A preliminary (pairwise) alignment of all of the full length sequences was made with a modified version of the method of Feng and Doolittle in ClustalW [1]. The sequences were then trimmed to produce a core motor domain. This core motor domain corresponds to residues 88 to 780 of chicken pectoralis muscle myosin II from which the first crystal structure of a myosin head was solved[5]. A second guide alignment with these core motor domain sequences was produced, followed by a final multiple alignment, with correction for multiple substitutions[6]. Optimally, when producing a phylogenetic tree from such an alignment, any positions in the alignment with gaps are excluded. Such a strategy would have excluded half of the data because of the large number of sequences, thus positions with gaps were included. An unrooted phylogenetic tree was constructed and tested for branching order confidence by bootstrapping[7]. Bootstrapping redraws 1000 trees with random samples from the multiple alignment. If the same branches were found at a certain node in >900 out of those 1000 random trees, then that node was accepted as being significant and therefore the branching order at that point in the tree was well supported. (Bootstrapping data).
A colour alignment in HTML is also available (NB 2.2 Mb)
See key below for expansion of organism names and other abbreviations. Where no formal name has been given in prior literature we have used the format: Nn XXA where Nn is the organism's genus and species, XX is the myosin class and A is an identifier given in date order of the gene/protien discovery and publication in the database. To avoid confusion in the plant myosin XI class a hyphen has been added to distinguish the myosin class from the 9th example discovered: At XI-I.
The residue number for Gg FSk (chicken fast skeletal) and the secondary structure assignments as derived from the chicken myosin S1 crystal structure are shown along the top. HC corresponds to Helix C, S1B to strand one of beta-sheet B. Since there are mnore than 26 helices identified the 27th and 28th helices are labelled HA' and HB'.
Tony
Hodge MRC-LMB Cambridge
& Jamie Cope
UC Berkeley
May 2000.
HC S1B S2B HD HE S4B HF HG HH S1C S6B S7B HI HJ HK HL S1D S2D HM HN S4D S3D HO S5B switch II HP HQ HR HS S1E S2E S3E HT HU HV HW S3B HX HY S1F HZ HA' S2F S3F (Long Helix to V826
<-----------> <-> <---> <-----> <---------> <----> <-------------> 25-50 Junction 25-50 Junction 25-50 Junction 25-50 Junction <-----> <-----------> <-> <----> <-------> <----> <-----> <------------> <-------------------> <> <-> <------> <-------> <> <> <--------------------------------------------------------> <----> <--------------------------------> <-------> <-----> <--------------> <--> <--> <--> <-----> <-------> <---> <------------------------------------> <------> <---------> <-----------> <> <------> <------> <---> <---------> Light Chain Binding)
Gg FSk residue # 90 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 600 620 640 660 680 700 720 740 760 780
