--RCNPLFVRCLKPNHKKEPG-----------------------------LFEPDVMMAQLRYSGVLETV----RIRKEGFPVRLPFQVFIDRYR---CLVAL----KLN-----VPA----------------DGDMCVSLLSRLCT--------VTP---DMYRVGISKLF--------LKEHL-HQLLESMRE--*
Hs XV -VEDMTQ-LEDLQ-ETTVLSNLKIRFER-NLIYTYIGSILVSVNPYQ-MFGIYGPE----------------QVQQYN--GRA------------LGENPPHLFAVANLAFAKMLD---------AKQNQCIIISGESGSGKTEATKLILRYLAAMN---------------------------------------------------------------------------------------------------------------------------------------------QK------------------------REVMQQIK--ILE--AT-----PLLESFGNAKTVRNDNSSRFGKFVEIFLEG-------GVISGAITSQYL-LEKSRIVF-QAKNERNYHIFYELLAGLPAQ-----------------------------------------LRQAFS---LQEAE----------TYYYLNQG-----------G----------------NCEIAG----------KSDADDFRRLLAAMEVLG----FSSEDQ-DSIFRILASILHLG-NVYFEKYE------TD-A---QEVASVVSA--R--EIQAVAELL-QISPEGLQKAITFKVTETMR--------EKIFTPLTVESAVDARDAIAKVLYALLFSWL---------------------------ITRVNALVSPR---------QDTLS----------IAILDIYGFEDL------SFNSFEQLCINYANENLQYL-FNKIVFQEEQEEYIREQID--WQEIT-FADN-QPRINLISL----------------------------------KP---YGILRILDDQCCFP----------------QATDHTFLQKCHYH--HGA-----NPLYSKPKMPLP-------------EFTIKHYA--GKVTYQVHKFLD-KNHDQVRQDVLDLFVRS-----------------RTRVVAHLFSSH----------------APQAAPQRLG-------KSSS--------------------------------------------------------------------------------------------------------------------------------VT------------------R-------LY-KAHTVAAKFQ-----------------------QSLLDLVEKME--RCNPLFMRCLKPNHKKEPG-----------------------------LFEPDVVMAQLRYSGVLETV----RIRKEGFPVRLPFQGFIDRYC---CLVAL----KHD-----LPA----------------NGDMCVSVLSRLCK--------VMP---NMYRVGVSKLF--------LKEHL-YQLLESMRE--*
Rn myrV IX -FDDLCN-LPELN-EANLLQSLKLRFVQ-QKIYTYAGSILVAINPFK-FLPIYNPK----------------YVKMYE--NQQ------------LGKLEPHVFALADVAYYTMLR---------KHVNQCIVISGESGSGKTQSTNFLIHCLTALS---------------------------------------------------------------------------------------------------------------------------------------------QKG-------------------------YASGVERTILG--AG-----PVLEAFGNAKTAHNNNSSRFGKFIQVNYLES------GIVRGAVVEKYL-LEKSRLVS-QEKDERNYHVFYYLLLGVSEE-----------------------------------------ERQEFQ---LKQPQ----------DYFYLNQHN---------LN------------------IEDG----------EDLKHDFERLQQAMEMVG----FLPATK-KQIFSVLSAILYLG-NVTYKKRA-------TGR---DEGLEVGPP--E--VLDTLSQLL-KVKRETLVEVLTKRKTITVN--------DKLILPYSLSEAITARDSMAKSLYSALFDWI---------------------------VLRINHALLNK---------KDMEEAV----SCLSIGVLDIFGFEDF------ERNSFEQFCINYANEQLQYY-FTQHIFKLEQEEYQGEGIS--WHNID-YTDN-VGCIHLISK----------------------------------KP---TGLFYLLDEESNFP----------------HATSHTLLAKFKQQ--HED-----NKYFLGTPVLEP-------------AFIIQHFA--GRVKYQIKDFRE-KNMDYMRPDIVALLRGSDSSYVRQLIGMDPVAVFRWAVLRAAIRAM----------------AVLREAGRLRA-----ERAEKAEAG--------------VSSPVTRSHVEELPR---------------------GANTPSEKLYRDLHNQIIKSLKGLPWQGEDPR--RLLQ---------SLSRLQKPRTFFLKSKGIKQKQIIPKNLLDSKSLRLIISMTLHDRTTKSLLHLHKKK-KPPSISAQFQ-----------------------TSLNKLLEALG--KAEPFFIRCIRSNAEKKEL-----------------------------CFDDELVLQQLRYTGMLETV----RIRRSGYSAKYTFQDFTEQFQ---VLLP------KD-----VQP----------------CREAIAALLE-KLQ--------VDR---QNYQIGKTKVF--------LKETE-RQALQERLHGE*
Mm 9b -FDDLCN-LPELT-EANLLQNLKLRFMQ-QKIYTYAGSILVAINPFK-FLPIYNPK----------------YVKMYE--NQQ------------LGKLEPHVFALADVAYYAMLR---------KHVNQCIVISGESGSGKTQSTNFLIHCLTALS---------------------------------------------------------------------------------------------------------------------------------------------QKG-------------------------YASGVERTILG--AG-----PVLEAFGNAKTAHNNNSSRFGKFIQVNYLEN------GIVRGAVVEKYL-LEKSRLVS-QEKDERNYHVFYYLLLGVSEE-----------------------------------------ERLEFQ---LKQPQ----------DYFYLNQHN---------LN------------------IEDG----------EDLKHDFERLQQAMEMVG----FLPATK-KQIFSVLSAILYLG-NVTYKKRA-------TGR---DEGLEVGPP--E--VLDTLSQLL-KVKRETLVEVLTKRKTVTVN--------DKLILPYSLSEAITARDSMAKSLYSALFDWI---------------------------VLRINHALLNK---------KDMEEAV----SCLSIGVLDIFGFEDF------ERNSFEQFCINYANEQLQYY-FTQHIFKLEQEEYQGEGIS--WHNID-YTDN-VGCIHLISK----------------------------------KP---TGLFYLLDEESNFP----------------HATSHTLLAKFKQQ--HED-----NKYFLGTPVLEP-------------AFIIQHFA--GRVKYQIKDFRE-KNMDYMRPDIVALLRGSDSSYVRQLIGMDPVAVFRWAVLRAAIRAM----------------AVLREAGRLRA-----ERAEKAAG---------------ISSPATRSHMEELPR---------------------GASTPSEKLYRDLHNQIIKSLKGLPWQGEDPR--RLLQ---------SLSLLQKPRTSFLKSKGIKQKQIIPKNLLDSKSLRLIISMTLHDRTTKSLLHLHKKK-KPPSISAQFQ-----------------------TSLNKLLEALG--KAEPFFIRCIRSNAEKKEL-----------------------------CFDDELVLQQLRYTGMLETV----RIRRSGYSAKYTFQDFTEQFQ---VLLP------KD-----VQP----------------CREAIAALLE-KLQ--------VDR---QNYQIGKTKVF--------LKETE-RQTLQEKLH--*
Hs IXa -FDDLCS-LPDLN-EKTLLENLRDRFKH-EKIYTYVGSILIVINPFK-FLPIYNPK----------------YVKMYD--NHQ------------LGKPEPHIYAVADVAYHAMLQ---------RKKNQCIVISGESGSGKTQSTNFLIHHLTALS---------------------------------------------------------------------------------------------------------------------------------------------QKG-------------------------FASGVEQIILG--AG-----PVLEAFGNAKTAHNNNSSRFGKFIQVNYQET------GTVLGAYVEKYL-LEKSRLVY-QEHNERNYHVFYYLLAGASED-----------------------------------------ERSAFH---LKQPE----------EYHYLNQIT---------KKPLRQSWDDYCYDSEPDCFTVEG----------EDLRHDFERLQLAMEMVG----FLPKTR-RQIFSLLSAILHLG-NICYKKKT-------Y-R---DDSIDICNP--E--VLPIVSELL-EVKEEMLFEALVTRKTVTVG--------EKLILPYKLAEAVTVRNSMAKSLYSALFDWI---------------------------VFRINHALLNS---------KDLEHNT----KTLSIGVLDIFGFEDY------ENNSFEQFCINFANERLQHY-FNQHIFKLEQEEYRTEGIS--WHNID-YIDN-TCCINLISK----------------------------------KP---TGLLHLLDEESNFP----------------QATNQTLLDKFKHQ--HED-----NSYIEFPAVMEP-------------AFIIKHYA--GKVKYGVKDFRE-KNTDHMRPDIVALLRSSKNAFISGMIGIDPVAVFRWAILRAFFRAM----------------VAFREAGKRNI-----HRKTGHDDTAPCAILKSMDSFSFLQHPVHQRSLEILQRCKEEKYSITRKNPRTPLSDLQGMNALNEKNQHDTFDIAWNGRTGIRQSRLSSG-TSLLDKDGIFANSTSSKLLERAHGILTRNKNFKSKPALPKHLLEVNSLKHLTRLTLQDRITKSLLHLHKKK-KPPSISAQFQ-----------------------ASLSKLMETLG--QAEPYFVKCIRSNAEKLPL-----------------------------RFSDVLVLRQLRYTGMLETV----QIRQSGYSSKYSFQDFVSHFH---VLLP------RN-----IIP----------------SKFNIQDFFR-KIN--------LNP---DNYQVGKTMVF--------LKEQE-RQHLQDLLH--*
Rn myr7 -FDDLCS-LPDLN-EKTLLENLRNRFKH-EKIYTYVGSILIAINPFK-FLPIYNPK----------------YVKMYD--NHQ------------LGKLEPHIYAVADVAYHAMLQ---------RKKNQCIVISGESGSGKTQSTNFLIHHLTALS---------------------------------------------------------------------------------------------------------------------------------------------QKG-------------------------FASGVEQIILG--AG-----PVLEAFGNAKTAHNNNSSRFGKFIQVNYQET------GTVLGAYVEKYL-LEKSRLVY-QEHNERNYHVFYYLLAGASEE-----------------------------------------ERLAFH---LKQPE----------EYHFLNQIT---------KKPLRQSWDDYCYDSEPDCFTVEG----------EDLRHDFERLQLAMEMVG----FLPKTR-RQIFSLLSAILHLG-NISYKKKT-------Y-R---DDSIDICNP--E--VLPIVSELL-EVKEEMLFEALVTRKTVTVG--------EKLILPYKLAEAVTVRNSMAKSLYSALFDWI---------------------------VFRINHALLNS---------KDLEKDT----KTLSIGVLDIFGFEDY------ENNSFEQFCINFANERLQHY-FNQHIFKLEQEEYRTEGIS--WHNID-YIDN-TCCINLISK----------------------------------KP---TGLLHLLDEESNFP----------------QATNQTLLDKFKHQ--HEE-----NSYIEFPAVMEP-------------AFIIKHYA--GKVKYGVKDFRE-KNTDHMRPDIVALLRSSRNAFVSGMTGIDPVAVFRWAVLRAFFRAV----------------VAFREAGKRHI-----QRKSGHDDTTPCTILKSMDSFSFLQHPVHQRSLEILQRCKEEKYSITRKNPRTPLSDLQGMNTLNEKNQHDTFDIAWNVRTGIRQSRLPTNNTSLLDKDGIFANSASSKLLERAHGILTRNKNFRSKPVLPKHLLEVNSLKHLTRLTLQDRITKSLLHLHKKK-KPPSISAQFQ-----------------------VSLSKLMETLD--QAEPYFVKCIRSNAEKLPL-----------------------------RFSDALVLRQLRYTGMLETV----RIRQSGYSSKYSFQDFVSHFH---VLLP------QH-----IIP----------------SKFNIQDFFR-KIN--------INP---DNYQVGKTMVF--------LKEHE-RQHLQDLLH--*
Ce HUM7 -YADLCN-LPELT-EQTLLDNLRERFAN-GHIYTYIGPILVAVNPFC-FFPIYNPK----------------YARLYFQ-SKR------------LGSLPPHIFAIADVCYHNMLR---------IKENQCVVISGESGSGKTESTNHLMSHLISLS---------------------------------------------------------------------------------------------------------------------------------------------QKGS------------------------TGCSTEQTLLS--AG-----PVLEAFGNAVTLTNNNSSRFGKFIKINYREN------GMVSGANVEIYL-LEKSRIIF-QTKGERNYHVFYYLLEGADEE-----------------------------------------ERKKYF---LLKPH----------DYKYLNQN-----------EP----------------FALEG----------VNERNEFDRLRHAMSSVG----FCAKTQ-QTIFGIISAVLLLG-NITYIKRH------GYHS---DESGYIENE--E--VVDLVANLL-HIKTDTLMQALTMKRHVMKT--------ETVVLRYSVSEATNTRDAMAKCIYNSLFHYI---------------------------VLRINQALLK----------KDFSAG-----KGYYIGILDIFGFEDVGS----QCNSFEQLCINYANEKLQSY-FNQHIFQFEQEEYLKEGIS--WTNIE-YTDN-TECVQLFQ----------------------------------------------------------------------------------------N-----NEYYETPQKKEP-------------AFIVAHYA--GKVKYQITGFRE-KNKDLMRQDVLNALKSSTSSVMKTLLGIDPVAVHRWNVLRSVFRAM----------------NAFKQSTRKLQ-----KKSAGHLR-------------------VMDSIVTSPRR---------------------GSDS---------------ALSAFLRGELRCEVPDFCD---------TS-MFNTIRNQARRTPAGKSD----DKMSLLKSLQILKEAIGGRRLAK----------KPSSVSKQFE-----------------------YSLTRLMSTLA--NATPYFIRCIKSNNDKIAN-----------------------------HFDDNIILRQLRYTGMLETV----RIRRAGYSVRIEYPSFVQQYR---ILLR------NG-----RDS----------------TVDDVKEYIHSHAS--------IDN---DNIQYGTNKIF--------MRDAE-KLILDDHLH--*
Dd IA -VEDLIM-LTEVS-ESSLHENLKIRYKE-GLIYTSIGPVLVSMNPYKQLG-IYGND----------------QINLYK--GKH------------EFEIPPHIYSIADKAYRALRS---------EGENQCIIISGESGAGKTEASKYIMQYIASIT----------------------------------------------------------------------------------------------------------------------------------------G----SST-------------------------EVERVKKTIL--ESN-----PLLEAFGNGKTLRNNNSSRFGKYMEIQFNLG------GDPEGGKITNYL-LEKSRVIN-QTQGERNFHIFYQLLKGHQGK-----------------------------------------KTYNL---LSPDQ------------YHYLTRNAS--------NGW---------------FSLPDG----------IDDQIGFKQTKNAMKVVG----IDEPLQ-KKSFATLSAILLLG-NLSFNKSA------SGNG------SVISDK--K--LANTIASLM-GVDAIVLESSLVSRQISTGQGA----RISTYSVPQTVEQAMYARDAFAKATYSKLFDFI---------------------------VRKINQSIEVK---------TIG----------KVIGVLDIYGFEIF------ENNSFEQFCINYVNETLQQI-FIDLTLKTEQEEYVQEGIT--WIPVQ-YINN-KACVDLIEK----------------------------------KP---IGILSLLDEECLFP----------------EGNDQTMIDKLNKH--FSN-----HTHYSKVERQKNS--Q----------FIINHYA--GKVFYNIDGFLD-KNRDTLFNDLVTLATSS-----------------SCSLLVEIFK---------------------YVPPLEVD-------PEQEKKNRDKFSKNGFANNA-----------------------------------------------------------------------------------------------------------------------------------AKTFIPTDKK-SPITAGFQFK-----------------------NQVTSLLKSLY--SCSPHYVRCIKPNSNMRAL-----------------------------EWDQSKCAEQVAYLGSFENL----LVRRAGYCYRQTFSKFMRRYY---MIGKS----TWP----KWSG---------------DAEKGVNLLMGELT---------QEINIKEEVQYGKTKIF--------IRNPQPLFLLEDKRN--*
Dd IE -VPDFVL-LNQIT-ENAFIDNLTMRHKS-DNIYTYIGDVVISRNPFKNLN-IYKES----------------DIKAYN--GRY------------KYEMPPHIYALANDAYRSMRQ---------SQENQCVIISGESGAGKTEASKKIMQFLTFVS----------------------------------------------------------------------------------------------------------------------------------------SN---QSP-------------------------NGERISKMLIRFQSN-----PLLEAFGNAKTLRNDNSSRFGKYMEMQFNAV------GSPIGGKITNYL-LEKSRVVG-RTQGERSFHIFYQMLKGLSQS-----------------------------------------KLNELG--LTPNAP----------AYEYLKK-----------SGC---------------FDVST-----------IDDSGEFKIIVKAMETLG----LKESDQ-NSIWRILAAILHIG-NITFAEAA------EQRT--GTTTVKVSDT--K--SLAAAASCL-KTDQQSLSIALCYRSISTGVGK----RCSVISVPMDCNQAAYSRDALAKALYERLFNWL---------------------------VSKINTLSIVH---------REG----------TVIGILDIYGFEVF------QNNSFEQLNINFCNEKLQQL-FIELTLKSEQEEY--KGIE--WKNIE-YFN--KPICELIEK----------------------------------KP---IGLISLLDEACLIA----------------KSTDQTFLDSICKQ--FEK-----NPHLQSYVVSKDR--SN-----GDTCFRLKHYA--GDVTYDVRGFLD-KNKDTLFGDLISSMQSS-----------------SDPLVQGLFP---------------------PTR------------PEDS-----------------------------------------------------------------------------------------------------------------------------------------------------------KK-RPETAGSQFR-----------------------NAMNALITTLL--ACSPHYVRCIKSNDNKQAG-----------------------------VIDEDRDRHQVRYLGLLENV----RVRRAGFAGRIEYTRFYNRYK---MLCKK----TWP----SFNG---------------TAKQATELILQQHN---------ID---KEEIRMGKTKVF--------IRIPRTLFYFEEKRE--*
Bt IC -VEDLVL-LEPLE-QESLIRNLQLRYEK-KEIYTYIGNVLVSVNPYQQLP-IYDLE----------------FVAKYR--DYT------------FYELKPHIYALANMAYQSLRD---------RDRDQCILITGESGAGKTEASKLVMSYVAAVC----------------------------------------------------------------------------------------------------------------------------------------GK---GE--------------------------QVNSVKEQLLQ--SN-----PVLEAFGNAKTIRNNNSSRFGKYMDIEFDFK------GFPLGGVITNYL-LEKSRVVK-QLEGERNFHIFYQLLAGADAQ-----------------------------------------LLKALK--LERDTG----------GYAYLNP-------------D---------------TSRVDG----------MDDDANFKVLQSAMTVIG----FSDEEI-RQVLEVAALVLKLG-NVELINEF------QANG---VPASGIRDG--R--GVQEIGELV-GLNSVELERALCSRTMETAK--------EKVVTTLNVIQAQYARDALAKNIYSRLFNWL---------------------------VNRINESIKVG---------TGEKR--------KVMGVLDIYGFEIL------EDNSFEQFVINYCNEKLQQV-FIEMTLKEEQEEYKREGIP--WVKVE-YFDN-GIICNLIEH----------------------------------NQ---RGILAMLDEECLRPG---------------VVSDSTFLAKLNQL--FSK-----HSHYESKVTQNAQ--RQYDHSMGLSCFRICHYA--GKVTYNVNSFID-KNNDLLFRDLSQAMWKA-----------------RHPLLRSLFP---------------------EGDPKQ---------ASL-------------------------------------------------------------------------------------------------------------------------------------------------------------K-RPPTAGAQFK-----------------------SSVTTLMKNLY--SKNPNYIRCIKPNEHQQRG-----------------------------HFSFELVSVQAQYLGLLENV----RVRRAGYAYRQAYGSFLERYR---LLSRS----TWP----RWNG---------------GDQEGVEKVLGELS---------MSS---EELAFGKTKIF--------IRSPKTLFYLEEQRR--*
Gg Bb -VGDLVM-LDPLS-EESLLRTLQERFSR-GEIYTYIGEVVISVNPYKPLP-IYTPE----------------KVEEYH--NCN------------FFAVKPHIYAIADDAYRSLRD---------RDRDQCILITGESGAGKTEASKLVMSYVAAVS----------------------------------------------------------------------------------------------------------------------------------------SK---GE--------------------------EVDKVKEQLLQ--SN-----PVLEAFGNAKTIRNDNSSRFGKYMDVEFDFK------GDPLGGVISNYL-LEKSRIVR-HVKGERNFHIFYQLLAGGSAQ-----------------------------------------LLQQLK--LRPDCS----------HYGYLNH-------------E---------------KSVLPG----------MDDAANFRAMQDAMAIIG----FAPAEV-TALLEVTAVVLKLG-NVKLSSCF------QASG---MEASSITEP--R--ELQEISQLI-GLDPSTLEQALCSRTVKVRD--------ESVLTALSVSQGYYGRDALAKNIYSRLFDWL---------------------------VNRINTSIQVK---------PGKQR--------KVMGVLDIYGFEIF------QDNGFEQFIINYCNEKLQQI-FILMTLKEEQEEYVREGIQ--WTPVE-FFDN-SIICDLIEN----------------------------------SK---VGILAMLDEECLRPG---------------TVNEDTFITKLNQI--FAS-----HKRYESKETLNAK--HVTDVSLPLRCFRIHHYA--GKVTYNVTGFIE-KNNDLLFRDLSQAMWAA-----------------RHTLLRSLFP---------------------EGDPQR---------PSL-------------------------------------------------------------------------------------------------------------------------------------------------------------K-LPPTTGSQFK-----------------------ASVATLMKNLY--SKNPNYIRCIKPNDTKTAM-----------------------------LFTPDLVLAQVRYLGLMENV----RVRRAGYAFRQLYQPFLERYK---MLSRK----TWP----RWTG---------------GDREGAEVLLAELK---------FPP---EELAYGHTKIF--------IRSPRTLFDLEKRRQ--*
