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A preliminary (pairwise) alignment of all of the full length sequences was made with a modified version of the method of Feng and Doolittle in ClustalW [1]. The sequences were then trimmed to produce a core motor domain. This core motor domain corresponds to residues 88 to 780 of chicken pectoralis muscle myosin II from which the first crystal structure of a myosin head was solved[5]. A second guide alignment with these core motor domain sequences was produced, followed by a final multiple alignment, with correction for multiple substitutions[6]. Optimally, when producing a phylogenetic tree from such an alignment, any positions in the alignment with gaps are excluded. Such a strategy would have excluded half of the data because of the large number of sequences, thus positions with gaps were included. An unrooted phylogenetic tree was constructed and tested for branching order confidence by bootstrapping[7]. Bootstrapping redraws 1000 trees with random samples from the multiple alignment. If the same branches were found at a certain node in >900 out of those 1000 random trees, then that node was accepted as being significant and therefore the branching order at that point in the tree was well supported. (Bootstrapping data)
See key below for expansion of organism names and other abbreviations. Where no formal name has been given in prior literature we have used the format: Nn XXA where Nn is the organism's genus and species, XX is the myosin class and A is an identifier given in date order of the gene/protien discovery and publication in the database. To avoid confusion in the plant myosin XI class a hyphen has been added to distinguish the myosin class from the 9th example discovered: At XI-I.
The residue number for Gg FSk (chicken fast skeletal) and the secondary structure assignments as derived from the chicken myosin S1 crystal structure are shown along the top. HC corresponds to Helix C, S1B to strand one of beta-sheet B. Since there are mnore than 26 helices identified the 27th and 28th helices are labelled HA' and HB'.
Colour scheme:
AILVPTWM
- 'Non Polar'
GSTYCNQ -
'Uncharged Polar' and Glycine
DE -
'Acidic'
HKR -
'Basic'
Tony
Hodge MRC-LMB Cambridge
& Jamie Cope
UC Berkeley
May 2000.
HC S1B S2B HD HE S4B HF HG HH S1C S6B S7B HI HJ HK HL S1D S2D HM HN S4D S3D HO S5B switch II HP HQ HR HS S1E S2E S3E HT HU HV HW S3B HX HY S1F HZ HA' S2F S3F (Long Helix to V826
<-----------> <-> <---> <-----> <---------> <----> <-------------> 25-50 Junction 25-50 Junction 25-50 Junction 25-50 Junction <-----> <-----------> <-> <----> <-------> <----> <-----> <------------> <-------------------> <> <-> <------> <-------> <> <> <--------------------------------------------------------> <----> <--------------------------------> <-------> <-----> <--------------> <--> <--> <--> <-----> <-------> <---> <------------------------------------> <------> <---------> <-----------> <> <------> <------> <---> <---------> Light Chain Binding)
Gg FSk residue # 90 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 600 620 640 660 680 700 720 740 760 780