Dm NinaC III -PEDLAA-LENPV-DENIIESLRHRILM-GESYSFIGDILLSLNSNEIKQ-EFP-QE---------------FHAKYRFKSRSE-----------NQ---PHIFSVADIAYQDMLH---------HKEPQHIVLSGESYSGKSTNARLLIKHLCYLGDGNR--------------------------------------------------------------------------------------------------------------------------------------------------------------------GATGRVESSIK-----------AILMLVNAGTPVNNDSTRCVLQYCLTFGKTG------KMSGAVFNMYM-LEKLRVAT-TDGTQHNFHIFYYFYDFINQQN----------------------------------------QLKEYN---LKADR----------NYRYLRV-----------------------------PPEVPPSKLKYRRDDPEGNVERYREFENILRDID-----FNHKQLETVRKVLAAILNIG-NIRFRQNG------KYA--------EVENT-----DIVSRIAELLRVDEKKFMWSLTNFIMVKGG--------IAERRQYTTEEARDARDAVASTLYSRLVDFI---------------------------INRINMNMSFP---------RAVFG------DTNAIIIHDMFGFECFN------RNGLEQLMINTLNEQMQYH-YNQRIFISEMLEMEAEDIDT-INLN--FYDNKTALDNLLTK-----------------------------------P---DGLFYIIDDASRSCQD-----------------QNLIMDRVSE--------K--HSQFVKKHTAT--------------EISVAHYT--GRIIYDTRAFTD-INRDFVPPEMIETFRSS-----------------LDESIMLMFTNQLTKAGNLTM---PFEAVQHKDESERKSYALNTLSAGC----------------------------------------------------------------------------------------------------------------------------------------------------------ISQVNNLRTLAANFR--------------------FTCLTLLKMLSQNA--NLGVHFVRCIRADLEYKPR-----------------------------SFHSDVVQQQMKALGVLDTV----IARQKGFSSRLPFDEFLRRYQF--LAFDFD-----EPVEM--------------------TKDNCRLLFLRLKMEG--------------WALGKTKVFLR------YYNDEFLARLYE-----*
Lp III -VDDLAF-LDSPT-EEVVLENLEQRYRK-GEIYTFAGDVLLTLNPGKVLP-LYG-DQ---------------TAVKYCERGRSD-----------NP---PHVFAVADRAYQQMLH---------HKSPQAVILSGVSGSGKSFCTHQVIRHLAFLGAQNKE-------------------------------------------------------------------------------------------------------------------------------------------------------------------GMREKLEYLCP-----------LLDTLGNAYTSTNPNSSHFVKILEVTFTKTG------KITGAILFTFL-LEARRLTD-IPKGERNFHVFYYFYEGLRSEG----------------------------------------RLKEFG---LEEK-----------NYRYL--------------------------------PELKSS-------NSPEYVKGYQQFLRALTSLA-----FTEEEIFAIQKVLAAILLLG-ETEIQN---------------------S-----------AAFKLLGAESSELENTLT--------------------------QDVNARDVYARAMYLRLFSWI---------------------------VAVVNRQLSFS---------RLVFG------DVYSVTVIDSPGFENGL------HNSLHQLCANVISDNLQNY-IQQIIFFKELEEYGEEGVNVPFNLEG-GVDHRTLVNKLMDS-----------------------------------G---QGLLTAISKATQYQRKGES------------GWMESLQEADSE--------E--LVEFSNVNGKP--------------IVSVKHIF--RKVSYDATDLVK-KNVEDKTRALTSTMQRS-----------------CDPRIRAIFSSENPSP--------------FLSSPRRSSIQENMLLP------------------------------------------------------------------------------------------------------------------------------------------------------------------ERTVTDSLH--------------------SALSSVLNLASTED--PP--HLILCMRPQKKELIN-----------------------------DYDSKSVQIQLHALNVLETI----LIRQFGFARRISFVDFLNRYQY--LAFDFN-----ENVEL--------------------TKENCRLLLLRLKMDG--------------WTLGKNKVFLK------YYSEEYLSRIYETHIKK*