Mm Brain IB -VGDMVL-LEPLN-EETFIDNLKKRFDH-NERYTYIGSVVISVNPYRSLP-IYSPE----------------KVEDYR--NRN------------FYELSPHIFALSDEAYRSLRD---------QDKDQCILITGESGAGKTEASKLVMSYVAAVC----------------------------------------------------------------------------------------------------------------------------------------GK---GA--------------------------EVNQVKEQLLQ--SN-----PVLEAFGNAKTVRNDNSSRFGKYMDIEFDFK------GDPLGGVISNYL-LEKSRVVK-QPRGERNFHVFYQLLSGASEE-----------------------------------------LLYKLK--LERDFS----------RYNYLSL-------------D---------------SAKVNG----------VDDAANFRTVRNAMQYVG----FLDHEA-EAVLEVVAAVLKLG-NIEFKPES------RVNG---LDESKIKDK--N--ELKEICELT-SIDQVVLERAFSFRTVEAKQ--------EKVSTTLNVAQAYYARDALAKNLYSRLFSWL---------------------------VNRINESIKAQ---------TKVRK--------KVMGVLDIYGFEIF------EDNSFEQFIINYCNEKLQQI-FIELTLKEEQEEYIREDIE--WTHID-YFNN-AIICDLIEN----------------------------------NT---NGILAMLDEECLRPG---------------TVTDETFLEKLNQV--CAT-----HQHFESRMSKCSR--FLNDTTLPHSCFRIQHYA--GKVLYQVEGFVD-KNNDLLYRDLSQAMWKA-----------------GHSLIKSLFP---------------------EGNPAK---------VNL-------------------------------------------------------------------------------------------------------------------------------------------------------------K-RPPTRSSQFK-----------------------ASVATLMRNLG--TKNPNYIRCIKPNDKKAAH-----------------------------IFNESLVCHQIRYLGLLENV----RVRRAGYAFRQAYEPCLERYK---MLCKQ----TWP----HWKG---------------PARSGVEVLFNELE---------IPV---EEHSFGRSKIF--------IRNPRTLFQLEDLRK--*
Rn MyrI IA -VGDTVL-LEPLN-EETFIDNLKKRFDH-NEIYTYIGSVVISVNPYRSLP-IYSPE----------------KVEDYR--NRN------------FYELSPHIFALSDEAYRSLRD---------QDKDQCILITGESGAGKTEASKLVMSYVAAVC----------------------------------------------------------------------------------------------------------------------------------------GK---GA--------------------------EVNQVKEQLLQ--ST-----PVLEAFGNAKTVRNDNSSRFGKYMDIEFDFK------GDPLGGVISNYL-LEKSRVVK-QPRGERNFHVFYQLLSGASEE-----------------------------------------LLHKLK--LERDFS----------RYNYLSL-------------D---------------SAKVNG----------VDDAANFRTVRNAMQIVG----FSDPEA-ESVLEVVAAVLKLG-NIEFKPES------RMNG---LDESKIKDK--N--ELKEICELT-SIDQVVLERAFSFRTVEAKQ--------EKVSTTLNVAQAYYARDALAKNLYSRLFSWL---------------------------VNRINESIKAQ---------TKVRK--------KVMGVLDIYGFEIF------EDNSFEQFIINYCNEKLQQI-FIELTLKEEQEEYIREDIE--WTHID-YFNN-AIICDLIEN----------------------------------NT---NGILAMLDEECLRPG---------------TVTDETFLEKLNQV--CAT-----HQHFESRMSKCSR--FLNDTTLPHSCFRIQHYA--GKVLYQVEGFVD-KNNDLLYRDLSQAMWKA-----------------GHALIKSLFP---------------------EGNPAK---------VNL-------------------------------------------------------------------------------------------------------------------------------------------------------------K-RPPTAGSQFK-----------------------ASVATLMKNLQ--TKNPNYIRCIKPNDKKAAH-----------------------------IFSESLVCHQIRYLGLLENV----RVRRAGYAFRQAYEPCLERYK---MLCKQ----TWP----HWKG---------------PARSGVEVLFNELE---------IPV---EEYSFGRSKIF--------IRNPRTLFQLEDLRKQR*
Mm IA -VGDMVL-LEPLN-EETFIDNLKKRFDH-NEIYTYIGSVVISVNPYRSLP-IYSPE----------------KVEDYR--NRN------------FYELSPHIFALSDEAYRSLRD---------QDKDQCILITGESGAGKTEASKLVMSYVAAVC----------------------------------------------------------------------------------------------------------------------------------------GK---GA--------------------------EVNQVKEQLLQ--SN-----PVLEAFGNAKTVRNDNSSRFGKYMDIEFDFK------GDPLGGVISNYL-LEKSRVVK-QPRGERNFHVFYQLLSGASEE-----------------------------------------LLYKLK--LERDFS----------RYNYLSL-------------D---------------SAKVNG----------VDDAANFRTVRNAMQIVG----FLDHEA-EAVLEVVAAVLKLG-NIEFKPES------RVNG---LDESKIKDK--I--ELNEKFASRPASVKVVLERAFSFRTVEAKR--------EKVSTTLNVAQAYYARDALAKNLYSRLFSWL---------------------------VNRINESIKAQ---------TKVRK--------KVMGVLDIYGFEIF------EDNSFEQFIINYCNEKLQQI-FIELTLKEEQEEYIREDIE--WTHID-YFNN-AIICDLIEN----------------------------------NT---NGILAMLDEECLRPG---------------TVTDETFLEKLNQV--CAT-----HQHFESRMSKCSR--FLNDTTLPHSCFRIQHYA--GKVLYQVEGFVD-KNNDLLYRDLSQAMWKA-----------------DHSLIKSLFP---------------------EGNPAK---------VNL-------------------------------------------------------------------------------------------------------------------------------------------------------------K-RPPTAGSQFK-----------------------ASVATLMRNLQ--TKNPNYIRCIKPNDKKAAH-----------------------------IFNESLVCHQIRYLGLLENV----RVRRAGYAFRQAYEPCLERYK---MLCKQ----TWP----HWKG---------------PARSGVEVLFNELE---------IPV---EEHSFGRSKIF--------IRNPRTLFQLEDLRKQR*
Rn Myr2 IB -VQDFVL-LENFTSEAAFIENLRRRFRE-NLIYTYIGPVLVSVNPYRDLQ-IYTRQ----------------HMERYR--GVS------------FYEVPPHLFAVADTVYRALRT---------ERRDQAVMISGESGAGKTEATKRLLQFYAETC----------------------------------------------------------------------------------------------------------------------------------------PA---PE--------------------------RGGAVRDRLLQ--SN-----PVLEAFGNAKTLRNDNSSRFGKYMDVQFDFK------GAPVGGHILSYL-LEKSRVVH-QNHGERNFHVFYQLLEGGEEE-----------------------------------------ALRRLG--LERNPQ----------SYLYLVK------------GQ---------------CAKVSS----------INDKSDWKVVRKALSVID----FTEDEV-EDLLSIVASVLHLG-NIHFAADE------DSN-------AQVTTE--N--QLKYLTRLL-GVEGTTLREALTHRKIIAKG--------EELLSPLNLEQAAYARDALAKAVYSRTFTWL---------------------------VRKINRSLASK---------DAESPSWR---STTVLGLLDIYGFEVF------QHNSFEQFCINYCNEKLQQL-FIELTLKSEQEEYEAEGIA--WEPVQ-YFNN-KIICDLVEE----------------------------------KF---KGIISILDEECLRPG---------------EATDLTFLEKLEDT--IKH-----HPHFLTHKLADQK--TR--KSLDRGEFRLLHYA--GEVTYSVTGFLD-KNNDLLFRNLKETMCSS-----------------TNPIMAQCFD---------------------KSELS-----------DK-------------------------------------------------------------------------------------------------------------------------------------------------------------K-RPETVATQFK-----------------------MSLLQLVEILR--SKEPAYIRCIKPNDAKQPG-----------------------------RFDEVLIRHQVKYLGLMENL----RVRRAGFAYRRKYEAFLQRYK---SLCPE----TWP----VWTG---------------RPQDGVAVLVRHLG---------YKP---EEYKMGRTKIF--------IRFPKTLFATEDSLE--*
Mm Ibeta -VQDFVL-LENFTSEAAFIENLRGGFRE-NLIYTYIGPVLVSVNPYRDLQ-IYRRK----------------HMERYR--GVS------------FYEVPPHLFAVADTVYRALRT---------ERRDQAVMISGESGAGKTEATKRLLQFYAETC----------------------------------------------------------------------------------------------------------------------------------------PA---PE--------------------------RGGAVRDRLLQ--SN-----PVLEAFGNAKTLRNDNSSRFGKYMDVQFDFK------GAPVGGHILSYL-LEKSRVVH-QNHGERNFHVFYQLLEGGEEE-----------------------------------------TLRRLG--LERNPQ----------SYLYLVK------------GQ---------------CAKVSS----------INDKSDWKVMRKALSVID----FTEDEV-EDLLSIVASVLHLG-NIHFAADE------DSN-------AQVTTE--N--QLKYLTRLL-GVEGTTLREALTHRKIIAKG--------EELLSPLNLEQAAYARDALAKAVYSRTFTWL---------------------------VRKINRSLASK---------DAESPSWR---STTVLGLLDIYGFEVF------QHNSFEQFCINYCNEKLQQL-FIELTLKSEQEEYEAEGIA--WEPVQ-YFNN-KIICDLVEE----------------------------------KF---KGIISILDEECLRPG---------------EATDLTFLEKLEDT--VKP-----HPHFLTHKLADQK--TR--KSLDRGEFRLLHYA--GEVTYSVTGFLD-KNNDLLFRNLKETMCSS-----------------MNPIMAQCFD---------------------KSELS-----------DK-------------------------------------------------------------------------------------------------------------------------------------------------------------K-RPETVATQFK-----------------------MSLLQLVEILR--SKEPAYIRCIKPNDAKQPG-----------------------------RFDEVLIRHQVKYLGLMENL----RVRRAGFAYRRKYEAFLQRYK---SLCPE----TWP----MWAG---------------RPQDGVAVLVRHLG---------YKP---EEYKMGRTKIF--------IRFPKTLFATEDSL---*
Hs Ib -VQDFVL-LENFTSEAAFIENLRRRFRE-NLIYTYIGPVLVSVNPYRDLQ-IYSRQ----------------HMERYR--GVS------------FYEVPPHLFAVADTVYRALRT---------ERRDQAVMISGESGAGKTEATKKLLQFYAETC----------------------------------------------------------------------------------------------------------------------------------------PA---PQ--------------------------RGGAVRDRLLQ--SN-----PVLEAFGNAKTLRNDNSSRFGKYMDVQFDFK------GAPVGGHILSYL-LEKSRVVH-QNHGERNFHIFYQLLEGGEEE-----------------------------------------TLRRLG--LERNPQ----------SYLYLVK------------GQ---------------CAKVSS----------INDKSDWKVVRKALTVID----FTEDEV-EDLLSIVASVLHLG-NIHFAANE------DSN-------AQVTTE--N--QLKYLTRLL-SVEGSTLREALTHRKIIAKG--------EELLSPLNLEQAAYARNALAKAVYSRTFTWL---------------------------VGKINRSLASK---------DVESPSWR---STTVLGLLDIYGFEVF------QHNSFEQFCINYCNEKLQQL-FIELPLKSEQEEYEAEGIA--WEPVQ-YFNN-KIICDLVEE----------------------------------KF---KGIISILDEECLRPG---------------EATDLTFLEKLEDT--VKH-----HPHFLTHKLADQR--TR--KSLGRGEFRLLHYA--GEVTYSVTGFLD-KNNDLLFRNLKETMCSS-----------------KNPIMSQCFD---------------------RSELS-----------DK-------------------------------------------------------------------------------------------------------------------------------------------------------------K-RPETVATQFK-----------------------MSLLQLVEILQ--SKEPAYVRCIKPNDAKQPG-----------------------------RFDEVLIRHQVKYLGLLENL----RVRRAGFAYRRKYEAFLQRYK---SLCPE----TWP----TWAG---------------RPQDGVAVLVRHLG---------YKP---EEYKMGRTKIF--------IRFPKTLFATEDAL---*
Bt Adren IA -VQDFVL-LENFTSEAAFIENLRRRFRE-NLIYTYIGPVLVSVNPYRDLQ-IYSRQ----------------HMERYR--GVS------------FYEVPPHLFAVADTVYRALRT---------ERGDQAVMISGESGAGKTEATKRLLQFYAETC----------------------------------------------------------------------------------------------------------------------------------------PA---PE--------------------------RGGAVRDRLLQ--SN-----PVLEAFGNAKTLRNDNSSRFGKYMDVQFDFK------GAPVGGHILSYL-LEKSRVVH-QNHGERNFHIFYQLLEGGEEE-----------------------------------------TLRRLG--LERNPQ----------SYLYLVK------------GQ---------------CAKVSS----------INDKSDWKVVRKALTVID----FTEDEV-EDLLSIVASVLHLG-NTHFAADE------ESN-------AQVTTE--N--QLKYLTRLL-GVEGSTLREALTHRKIIAKG--------EELLSPLNLEQAAYARDALAKAVYSRTFTWL---------------------------VAKINRSLASK---------DAESPSWR---STTVLGLLGIYGFEVF------QHNSFEQFCINYCNEKLQQL-FIELTLKSEQEEYEAEGIA--WEPVQ-YFNN-KIICDLVEE----------------------------------KF---KGIISILDEECLRPG---------------EATDLTFLEKLEDT--IKQ-----HPHFLTHKLADQR--TR--KSLDRGEFRLLHYA--GEVTYNVTGFLD-KNNDLLFRNLKETMCSS-----------------ENPILGQCFD---------------------RSELS-----------SK-------------------------------------------------------------------------------------------------------------------------------------------------------------K-RPETVATQFK-----------------------MSLLELVEILK--SKEPAYVRCIKPNDSKQPG-----------------------------RFDEVLIRHQVKYLGLMENL----RVRRAGFAYRRKYEAFLQRYK---SLCPE----TWP----TWTG---------------RRQDGVTVLVRHLG---------YKP---EEYKMGRTKIF--------IRFPKTLFATEDALE--*
Bt IB -VQDFVL-LENFTSEAAFIENLRRRFRE-NLIYTYIGPVLVSVNPYRDLQ-IYSRQ----------------HMERYR--GVS------------FYEVPPHLFAVADTVYRALRT---------ERRDQAVMISGESGAGKTEATKRLLQFYAETC----------------------------------------------------------------------------------------------------------------------------------------PA---PE--------------------------RGGAVRDRLLQ--SN-----PVLEAFGNAKTLRNDNSSRFGKYMDVQFDFK------GAPVGGHILSYL-LEKSRVVH-QNHGERNFHIFYQLLEGGEEE-----------------------------------------TLRRLGPGTERNPQ----------SYLYLVK------------GQ---------------CAKVSS----------INDKSDWKVVRKALTVID----FTEDEV-EDLLSIVASVLHLG-NNHFAADE------ESN-------AQVTTG--T--SSSTLPGPW--VWRLNVAGSLTHRRS-SQG--------EELLSPLNLEQAAYARDALAKAVYSRTFTWL---------------------------VAKIKRSLASK---------DAESPSWR---STTVLGLLDIYGFEVF------QHNSFEQFCINYCNEKLQQL-FIELTLKSEQEKYEAEGIA--WEPVQ-YFNN-KIICDLVEE----------------------------------KF---KGIISILDEECLRPG---------------EATDLTFLEKLEDT--IKQ-----HPHFLTHKLADQR--TR--KSLDRGEFRLLHYA--GEVTYNVTGFLD-KNNDLLFRNLKETMCSS-----------------ENPILGQCFD---------------------RSELS-----------DK-------------------------------------------------------------------------------------------------------------------------------------------------------------K-RPETVATQFK-----------------------MSLLELVEILK--SKEPAYVRCIKPNDSKQPG-----------------------------RFDEVLIRHQVKYLGLMENL----RVRRAGFAYRRKYEAFLQRYK---SLCPE----TWP----TWTG---------------RPQDGVTVLVRHLG---------YKP---EEYKMGRTKIF--------IRFPKTLFATEDALE--*
Rc IB -VQDFVL-LENYTSEAAFIENLRKRFKE-NLIYTYIGSVLVSVNPYKELE-IYSKQ----------------HMERYR--GVS------------FYEVSPHIYAIADNSYRSLRT---------ERKDQCILISGESGAGKTEASKKILQYYAVTC----------------------------------------------------------------------------------------------------------------------------------------PV---SD--------------------------QVETVKDRLLQ--SN-----PVLEAFGNAKTLRNDNSSRFGKYMDVQFDYK------GAPVGGHILNYL-LEKSRVVH-QNHGERNFHIFYQLLEGGEED-----------------------------------------LLRRLG--LDKNAQ----------NYQYLIK------------GQ---------------CARVSS----------INDKNDWKVVRRALSIIN----FNDDDI-EELLSIVASVLHLG-NVQFATDE------HGH-------AQVTTE--N--QIKYLARLL-SVDSTVLRESLIHKKIIAKG--------EELNSPLNLEQAAYARDALAKAIYGRTFSWL---------------------------VSKINKSLAYK---------GTDMHKLG---SASVIGLLDIYGFEVF------QHNSFEQFCINFCNEKLQQL-FIELTLKSEQDEYESEGIA--WEPVQ-YFNN-KIICDLVEE----------------------------------KF---KGIISILDEECLRPG---------------EATDMTFLEKLEDT--VKN-----HPHFVTHKLGDQK--TR--KVLGRDEFRLLHYA--GEVNYSVAGFLD-KNNDLLFRNLKEVMCDS-----------------GNPIAHQCFN---------------------RSELT-----------DK-------------------------------------------------------------------------------------------------------------------------------------------------------------K-RPETAATQFK-----------------------NSLSKLMEILM--SKQPSYVRCIKPNDAKQPA-----------------------------RFDEVLIRHQVKYLGLIENV----RVRRAGFAYRRKYEIFLQRYK---SLCPD----TWP----NWDG---------------RAMDGVAVLVKSLG---------YKP---EEYKMGRTKIF--------IRFPKTLFATEDALE--*