Dm NinaC III -PEDLAA-LENPV-DENIIESLRHRILM-GESYSFIGDILLSLNSNEIKQ-EFP-QE---------------FHAKYRFKSRSE-----------NQ---PHIFSVADIAYQDMLH---------HKEPQHIVLSGESYSGKSTNARLLIKHLCYLGDGNR--------------------------------------------------------------------------------------------------------------------------------------------------------------------GATGRVESSIK-----------AILMLVNAGTPVNNDSTRCVLQYCLTFGKTG------KMSGAVFNMYM-LEKLRVAT-TDGTQHNFHIFYYFYDFINQQN----------------------------------------QLKEYN---LKADR----------NYRYLRV-----------------------------PPEVPPSKLKYRRDDPEGNVERYREFENILRDID-----FNHKQLETVRKVLAAILNIG-NIRFRQNG------KYA--------EVENT-----DIVSRIAELLRVDEKKFMWSLTNFIMVKGG--------IAERRQYTTEEARDARDAVASTLYSRLVDFI---------------------------INRINMNMSFP---------RAVFG------DTNAIIIHDMFGFECFN------RNGLEQLMINTLNEQMQYH-YNQRIFISEMLEMEAEDIDT-INLN--FYDNKTALDNLLTK-----------------------------------P---DGLFYIIDDASRSCQD-----------------QNLIMDRVSE--------K--HSQFVKKHTAT--------------EISVAHYT--GRIIYDTRAFTD-INRDFVPPEMIETFRSS-----------------LDESIMLMFTNQLTKAGNLTM---PFEAVQHKDESERKSYALNTLSAGC----------------------------------------------------------------------------------------------------------------------------------------------------------ISQVNNLRTLAANFR--------------------FTCLTLLKMLSQNA--NLGVHFVRCIRADLEYKPR-----------------------------SFHSDVVQQQMKALGVLDTV----IARQKGFSSRLPFDEFLRRYQF--LAFDFD-----EPVEM--------------------TKDNCRLLFLRLKMEG--------------WALGKTKVFLR------YYNDEFLARLYE-----*
Lp III -VDDLAF-LDSPT-EEVVLENLEQRYRK-GEIYTFAGDVLLTLNPGKVLP-LYG-DQ---------------TAVKYCERGRSD-----------NP---PHVFAVADRAYQQMLH---------HKSPQAVILSGVSGSGKSFCTHQVIRHLAFLGAQNKE-------------------------------------------------------------------------------------------------------------------------------------------------------------------GMREKLEYLCP-----------LLDTLGNAYTSTNPNSSHFVKILEVTFTKTG------KITGAILFTFL-LEARRLTD-IPKGERNFHVFYYFYEGLRSEG----------------------------------------RLKEFG---LEEK-----------NYRYL--------------------------------PELKSS-------NSPEYVKGYQQFLRALTSLA-----FTEEEIFAIQKVLAAILLLG-ETEIQN---------------------S-----------AAFKLLGAESSELENTLT--------------------------QDVNARDVYARAMYLRLFSWI---------------------------VAVVNRQLSFS---------RLVFG------DVYSVTVIDSPGFENGL------HNSLHQLCANVISDNLQNY-IQQIIFFKELEEYGEEGVNVPFNLEG-GVDHRTLVNKLMDS-----------------------------------G---QGLLTAISKATQYQRKGES------------GWMESLQEADSE--------E--LVEFSNVNGKP--------------IVSVKHIF--RKVSYDATDLVK-KNVEDKTRALTSTMQRS-----------------CDPRIRAIFSSENPSP--------------FLSSPRRSSIQENMLLP------------------------------------------------------------------------------------------------------------------------------------------------------------------ERTVTDSLH--------------------SALSSVLNLASTED--PP--HLILCMRPQKKELIN-----------------------------DYDSKSVQIQLHALNVLETI----LIRQFGFARRISFVDFLNRYQY--LAFDFN-----ENVEL--------------------TKENCRLLLLRLKMDG--------------WTLGKNKVFLK------YYSEEYLSRIYETHIKK*