Rn XVI -SDDLAT-LSELN-DSSLLYEIQKRFGN-DQIHTFIGDIFLLVNPFKELP-IYS-TV---------------VSQMYLSPTGQR-----------SPSLPPHLFSCAERAFHRLFQ---------ERRPQNIILSGERGSGKTQASKQIMKHLTSRASSSCT-------------------------------------------------------------------------------------------------------------------------------------------------------------------MFDSRFKHAIC-----------ILEAFGHAKTTLNNVSSCLIQYWELQFCQRRK-----HVTGARISTYM-LEKPRLVA-QPPGQGSFLIFSWLMDGLSAEE----------------------------------------KCGLH----LSNFC----------AHRYVSQ-----------------------------GMREDVS-----TAERSLNKERLADLKHALNVIG-----FSALEVENLFAILSAILHIG-DIQFTALT------EADS------AFVSDL-----QLLEQVADMLQVSTDELASALTTDIQYFKG--------DVIIRRHTTQIAAFYRDLLAKSLYSRLFGFL---------------------------INTVNCCLQSQD--------EYKSL------QTLDIGILDIFGFEEFQ------KNEFEQLCVNLTNEKMHHY-IQEVLFLQEQTECVQEGVAMETACS--PGNQAGVLDFFFQK-----------------------------------P---SGFFSLLDEESQAIWSVEPNLPRKLQGLLESSNTNAVYSPMKD--------G--NGNVAFKGQGA--------------AFTVMHYA--GRVTYEIRGAVE-RNKDSLSQNLLFVMKTS-----------------ENVVISHLFQSKLSPTGSLISSYPSFKFGGHKSSLLSKRIASSMVGVNKNYLELSK-------------------------------------------------------------------------------------------------------------------------LLK-----------------KKGTCTFLQRLERGDPATTAS--------------------QLTKSLADITAKLQ--KGSPHFILCVKPNTSQLPG-----------------------------VFDHFYVSAQLQYLGVLGLV----RLFRYGYPVRPSFEDFLSRYEP--LASVLLG---EKKGQP--------------------AEERCRLVLQRCKLQG--------------WQMGVHKVFLK------YWQVDQLGDLWLQMQR-*
Tg myoA XIV -YGDIGM-LPHTN-IPCVLDFLKVRFMK-NQIYTTADPLVVAINPFRDLGNTTL-----------------DWIVRYR--DTFD-----------LSKLAPHVFYTARRALDNLHA---------VNKSQTIIVSGESGAGKTEATKQIMRYFAAAKTG----------------------------------------------------------------------------------------------------------------------------------------------------------------------SMDLRIQNAIMA--AN-----PVLEAFGNAKTIRNNNSSRFGRFMQLDVGRE------GGIKFGSVVAFL-LEKSRVLT-QDEQERSYHIFYQMCKGADAAM-----------------------------------------KERFHI---LPLS----------EYKYIN-------------PL---------------CLDAPG----------IDDVAEFHEVCESFRSMN----LTEDEV-ASVWSIVSGVLLLG-NVEVTATK------DGG--I-DDAAAIEG---KNLEVFKKACGLLFLDAERIREELTVKVSYAGN--------QEIRGRWKQEDGDMLKSSLAKAMYDKLFMWI---------------------------IAVLNRSIKPPGG-------FKI-----------FMGMLDIFGFEVFK------NNSLEQFFINITNEMLQKN-FVDIVFDRESKLYRDEGVS--SKELI-FTSN-AEVIKILTAK---------------------------------NN----SVLAALEDQCLAP----------------GGSDEKFLSTCKNALKGTT-------KFKPAKVSPNI------------NFLISHTV--GDIQYNAEGFLF-KNKDVLRAEIMEIVQQSK-----------------NPVVAQLFAGI------------------VMEKGK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAKGQLIGSQFL-----------------------SQLQSLMELIN--STEPHFIRCIKPNDTKKPL-----------------------------DWVPSKMLIQLHALSVLEAL----QLRQLGYSYRRPFKEFLFQFKF--IDLSASENPNLD------------------------PKEAALRLLKSS------------KLPSEEYQLGKTMVF--------LKQTGAKELTQIQRE--*
Pf PfMA -FGDIGL-LNHTN-IPCVLDFLKHRYLK-NQIYTTAVPLIVAINPYKDLGNTTN-----------------EWIRRYR--DTAD-----------HTKLPPHVFTCAREALSNLHG---------VNKSQTIIVSGESGAGKTEATKQIMRYFASSKSG----------------------------------------------------------------------------------------------------------------------------------------------------------------------NMDLRIQTAIMA--AN-----PVLEAFGNAKTIRNNNSSRFGRFMQLVISHE------GGIRYGSVVAFL-LEKSRIIT-QDDNERSYHIFYQFLKGANSTM-----------------------------------------KSKFGL---KGVT----------EYKLLN-------------PN---------------STEVSG----------VDDVKDFEEVIESLKNME----LSESDI-EVIFSIVAGILTLG-NVRLIEKQ------EAG--L-SDAAAIMD---EDMGVFNKACELMYLDPELIKREILIKVTVAGG--------TKIEGRWNKNDAEVLKSSLCKAMYEKLFLWI---------------------------IRHLNSRIEPEGG-------FKT-----------FMGMLDIFGFEVFK------NNSLEQLFINITNEMLQKN-FVDIVFERESKLYKDEGIS--TAELK-YTSN-KEVINVLCEK---------------------------------GK----SVLSYLEDQCLAP----------------GGTDEKFVSSCATNLKENN-------KFTPAKVASNK------------NFIIQHTI--GPIQYCAESFLL-KNKDVLRGDLVEVIKDSP-----------------NPIVQQLFEGQ------------------VIEKGK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------IAKGSLIGSQFL-----------------------NQLTSLMNLIN--STEPHFIRCIKPNENKKPL-----------------------------EWCEPKILIQLHALSILEAL----VLRQLGYSYRRTFEEFLYQYKF--VDIAAAEDSSVE------------------------NQNKCVNILKLS------------GLSESMYKIGKSMVF--------LKQEGAKILTKIQREK-*
Tg myoD -YGDIGG-LPHTN-EPCVLDFLARRYQS-KVIYTTAEPLIVAVNPFQDLKNAGP-----------------DTIALYR--DAPD-----------VDKLPPHVFYASRRAMTNMHQ---------LKKPQTIIVSGESGAGKTETTKMLMKYLATSAGG----------------------------------------------------------------------------------------------------------------------------------------------------------------------NLDLKIQTAIMA--AN-----PVLEAFGNAKTVRNNNSSRFGRFMLLDVARE------GGIQHGKVVAFL-LEKSRIVC-QDKDERNYHIFYQFLKGAPGHM-----------------------------------------RQRYML---QPLE----------AYTFIN-------------PH---------------CLDAPG----------IVDTEDFEQTVKSLESMN----MTETET-CTIWSIVSGVLLMG-NAKPTGKT------EAG--V-ENAACFVG---ESEAALRNACSLLFLDYPSILHELTVKTTYAGS--------NKIESRWTVPDSEMLRASLAKGMFEQLFLWI---------------------------IRKLNADIEPKGGS------FDV-----------FMGLLDIFGFEVFQ------NNSLEQLFINITNEVLQRN-FTDIVFEKELQLYSKEGIS--SKKIE-YTTN-EKLIETLLGK---------------------------------GT----SVLAALEDQCISP----------------SGTDEKFVSSLASKLAGNK-------CFIPSKNTKSL------------EFTVVHTI--GKVIYNADGFAF-KNKDVLRPEIIEITRAST-----------------NDVVRGLFEGV------------------KVEKGK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAKGMLIGSQFM-----------------------TQLKGLMEVIQ--KTESHFIRCIKPNDDKVPL-----------------------------KWVNSKVLIQLHALSILEAL----HLRQLAFSYRRTFEEFAAQFRF--INLGVSNKPGAD------------------------AKTICVELLKST------------SISADEYALGKTMVF--------LKPQAAKMLVRLQREA-*
Tg myoE -FPDIGL-LPHKN-CAAVLDFLKQRYLL-DLIYTTADPLLIAINPFKDLNNTTP-----------------EWLQLYR--DAPD-----------AEILAPHVFRLARTVLERLSA---------FMASQTIIVSGESGAGKTEATKQIMSYFAAGKRGE---------------------------------------------------------------------------------------------------------------------------------------------------------------------VSHQRIQNAVIA--AN-----PVLEAFGNAKTVRNNNSSRFGRFMQLQLGEK------GGIEYGSIRNFL-LEKVRVTS-QEQHERSYHIFYQLVKGADDAK-----------------------------------------RRQLHL---LNLE----------DYTYLS-------------KNG-------------GCYDCPG----------IDDVKDFKEMNKSLRSIG----LNLDDV-ESLWSIIAGVLLLG-NVHLESRE------TDG--Q-PNAAALTP---DGEATLQKCCALLFVDEEAVKKEILYKVKTIGD--------QQIESPNSLSDALMNRDSLAKAVYEKLFDWV---------------------------VRRVNATIEPPQG-------FGI-----------FMGMLDIFGFEMFE------NNSLEQLLINITNEQLQKN-FIQIVFARETKLYYEEGIG--NVKIT-WTDN-ENVIKALCGK---------------