Dm IB -VQDFVL-LENYQSEEAFIGNLKKRFQE-DLIYTYIGQVLISVNPYKQLP-IYTDN----------------HVKAYR--NKH------------FYEMPPHIFAVTDNAFRSLIE---------ENRGQCVLISGESGSGKTEASKKVLQFIAACS----------------------------------------------------------------------------------------------------------------------------------------GN---QT--------------------------TVEGVKDKLLK--SN-----PVLEAFGNAKTNRNDNSSRFGKYMDIQFDFK------GAPIGGNILNYL-LEKSRVVA-QMGGERNFHIFYQLLAGADEA-----------------------------------------LLQELG--LERALD----------TYSYLTD------------GL---------------NGTVTS----------INDADSFKQVQQALTVID----FGKEEQ-REIFGIVASILHLG-NVGFTEVE------G-N-------AKVNSR--D--LVVTAARLL-GVNASELEAALTHRTIDARG--------DVVTSPLNQELAIYARDALAKAVYDRLFSWL---------------------------VQRLNISLQAK---------ETRAS------RNNVMGILDIYGFEIF------QKNSFEQFCINFCNEKLQQL-FIELTLKSEQDEYRREGIE--WIPVE-YFDN-KVICNLIEE----------------------------------KH---KGIISILDEECLRPG---------------EPTDKTFLEKLTQK--LAQ-----HHHYVCHEKAPAH--IK--KIMLRDEFRLVHYA--GEVTYSVNGFLD-KNNDLLFRDLKETLSKA-----------------GNGIVRSCFP---------------------EKELR-----------SL-------------------------------------------------------------------------------------------------------------------------------------------------------------K-RPETAITQFR-----------------------ASLNNLMDILM--CKEPSYIRCIKPNDLQTAN-----------------------------VFNDELVLHQVKYLGLMENL----RVRRAGFAYRRTYELFLERYK---SLSKS----TWP----NYKGPG-------------GPKAGVQQLVKDLG---------WDE---EKYRVGETKLF--------IRWPRTLFDTEDAYQE-*
Rn Myr4 ID -KADFVL-MDTVS-MPEFMANLRLRFEK-GRIYTFIGEVVVSVNPYKVLN-IYGRD----------------TIEQYK--GRE------------LYERPPHLFAILDAAYKAMKR---------RSKDTCIMISGESGAGKTEASKYIMQYIAAIT----------------------------------------------------------------------------------------------------------------------------------------NP---SQR------------------------AEIERVKNMLLK--SN-----CVLEAFGNAKTNRNDNSSRFGKYMDINFDFK------GDPIGGHINNYL-LEKSRVIV-QQPGERSFHSFYQLLQGGSEQ-----------------------------------------MLHSLH--LQKSLS----------SYNYIRV------------G----------------AQLKSS----------INDAAEFKVVADAMKVIG----FKPEEI-QTVYKILAAILHLG-NLKFIVDG------DTP--------LIENG--K--VVSVIAELL-STKADMVEKALLYRTVATGR--------DIIDKQHTEQEASYGRDAFAKAIYERLFCWI---------------------------VTRINDIIEVK---------NYDTTVHG---KNTVIGVLDIYGFEIF------DNNSFEQFCINYCNEKLQQL-FIQLVLKQEQEEYQREGIP--WKHID-YFNN-QIIVDLVEQ----------------------------------QH---KGIIAILDDACMNVG---------------KVTDGMFLEALNSK--LGK-----HGHFSSRKTCASD--KI---LEFDRDFRIRHYA--GDVVYSVIGFID-KNKDTLFQDFKRLMYNS-----------------SNPVLKNMWP---------------------ERKLSI---------TEVT------------------------------------------------------------------------------------------------------------------------------------------------------------K-RPLTAATLFK-----------------------NSMIALVDNLA--SKEPYYVRCIKPNDKKSPQ-----------------------------IFDDERGRHQVEYLGLLENV----RVRRAGFAFRQTYEKFLHRYK---MISEF----TWP----NHDLPS-------------D-KEAVKKLIERCG---------FQ----DDVAYGKTKIF--------IRTPRTLFTLEELRA--*
Dm IA -VQDFVL-LDQVS-MEKFMDNLRKRFQN-GSIYTYIGEVCVSMNPYRQMN-IYGPE----------------TIRKYK--GRE------------LFENAPHLFAIADSAYRVLKQ---------RQQDTCILISGESGAGKTEASKIIMKYIAAVT----------------------------------------------------------------------------------------------------------------------------------------NA---QGQ------------------------NEIERVKNVLIQ--SN-----AILETFGNAKTNRNDNSSRFGKYMDIEFDYK------ADPVGGIITNYL-LEKSRVVQ-QQPGERNFHSFYQLLRGANDN-----------------------------------------ELRQYE--LQKETG----------KYHYLNQ------------G----------------S--MDI----------LTEKSDYKGTCNAFKTLG----FSTDEV-QTIWRTIAAVLHLG-NVEFQTIE------DEL--------VISNK--Q--HLKSTAKLL-QVTETELSTALTKRVIAAGG--------NVMQKDHNATQAEYGKDALAKAIYDRLFTWI---------------------------ISRINRAILFR---------GSKTQAR----FNSVIGVLDIYGFEIF------DSNSFEQFCINYCNEKLQQL-FIELVLKQEQEEYQREGIE--WTNIE-YFNN-KIICDLVEQ----------------------------------PH---KGIIAIMDEACLSVG---------------KVTDDTLLGAMDKN--LSK-----HPHYTSRQLKPTD--KE---LKHREDFRITHYA--GDVIYNINGFIE-KNKDTLYQDFKRLLHNS-----------------KDANLSEMWP---------------------EGAQDI---------KKTT------------------------------------------------------------------------------------------------------------------------------------------------------------K-RPLTAGTLFQ-----------------------RSMADLVVTLL--KKEPFYVRCIKPNDLKSST-----------------------------VFDEERVEHQVRYLGLLENL----RVRRAGFVHRQRYDKFLLRYK---MISQY----TWP----NFRAGS-------------D-RDGVRVLIEEKK---------FA----QDVKYGHTKIF--------IRSPRTLFALEHQRNE-*
Ce IA -VEDLVL-LSTID-LKSVVQNLQLRFQK-GRIYTYIGEVLVAVNPYRQLG-IYEKS----------------TVDQYK--GRE------------IYERAPHVFAIADAAYRSMKR---------FGRDSCIVISGESGAGKTETSKIIMKYLAAIT----------------------------------------------------------------------------------------------------------------------------------------NV---RQQ------------------------GEIERVKNVLLR--SN-----CILEAFGCAKTTRNDNSSRFGKYMHINFDYD------GDPVGGNISNYL-LEKSRVVR-QQEGERNFHVFYQLVNGGDDG-----------------------------------------LLRQFG--LTKDAK----------QYYFLNQ------------GQ---------------SHKVAS----------INDSRDFAEVQTALRSIHT---FDKQDV-ESMWSVIAGLIHLG-NVRFIDGE------NSSG-----AVHIAEK--A--ALQNAARCL-NVTPDELAKSLSSQVVAAHG--------DIVKKQHDVNAAYYTRDALAKALYERLFSWM---------------------------VSKVNEAISVQ---------NSSRYSK-----SHVIGVLDIYGFEIF------GTNSFEQLCINYCNEKLQQL-FIELVLKQEQEEYEREGIK--WVKIE-YFNN-KVICDLVEI----------------------------------PR---TGILSILDEACASIG---------------NVTDKVFLGELDKK--LKS-----HKHYTSRNLKQSD--KS---MGF-EEFKITHYA--GDVTYSVMGFMD-KNKDTLFQDLKRLLYHS-----------------KNRLVKSLFP---------------------DGSKSM---------AEVN------------------------------------------------------------------------------------------------------------------------------------------------------------R-RPPTAGFLFK-----------------------NSMSELVKQLA--QKEPHYIRCIKPNEEKNSN-----------------------------VFDLERVEHQVRYLGLLENV----RVRRAGFAHRMPYDRFVNRYK---LICAS----TWP----NPRRGQ-------------QLKDSCMQILESAG---------LA----QDCVQGRTKIF--------IRSPQTVFRLEELRT--*
Ac IB -VDDLVL-MPKIT-EQDICANLEKRYFN-DLIYTNIGPVLISVNPFRRIDALLTDE----------------CLHCYR--GRY------------QHEQPPHVYALAEAAYRGVKS---------ENINQCVIISGESGAGKTEASKLVMQYVAAVS----------------------------------------------------------------------------------------------------------------------------------------G-----NS------------------------GGVDFVKH------SN-----PLLEAFGNAKTLLNNNSSRFGKYFEIHFNRL------GEPCGGRITNYL-LEKSRVTF-QTRGERSFHIFYQLLAGASDA-----------------------------------------EAQEMQ--L-YAPE----------NFNYLNQ------------SA---------------CYTVDG----------IDDIKEFADTRNAINVMG----MTAEEQ-RQVFHLVAGILHLG-NVAFHDGG------KGT-------AAVHDR-----------------TPFALKNALLFRVLNTGGAG--AKKMSTYNVPQNVEQAASARDALAKTIYSRMFDWI---------------------------VSKVNEALQKQ---------GGSGDH-----NNNMIGVLDIFGFEIF------EQNGFEQFCINYVNEKLQQY-FIELTLKAEQEEYVNEGIQ--WTPIK-YFNN-KVVCELIEG----------------------------------KR--PPGIFSLLDDICFTMHA-QS-----------DGMDGKFLQKCQGG--FPS-----HLHFRGMNNA----------------FSIKHYA--GEVTYEAEGFCE-KNKDTLFDDLIAVIQES-----------------ENRLLVSWFP---------------------EDTKQL----------QK-------------------------------------------------------------------------------------------------------------------------------------------------------------K-RPTTAGFKLK-----------------------TSCDALMEALS--RCSPHYIRCIKPNDNKAYH-----------------------------DWDATRTKHQVQYLGLLENV----RVRRAGFAYRAEFDRFLRRYK---KLSPK----TWGI-WGEWSG---------------APKDGCQTLLNDLG---------LDT---SQWQLGKSKVF--------IRYPETLFHLEECLD--*
Dd IB -TDDLVM-LPKVS-EDEICENLKKRYMN-DFIYTNIGPVLISVNPFRNLNNSGPD-----------------FIEAYR--GKH------------AQEVPPHVYQLAESAYRAMKN---------DQENQCVIISGESGAGKTEAAKLIMGYVSAIS----------------------------------------------------------------------------------------------------------------------------------------G-----ST------------------------EKVEYVKHVILE--SN-----PLLEAFGNAKTLRNNNSSRFGKYFEIQFDKA------GDPVGGKIYNYL-LEKSRVVY-QNPGERNFHIFYQLLRGASAQ-----------------------------------------EKRDYV--L-SSPE----------SYYYLNQ------------SQ---------------CYTVDG----------INDVSDYAEVRQAMDTIG----LTAQEQ-SDIIRIVACVLHIG-NIYFIEDD------KGN-------AAIYDP--N--ALELAASML-CIDSATLQNAILFRVINTGGAGGAGNRRSTYNVPQNVEQANGTRDALARTIYDRMFSWL---------------------------VEKVNQSLSYY---------KSP--------YQNVIGILDIFGFEIF------EKNGFEQFCINFVNEKLQQF-FIELTLKAEQEEYVREGIK--WEPIK-YFNN-QIVCDLIEG----------------------------------KS--PPGIFSLLDDICSTLHA-QS-----------TGTDQKFLEKMAGI--YDG-----HLHWRGMTGA----------------FAIKHYA--GEVTYEAEGFSD-KNKDTLFFDLIEAIQCS-----------------KMPFLASLFN---------------------EDTGSL----------QK-------------------------------------------------------------------------------------------------------------------------------------------------------------K-RPTTAGFKIK-----------------------TSAGELMKALS--QCTPHYIRCIKPNETKKAK-----------------------------DWENSRVKHQVQYLGLLENV----RVRRAGFAYRNTFDKVLKRYK---KLSSK----TWGI-WGEWKG---------------DAIEGCKTIFQDMN---------LEA---GQWQLGKTKVF--------IRHPETVFLLEEALD--*
Eh IB -VDDLVM-LPKID-ENEIVDNLKKRYNY-DAIYTNIGPVLIVINPFKDLG-LTTDE----------------YVHLYK--GEF------------RQELPPHIFALSEETYRNMKN---------EKCNQCCIISGESGAGKTVAAKQIMQYIAAVS----------------------------------------------------------------------------------------------------------------------------------------G-----GN------------------------EEVVYVKNVILD--SN-----PLLEAFGNAKTLRNNNSSRFGKYFEINFDDH------ADPVGGTITNYL-LEESRVCT-QQTGERNYHIFYQLLAGAPEN-----------------------------------------YYNDFY--L-TTPG----------YFVYTNQ------------SN---------------CMVVDG----------IDDKKDYADCVKAMNTIG----ISADEQ-YWIFQLVAAILHLG-NVYFTENS------SGY-------AEITDK--S--ALETAAYLL-EVDPGQLEHVMLVRKLTTG-VG---ARAEVFDSPLTVEQAEATKNAIAKEIYDRIFTML---------------------------VQKVNIALQKH---------GIE--------HQCVIGILDIFGFEIF------PVNGFEQFCINYVNEKLQQY-FIELTLKTEQEEYLAEGIK--WTPIK-YFNN-KVVCDLIEG----------------------------------KN--PPGMFSLLDDICATMHA-QT-----------EGADFKFLEKCCSV--HST-----NQHFIPSGET----------------FTVQHYA--GPVSYYCEGFCE-KNKDTLFLECVECLQTS-----------------NNQLLYDLFPWS----------------AEQEAAKTG----------QK-------------------------------------------------------------------------------------------------------------------------------------------------------------K-RPTTAGFKIK-----------------------TSANELMAALS--QCQPHYIRCIKPNETKKPQ-----------------------------DWDADRVKHQVKYLGLLENV----KVRRAGFAYRAPFARFLQTYK---KYHQM----TWGT-WGEWTG---------------DAKEGCRLILEGLTN--------IEP---GQWQFGTTKLF--------IRLPESIFAIEEML---*
Rn Myr3 IC -VDDMVL-LSKIT-ESSIVENLKKRYMD-DYIFTYIGSVLISVNPFKQMP-YFGEK----------------EIEMYQ--GAA------------QYENPPHIYALADSMYRNMII---------DRENQCVIISGESGAGKTVAAKYIMSYVSRVS----------------------------------------------------------------------------------------------------------------------------------------G-----GG------------------------PKVQHVKDIILQ--SN-----PLLEAFGNAKTVRNNNSSRFGKYFEIQFSPG------GEPDGGKISNFL-LEKSRVVM-RNPGERSFHIFYQLIEGASPE-----------------------------------------QKQSLG--I-TSMD----------YYYYLSL------------SG---------------SYKVDD----------IDDKRDFQETLHAMNVIG----IFSEEQ-TLVLQIVAGILHLG-NINFKEVG------N-Y-------AAVESE--E--FLAFPAYLL-GINQDRLKEKLTSRQMDSKWGG----KSESIHVTLNVEQACYTRDALAKALHARVFDFL---------------------------VDSINKAMEKD---------HEE----------YNIGVLDIYGFEIF------QKNGFEQFCINFVNEKLQQI-FIELTLKAEQEEYVQEGIR--WTPIE-YFNN-KIVCDLIES----------------------------------KVN-PPGIMSILDDVCATMHA-VG-----------EGADQTLLQKLQMQ--IGS-----HEHFNSWNQG----------------FIIHHYA--GKVSYDMDGFCE-RNRDVLFMDLIELMQSS-----------------ELPFIKSLFP---------------------ENLQAD----------KK-------------------------------------------------------------------------------------------------------------------------------------------------------------G-RPTTAGSKIK-----------------------KQANDLVSTLM--KCTPHYIRCIKPNETKKPK-----------------------------DWEESRVKHQVEYLGLKENI----RVRRAGYAYRRVFQKFLQRYA---ILTKA----TW----PVWRG---------------DEKQGVLHLLQSVN---------MDS---DQFQLGRSKVF--------IKAPESLFLLEEMRE--*
Hs IC -VDDMVL-LSKIT-ENSIVENLKKRYMD-DYIFTYIGSVLISVNPFKQMP-YFGEK----------------EIEMYQ--GAA------------QYENPPHIYALADNMYRNMII---------DRENQCVIISGESGAGKTVAAKYIMSYISRVS----------------------------------------------------------------------------------------------------------------------------------------G-----GG------------------------TKVQHVKDIILQ--SN-----PLLEAFGNAKTVRNNNSSRFGKYFEIQFSPG------GEPDGGKISNFL-LEKSRVVM-RNPGERSFHIFYQLIEGASAE-----------------------------------------QKHSLG--I-TSMD----------YYYYLSL------------SG---------------SYKVDD----------IDDRREFQETLHAMNVIG----IFAEEQ-TLVLQIVAGILHLG-NISFKEVG------N-Y-------AAVESE--E--FLAFPAYLL-GINQDRLKEKLTSRQMDSKWGG----KSESIHVTLNVEQACYTRDALAKALHARVFDFL---------------------------VDSINKAMEKD---------HEE----------YNIGVLDIYGFEIF------QKNGFEQFCINFVNEKLQQI-FIELTLKAEQEEYVQEGIR--WTPIE-YFNN-KIVCDLIEN----------------------------------KVN-PPGIMSILDDVCATMHA-VG-----------EGADQTLLQKLQMQ--IGS-----HEHFNSWNQG----------------FIIHHYA--GKVSYDMDGFCE-RNRDVLFMDLIELMQSS-----------------ELPFIKSLFP---------------------ENLQAD----------KK-------------------------------------------------------------------------------------------------------------------------------------------------------------G-RPTTAGSKIK-----------------------KQANDLVSTLM--KCTPHYIRCIKPNETKKPR-----------------------------DWEESRVKHQVEYLGLKENI----RVRRAGYAYRRIFQKFLQRYA---ILTKA----TW----PSWQG---------------EEKQGVLHLLQSVN---------MDS---DQFQLGRSKVF--------IKAPESLFLLEEMRE--*
Gg IB -VDDMVL-LAKIS-EEAIVENLKKRFMD-DYIFTYIGPVLISVNPFKQMP-YFTDR----------------EIELYQ--GAA------------QYENPPHIYALTDNMYRNMLI---------DGENQCVIISGESGAGKTVAAKYIMGYISKVS----------------------------------------------------------------------------------------------------------------------------------------G-----GG------------------------DKVQHVKDIILQ--SN-----PLLEAFGNAKTVRNNNSSRFGKYFEIQFSRG------GEPDGGKISNFL-LEKSRVVS-QNEHERNFHVYYQLIEGASQE-----------------------------------------QRQNLG--I-MSPD----------YYYYLNQ------------SD---------------TYQVEG----------TDDRSDFLETMNAMQVIG----IRGEDQ-QLVLQIVAGILHLG-NISFREEG------N-Y-------ARVENA--D--SLAFPAYLL-GIDRDRLNDKITSRKMDSKWGG----RSESITVTLNVEQAAYTRDALAKGLYARVFDFL---------------------------VESINRAMQKP---------YEE----------YSIGVLDIYGFEIF------QKNGFEQFCINFVNEKLQQI-FIELTLKAEQEEYVQEGIK--WTQIQ-YFNN-KVVCDLIEN----------------------------------KLN-PPGIMSVLDDVCATMHA-TG-----------EGADQTLLQKLQAA--VGT-----HEHFNSWSSG----------------FVIHHYA--GKVSYDVNGFCE-RNRDVLFTDLIELMQSS-----------------EYAFIRMLFP---------------------EKLDAD----------KK-------------------------------------------------------------------------------------------------------------------------------------------------------------G-RPTTAGSKIK-----------------------KQANDLVNTLM--KCTPHYIRCIKPNETKKPR-----------------------------DWEESRVKHQVEYLGLKENI----RVRRAGFAYRRIFHKFLQRYA---ILTPE----TW----PSWRG---------------DERQGVQHLLRSVN---------MDP---DQYQMGRSKVF--------VKNPESLFLLEEMRE--*