Rn XVI -SDDLAT-LSELN-DSSLLYEIQKRFGN-DQIHTFIGDIFLLVNPFKELP-IYS-TV---------------VSQMYLSPTGQR-----------SPSLPPHLFSCAERAFHRLFQ---------ERRPQNIILSGERGSGKTQASKQIMKHLTSRASSSCT-------------------------------------------------------------------------------------------------------------------------------------------------------------------MFDSRFKHAIC-----------ILEAFGHAKTTLNNVSSCLIQYWELQFCQRRK-----HVTGARISTYM-LEKPRLVA-QPPGQGSFLIFSWLMDGLSAEE----------------------------------------KCGLH----LSNFC----------AHRYVSQ-----------------------------GMREDVS-----TAERSLNKERLADLKHALNVIG-----FSALEVENLFAILSAILHIG-DIQFTALT------EADS------AFVSDL-----QLLEQVADMLQVSTDELASALTTDIQYFKG--------DVIIRRHTTQIAAFYRDLLAKSLYSRLFGFL---------------------------INTVNCCLQSQD--------EYKSL------QTLDIGILDIFGFEEFQ------KNEFEQLCVNLTNEKMHHY-IQEVLFLQEQTECVQEGVAMETACS--PGNQAGVLDFFFQK-----------------------------------P---SGFFSLLDEESQAIWSVEPNLPRKLQGLLESSNTNAVYSPMKD--------G--NGNVAFKGQGA--------------AFTVMHYA--GRVTYEIRGAVE-RNKDSLSQNLLFVMKTS-----------------ENVVISHLFQSKLSPTGSLISSYPSFKFGGHKSSLLSKRIASSMVGVNKNYLELSK-------------------------------------------------------------------------------------------------------------------------LLK-----------------KKGTCTFLQRLERGDPATTAS--------------------QLTKSLADITAKLQ--KGSPHFILCVKPNTSQLPG-----------------------------VFDHFYVSAQLQYLGVLGLV----RLFRYGYPVRPSFEDFLSRYEP--LASVLLG---EKKGQP--------------------AEERCRLVLQRCKLQG--------------WQMGVHKVFLK------YWQVDQLGDLWLQMQR-*
Tg myoA XIV -YGDIGM-LPHTN-IPCVLDFLKVRFMK-NQIYTTADPLVVAINPFRDLGNTTL-----------------DWIVRYR--DTFD-----------LSKLAPHVFYTARRALDNLHA---------VNKSQTIIVSGESGAGKTEATKQIMRYFAAAKTG----------------------------------------------------------------------------------------------------------------------------------------------------------------------SMDLRIQNAIMA--AN-----PVLEAFGNAKTIRNNNSSRFGRFMQLDVGRE------GGIKFGSVVAFL-LEKSRVLT-QDEQERSYHIFYQMCKGADAAM-----------------------------------------KERFHI---LPLS----------EYKYIN-------------PL---------------CLDAPG----------IDDVAEFHEVCESFRSMN----LTEDEV-ASVWSIVSGVLLLG-NVEVTATK------DGG--I-DDAAAIEG---KNLEVFKKACGLLFLDAERIREELTVKVSYAGN--------QEIRGRWKQEDGDMLKSSLAKAMYDKLFMWI---------------------------IAVLNRSIKPPGG-------FKI-----------FMGMLDIFGFEVFK------NNSLEQFFINITNEMLQKN-FVDIVFDRESKLYRDEGVS--SKELI-FTSN-AEVIKILTAK---------------------------------NN----SVLAALEDQCLAP----------------GGSDEKFLSTCKNALKGTT-------KFKPAKVSPNI------------NFLISHTV--GDIQYNAEGFLF-KNKDVLRAEIMEIVQQSK-----------------NPVVAQLFAGI------------------VMEKGK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAKGQLIGSQFL-----------------------SQLQSLMELIN--STEPHFIRCIKPNDTKKPL-----------------------------DWVPSKMLIQLHALSVLEAL----QLRQLGYSYRRPFKEFLFQFKF--IDLSASENPNLD------------------------PKEAALRLLKSS------------KLPSEEYQLGKTMVF--------LKQTGAKELTQIQRE--*
Pf PfMA -FGDIGL-LNHTN-IPCVLDFLKHRYLK-NQIYTTAVPLIVAINPYKDLGNTTN-----------------EWIRRYR--DTAD-----------HTKLPPHVFTCAREALSNLHG---------VNKSQTIIVSGESGAGKTEATKQIMRYFASSKSG----------------------------------------------------------------------------------------------------------------------------------------------------------------------NMDLRIQTAIMA--AN-----PVLEAFGNAKTIRNNNSSRFGRFMQLVISHE------GGIRYGSVVAFL-LEKSRIIT-QDDNERSYHIFYQFLKGANSTM-----------------------------------------KSKFGL---KGVT----------EYKLLN-------------PN---------------STEVSG----------VDDVKDFEEVIESLKNME----LSESDI-EVIFSIVAGILTLG-NVRLIEKQ------EAG--L-SDAAAIMD---EDMGVFNKACELMYLDPELIKREILIKVTVAGG--------TKIEGRWNKNDAEVLKSSLCKAMYEKLFLWI---------------------------IRHLNSRIEPEGG-------FKT-----------FMGMLDIFGFEVFK------NNSLEQLFINITNEMLQKN-FVDIVFERESKLYKDEGIS--TAELK-YTSN-KEVINVLCEK---------------------------------GK----SVLSYLEDQCLAP----------------GGTDEKFVSSCATNLKENN-------KFTPAKVASNK------------NFIIQHTI--GPIQYCAESFLL-KNKDVLRGDLVEVIKDSP-----------------NPIVQQLFEGQ------------------VIEKGK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------IAKGSLIGSQFL-----------------------NQLTSLMNLIN--STEPHFIRCIKPNENKKPL-----------------------------EWCEPKILIQLHALSILEAL----VLRQLGYSYRRTFEEFLYQYKF--VDIAAAEDSSVE------------------------NQNKCVNILKLS------------GLSESMYKIGKSMVF--------LKQEGAKILTKIQREK-*
Tg myoD -YGDIGG-LPHTN-EPCVLDFLARRYQS-KVIYTTAEPLIVAVNPFQDLKNAGP-----------------DTIALYR--DAPD-----------VDKLPPHVFYASRRAMTNMHQ---------LKKPQTIIVSGESGAGKTETTKMLMKYLATSAGG----------------------------------------------------------------------------------------------------------------------------------------------------------------------NLDLKIQTAIMA--AN-----PVLEAFGNAKTVRNNNSSRFGRFMLLDVARE------GGIQHGKVVAFL-LEKSRIVC-QDKDERNYHIFYQFLKGAPGHM-----------------------------------------RQRYML---QPLE----------AYTFIN-------------PH---------------CLDAPG----------IVDTEDFEQTVKSLESMN----MTETET-CTIWSIVSGVLLMG-NAKPTGKT------EAG--V-ENAACFVG---ESEAALRNACSLLFLDYPSILHELTVKTTYAGS--------NKIESRWTVPDSEMLRASLAKGMFEQLFLWI---------------------------IRKLNADIEPKGGS------FDV-----------FMGLLDIFGFEVFQ------NNSLEQLFINITNEVLQRN-FTDIVFEKELQLYSKEGIS--SKKIE-YTTN-EKLIETLLGK---------------------------------GT----SVLAALEDQCISP----------------SGTDEKFVSSLASKLAGNK-------CFIPSKNTKSL------------EFTVVHTI--GKVIYNADGFAF-KNKDVLRPEIIEITRAST-----------------NDVVRGLFEGV------------------KVEKGK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAKGMLIGSQFM-----------------------TQLKGLMEVIQ--KTESHFIRCIKPNDDKVPL-----------------------------KWVNSKVLIQLHALSILEAL----HLRQLAFSYRRTFEEFAAQFRF--INLGVSNKPGAD------------------------AKTICVELLKST------------SISADEYALGKTMVF--------LKPQAAKMLVRLQREA-*
Tg myoE -FPDIGL-LPHKN-CAAVLDFLKQRYLL-DLIYTTADPLLIAINPFKDLNNTTP-----------------EWLQLYR--DAPD-----------AEILAPHVFRLARTVLERLSA---------FMASQTIIVSGESGAGKTEATKQIMSYFAAGKRGE---------------------------------------------------------------------------------------------------------------------------------------------------------------------VSHQRIQNAVIA--AN-----PVLEAFGNAKTVRNNNSSRFGRFMQLQLGEK------GGIEYGSIRNFL-LEKVRVTS-QEQHERSYHIFYQLVKGADDAK-----------------------------------------RRQLHL---LNLE----------DYTYLS-------------KNG-------------GCYDCPG----------IDDVKDFKEMNKSLRSIG----LNLDDV-ESLWSIIAGVLLLG-NVHLESRE------TDG--Q-PNAAALTP---DGEATLQKCCALLFVDEEAVKKEILYKVKTIGD--------QQIESPNSLSDALMNRDSLAKAVYEKLFDWV---------------------------VRRVNATIEPPQG-------FGI-----------FMGMLDIFGFEMFE------NNSLEQLLINITNEQLQKN-FIQIVFARETKLYYEEGIG--NVKIT-WTDN-ENVIKALCGK---------------------------------SS----SVLAILEDKSLAP----------------GGTDEAIVTSMNQALKSSD-------VWKPGQKNPRI------------CFCICHTI--ADIQYDATGFIE-KNKDLLKPELCSIVQASS-----------------NNVAKELFEGV------------------VMQKGK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------IAKGQLIASQFM-----------------------RSLDALLTLIS--STESHFIRCLKPNETKNPH-----------------------------DWSNGKVLAQLFSLSILEAL----QLKNLSFSYRRPYADFLKQFEQ--LDLEVTRKSGN-------------------------AKEKTKQLLTRA------------NVPQAKWALGNTMVF--------MKPDAVRELTQKMRL--*