------------------SS----SVLAILEDKSLAP----------------GGTDEAIVTSMNQALKSSD-------VWKPGQKNPRI------------CFCICHTI--ADIQYDATGFIE-KNKDLLKPELCSIVQASS-----------------NNVAKELFEGV------------------VMQKGK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------IAKGQLIASQFM-----------------------RSLDALLTLIS--STESHFIRCLKPNETKNPH-----------------------------DWSNGKVLAQLFSLSILEAL----QLKNLSFSYRRPYADFLKQFEQ--LDLEVTRKSGN-------------------------AKEKTKQLLTRA------------NVPQAKWALGNTMVF--------MKPDAVRELTQKMRL--*
Tg myoB XIV --LPLRR-VRDTV-PRAEFGTRKSRFLR-SIIYTTAEPLLVAINPFKDLGNTTD-----------------AWISTYR--NASK-----------PEMLPPHVFKTARAALEDLEG---------YKKNQSIIVSGESGAGKTEATKQIMRFFASASS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------EVRTTIQDTIMA--GN-----PILEAFGNAKTIRNNNSSRFGRFMMLDVSSH------RGIQHGSISNFL-LEKVRVVS-QEANERSYHIFYQLLKGATSEM-----------------------------------------RAKYHL---RSLK----------EYAYLNG------------KNG-------------GCYDVPG----------IDDKADFEEVLQSLDAMQ----ITGSKR-HSVFSILSGLLLIG-NVSIEGKD------AQG--V-PDAAYISP---QSEEILEEACQLLSVDDAALKKEILVKSTKVGP--------QVIEGVRTKDEAKTSVLSLSKNVYDKLFDWL---------------------------VRQLNSLIDAPDG-------MPN-----------FIGILDIFGFEVLE------VNSLEQVLINITNEYLQKH-FIDVVFDMETKLYQAEGVP--TEALE-YTDN-LALVGALCGK---------------------------------ND----SFFALLEDACLGI----------------RSTDEGFCGTILRRLEPSG-------FFLESRRDKRL------------KFIIRHTI--ADIEYTCEGMLE-KNKDFLRKEVMDVMKAST-----------------DPVTKALFEGI------------------EIEAGK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------IGKGTLIASRFL-----------------------KNLEEMIGIVA--QTEAHFIRCLKPNEEKKPL-----------------------------GWNGSKVLNQLFSLSILEAL----QLRQVGYAYRRNFSEFCSHFRW--LDLGLVN-SDRD------------------------RKEVAHVLLEQS------------GIPESSWVIGKTMVF--------VKPDAAKELSILQRE--*
Tg myoC -VDDIGY-LPHTN-VACVLDVLKSRFLR-SIIYTTAEPLLVAINPFKDLGNTTD-----------------AWISTYR--NASK-----------PEMLPPHVFKTARAALEDLEG---------YKKNQSIIVSGESGAGKTEATKQIMRFFASASS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------EVRTTIQDTIMA--GN-----PILEAFGNAKTIRNNNSSRFGRFMMLDVSSH------RGIQHGSISNFL-LEKVRVVS-QEANERSYHIFYQLLKGATSEM-----------------------------------------RAKYHL---RSLK----------EYAYLNG------------KNG-------------GCYDVPG----------IDDKADFEEVLQSLDAMQ----ITGSKR-HSVFSILSGLLLIG-NVSIEGKD------AQG--V-PDAAYISP---QSEEILEEACQLLSVDDAALKKEILVKSTKVGP--------QVIEGVRTKDEAKTSVLSLSKNVYDKLFDWL---------------------------VRQLNSLIDAPDG-------MPN-----------FIGILDIFGFEVLE------VNSLEQVLINITNEYLQKH-FIDVVFDMETKLYQAEGVP--TEALE-YTDN-LALVGALCGK---------------------------------ND----SFFALLEDACLGI----------------RSTDEGFCGTILRRLEPSG-------FFLESRRDKRL------------KFIIRHTI--ADIEYTCEGMLE-KNKDFLRKEVMDVMKAST-----------------DPVTKALFEGI------------------EIEAGK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------IGKGTLIASRFL-----------------------KNLEEMIGIVA--QTEAHFIRCLKPNEEKKPL-----------------------------GWNGSKVLNQLFSLSILEAL----QLRQVGYAYRRNFSEFCSHFRW--LDLGLVN-SDRD------------------------RKEVAHVLLEQS------------GIPESSWVIGKTMVF--------VKPDAAKELSILQRE--*