Mm I -VDDMVL-LSQIT-EDAIVRNLHKRFMD-DYIFTYIGSVLISVNPFKQMP-YFTDR----------------EIDLYQ--GAV------------QYEEPPHIYALTDNMYRNMLI---------DCENQCVIISGESGAGKTVAAKYIMGYISKVS----------------------------------------------------------------------------------------------------------------------------------------G-----GG------------------------DKVQHVKDIILQ--SN-----PLLEAFGNAKTVRNNNSSRFGKYFEIQFSRG------GEPDGGKISNFL-LEKSRVVM-QNENERNFHIYYQLLEGASQE-----------------------------------------QQQNLG--I-MSQD----------YYYYLNQ------------SD---------------TYKVEG----------TDDRSDFSETLSAMQVMG----FRQACQ-QLVLQLVAGILHLG-NISFCEEG------N-Y-------ARVESV--D--SLAFPAYLL-GIDSGRLQEKLTSRKMDSKWGG----RSESIDVTLNVEQAAYTRDALAKGLYARLFDFL---------------------------VEAINRAMQKP---------QEE----------YSIGVLDIYGFEIF------QKNGFEQFCINFVNEKLQQI-FIELTLKAEQEEYVQEGIR--WTPIE-YFNN-KIVCDLIEN----------------------------------KLS-PPGIMSVLDDVCATMHA-TG-----------GGADQTLLQKLQAA--VGT-----HEHFNSWSAG----------------FVIHHYA--GKVSYDVSGFCE-RNRDVLFSDLIELMQSS-----------------DQDFLRMLFP---------------------EKLNID----------KK-------------------------------------------------------------------------------------------------------------------------------------------------------------G-RPSTAGSKIK-----------------------KQANDLVSTLK--KCTPHYIRCIKPNETKRPR-----------------------------DWEESRVKHQVEYLGLRENI----RVRRAGFAYRRQFSKFLQRYA---ILTPE----TW----PRWRG---------------DERQGVQHLLRAVN---------MEP---DQYQMGSTKVF--------VKNPESLFLLEEMR---*
Ac IC -VDDMVM-LTSIS-NDAINDNLKKRFAA-DLIYTYIGHVLISVNPYKQINNLYTER----------------TLKDYR--GKY------------RYELPPHVYALADDMYRTMLS---------ESEDQCVIISGESGAGKTEASKKIMQYIAAVS----------------------------------------------------------------------------------------------------------------------------------------G-----AT------------------------GDVMRVKDVIL-------------EAFGNAKTIRNNNSSRFGKYMEIQFDLK------GDPVGGRISNYL-LEKSRVVY-QTNGERNFHIFYQLLAARARR-----------------------------------------PEAKFG--L-QTPD----------YYFYLNQ------------GK---------------TYTVDG----------MDDNQEFQDTWNAMKVIG----FTAEEQ-HEIFRLVTAILYLG-NVQFVDDG------KGG-------STIAD-----------------SRPVAVETALLYRTITTGEQGR--GRSSVYSCPQDPLGAIYSRDALSKALYSRMFDYI---------------------------IQRVNDAM-YI---------DDP--------EALTTGILDIYGFEIF------GKNGFEQLCINFVNEKLQQI-FIQLTLKAEQEEYGAEGIQ--WENID-YFNN-KICCDLIEE----------------------------------KR--PPGLMTILDDVCN-----FP-----------KGTDDKFREKLLGA--FPT-----HAHLAATSQPD----E----------FVIKHYA--GDVVYNVDGFCD-KNKDLLFKDLIGLAECT-----------------SSTFFAGLFP--------------------EAKEVAT----------SK-------------------------------------------------------------------------------------------------------------------------------------------------------------K-KPTTAGFKIK-----------------------ESINILVATLS--KCTPHYIRCIKPNEKKAAN-----------------------------AFNNSLVLHQVKYLGLLENV----RIRRAGYAYRQSYDKFFYRYR---VVCPK----TWS----GWNG---------------DMVSGAEAILNHVG---------MSLG--KEYQKGKTKIF--------IRQPESVFSLEELRD--*
Dd ID -VDDMVM-LSKIA-NDSILDNLKKRYGG-DVIYTYIGNVLISVNPFKQIKNLYSER----------------NLLEYR--GKF------------RYELPPHAYAVADDMYRSMYA---------EGQSQCVIISGESGAGKTEAAKLIMQYIAAVS----------------------------------------------------------------------------------------------------------------------------------------G-----KG------------------------ADVSRVKDVILE--SN-----PLLEAFGNAKTLRNNNSSRFGKYMEVQFNGI------GDPEGGRVTNYL-LEKSRVVY-QTKGERNFHIFYQLLSGANQQ-----------------------------------------LKSELR--L-DTPD----------KFNYLSA------------SG---------------CYTVDG----------VDDSGEFQDVCKAMKVIG----LTDSEQ-KEVFRLVAAILYLG-NVGFKNNA------KDE-------AAIDQQ--SKKALENFAFLM-QTDVSSCEKALCFRTISTGTQGRS-ARVSTYACPQNSEGAYYSRDALAKALYSRLFDWI---------------------------VGRVNSALGYK---------QNS--------QSLMIGILDIYGFEIF------EKNGFEQMVINYVNERLQQI-FIELTLKTEQEEYFNEGIQ--WEQID-YFNN-KICCDLIES----------------------------------KK--PAGILTILDDVCN-----FP-----------KGDDQKFLDRLKES--FSS-----HAHFQSAAQSS----SS---------FTIKHYA--GDVEYCAEGFVD-KNKDLLFNDLVELAACT-----------------TSKLIPQLFP--------------------EIN-CEK----------DK-------------------------------------------------------------------------------------------------------------------------------------------------------------R-KPTTAGFKIK-----------------------ESIGALVKALS--ACTPHYIRCIKPNGNKRAN-----------------------------DFDTSLVMHQVKYLGLLENVRIFGRIRRAGYAYRQTYDKFFYRYR---VCCKE----TWP----NWTG---------------GFESGVETILKSMD---------LEP---KQYSKGKTKIF--------IRAPETVFNLEELRE--*
Sc MYO3 IA -ISDLTL-LSKIS-DESINENLKKRFKN-GIIYTYIGHVLISVNPFRDLG-IYTNA----------------VLESYK--GKN------------RLEVPPHVFAIAESMYYNLKS---------YNENQCVIISGESGAGKTEAAKRIMQYIAAAS----------------------------------------------------------------------------------------------------------------------------------------N----SHS------------------------ESIGKIKDMVLA--TN-----PLLESFGCAKTLRNNNSSRHGKYLEIKFNSQ------FEPCAGNITNYL-LEKQRVVG-QIKNERNFHIFYQFTKGASDT-----------------------------------------YKQMFG--V-QMPE----------QYIYTAA------------AG---------------CTSADQ----------LMR-KDYEGTLEAMRTIG----LVQEEQ-DQIFRMLAAILWIG-NISFIENE------EGN-------AQVGDT--S--VTDFVAYLL-QVDASLLVKCLVERIMQTSHGM---KRGSVYHVPLNPVQATAVRDALAKAIYNNLFDWI---------------------------VDRVNVSLQAF---------PGA---------DKSIGILDIYGFEIF------EHNSFEQICINYVNEKLQQI-FIQLTLKAEQETYEREKIK--WTPIK-YFDN-KVVCDLIEA----------------------------------KN--PPGILAAMNDSIATAHA-DS-----------NAADQAFAQRLN-L--FNS-----NPYFELRANK----------------FVIKHYA--GDVTYDINGITD-KNKDQLQKDLIELIGTT-----------------TNTFLSTIFP---------------------DDVDKD----------SK-------------------------------------------------------------------------------------------------------------------------------------------------------------R-RPPTAGDKII-----------------------KSANELVETLS--KAEPSYIRTIKPNQTKSPN-----------------------------DYDDHQVLHQVKYLGLQENV----RIRRAGFAYRQTFEKFVERFY---LLSPD----CSYAGDYTWDG---------------DTLEAVKLILRDAM---------IPE---KEFQLGVTSVF--------IKTPESLFALEDMR---*
Sc MYO5 IB -VSDLTL-LSKIS-DEAINENLKKRFLN-ATIYTYIGHVLISVNPFRDLG-IYTDA----------------VMNEYK--GKN------------RLEVPPHVFAIAESMYYNMKS---------YNENQCVIISGESGAGKTEAAKRIMQYIAAAS----------------------------------------------------------------------------------------------------------------------------------------S----THT------------------------ESIGKIKDMVLA--TN-----PLLESFGCAKTLRNNNSSRHGKYLEIKFNNQ------FEPCAGNITNYL-LEKQRVVS-QIKNERNFHIFYQFTKGASDA-----------------------------------------YRQTFG--V-QKPE----------QYVYTAA------------AG---------------CISAET----------IDDLQDYQETLKAMRVIG----LGQEEQ-DQIFRMLAAILWIG-NVSFIENE------EGN-------AQVRDT--S--VTDFVAYLL-QIDSQLLIKSLVERIMETNHGM---KRGSVYHVPLNIVQADAVRDALAKAIYNNLFDWI---------------------------VSRVNKSLQAF---------PGA---------EKSIGILDIYGFEIF------EHNSFEQICINYVNEKLQQI-FIQLTLKSEQETYEREKIQ--WTPIK-YFDN-KVVCDLIEA----------------------------------RR--PPGIFAAMNDSVATAHA-DS-----------NAADQAFAQRLN-L--FTT-----NPHFDLRSNK----------------FVIKHYA--GDVTYDIDGITD-KNKDQLQKDLVELIGTT-----------------TNTFLATIFP---------------------DTVDRE----------SK-------------------------------------------------------------------------------------------------------------------------------------------------------------R-RPPTAGDKII-----------------------KSANDLVETLS--KAQPSYIRTIKPNETKSPN-----------------------------DYDDRQVLHQIKYLGLQENV----RIRRAGFAYRQVFEKFVERFY---LLSPH----CSYAGDYTWQG---------------DTLDAVKYILQDSS---------IPQ---QEYQLGVTSVF--------IKTPETLFALEHMR---*
En MyoA IA -VSDLTL-LSKIS-NEAINDNLKLRFQH-DEIYTYIGHVLVSVNPFRDLG-IYTDS----------------VLNSYR--GKN------------RLEVPPHVFAVAESAYYNMKS---------YKDNQCVIISGESGAGKTEAAKRIMQYIASVS----------------------------------------------------------------------------------------------------------------------------------------G----GSD------------------------SSIQQTKDMVLA--TN-----PLLESFGNAKTLRNNNSSRFGKYLELEFNAQ------GEPVGANITNYL-LEKSRVVG-QITNERNFHIFYQFAKGAPQK-----------------------------------------YRDSFG--V-QQPQ----------SYLYTSR------------SK---------------CFDVPG----------VDDVAEFQDTLNAMSVIG----MSEAEQ-DNVFRMLAAILWMG-NIQFAEDD------SGN-------AAITDQ--S--VVDFVAYLL-EVDAGQVNQALTIRMMETSRGG---RRGSVYEVPLNTTQALAVRDALAKAIYFNLFDWI---------------------------VGRVNQSLTAK---------GAV---------ANSIGILDIYGFEIF------EKNSFEQLCINYVNEKLQQI-FIQLTLKAEQDEYEREQIT--WTPIK-YFDN-KVVCSLIED----------------------------------KR--PPGVFAALNDACATAHA-DS-----------GAADNTFVGRLN-F--LGQ-----NPNFENRQGQ----------------FIIKHYA--GDVSYAVQGMTD-KNKDQLLKDLLNLVQSS-----------------SNHFVHTLFP---------------------EQVNQD----------DK-------------------------------------------------------------------------------------------------------------------------------------------------------------R-RPPTASDKIK-----------------------ASANDLVAMLM--KAQPSYIRTIKPNDNKAPK-----------------------------EFNESNVLHQIKYLGLQENV----RIRRAGFAYRQTFDKFVERFY---LLSPK----TSYAGDYTWTG---------------DVETGARQILKDTR---------IPA---EEYQMGITKVF--------IKTPETLFALEAMRD--*
Dd IC -LDDMTL-LSKVS-NDQILDNLKKRFEK-DIIYTNIGDVLISVNPFKFIDGMYSDE----------------VLQEYI--GKS------------RIELPPHVFAVAEQTYRSMIN---------EKENQCVIISGESGAGKTEAAKKIMQYIADVS----------------------------------------------------------------------------------------------------------------------------------------GERGSSSN------------------------QKVEHVKSIILE--TN-----PLLEAFGNAKTLRNNNSSRFGKYFEIQFNQK------NEPEGGKITNYL-LEKSRVVF-QLKGERNFHIFYQFCRGATPQ-----------------------------------------EQQEFG--I-YGPE----------NFAYLTK------------GD---------------TLDIDG----------VDDVEEFALTRNAMNVIG----IPANEQ-KQIFKLLAAILWIG-NIDFKEQA------GDK-------VTIADT--S--VLDFVSQLL-DVPSHFLKTALEFRQMETRHGN---QRGTQYNVPLNKTQAIAGRDALAKAIYDRLFNWL---------------------------VDRINKEMDN----------PQK---------GLMIGVLDIYGFEVF------DRNGFEQFCINYVNEKLQQI-FIEFTLKMEQEEYVREGIK--WEPIP-FFDN-KIVCELIEG----------------------------------KN--PPGIFSILDDVCRAVHS-QA-----------EVPIKSYFNPLP-F--VNQ-----IHISILVGNA----------------FCVKHYA--GDVVYEGPGMIE-KNKDTLLKDHLEILQMS-----------------ANNFLVGLFP---------------------DVIDTD----------SK-------------------------------------------------------------------------------------------------------------------------------------------------------------K-LPSTAGFKIK-----------------------SQAAELVATLM--KSTPHYIRTIKPNDLKKPN-----------------------------ILEGGRVLHQVKYLGLLDNI----KVRRAGFAYRATFDRFFQRYY---LLSDK----TCYAGNNIWKG---------------DALSACRAILASQN---------VDN---TQYQIGKTKIF--------IRYPEMLFSLEETRE--*
Dd myoK -VDDLVL-VSNPS-NGEVTSQIGARFDR-ELIYTNIGEVLIAVNPYKALP-ITGPE----------------FIKLYQ--NAS------------GSDASPHIYALAERAYRRMVD---------ENESQCVIISGESGAGKTVSAKLILQYVTSVSPNNSSGGGIGGSGGGNGGIPQYDGGSDDRPSPPMGRGMGMPGMVGRGGLPTRGGGPPSRGGGPPPTRGRGGPPPPIPQNRGAPPPVSNGGAPPPVARGPVAPPPTRGAPPTRGGGPANRGGRGGGPPPVSTSRGGGGYGGSSKT------------------------VDVEHIKKVILD--SN-----PLMEAIGNAKTVRNDNSSRFGKYLEIQFDDN------NAPVGGLISTFL-LEKTRVTF-QQKNERNFHIFYQMLGGLDQT-----------------------------------------TKSEWG--L-TQAT----------DFYYLAQ------------SK---------------CTTVED----------VDDGKDFHEVKAAMETVG----ISRDEQ-TEIFRILAAILHVG-NIRFQGEA------P---------ASVIDE--T--PLQWAASLL-GCDPTFLCQSLNHRQIQSGSAR-----HTQYQVPQNPDQSAGLRDALAKTLYERIFDFI---------------------------VARVNKAMSFS---------GNC----------KVIGVLDIYGFEVF------ERNSFEQFCINYVNERLQQI-FIDLTVRGEQREYHEEGMK--WKDIS-FFDN-KIVVDLIDG----------------------------------NK--PPGIMRVLDDVCKTVHAVDS-----------AAADIKFMEKLIHS--IQS-----HPHLVISNTGSSA--DE---------FTIKHYA--GEVSYSIEEFCF-KNNDNLYASIVGCLQNS-----------------TYQFIVSLFP---------------------EN-IQD----------NK-------------------------------------------------------------------------------------------------------------------------------------------------------------Q-APTTSSFKIR-----------------------QSSSYLVTRLS--ACTPHYIRCIKPNDKKQPM-----------------------------NFVSSRVEHQVKYLGILENI----KVKRSGYAYRQLKDIFLNRFG---KIMDV----QP--------R---------------NVQEFVEYITRTHKD--------INA---DEFEEGKTKIF--------VKNPETIFVMEDLL---*
Ac HMWMI IV -VDDLVQ-MDDIN-EAMIVHNLRKRFKN-DQIYTNIGTILISVNPFKRLP-LYTPT----------------VMDQYM--HKV------------PKEMPPHTYNIADDAYRAMID---------NRMNQSILISGESGAGKTECTKQCLTYFAELAG---------------------------------------------------------------------------------------------------------------------------------------------S---------------------------TNGVEQNILL--AN-----PILESFGNAKTLRN-NSSRFGKWVEIHFDQK------GSICGASTINHL-LEKSRVVY-QIKGERNFRIVATELVKAPPR-----------------------------------------SRGGGS--SPARPE----------SFKFLSQ------------SG---------------CIDVEG----------VDDVKEFEERVLCHGQARVRVQFSEDDI-NNCMELISAILHLG-NFEFVSGQ------GKN----VETSTVANR--E--EVKIVATLL-KVDPATLEQNVTSKLMEIKG-------CDPTRIPLTPVQATDATNALAKAIYSKLFDWL---------------------------VKKINESMEPQ---------KGAK--------TTTIGVLDIFGFEIF------DKNSFEQLCINFTNEKLQQH-FNQYTFKLEEKLYQSEEVK--YEHIT-FIDN-QPVLDLIEK----------------------------------KQ--PQGLMLVLDEQISIP----------------KSSDATFFIKANQT--QAA-----RSTQLRGGEDSR------------TDFIIKHYA--GDVIYDSTGMLE-KNKDTLQKDLLVLSESS-----------------KQKLMKLLFP---------------------PSEGD-----------QK-------------------------------------------------------------------------------------------------------------------------------------------------------------T-SKVTLGGQFR-----------------------KQLDSLMTALN--ATEPHYIRCIKPNSEKQAD-----------------------------LFHGFMSLQQLRYAGVFEAV----RIRQTGYPFRYSHENFLKRYG---FLVKD----IHK----RYGP---------------NLKQNCDLLLKSMKG--------DWS----KVQVGKTRVL--------YRAPE-QRGLELQRNI-*