Tg myoB XIV --LPLRR-VRDTV-PRAEFGTRKSRFLR-SIIYTTAEPLLVAINPFKDLGNTTD-----------------AWISTYR--NASK-----------PEMLPPHVFKTARAALEDLEG---------YKKNQSIIVSGESGAGKTEATKQIMRFFASASS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------EVRTTIQDTIMA--GN-----PILEAFGNAKTIRNNNSSRFGRFMMLDVSSH------RGIQHGSISNFL-LEKVRVVS-QEANERSYHIFYQLLKGATSEM-----------------------------------------RAKYHL---RSLK----------EYAYLNG------------KNG-------------GCYDVPG----------IDDKADFEEVLQSLDAMQ----ITGSKR-HSVFSILSGLLLIG-NVSIEGKD------AQG--V-PDAAYISP---QSEEILEEACQLLSVDDAALKKEILVKSTKVGP--------QVIEGVRTKDEAKTSVLSLSKNVYDKLFDWL---------------------------VRQLNSLIDAPDG-------MPN-----------FIGILDIFGFEVLE------VNSLEQVLINITNEYLQKH-FIDVVFDMETKLYQAEGVP--TEALE-YTDN-LALVGALCGK---------------------------------ND----SFFALLEDACLGI----------------RSTDEGFCGTILRRLEPSG-------FFLESRRDKRL------------KFIIRHTI--ADIEYTCEGMLE-KNKDFLRKEVMDVMKAST-----------------DPVTKALFEGI------------------EIEAGK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------IGKGTLIASRFL-----------------------KNLEEMIGIVA--QTEAHFIRCLKPNEEKKPL-----------------------------GWNGSKVLNQLFSLSILEAL----QLRQVGYAYRRNFSEFCSHFRW--LDLGLVN-SDRD------------------------RKEVAHVLLEQS------------GIPESSWVIGKTMVF--------VKPDAAKELSILQRE--*
Tg myoC -VDDIGY-LPHTN-VACVLDVLKSRFLR-SIIYTTAEPLLVAINPFKDLGNTTD-----------------AWISTYR--NASK-----------PEMLPPHVFKTARAALEDLEG---------YKKNQSIIVSGESGAGKTEATKQIMRFFASASS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------EVRTTIQDTIMA--GN-----PILEAFGNAKTIRNNNSSRFGRFMMLDVSSH------RGIQHGSISNFL-LEKVRVVS-QEANERSYHIFYQLLKGATSEM-----------------------------------------RAKYHL---RSLK----------EYAYLNG------------KNG-------------GCYDVPG----------IDDKADFEEVLQSLDAMQ----ITGSKR-HSVFSILSGLLLIG-NVSIEGKD------AQG--V-PDAAYISP---QSEEILEEACQLLSVDDAALKKEILVKSTKVGP--------QVIEGVRTKDEAKTSVLSLSKNVYDKLFDWL---------------------------VRQLNSLIDAPDG-------MPN-----------FIGILDIFGFEVLE------VNSLEQVLINITNEYLQKH-FIDVVFDMETKLYQAEGVP--TEALE-YTDN-LALVGALCGK---------------------------------ND----SFFALLEDACLGI----------------RSTDEGFCGTILRRLEPSG-------FFLESRRDKRL------------KFIIRHTI--ADIEYTCEGMLE-KNKDFLRKEVMDVMKAST-----------------DPVTKALFEGI------------------EIEAGK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------IGKGTLIASRFL-----------------------KNLEEMIGIVA--QTEAHFIRCLKPNEEKKPL-----------------------------GWNGSKVLNQLFSLSILEAL----QLRQVGYAYRRNFSEFCSHFRW--LDLGLVN-SDRD------------------------RKEVAHVLLEQS------------GIPESSWVIGKTMVF--------VKPDAAKELSILQRE--*