Sc Myo2 Va -TEDLTS-LSYLN-EPAVLHAIKQRYSQLN-IYTYSGIVLIATNPFDRVDQLYTQD----------------MIQAYA--GKR------------RGELEPHLFAIAEEAYRLMKN---------DKQNQTIVVSGESGAGKTVSAKYIMRYFASVEEE-------------------------------------------------------------------------------------------------------------------------------------------NSAT-------------------VQHQVEMSETEQKILA--TN-----PIMEAFGNAKTTRNDNSSRFGKYLEILFDKD------TSIIGARIRTYL-LERSRLVY-QPPIERNYHIFYQLMAGLPAQ-----------------------------------------TKEELH---LTDAS----------DYFYMNQ------------GG---------------DTKING----------IDDAKEYKITVDALTLVG----ITKETQ-HQIFKILAALLHIG-NIEIK--K------TRN-------DASLSA--DEPNLKLACELLGIDA-YNFAKWVTKKQI-ITR-------SEKIVSNLNYSQALVAKDSVAKFIYSALFDWL---------------------------VENINTVLCNPAVN------DQISS---------FIGVLDIYGFEHF------EKNSFEQFCINYANEKLQQE-FNQHVFKLEQEEYVKEEIE--WSFIE-FNDN-QPCIDLIEN----------------------------------K----LGILSLLDEESRLP----------------AGSDESWTQKLYQTLDKSPT----NKVFSKPRFGQT-------------KFIVSHYA--LDVAYDVEGFIE-KNRDTVSDGHLEVLKAST-----------------NETLINILEG--LEK----------AAKKLEEAKKLEL-----EQAGSKKPGP----------------------------------------------------------------------------------------------------------------------------------------------------IRTVN-RKPTLGSMFK-----------------------QSLIELMNTIN--STNVHYIRCIKPNADKEAW-----------------------------QFDNLMVLSQLRACGVLETI----RISCAGFPSRWTFEEFVLRYY---ILIPH----EQWDLIFKKKETT-----------EEDIISVVKMILDATVK--------DKS----KYQIGNTKIF--------FKAGM-LAYLEKLRS--*
Sc Myo4 Vb -TDDLTT-LSYLN-EPAVLHAIKKRYMNGQ-IYTYSGIVLIAANPFDKVDHLYSRE----------------MIQNYS--SKR------------KDELEPHLFAIAEEAYRFMVH---------EKANQTVVVSGESGAGKTVSAKYIMRYFASVQES-------------------------------------------------------------------------------------------------------------------------------------------NNR---------------------EGEVEMSQIESQILA--TN-----PIMEAFGNAKTTRNDNSSRFGKYLQILFDEN------TTIRGSKIRTYL-LEKSRLVY-QPETERNYHIFYQILEGLPEP-----------------------------------------VKQELH---LSSPK----------DYHYTNQ------------GG---------------QPNIAG----------IDEAREYKITTDALSLVG----INHETQ-LGIFKILAGLLHIG-NIEMK--M------TRN-------DASLSS--EEQNLQIACELLGIDP-FNFAKWIVKKQI-VTR-------SEKIVTNLNYNQALIARDSVAKFIYSTLFDWL---------------------------VDNINKTLYDPELDQ----QDHVFS---------FIGILDIYGFEHF------EKNSFEQFCINYANEKLQQE-FNQHVFKLEQEEYVKEEIE--WSFIE-FSDN-QPCIDLIEN----------------------------------K----LGILSLLDEESRLP----------------SGSDESWASKLYSAFNKPPS----NEVFSKPRFGQT-------------KFIVSHYA--VDVEYEVEGFIE-KNRDSVSLGHLDVFKATT-----------------NPIFKQILD-----------------NRELRSDDAPEE-----QNTEKKIMIP----------------------------------------------------------------------------------------------------------------------------------------------------ARLSQ-KKPTLGSMFK-----------------------KSLGELMAIIN--STNVHYIRCIKPNSEKKPW-----------------------------EFDNLMVLSQLRACGVLETI----RISCAGFPSRWTFDEFVQRYF---LLTDY----SLWSGILYNPDLP-----------KEAIVNFCQSILDATIS--------DSA----KYQIGNTKIF--------FKAGM-LAFLEKLRT--*
Mm Dilute V -ENDLTA-LSYLH-EPAVLHNLRVRFIDSKLIYTYCGIVLVAINPYEQLP-IYGED----------------IINAYS--GQN------------MGDMDPHIFAVAEEAYKQMAR---------DERNQSIIVSGESGAGKTVSAKYAMRYFATVSGS-------------------------------------------------------------------------------------------------------------------------------------------AS---------------------------EANVEEKVLA--SN-----PIMESIGNAKTTRNDNSSRFGKYIEIGFDKR------YRIIGANMRTYL-LEKSRVVF-QAEEERNYHIFYQLCASAKLP-----------------------------------------EFKMLR---LGNAD----------SFHYTKQ------------GG---------------SPMIEG----------VDDAKEMAHTRQACTLLG----ISESYQ-MGIFRILAGILHLG-NVGFA--S-------RD-----SDSCTIPP--KHEPLTIFCDLMGVDY-EEMCHWLCHRKL-ATA-------TETYIKPISKLQATNARDALAKHIYAKLFNWI---------------------------VDHVNQALHS---------AVKQHS---------FIGVLDIYGFETF------EINSFEQFCINYANEKLQQQ-FNMHVFKLEQEEYMKEQIP--WTLID-FYDN-QPCINLIES----------------------------------K----LGILDLLDEECKMP----------------KGTDDTWAQKLYN-THLNK-----CALFEKPRMSNK-------------AFIIKHFA--DKVEYQCEGFLE-KNKDTVFEEQIKVLKSSK-----------------FKMLPELFQDDEKAI----------SPTSATSSGRTPL-----TRVPVKPTKGR---------------------------PG----------------------------------------------------------------------------------------------------------------------QTAKE-HKKTVGHQFR-----------------------NSLHLLMETLN--ATTPHYVRCIKPNDFKFPF-----------------------------TFDEKRAVQQLRACGVLETI----RISARGFPSRWTYQEFFSRYR---VLMKQ----KDVLG--DRKQT-------------------CKNVLEKLIL--------DKD----KYQFGKTKIF--------FRAGQ-VAYLEKLRA--*
Rn myo5a V GENDLTA-LSYLH-EPAVLHNLRVRFIDSKLIYTYCGIVLVAINPYEQLP-IYGED----------------IINAYS--GQN------------MGDMDPHIFAVAEEAYKQMAR---------DERNQSIIVSGESGAGKTVSAKYAMRYFATVSGS-------------------------------------------------------------------------------------------------------------------------------------------AS---------------------------EANVEEKVLA--SN-----PIMESIGNAKTTRNDNSSRFGKYIEIGFDKR------YRIIGANMRTYL-LEKSRVVF-QAEEERNYHIFYQLCASAKLP-----------------------------------------EFKMLR---LGNAD----------SFHYTKQ------------GG---------------SPMIEG----------VDDAKEMAHTRQACTLLG----ISESYQ-MGIFRILAGILHLG-NVGFA--S-------RD-----SDSCTIPP--KHEPLIIFCDLMGVDY-EEMCHWLCHRKL-ATA-------TETYIKPISKLQATNARDALAKHIYAKLFNWI---------------------------VGHVNQALHS---------AVKQHS---------FIGVLDIYGFETF------EINSFEQFCINYANEKLQQQ-FNMHVFKLEQEEYMKEQIP--WTLID-FYDN-QPCINLIES----------------------------------K----LGILDLLDEECKMP----------------KGTDDTWAQKLYN-THLNK-----CALFEKPRMSNK-------------AFIIKHFA--DKVEYQCEGFLE-KNKDTVFEEQIKVLKSSK-----------------FKMLPELFQDDEKAI----------SPTSATSSGRTPL-----TRVPVKPTKGR---------------------------PG----------------------------------------------------------------------------------------------------------------------QTAKE-HKKTVGLQFR-----------------------NSLHLLMETLN--ATTPHYVRCIKPNDFKFPF-----------------------------TFDEKRAVQQLRACGVLETI----RISAAGFPSRWTYQEFFSRYR---VLMKQ----KDVLG--DRKQT-------------------CQNVLEKLIL--------DKD----KYQFGKTKIF--------FRAGQ-VAYLEKLRAD-*
Gg p190 V -ENDLTA-LSYLH-EPAVLHNLKVRFIDSKLIYTYCGIVLVAINPYEQLP-IYGED----------------IINAYS--GQN------------MGDMDPHIFAVAEEAYKQMAR---------DERNQSIIVSGESGAGKTVSAKYAMRYFATVSGS-------------------------------------------------------------------------------------------------------------------------------------------AS---------------------------EANVEEKVLA--SN-----PIMESIGNAKTTRNDNSSRFGKYIEIGFDKR------YRIIGANMRTYL-LEKSRVVF-QAEEERNYHIFYQLCASAALP-----------------------------------------EFKTLR---LGNAN----------YFHYTKQ------------GG---------------SPVIDG----------IDDAKEMVNTRQACTLLG----ISDSYQ-MGIFRILAGILHLG-NVEFA--S-------RD-----SDSCAIPP--KHDPLTIFCDLMGVDY-EEMAHWLCHRKL-ATA-------TETYIKPISKLHAINARDALAKHIYANLFNWI---------------------------VDHVNKALHS---------TVKQHS---------FIGVLDIYGFETF------EINSFEQFCINYANEKLQQQ-FNMHVFKLEQEEYMKEQIP--WTLID-FYDN-QPCINLIEA----------------------------------K----MGVLDLLDEECKMP----------------KGSDDTWAQKLYN-THLNK-----CALFEKPRLSNK-------------AFIIKHFA--DKVEYQCEGFLE-KNKDTVYEEQIKVLKSSKK----------------FKLLPELFQDEEKAI----------SPTSATPSGRVPL-----SRTPVKPAKAR---------------------------PG----------------------------------------------------------------------------------------------------------------------QTSKE-HKKTVGHQFR-----------------------NSLHLLMETLN--ATTPHYVRCIKPNDFKFPF-----------------------------TFDEKRAVQQLRACGVLETI----RISAAGFPSRWTYQEFFSRYR---VLMKQ----KDVLS--DRKQT-------------------CKNVLEKLIL--------DKD----KYQFGKTKIF--------FRAGQ-VAYLEKIRA--*
Rn myr6 -ENDLTA-LSHLH-EPAVLHNLKVRFLESNHIYTYCGIVLVAINPYEQLP-IYGQD----------------VIYAYS--GQN------------MGDMDPHIFAVAEEAYKQMAR---------DEKNQSIIVSGESGAGKTVSAKYAMRYFATVGGS-------------------------------------------------------------------------------------------------------------------------------------------AS---------------------------DTNIEEKVLA--SS-----PIMEAIGNAKTTRNDNSSRFGKYIEIGFDKK------YHIIGANMRTYL-LEKSRVVF-QADDERNYHIFYQLCAAASLP-----------------------------------------EFKELA---LTCAE----------DFFYTAH------------GG---------------NTTIEG----------VDDAEDFEKTRQALTLLG----VRESHQ-ISIFKIIASILHLG-SVEIQ--A------ERD-----GDSCSISP--QDEHLSNFCRLLGIEH-SQMEHWLCHRKL-VTT-------SETYVKTMSLQQVVNARNALAKHIYAQLFSWI---------------------------VEHINKALQT---------SLKQHS---------FIGVLDIYGFETF------EINSFEQFCINYANEKLQQQ-FNSHVFKLEQEEYMKEQIP--WTLID-FYDN-QPCIDLIEA----------------------------------K----LGILDLLDEECKVP----------------KGTDQNWAQKLYE-RHSN------SQHFQKPRMSNT-------------AFIVIHFA--DKVEYLSDGFLE-KNRDTVYEEQINILKASK-----------------FPLVADLFRDDEDSV----------PATNTAKSRSS-------SKINVRSSRPL---------------------------MK----------------------------------------------------------------------------------------------------------------------APNKE-HKKSVGYQFR-----------------------TSLNLLMETLN--ATTPHYVRCIKPNDEKLPF-----------------------------HFDPKRAVQQLRACGVLETI----RISAAGYPSRWTYHDFFNRYR---VLMKK----RELANTTDKKNI-------------------CKSVLESLIK--------DPD----KFQFGRTKIF--------FRAGQ-VAYLEKLRA--*
Ce hum2 -KDDLTL-LSYLH-EPAVLHNLQVRFVKGSSIYTYCGIVLVAINPYADCSHIYGEE----------------IIQVYRGAGKS------------AREMDPHIFAVAEEAHFDMGA---------FGKSQSIIVSGESGAGKTVSAKFVMRYLASVAAS-------------------------------------------------------------------------------------------------------------------------------------------KTR-----------------------NGGTTSIEARVLA--SN-----PIMESIGNAKTIRNDNSSRFGKFIQINFCERG-----RRIVGAEMKTYL-LEKSRLVF-QAPGERNYHIFYQLCAARNHQ-----------------------------------------VLKDLH---LGPCE----------SYSYLTQ------------GG---------------DSRIPG----------VDDKADFEALLKALQLLG----FDEKQM-SDVFRLLAGLLLLG-NVHFE--N------GEG-----SSAVSASS--CQEISRLCREFWKISE-SDLRIWLTRREI-RAV-------NEIVTKPLTKNEAVRSRDALTKMLYSHLFGWL---------------------------VDKINEALNEKDKLDGTNQKKRPDR---------FIGVLDIYGFETF------DVNSFEQFSINYANEKLQQQ-FNQHVFKLEQEEYIREEIE--WVRVD-FHDN-QPAIDLIEG----------------------------------P----VGMINLLDEQCKRL----------------NGSDADWLSQLQNSTELKR-----NPQLAFPKVRSN-------------DFIVRHFA--ADVTYSTDGFVE-KNRDAIGEQLLDVVVASK-----------------FPFIRTVIG----ST----------APTSVSSSSSS--------STPGK-----------------------------------------------------------------------------------------------------------------------------------------------------------RT-IKKTVASQFR-----------------------DSLKELMSVLC--STRPHYVRCIKPNDSKISF-----------------------------DFEPKRAIQQLRACGVLETV----RISAAGFPSRYPYEEFARRYR---VIYTK----EAALWR-DKPKQ-------------------FAELACQQCL--------EEG----KYAVGKTKIF--------LRTGQ-VAVLERVRL--*
At ATM VIII -VDDLMQ-LSYLN-EPSVLYNLNYRYNQ-DMIYTKAGPVLVAVNPFKEVP-LYGNR----------------YIEAYR---K-------------KSNESPHVYAIADTAIREMIR---------DEVNQSIIISGESGAGKTETAKIAMQYLAALGGG-------------------------------------------------------------------------------------------------------------------------------------------S------------------------------GIEYEILK--TN-----PILEAFGNAKTLRNDNSSRFGKLIEIHFSES------GKISGAQIQTFL-LEKSRVVQ-CAEGERSYHIFYQLCAGASPA-----------------------------------------LREKLN---LTSAH----------EYKYLGQ------------SN---------------CYSING----------VDDAERFHTVKEALDIVH----VSKEDQ-ESVFAMLAAVLWLG-NVSFT--V------IDN------ENHVEPV--ADESLSTVAKLIGCNI-NELTLTLSKRNM-RVR-------NDTIVQKLTLPQAIDARDALAKSIYSCLFDWL---------------------------VEQINKSLAVG--------KRRTGR---------SISILDIYGFESF------DKNSFEQFCINYANERLQQH-FNRHLFKLEQEEYIQDGID--WTRVD-FEDN-QNCLSLFEK----------------------------------KP---LGLLSLLDEESTFP----------------NGTDLTLANKLKQ--HLQS-----NSCFRGDKGK---------------LFTVVHYA--GEVTYETTGFLE-KNRDLLHSDSIQLLSSCS------------------CLLPQAFA-----------------SSMLIQSEKP---------VVGPLYKA----------------------------------------------------------------------------------------------------------------------------------------------------GGADS-QRLSVATKFK-----------------------SQLFQLMQRLG--NTTPHFIRCIKPNNIQSPG-----------------------------VYEQGLVLQQLRCCGVLEVV----RISRSGFPTRMSHQKFSRRYG---FLLVE----NIADR--DPLSV-------------------SVAILHQFNI--------LPE----MYQVGYTKLF--------FRTGQ-IGVLEDTRN--*
At VIIIA -VDDLMQ-LSYLN-EPAVLYNLEYRYNQ-DMIYTKAGPVLVAVNPFKEVP-LYGNR----------------NIEAYR---K-------------RSNESPHVYAIADTAIREMIRVLSFPVSITDEVNQSIIISGESGAGKTETAKIAMQYLAALGGG-------------------------------------------------------------------------------------------------------------------------------------------S------------------------------GIEYEILK--TN-----PILEAFGNAKTLRNDNSSRFGKLIEIHFSET------GKISGAQIQT--------LVQ-CTEGERSYHIFYQLCAGASPT-----------------------------------------LREKLN---LTSAK----------QYNYLKQ------------SN---------------CYSING----------VDDAERFHAVKEALDIVH----VSKEDQ-ENVFAMLAAVLWLG-NVSFT--I------IDN------ENHVEPE--PDESLSTVAKLIGCNI-NELKLALSKRNM-RVN-------NDTIVQKLTLSQAIDARDALAKSIYACLFDWL---------------------------VEQINKSLAVG--------KRRTGR---------SISILDIYGFESF------NKNSFEQFCINYANERLQQH-FNRHLFKLEQEEYIQDGID--WTRVD-FEDN-QECLSLFEK----------------------------------KP---LGLLSLLDEESTFP----------------NGTDLTLANKLKQ--HLND-----NSCFRGDRGK---------------AFTVAHYA--GEVTYETTGFLE-KNRDLLHSDSIQLLSSCS------------------CHLPQAFA-----------------SSMLIYSEKP---------LVGPLHKA----------------------------------------------------------------------------------------------------------------------------------------------------GGADS-QRLSVATKFK-----------------------GQLFQLMQRLG--NTTPHFIRCIKPNNVQSAG-----------------------------LYEQGLVLQQLRCCGVLEVV----RISRSGFPTRMFHHKFARRYG---FLLLE----NIAAK--DPLSV-------------------SVAILHQFNI--------LPE----MYQVGYTKLF--------FRTGQ-IGVLEDTRN--*
Ha hamy1 -VDDLMQ-LSYLN-EPSVLYNLQYRYDR-DMIYSKAGPVLVAINPFKKIP-LYGSD----------------YIEAYK---R-------------KSIDNPHVYAIADTAIREMIR---------DEVNQSIVISGESGAGKTETPKIAMQYLAALGGG-------------------------------------------------------------------------------------------------------------------------------------------D------------------------------ARESGILS--HNGCRTPRRAEAFGNAKTSRDNNSSRIGKLIEIHFSET------GKISGAKIQTFL-LEKSRVVQ-CTDGERSYHSFYQLCAGAPPS-----------------------------------------LREKLN---LKSAR----------EYKYFQQ------------ST---------------CYSING----------VDDAEEFRVVVEALDAVH----VSKENQ-ENAFAMLAAVLWLG-NVTFS--I------VDN------ENHVEPI--IDDALLNVAKLIGCEA-DDLKLALSTRNM-KVG-------NDIIVQKLTLAQAIDTRDALAKSIYSCLFDWL---------------------------VEQINKSLAVG--------KRRTGR---------SISILDIYGFESF------DVNSFEQFCINYANERLQQH-FNRHLFKLEQEEYIQDGID--WAKVD-FEDN-QDCLNLFEK----------------------------------KP---LGLMTLLDEESTFP----------------NGTDMTFATKLKQ--HLKT-----NSCFRGERGK---------------AFTVHHYS--GEVTYDTSGFLE-KNRDLLHLDSIQLLSSCT------------------CELPQAFA-----------------SNMLSLSEKP---------VPGPLHKS----------------------------------------------------------------------------------------------------------------------------------------------------GGADS-QKLSVVTKFK-----------------------GQLFQLMQRLE--STTPHFIRCIKPNNSQSPG-----------------------------IYHQGLVLQQLRCCGVLEVV----RISRSGFPTRMSHQKFARRYG---FLLLE----HVASQ--DPLSV-------------------SVAILHQFDI--------LPE----MYQIGYTKLF--------FRTGQ-IGKLEDTRNR-*
Zm ZMM3 VIII -VDDLMQ-LSYLS-EPSVLYNLQYRYSK-DMIYTKAGPVLVAVNPFKKVS-LYGNE----------------YIDAYR---N-------------KSMDSPHVYAIADAALCEMKR---------DEVNQSIIISGESGAGKTETAKIAMQYLASLGGG-------------------------------------------------------------------------------------------------------------------------------------------S------------------------------GIEYEILQ--TN-----PILEAFGNAKTLRNDNSSRFGKLIEIHFSTT------GRICGAMIQTFL-LEKSRVVQ-CAVGERSYHIFYQLCAGAPAS-----------------------------------------LKEKLN---LKKVD----------GYKYLKQ------------SC---------------CYSIAG----------VDDAQMFRTVTQAMNIVH----ISKEDQ-ESVFAMVSAVLWLG-DVSFT--V------IDN------ENHVEII--VDEASKTVSELLGCSI-EDLNLALSKRHM-KVN-------NENIVQKLTLAQATDIRDALAKSVYASLFEWL---------------------------VEQINKSLSVG--------KRRTGR---------SISILDIYGFESF------DKNSFEQFCINYANERLQQH-FNRHLFKLEQEEYVEDGID--WAKVD-FEDN-QDCLSLFEK----------------------------------KP---LGLLSLLDEESTFP----------------NATDLTFANKLKQ--HLDS-----NSCFRGERGK---------------AFAVRHYA--GEVAYDTSGFLE-KNRDLLHMDSIQLLAKCK------------------TSLPKMFA-----------------SKMLVQSDNS---------MSVP-YRS----------------------------------------------------------------------------------------------------------------------------------------------------SAADS-QKLSVAMKFK-----------------------GQLFQLMQRLE--STTPHFIRCIKPNNLQLPA-----------------------------IYEQGLVLQQLKCCGVLEVV----RISRSGYPTRMTHQKFARRSG---FLLVE----DVASQ--DPLSV-------------------SVAILHQFNI--------LPE----MYQVGYTKLF--------FRTGQ-IGNLEDTRN--*
At ATM2 VIII -VEDLIQ-LSYLN-EPSVLYNLRVRYLQ-DVIYSKAGPVLIAVNPFKNVE-IYGND----------------VISAYQ---K-------------KVMDAPHVYAVADAAYDEMMR----------EKNQSLIISGESGAGKTETAKFAMQYLAALGGG-------------------------------------------------------------------------------------------------------------------------------------------SC-----------------------------GVEYEILK--TT-----CILEAFGNAKTSRNANSSRFGKLIEIHFSAM------GKICGAKLETFL-LEKSRVVQ-LFNGERSYHIFYELCAGASPI-----------------------------------------LKERLK---LKTAS----------EYTYLSQ------------SD---------------CLTIAG----------VDDAQKFHKLLEAFDIVQ----IPKEHQ-ERAFALLAAVLWLG-NVSFR--V------TDN------ENHVEVV--ADEAVANAAMLMGCNT-EELMVVLSTRKL-QAG-------TDCIAKKLTLRQATDMRDGIAKFIYANLFDWL---------------------------VEQINIALEVG--------KSRTGR---------SISILDIYGFESF------KNNSFEQFCINYANERLQQH-FNRHLFKLEQEEYEEDGID--WTKVE-FVDN-QECLDLIEK----------------------------------KP---IGLLSLLDEESNFP----------------KATDLTFANKLKQ--HLKT-----NSCFKGERGR---------------AFRVNHYA--GEVLYDTNGFLE-KNRDPLPADLINLLSSCD------------------CQLLKLFS-----------------TKMRGKSQKP---------LMLS-----------------------------------------------------------------------------------------------------------------------------------------------------------DS-TNQTVGTKFK-----------------------GQLFKLMNKLE--NTSPHFIRCIKPNSKQLPR-----------------------------VYEEDLVLQQLRCCGVLEVV----RISRSGYPTRLTHQEFAGRYG---FLLSD----KKVAQ--DPLSV-------------------SIAVLKQYDV--------HPE----MYQVGYTKLY--------LRTGQ-IGIFEDRRK--*
At VIIIB -VEDLTQ-LSYLN-EPSLLYNLRVRYSQ-DLIYSKAGPVLIAVNPFKNVQ-IYGEE----------------FLSAYQ---K-------------NALDAPHVYAVADAAYDDMMR------------G-----DGESGAGKTETAKYAMQYLEALGGG-------------------------------------------------------------------------------------------------------------------------------------------SF-----------------------------GVENEILK--TN-----CILEAFGNAKTSRNDNSSRFGKLMEIHFSAK------GKICGAKLETFS-LDQSRVAQ-LCNGERCYHIFYQLCAGASPI-----------------------------------------LKERLK---IKAAS----------EYNYLNQ------------SN---------------CLTIDR----------TDDAQKFHKLMEAFNIVQ----IPQEYQ-ERTFALLAAVLWLG-NVSFE--V------IDN------ENHVEVV--ADEAVTNVAMLMGCNS-KKLMVVLSTCKL-QAG-------RDCIAKRLTLRQATDMRDSLAKIIYASLFNWL---------------------------VEQINISLEVG--------NSRTGR---------SISILDIYGFESF------KDNSFEQFCINYANERLQQH-FNRHLFKLEQEEYEGDGID--WTKVE-FIDN-QECLNLIEK----------------------------------KP---IGLVSLLNEESNFP----------------KATDTTFANKLKQ--HLNA-----NSCFKGERGR---------------GFRIKHYA--GEVLYNTNGFLE-KNRDPLHVDLIQLLSLCK------------------CQLLNLFS-----------------TKMHHDFLKP---------ATFS-----------------------------------------------------------------------------------------------------------------------------------------------------------DS-MNQSVIAKFK-----------------------GQLFKLMNKLE--DTTPHFIRCIKPNSNQLPG-----------------------------LYEENHVLQQLRCCGVLEIV----RISRSGYPTRLTHQELAVRYG---CLLLD----TRISQ--DPLST-------------------SKAILKQCNL--------PPE----MYQVGYTKIY--------LRTGV-ISVLEERKK--*
Ha hamy3 -VADLVE-LSYLN-EPSVLHSLQYRYNR-DIIYSKAGPVLLAFNPFKDVN-IYGDD----------------FVAAYK---E-------------KILDNPHVYAVADAAYNDMMK---------DGVNQSIIISGESGAGKTETAKFAMQYLASVKSQ-------------------------------------------------------------------------------------------------------------------------------------------NY-----------------------------EMKSKLIQ--TS-----CILEAFGNAKTSRNWNSSRFGKLIDIHYSAE------GMISNACIQTYL-FEKSRVSQ-ICRGERSYHVFYQMCAGAPPV-----------------------------------------LKDNLN---LKMSS----------EYKFLNQ------------SG---------------CLKING----------VDDAHNFIKLVDAFDTLG----IHGLDQ-ENIFELLAAILWLG-NISFA--A------ID-------EELVEPV--ADEASRSAARLMGCKM-DDLMMVLSTN---RAH-------N--MTEPLTLQQATDKRNTLANFVYESLFNWL---------------------------IEEVNTSLKGN--------TQHTRH---------AISILDTYGFESL------QRNSLQQLFINYADERLQQH-FIRHLCKLEQEEYELEGIH--WKKVE-FEDN-QECLDLFEK----------------------------------KP---MGIISMLNECSNSS----------------IATDTTFTEKIKQ--HLSY-----NLCISCEEG----------------AFRVRHYA--REVQYDASGLLE-KDSDKLQFDTIQLLSSCK------------------KPLNLSGS-----------------ASGVMNQVQA---------AG------------------------------------------------------------------------------------------------------------------------------------------------------------------QSVGSKFM-----------------------DHLSKLINQME--NSKQHFIRCIKPNTKKLPG-----------------------------IYESDIVWEQLKCSQVMEVM----QISKSRYPLRFTHQEFASRFG---CLLST----NVMCM--DPLST-------------------SVAILQQHRV--------PTQ----MYQVGFQKLF--------FR-GQ-VDALENLRQ--*
Ha hamy5 -VDDMTR-LSYLH-EPGVLQNLATRYEL-NEIYTYTGNILIAINPFQRLPHLYDTH----------------MMEQYK--GAG------------FGELSPHVFAVADVAYRAMIN---------EGKSNSILVSGESGAGKTETTKMLMRYLAHLGGR-------------------------------------------------------------------------------------------------------------------------------------------SGV-------------------------EGRTVEQQVLE--SN-----PVLEAFGNAKTVRNNNSSRFGKFVEIQFDKS------GRISGAAIRTYL-LERSRVCQ-ISDPERNYHCFYLLCAAPPDE-----------------------------------------DREKFK---LESPQ----------SYHYLNQ------------SK---------------SFALEG----------VNDAHEYLATRRAMDIVG----IGEEEQ-EAIFRVVAAILHLG-NVEFA--K------GKEI---DSSVLKDEK--SRFHLNVTAELLMCDA-KSLEDALIKRVM-VTP-------EEVITRTLDPEAALGSRDALAKTIYSRLFDW---------------------------IVEKINS--SIGQ-------DPNSKS---------LIGVLDIYGFESF------KHNSFEQFCINFTNEKLQQH-FNQHVFKMEQEEYTKEAIN--WSYIE-FVDN-QDVLDLIEK----------------------------------KP---GGIISLLDEACMFP----------------KSTHETFAQKLYQT--FPK-----NKRFIKPKLSRT-------------SFTISHYA--GEVTYLADQFLD-KNKDYVVAEHQDLLTASK-----------------CPFVVGLFPP--------------------LPVESS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------KSS-KFSSIGSRFK-----------------------LQLQSLMETLS--TTEPHYIRCVKPNNVLKPA-----------------------------IFENLNIIQQLRCGGVLEAI----RISCAGYPTRRTFDEFLLRFG---VLYPD----VLDGNY-D-------------------EKVACQMLLDKMGL--------KG------YQIGKTKVF--------LRAGQ-MAELDARRAE-*
Ha hamy2 -VDDMTR-LSYLH-EPGVLQNLATRYEL-NEIYTYTGNILIAINPFQRLPHLYDTH----------------MMEQYK--GAG------------FGELSPHVFAVADVAYRAMIN---------EGKSNSILVSGESGAGKTETTKMLMRYLAYLGGR-------------------------------------------------------------------------------------------------------------------------------------------SGV-------------------------EGRTVEQQVLE--SN-----PVLEAFGNAKTVRNNNSSRFGKFVEIQFDKS------GRISGAAIRTYL-LERSRVCQ-ISDPERNYHCFYLLCAAPP-E-----------------------------------------DREKFK---LESPQ----------SYHYLNQ------------SK---------------SFELEG----------VSDAHEYLATRRAMDIVG----ISEEEQ-DAIFRVVAAILHLG-NIEFA--K------GEEI---DSSVLKDGK--SRFHLNVTAELLMCDA-KSLEDALIKRVM-VTP-------EEVITRTLDPEAALGSRDALAKTIYSRLFDW---------------------------IVEKINN--SIGQ-------DPNSKS---------LIGVLDIYGFESF------KHNSFEQFCINFTNQKLQQH-FNQHVFKMEQEEYTKEAIN--WSYIE-FVDN-QDVLDLIEK----------------------------------KP---GGIISLLDEACMFP----------------KSTHETFAQKLYQT--FPK-----NKRFIKPKLSRT-------------SFTIAHYA--GEVIYLADQFLD-KNKDYVVAEHQDLLTASK-----------------CPFVVGLFPP--------------------LPVESS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------KSS-KFSSIGSRFK-----------------------LQLQSLMETLS--TTEPHYIRCVKPNNVLKPA-----------------------------IFENLNIIQQLRCGGVLEAI----RISCAGYPTRRTFDEFLLRFG---VLYPD----VLDGKY-D-------------------EKVACQMLLDKMGL--------RG------YQIGKTKVF--------LRAGQ-MAELDARRA--*
At XIE -VDDMTK-LSYLH-EPGVLQNLKIRYEL-NEIYTYTGNILIAINPFQRLPHIYDAH----------------MMQQYK--GAP------------FGELSPHVFAVADVAYRAMIN---------EGKSNSILVSGESGAGKTETTKMLMRYLAYLGGR-------------------------------------------------------------------------------------------------------------------------------------------AVT-------------------------EGRTVEQQVLE--SN-----PVLEAFGNAKTVRNNNSSRFGKFVEIQFDKQ------GRISGAAVRTYL-LERSRVCQ-ISDPERNYHCFYLLCAAPQEQ-----------------------------------------ELEKYK---LGHPK----------TFHYLNQ------------SK---------------CFELVG----------ISDAHDYIATRRAMDIVG----MSEKEQ-EAIFRVVAAILHLG-NVEFT--K------GKEV---DSSVPKDDK--SKFHLNTVAELLMCDV-KALEDALCKRVM-VTP-------EEVIKRSLDPQSALISRDGLAKTIYSRLFDWYFVTSNTTQVLVIDRFDSKLTSLVICRLVEKINV--SIGQ-------DATSRS---------LIGVLDIYGFESF------KTNSFEQFCINFTNEKLQQH-FNQHVFKMEQEEYTKEAID--WSYIE-FVDN-QDVLDLIEK----------------------------------KP---GGIVALLDEACMFP----------------KSTHETFANKLYQT--FKT-----HKRFIKPKLSRT-------------DFAVAHYA--GEVQYQSDLFLD-KNKDYVIPEHQDLLGASK-----------------CPFVVGLFPP--------------------LPEETS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------KSS-KFSSIGSRFKVDRLNSLKVFQCRVLSVLSRLMQLQLQQLMETLN--STEPHYIRCVKPNNLLKPA-----------------------------VFENVNIMQQLRCGGVLEAI----RISCAGYPTRKPFFEFINRFG---LLYPR----ALEGNY-E-------------------EKAAAQKILDNIGL--------KG------YQVGKTKVF--------LRAGQ-MAELDARRT--*
At XIC -VDDMTK-LSYLH-EPGVLQNLKIRYEL-NEIYTYTGNILIAINPFQRLPHIYDAH----------------MMQQYK--GAP------------LGELSPHVFAVADVAYRAMIN---------EGKSNSILVSGESGAGKTETTKMLMRYLAYLGGR-------------------------------------------------------------------------------------------------------------------------------------------AVT-------------------------EGRTVEQQVLE--SN-----PVLEAFGNAKTVRNNNSSRFGKFVEIQFDKQ------GRISGAAIRTYL-LERSRVCQ-ISDPERNYHCFYLLCAAPQE------------------------------------------EIEKYK---LGHPK----------TFHYLNQ------------SK---------------CFELVG----------ISDAHDYLATRRAMDIVG----ISEKEQ-EAIFRVVAAILHIG-NIDFT--K------GKEV---DSSVPKDEK--SKFHLKTAAELLMCDL-KALEDALCKRVM-ITP-------EEVIKRSLDPQSAVTSRDGLAKTVYSRLFDW------------L---------------VDKINK--SIGQ-------DANSRS---------LIGVLDIYGFESF------KTNSFEQFCINFTNEKLQQH-FNQHVFKMEQEEYTKEAID--WSYIE-FVDN-QDVLDLIEKVISEPRKDNVNKITPHTGWILLSHFISPFIFHLQKP---GGIVALLDEACMFP----------------KSTHETFANKLYQT--FKT-----HKRFIKPKLSRT-------------DFAVAHYA--GEVLYQSELFLD-KNKDYVIPEHQDLLGASK-----------------CPFVVGLFPP--------------------LPEETS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------KSS-KFSSIGSRFK-----------------------LQLQQLMETLN--CTEPHYIRCVKPNNLLKPA-----------------------------IFENVNIMQQLRCGGVLEAI----RISCAGYPTRKPFFEFINRFG---LLSPA----ALEGNF-D-------------------EKVACQKILDNMGL--------KG------YQIGKTKVF--------LRAGQ-MAELDARRA--*
Zm MYO1 -VDDMTR-LSYLH-EPGVLQNLATRYEL-NEIYTYTGSILIAVNPFQRLPHLYDTH----------------MMEQYK--GAD------------FGELSPHDFAIADVAYRAMDN---------EGKSNSILVSGESGAGKTETTKMLMRYLAHLGGR-------------------------------------------------------------------------------------------------------------------------------------------SGV-------------------------EGRTVEQQVLE--SN-----PVLEAFGNAKTVRNNNSSRFGKFVEIQFDKT------GRISGAAIRTYL-LERSRVCQ-INSPERNYHCFYFLCAAPP-E-----------------------------------------YTQRYK---LSDPR----------SFHYLNQ------------SS---------------CIEVDG----------INDAEEYLATRRAMDIVG----INEEEQ-EGIFRVVAAVLHLG-NINFA--K------GTEI---DSSVIKDDK--SRFHLNIAAELLKCDC-QNLEKALITRVI-VTP-------EEVITRTLDPASAVASRDALAKIIYSRLFDW---------------------------IVEKINV--SIGQ-------DPNSKQ---------LIGVLDIYGFESF------KVNSFEQLCINYTNEKLQQH-FNQHVFKMEQEEYTREEIN--WSYIE-FVDN-QDVLDLIEK-----------------------------------K---GGLIALLDEACMFP----------------RSTHETFAQKLYTT--FKN-----NKRFAKPKLSRT-------------DFTVVHYA--GDVTYQADYFLD-KNKDYVVAEHQDLLNASS-----------------CLFVAGLFPP--------------------LPQETA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------KSS-KFSSIGSRFK-----------------------LQLQSLMETLS--STEPHYIRCVKPNNLLKPA-----------------------------IFENTNVIQQLRCGGVLEAI----RISCAGYPTRKTFYEFVNRFG---VLAPE----VLEGSN-D-------------------DKIACQKILEKMGL--------EN------YQIGKTKVF--------LRAGQ-MADLDARRA--*
At MYA1 XI -VDDMTK-LSYLH-EPGVLRNLETRYEL-NEIYTYTGNILIAVNPFQRLPHIYETD----------------MMEQYK--GIA------------LGELSPHVFAIGDAAYRAMIN---------EGKNNSILVSGESGAGKTETTKMLMRYLAFLGGR-------------------------------------------------------------------------------------------------------------------------------------------SGV-------------------------EGRTVEQQVLE--SN-----PVLEAFGNAKTLRNNNSSRFGKFVEIQFDKN------GRISGAAIRTYL-LERSRVCQ-ISDPERNYHCFYLLCAAPP-E-----------------------------------------DIKKYK---LENPH----------KFHYLNQ------------SS---------------CYKLDG----------VDDASEYLETRRAMDVVG----ISNEEQ-EAIFRVVAAILHLG-NIDFG--R------GKEI---DSSVIKDKD--SRSHLNMAAELLMCNA-QSLEDALIRRVM-VTP-------EEIITRTLDPDNAIASRDTLAKTIYSHLFDW---------------------------IVNKINT--SIGQ-------DPRSKS---------IIGVLDIYGFESF------KCNSFEQFCINFTNEKLQQH-FNQHVFKMEQEEYTKERIA--WSYIE-FIDN-QDVLELIEK----------------------------------KP---GGIISLLDEACMFP----------------KSTHETFSQKLFQT--FKE-----HERFAKPKLSRT-------------DFTISHYA--GEVTYQSNHFID-KNKDYIVAEHQALFTASN-----------------CKFVAGLFHA--------------------LHEDSS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------RSS-KFSSIGSRFK-----------------------QQLHSLMESLN--GTEPHYIRCIKPNNVLKPG-----------------------------IFENFNVIHQLRCGGVLEAI----RISCAGYPTRLAFYDFLDRFG---LLAPE----VLEGNY-D-------------------DKVACQMILDKKSL--------TD------YQIGKTKIF--------LRAGQ-MAELDARRAE-*