Pf PfMB -SHRLND-MVHQN-SAEVLNTLALRYEK-NYIYTIAEPMLISVNPYQVIDTD---------------------MNEYK--NKS------------TDLLPPHVYTYAKDAMLDFIN---------TKNSQSIIISGESGSGKTEASKLVIKFYLSGVR-----------------------------------------------------------------------------------------------------------------------------------------------------------------------E-DNDISKTLWD--SN-----FILEAFGNAKTVKNNNSSRYGKYIKIQLDEN------QNIVSSSIEIFL-LEKIRVVS-QEPDERCYHIFYEILKGMNDEM-----------------------------------------KKKYKI---KSEE----------DYKYISN------------KS----------------INIPE----------IDDAKDFENLMISFDKMK----MS-DLK-DDLFLTLSGLLLLG-NIQFNGIE------KGG--K-SNCSELDD---ENLEVVNEASELLGIDYESLKNSLVITEKSIAN--------QKIEIPLSIEESLSICRSISKDIYNKIFEYI---------------------------TKRINNFLNNNKE-------LEN-----------FIGILDIFGFEIFV------KNSLEQLLINIANEEIHNI-YLFVVYEKESYLYKKEGPL--IESVK-YTNN-ESIIDLLRG----------------------------------NT----SIISILEDNCLAP----------------GKKDESIVSVYTNKFSKNE-------HYSVCKKNITE------------SFVIKHTV--SDVTYSISNFIS-KNKDILSPNILKLLKVSN-----------------NKLIQNLYDDA------------------EVTDS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------LGRKNLITYKYL-----------------------ENLKQICSYLK--STNIYFIKCIKPNETKEKN-----------------------------NFNPKKVYPQLFSLSIVETL----NIKYF-FQYKYTFASFLSYYQY--LDIAVSNDSSLD------------------------EKTKVTMLLER-------------NFDKDSYKVGHTMVF--------LKKEAVHKIRDIINSN-*
Tt MYO1 -YSDMVH-MKYLN-EAEIINNLRKRYQN-NMIFTYIGPTLVVMNPYKEIEGVQDNQVIDKIKSDLGIKFEEDFKMNNL--STNQ-----------NIINTPHTYTVSGLAYKQMFS---------NKKNQAIVISGESGAGKTENAKLSMQFLTSLKEF-----------------------------------------------------------------------------------------------------------------------------------------------------------------------NQFAIEVKILA--CN-----PILEAFGNAKTVRNNNSSRFGKYVKIYIDKTS-----QKINGASIDSYL-LEKSRIPC-PGKGERNYHIFYHMLKGNQELSN----------------------------------------LRLSQF---KNLS----------DFDYLKK------------SD---------------CFEVEN----------IQDAKLYLEVKKSFRQMN----FSNQEQ-EAIFSLISAILLLG-NANLDSSK------VSD--T-QAPTFLNMSLPTHHKEFKNASELLQVNPKDLEESLVFKVRKVGT--------TVIKSPQTAEECLSMRDSLSKNLYDSLFNFL---------------------------VWKLNQNLLPPQDL------LNKS---------LSIGLLDIFGFESFD------INSFEQLCINFTNEKFQQL-YVQYVFKSEEEDYKQEGILDVFSDLQ-YQEN-QLIIDTIEKK---------------------------------PN----GIMVLLDENCSLG----------------SGTDDSFLNQITKNHSKNQ-------LVSFPKKD-KY------------SFSLSHTA--KRVVYDVRGFRD-KNKDEVSTEVEKSLQSSK-----------------CPVIANLLSYQ------------------GSQTQQNKETQNLQNFGNNLNFKKAE----------------------------------------------------------------------------------------------------------------------------------------------ISNQMNSSKKNVKFLGQKFR-----------------------QSLQELMIELN--NSDVHFIRCIKPNEEKKKN-----------------------------FFKYDYVYQQVQYLGILDSI----KIRKVGYSYRMTYENFFLEYQE--LGQKTKGLTLQK------------------------VQQQKPIYLQNK------------QLPQKCVAFGKTKIF--------LKNEVMKILHEK-----*
Dd myoM -FSDMVE-IQDLS-EAIILNNLGLRYKS-DQIYTYIGNVLISINPYKEIKDIYS----------------LNILNKYK--DINT-----------IKSNPPHIYAVALRAYQSMVS---------EKKNQSIIISGESGSGKTEASKTILQYLINTSNSNSN----------------------------------------------------------------------------------------------------------------------------------------NNTNIN---------------------NNNNSIEKDILN--SN-----PILEAFGNSRTTKNHNSSRFGKFLKIEFRSSD-----MKIDGASIETYL-LEKSRISHRPDVNNLSYHIFYYLVMGASKEER----------------------------------------ERLGLD---NDPS----------KYRYLDASTSVIESFKKQSNGG-------------SGGGSGN----------NDLSESLQLVKQSLESMS----IAKEQC-DDIFLTLAAILHLG-NIEFEVDQ------TENEQT-