At XIF ----MTK-LAYLH-EPGVLHNLDCRFAL-NEIYTYTGNILIAVNPFQRLPHLYSVH----------------MMEQYK--GAA------------FGELSPHLFAVADTSYRAMIN---------EARSQSILVSGESGAGKTETTKMLMRYLAFMGGR-------------------------------------------------------------------------------------------------------------------------------------------SDT-------------------------EGRSVEQQVLE--SN-----PVLEAFGNAKTVKNNNSSRFGKFVEIQFDKR------GKISGAAIRTYL-LERSRVCQ-VSDPERNYHCFYMLCAAPP-E-----------------------------------------EAKKFK---VGDPR----------TFHYLNQ------------TN---------------CYEVSN----------VDDAREYLETRNAMDIVG----IGQEAQ-DAIFRVVAAILHLG-NVNFI--K------GEEA---DSSKLRDDK--SRYHLQTAAELLMCNE-KMMEDSLCKRVI-VTP-------DGNITKPLDPESAASNRDALAKTVYSRLFDW---------------------------IVDKINS--SIGQ-------DPDAKS---------LIGVLDIYGFESF------KINSFEQLCINLTNEKLQQH-FNQHVFKMEQEEYTREEIN--WSYVE-FVDN-QDVLDLIEK----------------------------------KP---GGIIALLDEACMFP----------------KSTHETFAQKMYQT--YKG-----HKRFSKPKLAQT-------------AFTVNHYA--GDVTYSAEQFLD-KNKDYVVAEHQALLDASK-----------------CSFVANLFPP--------------------LPEDAS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------KQS-KFSSIGTRFK-----------------------QQLQALMETLN--TTEPHYIRCVKPNAVLKPG-----------------------------IFENDNVLNQLRCGGVLEAI----RISCAGYPTKRAFDEFLDRFV---MLATD----VPEGS--D-------------------EKSACASICNKMGL--------KG------YQIGKTKIF--------LRAGQ-MAELDARRT--*
At MYA2 XI -VDDMTR-LAYLH-EPGVLQNLHSRYDI-NEIYTYTGSILIAVNPFRRLPHLYSSH----------------MMAQYK--GAS------------LGELSPHPFAVPDAAYRQMIN---------DGVSQSILVSGESGAGKTESTKLLMRYLAYMGGR-------------------------------------------------------------------------------------------------------------------------------------------AAA-------------------------EGRSVEQKVLE--SN-----PVLEAFGNAKTVRNNNSSRFGKFVEIQFDEK------GRISGAAIRTYL-LERSRVCQ-VSDPERNYHCFYMLCAAPQ-E-----------------------------------------DVKKFK---LEEPK----------KYHYLNQ------------SK---------------CLELDS----------INDAEEYHATRRAMDVVG----ISTEEQ-DAIFSVVAAILHIG-NIEFA--K------GEEI---DSSISKDDK--SLFHLKTAAELLSCDE-KALEDSLCKRIM-VTR-------DETITKTLDPEAATLSRDALAKVMYSRLFDWL---------------------------VDKINS--SIGQ-------DHDSKY---------LIGVLDIYGFESF------KTNSFEQFCINLTNEKLQQH-FNQHVFKMEQEEYKKEEIN--WSYIE-FVDN-QDILDLIEK----------------------------------KP---GGIIALLDEACMFP----------------RSTHETFAQKLYQT--FKT-----HKRFTKPKLARS-------------DFTICHYA--GDVTYQTELFLD-KNKDYVIAEHQALLNSSS-----------------CSFVASLFPP--------------------MSDDS------------------------------------------------------------------------------------------------------------------------------------------------------------------------KQS-KFSSIGTRFK-----------------------QQLVSLLEILN--TTEPHYIRCIKPNNLLKPG-----------------------------IFENENILQQLRCGGVMEAI----RISCAGYPTRKHFDEFLARFG---ILAPE----VLVKNS-D-------------------DPAACKKLLDKVGL--------EG------YQIGKTKVF--------LRAGQ-MADLDTRRTE-*
At XIB -VEDMTR-LAYLH-EPGVLQNLQSRYDI-NEIYTYTGSILIAVNPFRRLPHLYSSH----------------MMTQYK--GAS------------LGELSPHPFAVADAAYRQMVN---------EGVSQSILVSGESGAGKTESTKLLMRYLAFMGGRG------------------------------------------------------------------------------------------------------------------------------------------AAT-------------------------EGRTVEQKVLE--SN-----PVLEAFGNAKTVKNNNSSRFGKFVEIQFDQS------GRISGAAIRTYL-LERSRVCQ-VSDPERNYHCFYMLCAAPE-E-----------------------------------------DAKKFK---LGDPK----------IYHYLNQ------------SK---------------CIQLDA----------MNDAEEYHATKKAMDVVG----ISSEEQ-DAIFRVVASILHLG-NIEFA--K------GTEI---DSSIPRDEK--SWFHLKTAAELLMCNE-KSLEDSLCKRIM-ATR-------DETITKTLDPEAALLSRDALAKVMYSRLFDWL---------------------------VEKINT--SIGQ-------DPDSKY---------LIGVLDIYGFESF------KTNSFEQFCINLTNEKLQQH-FNQHVFKMEQEEYKKEEIN--WSYIE-FVDN-QDILDLIEK----------------------------------KP---GGIIALLDEACMFP----------------RSTHETFAQKLYQT--YKN-----HKRFTKPKLARS-------------DFTICHYA--GDVTYQTELFLD-KNKDYVIAEHQALLNAST-----------------CSFVANLFPP--------------------VSDDS------------------------------------------------------------------------------------------------------------------------------------------------------------------------KQS-KFSSIGTRFK-----------------------QQLVSLLEILN--TTEPHYIRCIKPNNLLKPG-----------------------------IFENQNVLQQLRCGGVMEAI----RISCAGYPTRKHFDEFLNRFG---IIAPQ----VLDKNS-N-------------------EPAACKKLLDKAGL--------EG------YQIGKSKVF--------LRAGQ-MADLDTRRT--*
Ha hamy4 -VDDMTK-LAYLH-EPGVLNNLRSRYDI-NEIYTYTGSILIAVNPFTRLPHLYDSH----------------MMAQYK--GAA------------FGELSPHPFAVADAAYRVMIN---------EGISQSILVSGESGAGKTESTKQLMRYLAYMGGR-------------------------------------------------------------------------------------------------------------------------------------------AST-------------------------DGRSVEQKVLE--SN-----PVLEAFGNAKTVRNNNSSRFGKFVEIQFDQK------GRISGAAIRTYL-LERSRVCQ-LSDPERNYHCFYMLCAAPP-E-----------------------------------------DLKRYK---VGDPK----------TFHYLNQ------------SN---------------CYQIDG----------LDESKEYIATRTAMDVVG----INSEEQ-DAIFRVVAAILHLG-NIEFA--K------GKEM---DSSTPKDDK--SWFHLKTAAELFMCDV-KALEDSLCKRVI-VTR-------DETITKWLDPEAAAVSRDALAKVVYSRLFDWL---------------------------VDRINS--SIGQ-------DPDSKY---------IIGVLDIYGFESF------KTNSFEQFCINLTNEKLQQQRFNQHVFKMEQEEYEAEYFP--FSYIE-FIDN-QDILDLIEK----------------------------------KP---GGIIALLDEACMFP----------------RSTHETFAQKLYQT--FKN-----HKRFAKPKLARS-------------DFTICHYA--GDVTYQTELFLD-KNKDYVIAEHQALLSAST-----------------CSFVASLFPT--------------------SSDESS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------KSS-KFSSIGTRFK-----------------------QQLQQLLETLS--STEPHYIRCVKPNNLLKP------------------------------IFENHNVLQQLRCGGVLEAI----RISCAGYPTRKPFDEFVDRFG---ILAPE----VLDGNS-D-------------------EIRACKMLLEKAGL--------EG------YQIGKTKVF--------LRAGQ-MAELDARRTE-*
At XIH -VDDMTR-LAYLH-EPGVLQNMKSRFDI-NEIYTYTGNILIAVNPFRRLPHLYNNH----------------MMQQYK--GAG------------FGELSPHPFAVADAAYRQMKN---------QGISQSILVSGESGAGKTETTKLLMQYLADMGGR-------------------------------------------------------------------------------------------------------------------------------------------AVS-------------------------EGRTVEKKVLE--SN-----PVLEAFGNAKTVRNNNSSRFGKFVEIQFDQR------GRISGAAIRTYL-LERSRVCQ-VSDPERNYHCFYMLCAAPP-E-----------------------------------------DIKKWK---LADPR----------KFHYLNQ------------SQ---------------CIELER----------MDDAKEYRETRKAMDVVG----INSEEQ-EAIFQVVAAILHLG-NVEFG--K------GKEA---DSSAPKDDT--SNYHLKTAAELFMCDE-QALEDSLCKRVI-VTR-------GETITKCLDQESAALSRDALAKTVYSRLFDWI---------------------------VNKIND--SIGQ-------DPDSEY---------LIGVLDIYGFESF------KTNSFEQFCINLTNEKLQQH-FNQHVFKMEQDEYNKEEID--WSYIE-FVDN-QEILDLIEK----------------------------------KA---GGIISLLNEACMFP----------------RATHETFAEKMYQT--FKD-----HKHFSKPKLSRT-------------DFTICHYA--GDVTYQTEQFLE-KNKDYVVAEHQTLLNASR-----------------CAFVASLFPL--------------------LAEDAN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------KKS-KFSSISSRFK-----------------------QQLVTLLETLS--TTEPHYIRCVKPNNLLKPL-----------------------------IFENQNVLQQLRCGGVMEAI----RISCAGFPTRKKFEEFLERFS---VLAPE----VLDKST-DGWPLS------------STDDVACKKLLEKVAL--------QG------YQIGKTKVF--------LRAGQ-MADLDARRN--*
At XID -VDDMTK-LAYLH-EPGVLLNLKARYNA-NEIYTYTGNILIAVNPFKRLPHLYGNE----------------IMEQYK--GTD------------FGELSPHPFAVADSAYRKMIN---------EGVSQAILVSGESGAGKTESTKMLMQYLAYMGGK-------------------------------------------------------------------------------------------------------------------------------------------AES-------------------------EGRSVEQQVLE--SN-----PVLEAFGNAKTVRNNNSSRFGKFVEIQFNHM------GRISGAAIRTYL-LERSRVCQ-VSDPERNYHCFYMLCAAPE-Q-----------------------------------------ETERYQ---LGKPS----------TFHYLNQ------------SN---------------CHALDA----------IDDSKEYLATRKAMDVVG----ISPEEQ-DAIFRVVAAILHLG-NIEFA--K------SEES---DGAEPKDDK--SRFHLKVAAKLFMCDE-KALENSLCNRVM-VTR-------GESITKPLDPGSAALSRDALAKIVYSKLFDWL---------------------------VTKINN--SIGQ-------DSSSKY---------IIGVLDIYGFESF------KTNSFEQFCINLTNEKLQQH-FNQHVFKMEQEEYTKEEID--WSYIE-FIDN-QDVLDLIEK----------------------------------KP---GGIIALLDEACMFP----------------RSTHDTLAEKLYQT--FGS-----HKRFTKPKLART-------------DFTICHYA--GDVTYQTELFLD-KNKDYVVGEHQSLMNSSD-----------------CSFVSSLFPK--------------------SREESS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------KSS-KFSSIGSQFK-----------------------QQLQSLLETLN--TTEPHYIRCVKPNNVLKPE-----------------------------IFENVNVLHQLRCGGVMEAI----RISCAGYPTRKPFNEFLTRFR---ILAPE----ATERSF-D-------------------EVDACKKLLARVDL--------KG------FQIGKTKVF--------LRAGQ-MAELDAHRA--*
At XIA -VDDMTK-LAYLH-EPGVLLNLKCRYNA-NEIYTYTGNILIAVNPFKRLPHLYGSE----------------TMKQYK--GTA------------FGELSPHPFAVADSAYRKMIN---------EGVSQAILVSGESGAGKTESTKMLMQYLAYMGGR-------------------------------------------------------------------------------------------------------------------------------------------AES-------------------------EGRSVEQQVLE--SN-----PVLEAFGNAKTVRNNNSSRFGKFVEIQFDQR------GRISGAAIRTYL-LERSRVCQ-VSDPERNYHCFYMLCAAPE-Q-----------------------------------------ETERYK---LGKPS----------TFRYLNQ------------SN---------------CYALDG----------LDDSKEYLATRKAMDVVG----INSEEQ-DGIFRVVAAILHLG-NIEFA--K------GEES---EASEPKDEK--SRFHLKVAAELFMCDG-KALEDSLCKRVM-VTR-------DESITKSLDPDSAALGRDALAKIVYSKLFDWLY---------------N----FLAYRLVTKINN--SIGQ-------DPNSKH---------IIGVLDIYGFESF------KTNSFEQFCINLTNEKLQQH-FNQHVFKMEQEEYTKEEID--WSYIE-FIDN-QDVLDLIEK----------------------------------KP---GGIIALLDEACMFP----------------RSTHDTFAQKLYQT--FKN-----HKRFGKPKLAQT-------------DFTICHYA--GDVTYQTELFLD-KNKDYVVGEHQALLSSSD-----------------CSFVSSLFPP--------------------LPEESS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------KTS-KFSSIGSQFK-----------------------QQLQSLLESLS--TTEPHYIRCVKPNNLLKPD-----------------------------IFENINILHQLRCGGVMEAI----RISCAGYPTRKPFNEFLTRFR---ILAPE----TTKSSY-D-------------------EVDACKKLLAKVDL--------K----------G-----------------Q-MAEMDAHRA--*
At XIG -VDDMTT-LAYLH-EPGVLQNLKSRYYI-DEIYTYTGNILIAVNPFKQLPNLYNDH----------------MMAQYK--GAA------------LGELSPHPFAVADAAYRQMIN---------EGISQSILVSGESGAGKTETAKMLMKYLAKMGGR-------------------------------------------------------------------------------------------------------------------------------------------AVS-------------------------DRRTVEDQVLE--SN-----PVLEAFGNAKTVKNNNSSRFGKFVEIQFDQR------GRISGAAIRTYL-LERSRVCQ-VSDPERNYHCFYMLCAAPP-E-----------------------------------------DKRKLK---LNDPT----------EFRYLNQ------------SH---------------CIKLDG----------VDDSKEYTKTREAMGIVG----INLEEQ-EAIFRVVAAILHLG-NIEFA--I------GEEP---DSSVPTDE---SKKYLKIAAELFMCDE-QALEDSLCKRIM-VTP-------EETISRCLDPNSAALSRDALAKFVYSRLFDWI---------------------------VNKINN--SIGQ-------DPDSKD---------MIGVLDIYGFESF------KTNSFEQFCINLTNEKLQQH-FTQHVLKMEQEEYTKEEIE--WSQIT-FPDN-RYVLELIEK----------------------------------KR---GGIIALLDEACMFP----------------RSTHKTFSQKLYET--LKD-----NKYFSKPKLSRT-------------DFTICHYA--GDVTYQTEQFLE-KNKDYVVAEHQALLGASR-----------------CTFIAGLFPP--------------------LVEDAN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------KQS-KFSSIASQFK-----------------------QQLASLIEGLN--TTEPHYIRCVKPNNLLKPS-----------------------------IFENQNSLQQLRCGGVMETI----RVCRAGYPTRKHFDEFLDRFG---ILDSA----TLDKSS-D-------------------EKAACKKLLETVGL--------NG------FQIGKTKVF--------LKAGQ-MAELDDRRT--*
Cc ccm -VDDMTK-LSYLH-EPGVLHNLYTRFKH-DEIYTFTGNILIAVNPFTRLPHLFNTY----------------MMKQYQ--DAQ------------PGDLNPHVYSVADAAYKAMME---------EMKSQAILVSGESGAGKTETTKQIMQYLAFVGGR-------------------------------------------------------------------------------------------------------------------------------------------TVG-------------------------DERSVEQQVLQ--SN-----PLLEAFGNAKTVRNNNSSRFGKFVEIQFNN-------GKISGAAVRTYL-LERSRVTQ-ISSPERNYHCFYQLVAGASPE-----------------------------------------DAERLK---LGPPD----------SFHYLNQ------------SK---------------CVEVGA----------IDDCKEYQLTREAMDIVG----ITTEEQ-EAIFRTIAAVLHLG-NIEFD--S------G-ES---DASEVSTEK--SKFHLKAAAEMLMCDE-QMLEKSLTTRIMKATR-------TESITKILNKSQATDNRDSIAKTIYAKLFDWL---------------------------VNKVNK--SIGQ-------DPHSTV---------LIGVLDIYGFESF------EINSFEQFCINLTNEKLQQH-FNTHVFKMEQAEYRKEEIN--WDNID-FVDN-IDVLDLIEK----------------------------------KP---LGIIALLDEACMLP----------------RSTAESFARKLGDT--FNN-----HRRFSKHKFKRT-------------AFTIDHYA--GQVEYRADLFLE-KNKDFVVPEHQQLLHASR-----------------CAFVSGLFP---------------------ADEGTK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------APS-KFMSIGSQFK-----------------------LQLAALMETLK--LTAPHYIRCVKPNMQLKPQ-----------------------------IFENKNVLQQLRCSGVLEAV----RISCAGFPTRRTFEEFLDRFG---LLHPE----VLIESA-EES---------------ADEKVACQNLLEKCNL--------KG------YQIGKTKVF--------LRAGQ-MAILDTLRSNV*
At XII -VDDMTK-LTYLH-EAGVLYNLQRRYAL-NDIYTYTGSILIAVNPFKKLPHLYNGH----------------MMEQYM--GAP------------FGELSPHVFAVSDVAYRAMID---------DSRSQSILVSGESGAGKTETTKLIMQYLTFVGGR-------------------------------------------------------------------------------------------------------------------------------------------ATD-------------------------DDRSVEQQVLE--SN-----PLLEAFGNAKTVRNDNSSRFGKFVEIQFDTN------GRISGAAIRTYL-LERSRVVR-ITDPERNYHCFYQLCASGN-------------------------------------------DAEKYK---LSNPR----------QFHYLNQ------------SK---------------TYELEG----------VSSAEEYKNTRRAMDIVG----ISQDEQ-EGIFRTLAAILHLG-NVEFS--S------GREH---DSSVVKDPE--SRHHLQMAADLFKCDA-NLLLASLCTRSI-LTR-------EGIIIKALDPNAAVTSRDTLAKTVYAHLFDWL---------------------------VDKINK--SVGQ-------DPESRF---------QIGVLDIYGFECF------KNNSFEQFCINFANEKLQQH-FNEHVFKMEQDEYRKEEIN--WSYIE-FIDN-QDVLDLIEK----------------------------------KP---IGVIALLDEACMFP----------------RSTHESFSMKLFQN--FRF-----HPRLEKPKFSET-------------DFTLSHYA--GKAT-----FLD-KNRDYTIVEHCNLLSSSK-----------------CPFVAGIFPS--------------------APEEST-----------------------------------------------------------------------------------------------------------------------------------------------------------------------RSSYKFSSVSSRFK-----------------------QQLQALMETLS--KTEPHYVRCVKPNSLNRPQ-----------------------------KFESLSVLHQLRCGGVLEAV----RISLAGYPTRRNYSDFVDRFG---LLAPE----FMDESN-D-------------------EQALTEKILSKLGL--------GN------YQLGRTKVF--------LRAGQ-IGILDSRRA--*
Cr MYOI -AEDMTT-LSYLH-EPAVLWNLNTRYAY-DDIYTYTGTILIAINPFAALPHLYGEH----------------MMNQYR--GVE------------IGDYAPHVYAIADAAYRQMRK---------EGKGQSILVSGESGAGKTETSKLIMKYLAYMGGYT-----DA---------------------------------------------------------------------------------------------------------------------------------GEATG-------------------------SGRSVEEQVLE--SN-----PLLEAFGNAKTTRNNNSSRFGKYVEINFNDK------GVISGAAIRTYL-LERSRVVA-INNPERNYHIFYQLTDGASAE-----------------------------------------QRTQWR---LKTAQ----------EYRYLNQ------------ST---------------CFQLPG----------TDNAEDFKRTIYAMERVG----IPTADQ-DAIFRTVAAILHLG-NIQFS--A------GPE----DSSLVTPA---TEDELDATAALLGVEK-EGLRKALTTRVR-QTP-------EGPIVSPLDALAAGETRDSLAKIIYAKMFDWL---------------------------VGMINS--AIGE-------DKNCAA---------SVGVLDIYGFEQF------QYNDFEQFCINLANEKLQQH-FNQHVFKMEQAEYEREQID--WSYIE-FVDN-QDVLDLIEG-----------------------------------K---LGILDLLDEVCRFV----------------EAKGKDFAEKLYTSGTCKD-----SRRFSKPKTSVT-------------QFIIDHYA--GPVKYDTANFLD-KNKDFVVPEHQALLCAST-----------------QSFTAQLFAE--------------------AAADADSA-----PPAPGRRGGA------------------------------------------------------------------------------------------------------------------------------------------------------TKGTKFNSVGSQFK-----------------------KQLAELMVQLH--AMEPHYIRCIKPNESAQPS-----------------------------VFENKNVLHQLKCGGVMEAV----RISCAGFPSKRPYGEFVDHFW---QLAPD----LLKTDA-D-------------------DKAITKAILAKTNV--------GG------YQLGLSKVF--------MRAGQ-MAQLDKMRT--*
Dd myoJ -VDDLSF-LSHLH-EPAILHNLHHRYNL-NQIYTYIGKILIAINPYTSLP-LYGKE----------------MISAYY--GKQ------------LGTLAPHVYAVAEDAFKDMRY---------DGTSQSILVSGESGAGKTETTKFLLQYLAAMGNMI-----KE---------------------------------------------------------------------------------------------------------------------------------STSSSSINGINTSSDGIPVTPPPSPMKKSPVDKSVEERVLE--ST-----PLLEAFGNAKTLRNDNSSRFGKFIEIHFNEM------GSIIGAKILAYL-LEKSGIVR-QVYNERNYHIFYQLLSGASEE-----------------------------------------LKEKLN---LKTIE----------EYSYLNK------------SG---------------CFEIEG----------VSDEEHFNKTCHAMQVAG----ITLVEQ-ENVFRILSAILLIG-NFEFENIA------GSND---DSCQLID-----RDPLEKVSVLLGCAQPDELLNSMLTRKV-VTG-------KESYISHNTKERAENARDSLSMFLYGMMFDWL---------------------------VVKINSSMSIST-------QQKSKS---------FIGVLDIYGFESF------EVNGFEQFCINYANEKLQQL-FNQHVFKEEQQEYIKEKID--WSYID-FNDN-QDTLDLIEK----------------------------------NP---ICILTLLDEETMFP----------------KATPQTLATKLYSK--MTS-----HSKFEKPRFSST-------------AFTINHYA--GKVTYETDQFLD-KNKDFIIPEQISILQRSN-----------------FSFIKVLMSHSDKFT----------QSPGGHPQGNGGP-----TSSNTKGTSG------------------------------------------------------------------------------------------------------------------------------------------------------SSSMKFLSVGSQFS-----------------------TSLATLMKTIS--TTTPHYVRCIKPNPEKLPQ-----------------------------TFNKQDVIHQLRCGGVMESV----RICCAGFPTRRLLSEFYQRYK---ILYVK----DINTGS-GGGKKGSNNNK------IKDPKILVQNLLTGIEL--------SDD----KYKIGLTKVF--------LR---------------*
Acl myo1 XIII -VADLVD-SDFLH-EPGVLSTLKVRYQK-AEIYTFSGTILIAVNPHKPCPHLYTQQ----------------QMNLYH--SKT------------LGEQPPHVYAIAEHAFQSMLI---------ENQRQAILISGESGAGKTESAKMVMQYLAHRAKQD-----NG---------------------------------------------------------------------------------------------------------------------------------FIKNGECGRM-------------HNNGSFQGARPIEEQVLE--SN-----PLLEAFGNAKTMRNNNSSRFGKFVEMSFGDY------GFVRGASIAVFL-LERSRVVS-INPPERSYHIFYQLTKGATQH-----------------------------------------QQQKYR---LKPPE----------QFRYLAQ------------SN---------------SFSLGD----------RDDVEEFRKTMEAMRIVG----LTELEQ-DSVLRIVAAILHLG-DVTFS--A------EDQD---SQTHLANEQ--AEQAARNCADLLEVDV-ELLKKGLLSRSI-DTP-------HGRIHKPLNKFGAEESRDAFSKTLYSQLFEWL---------------------------VGAINRKIQMLG-------SGERRP--------HTIGILDIYGFESF------ESNSFEQLCINLANERLQQQ-FNHHVLQGEQQQYINEGIK--WSYVE-FIDN-QDCLDLLEG--SKSN----------------------------PR---QGIFPLIDEACRLP----------------NVTNSDLAISMRTQ--LKN-----MTRFESPKRDQS-------------AFTIDHYA--GQVHYTTDQLIE-KNRDYIVEEHKSIITSSA-----------------NELIRKLG----FQQ----------IGGNQNAELNKRA-----LQRSNSSRSA------------------------------------------------------------------------------------------------------------------------------------------------------QSAFKLTSVGYRFR-----------------------RQLQDLSDTLS--ECQPLYIRCIKPNPQSQPG-----------------------------EFVFPFVLGQLHALGVLVAV----RIACAGFPTRKTYSTFVKRYY---MLARQ----QTKLKN-INQND------------FNECKTCTVKILQHMEI--------EG------FQMGKTKLF--------LRAGQ-LAILEAARGR-*
Acl myo2 XIII -VDDLVK-SDFLH-EPGVLQTLRARYES-DEMYTFSSNILIAINPHKRMPHLTTPD----------------VQIGYH--NTI------------LGEHPPHVYAIAEQAFSVMLN---------DGQKQAILISGESGAGKTESAKMVMQYLAKRAQP------AA---------------------------------------------------------------------------------------------------------------------------------FIKTN------------------LSVSLFTEIAPIEEQVLE--SN-----PLLEAFGNAKTMRNNNSSRFGKFVEMRFDDF------GHVCGAQISVFL-LERSRVVQ-VSKGERSYHIFYQLCKGATDE-----------------------------------------QRSKYH---LKSVE----------EFRYLNQ------------SD---------------TSELGD----------RDDVEEFKLCLNAMRTIG----MSTGEQ-DSVFRIVAAILHLGGNITFM--G------SDE------AEFSGSE--AEESAQNCADLLKIPV-QQLKTALTKRNL-KNT-------AGIIVTPLKVPAAEESRDALAKTIYSRLFDWL---------------------------VSAIKEKISFFR-------DTKSATSD------RTIGILDIYGFESF------EKNSFEQLCINLANEKLQQQ-FNHHVLEGEQQQYIAEGIS--WSYVD-FVDN-QDCLDLLEG--GGKN----------------------------KA---KGIFPLIDEACKMP----------------NVTYQNLANSLRTQ--LAG-----LERFEAPKKDPN-------------AFTVDHYA--GEVTYQTNQLMD-KIRDYVASEHQALMMASN-----------------DVLLVSLFEE--SDD----------QNSDSNSENSSSN-----ANVRNARNGN------------------------------------------------------------------------------------------------------------------------------------------------------QSSFKLSSVGFQFR-----------------------KQLTELANKLN--QCQPHYIRCIKPNKFSKSG-----------------------------LLVPEFILGQLHALGILVAV----RIACAGYPTRRDIVQFGQKYF---MLVQE----QFKNID-PRCMN------------QEVARKVCESVLEQSNL--------NG------WQMGFTKVF--------LRTGQ-LAVLEGERGR-*
Pf PfMC ---DLTK-LTHLH-EASILHSLNLRFDI-DEIYTFTGPILIAVNPFKIIKDLYSDN----------------MLAKHV---QP------------IKSKSPHIFATSNSAYLGMCN---------NNKSQTILISGESGAGKTESTKYVMKFLACAG---------------------------------------------------------------------------------------------------------------------------------------------SDIK------------------------KRSLIESQVLE--SN-----PLLEAFGNARTLRNNNSSRFGKYIELQFSVDHKNYIKGKLCGAKILTYL-LEKVRVCD-QQEGERNYHIFYQLCKAVKEANIVDNSIMSNNENDDVENYVNYKCDEDKNKDHIENNICEEPTQKKKKWYHFPSTS----------KFRNLENVEP--------MKIDFTDFKEHVHFRYLTKSSVYELN-------EVNELEEFESTVHAMQTIG----ISNTEQ-YQIFKILEGILYIG-NILFNNDE------T-K-----EEATILEV--SNDDLRKAAYFLDIDE-NDLINSLCYKTIVANN--------EHYKKPVNSNVANDIRDALSRAIYGCLFLKV---------------------------VERTNESIGY--------IKDIN----------LFCGVLDIFGFESFP------VNSFEQLCINYTNECLQQF-FNNFIFKCEEKLYMEEGIR--WDPLD-FPDN-KDCIDILES----------------------------------KP---YGVFCMLDEECYIP----------------SGRDKSFCSKIISKHTSSSNNNQSNKRFKSIKTDSS-------------SFIIVHFA--GQVVYNSTGFLE-KNKDQLSLDAQKLLLHS-----------------KNTYVSHLFET-------------------YLRRNTD-------------------------------------------------------------------------------------------------------------------------------------------------------------------------KRKFVTVSSEFK-----------------------EQLNLLMTRIK--ETEPHFIRCIKPNAQNVPD-----------------------------VFDRISVNEQLKYGGVLQAI----KVSRAGYPVRLSHAECVQDYK---ILLNKEDRHKLEMYNKDNKSWSYKANF------ILSSLYVTKEIQEYINN--------LKLLK-DKKKEEENKFFGKLSSKKNKKMQDTTTTMNEVSNNV*
En csmA -MVGTLPAGHTPSHVQSSLPSLPAHLQSDTHLTAHLASRFHVGLPTARLSSHALIS-----------------LNNYTSSSKGPDGGK-------EGSAMGETEDLARRAYTRLGAR---------GENQAIVFLGESGAGKTTLRSHLLSSFLSFSS------------------------------------------------------------------------------------------------------------------------------------------------------------------------TPLSSKLSYAA--F-------IFDTLTTTKSLTTPTASKAGLFLELQYDASSSVN--PTLIGGKIIDHR-LERSRIAS-VPTGERSFHVLYYLLAGTSAAEK---------------------------------------AHLGLDSPIHVTTAGGRLSSADHKRWRYLGHP----------------------------TQLKVG----------INDADGFQHFKTALRKLE-----FPRSEIAEICQILAAILHIG-QLDFGSGQATLTGAEESGGYSHEGGETVTVVKNKDVLSIIAAFLG-LGVGELEASFGYRTKTIHR--------ERVTVMLDPKGARRSADELSRVLYSLLVAYV---------------------------IENVNQRICAA---------EDSVAN--------TVSIIDFPGFAQACS----TGSTLDQLLNNAACESLYNF-CLRSFFDRKADMLEREEVA--VPATS-YFDNTDAVRGLLKQG---------------------------------N-----GLLSILDDQTRRG-----------------RTDAQFVEAVRRRFENKN------PAITAGASGSGN-GYGMVSQNARSSFTVKHFA--GEVDYSATGLLE-ENGEVISGDLMNLMKSTR-----------------SDFVRELFGQEALQTVAHPKEKTAIMQAQVSSKPLRMPSMARRKTSPASRLTFDA-------------------------------------------------------------------------------------------------------------------------TPA----------EDPYETESQTGSSAKNSSAKRKSGMLMGGM-------------QCAAGQFLSSLDIVNKCLTSGNLNPYFVFCLKPNDRRIAN-----------------------------QFDSKCVRTQIQTLGIAEIS---QRLRNADFSVFLPFAEFLGLAEVGNVVVGS-------------------------------DKEKSEVVLDEKR---------WPG---NEARVGSTGVFLS------ERCWADLAKVGERVIPS*
Pg csm1 MAQHRCVGGNGGAHTQPSLPALPAHLQSNTHLTGHLASRFHVSLPTAKLSSHAFIS-----------------INTYTSSSKGQDGGK-------AGSAQGEAEDMADRAFLRLGHR---------SENQAILFLGESGSGKTTIRSHILTALLNKTS------------------------------------------------------------------------------------------------------------------------------------------------------------------------TPLSTKVSLAA--Y-------VFDTLTTTKTATTPTASKAGLFYELQYDTASTTS--PLLIGGKLLDHR-LERSRITD-VPTGERNFHILYYILAGTSAAEK---------------------------------------THLGFGEPDAGTGS---------KRWRYLGHP----------------------------TQLKVG----------INDAQGFQLFKTALRKLE-----FPRSEIAEICQVLASILHIG-QLEFESSENTTVAGDESGGFSHEGGQITTVAKNKDVLAIVAAFLG-VSAAELQTTLGYKTKIIHK--------ERVTVMLDPAGARANANELARTLYSLLVAYV---------------------------IENINQKICAP---------EEAIVN--------TVSIIDFPGFSQQSS----TGSSLDLLLNNAAAEAMYNL-TLQNFFDRKADLLETEEVS--VPPTS-YFDNSDAVKGLLKTG---------------------------------N-----GLLSILDDQTRRH-----------------RTDMQLLESLRKRFEGKN------PAIGVSAATAKLPGSNFLSENTAASFTVRHFA--GEVEYSIKGLVE-ENGEVISGDLLNLVNSTK-----------------SDFIARLFGQEALHTVTHPQERTTVMQASVSSKPMRAPSVMSRKIRPGTARTTRQ-------------------------------------------------------------------------------------------------------------------------RKE----------SISGRQDTLDDIASERGDSRRPVNKPSE---------------EGASGQFLHSLDNVTKSFHAQNTNAYFVFCLKPNDRRIAN-----------------------------QFDSKCVRTQMQTFGIAEIS---QRIRSADFSVFLPFGEFLGLADVDTLLVGS-------------------------------EREKVEAVVDEKR---------WPT---NEIQIGSTGVFIS------ERCWMEIAQLSDMVTGR*
Ce HUM4 XII -SEEMESSTPIHG--FYKEKTSKPSWLASLVILKPFKQPTKASNVLVFVNDFNDKD----------------SEDQLS----------------WETSSTSGVNAVAKNALNKIFN--------MSSNAESIVFGGESGSGKSYNVFKAFKYLTSQPKS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------KVSTKHSS-SIE-----FVFKSFGCAKTLKNDEATRFGCSIDLLYKRN-------VLTGLNLKYTVPLEVPRVIS-QKPGERNFNIFYEVYHGLSDE-----------------------------------------MKAKFG---IKGLQ----------KFFYINQ-----------------------------GNSSEN---------IQHDVNRFKHLESALHVLG----FS-DDHCMSIYKIISTILHIG-NIYFRTKR------NPN-------VEQDVVEIGNLAELKWIAFLLEVDFDQLVKFLLPTSEDGS--------------TIELNAALDNRDSFAMMIYEELFKWV---------------------------LNRIGLQLKCS---------LHTG----------VISILDHYGFEKYN------NNGVEEFLINSVNERIENL-FVKHCFHDQLIDYAKDGISVDYKVPN-SIENGKTVELLFKKP--------------------------------------YGLLSLLTDECKFP----------------KGTHETYLEHCNLN--HTD-----RSAYGKARNKER------------LEFGVRHCI--GTTWYNVTDFFA-RNKRIISLSAVQLMRNSK-----------------NPIIGLLFES--------------------YGGNTS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------DIIVSQAQFVLR------------------------GAQDIADKIN--VSHVHFVRCIKSNNERQST-----------------------------KFDIPLVNRQIKNLLLAELLS----FRVKGYPVKISKTTFARQYR---CLLPG----DIAQCQ--------------------NEKEIIQDILQGQG-----------VKYEDDFKIGTEYVF--------LR-----ERLAERYD--*
Hs MysPDZ ------------------------------------------MHMFKGCR---------------------------------------------REDMAPHIYAVAQTAYRAMLMS---------RQDQSIILLGSSGSGKTTSCQHLVQYLATIAG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------ISGNKVFS-VEKWQALYTLLEAFGNSPTIINGNATRFSQILSLDFDQA------GQVASASIQTML-LEKLRVAR-RPASEATFNVFYYLLACGDGT-----------------------------------------LRTELHLNHLAENN----------VFGIVP-----------------------------LAKPEEK----------QKAAQQFSKLQAAMKVLG----ISPDEQ-KACWFILAAIYHLGAAGATKEAAEAG---RKQFARHEWAQKAAYLLGCSLEELSSAIFKHQHKGGTLQRSTSFRQGPEES--------GLGDGTGPKLSALECLEGMAAGLYSELFTLL---------------------------VSLVNRALKSS---------QHS---------LCSMMIVDTPGFQNPEQGGSARGASFEELCHNYTQDRLQRL-FHERTFVQELERYKEENIELAFDDLEPPTDDSVAAVDQASHQSLVR--------------------------SLARTDEARGLLWLLEEEALVP----------------GASEDTLLERLFSYYGPQEG----DKKGQSPLLHSSK---------P-HHFLLGHSHGTNWVEYNVTGWLNYTKQNPATQNVPRLLQDSQ-----------------KKIISNLFLGRAG-------------SATVLSGSIAGLEGGSQLALRRATSMR------------------------------------------------------------------------------------------------------------------------------------------------KTFTTGMVAVKKKSLCIQMK-----------------------LQVDALIDTIK--KSKLHFVHCFLPVAEGWAGEPRSASSRRVSSSSELDLPSGDHCEAGLLQLDVPLLRTQLRGSRLLDAM----RMYRQGYPDHMVFSEFRRRFD---VLAPHLTKKHGRN------------------YIVVDERRAVEELLECLDLE--------K----SSCCMGLSRVF--------FRAGT-LARLEEQRDE-*
Key:
Abbreviation Full Terms
Ac Acanthamoeba castellanii
Acl Acetabularia cliftonii
Ai Aequipecten irradians (scallop)
At Arabidopsis thaliana (thale cress)
Bm Brugia malayi
Bt Bos taurus (cow)
Cc Chara corallina
Ce Caenorhabditis elegans
Cr Chlamydomonas reinhardtii
Dd Dictyostelium discoidium
Dm Drosophila melanogaster
En Emiricella nidulans (Aspergillus)
Eh Entamoeba histolytica
Gg Gallus gallus (chicken)
Ha Helianthus annus (sunflower)
Hs Homo sapiens (human)
Lp Limulus polyphemus (horseshoe crab)
Ma Mesocricetus auratus (hamster)
Mm Mus musculus (mouse)
Ms Morone saxatilis (striped bass)
Oc Oryctolagus cuniculus (rabbit)
Ov Onchocerca volvulus (a nematode)
Pf Plasmodium falciparum (malaria)
Pg Pyricularia grisea (rice blast fungus)
Rc Rana catesbeiana (bullfrog)
Rn Rattus norvegicus (rat)
Sc Saccharomyces cerevisiae (yeast)
Sm Schistosoma mansoni
Ss Sus scrofa domestica (domestic pig)
Tg Toxoplasma gondii
Tt Tetrahymena thermophila
Xl Xenopus laevis (clawed toad)
Zm Zea mays (maize)
Adren Bovine Adrenal (myosin I)
ank Ankyrin like repeats
Bb Brush Border Myosin I
CaA Cardiac alpha (myosin II)
CaB Cardiac beta (myosin II)
chs Chitin synthase type V homology
csm Chitin synthase-myosin
FSk Fast Skeletal (myosin II) = striated
FSkE Embryonic Fast Skeletal (myosin II)
HMWMI High Molecular Weight Myosin I
kin Kinase domain
neur Neuronal (myosin II)
nm Non-muscle (myosin II)
PDZ Myosin like protein with a PDZ domain.
Peri Perinatal (myosin II)
sm Smooth muscle (myosin II)
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Last updated Wednesday, 12th June 2002