Pf PfMB -SHRLND-MVHQN-SAEVLNTLALRYEK-NYIYTIAEPMLISVNPYQVIDTD---------------------MNEYK--NKS------------TDLLPPHVYTYAKDAMLDFIN---------TKNSQSIIISGESGSGKTEASKLVIKFYLSGVR-----------------------------------------------------------------------------------------------------------------------------------------------------------------------E-DNDISKTLWD--SN-----FILEAFGNAKTVKNNNSSRYGKYIKIQLDEN------QNIVSSSIEIFL-LEKIRVVS-QEPDERCYHIFYEILKGMNDEM-----------------------------------------KKKYKI---KSEE----------DYKYISN------------KS----------------INIPE----------IDDAKDFENLMISFDKMK----MS-DLK-DDLFLTLSGLLLLG-NIQFNGIE------KGG--K-SNCSELDD---ENLEVVNEASELLGIDYESLKNSLVITEKSIAN--------QKIEIPLSIEESLSICRSISKDIYNKIFEYI---------------------------TKRINNFLNNNKE-------LEN-----------FIGILDIFGFEIFV------KNSLEQLLINIANEEIHNI-YLFVVYEKESYLYKKEGPL--IESVK-YTNN-ESIIDLLRG----------------------------------NT----SIISILEDNCLAP----------------GKKDESIVSVYTNKFSKNE-------HYSVCKKNITE------------SFVIKHTV--SDVTYSISNFIS-KNKDILSPNILKLLKVSN-----------------NKLIQNLYDDA------------------EVTDS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------LGRKNLITYKYL-----------------------ENLKQICSYLK--STNIYFIKCIKPNETKEKN-----------------------------NFNPKKVYPQLFSLSIVETL----NIKYF-FQYKYTFASFLSYYQY--LDIAVSNDSSLD------------------------EKTKVTMLLER-------------NFDKDSYKVGHTMVF--------LKKEAVHKIRDIINSN-*
Tt MYO1 -YSDMVH-MKYLN-EAEIINNLRKRYQN-NMIFTYIGPTLVVMNPYKEIEGVQDNQVIDKIKSDLGIKFEEDFKMNNL--STNQ-----------NIINTPHTYTVSGLAYKQMFS---------NKKNQAIVISGESGAGKTENAKLSMQFLTSLKEF-----------------------------------------------------------------------------------------------------------------------------------------------------------------------NQFAIEVKILA--CN-----PILEAFGNAKTVRNNNSSRFGKYVKIYIDKTS-----QKINGASIDSYL-LEKSRIPC-PGKGERNYHIFYHMLKGNQELSN----------------------------------------LRLSQF---KNLS----------DFDYLKK------------SD---------------CFEVEN----------IQDAKLYLEVKKSFRQMN----FSNQEQ-EAIFSLISAILLLG-NANLDSSK------VSD--T-QAPTFLNMSLPTHHKEFKNASELLQVNPKDLEESLVFKVRKVGT--------TVIKSPQTAEECLSMRDSLSKNLYDSLFNFL---------------------------VWKLNQNLLPPQDL------LNKS---------LSIGLLDIFGFESFD------INSFEQLCINFTNEKFQQL-YVQYVFKSEEEDYKQEGILDVFSDLQ-YQEN-QLIIDTIEKK---------------------------------PN----GIMVLLDENCSLG----------------SGTDDSFLNQITKNHSKNQ-------LVSFPKKD-KY------------SFSLSHTA--KRVVYDVRGFRD-KNKDEVSTEVEKSLQSSK-----------------CPVIANLLSYQ------------------GSQTQQNKETQNLQNFGNNLNFKKAE----------------------------------------------------------------------------------------------------------------------------------------------ISNQMNSSKKNVKFLGQKFR-----------------------QSLQELMIELN--NSDVHFIRCIKPNEEKKKN-----------------------------FFKYDYVYQQVQYLGILDSI----KIRKVGYSYRMTYENFFLEYQE--LGQKTKGLTLQK------------------------VQQQKPIYLQNK------------QLPQKCVAFGKTKIF--------LKNEVMKILHEK-----*
Dd myoM -FSDMVE-IQDLS-EAIILNNLGLRYKS-DQIYTYIGNVLISINPYKEIKDIYS----------------LNILNKYK--DINT-----------IKSNPPHIYAVALRAYQSMVS---------EKKNQSIIISGESGSGKTEASKTILQYLINTSNSNSN----------------------------------------------------------------------------------------------------------------------------------------NNTNIN---------------------NNNNSIEKDILN--SN-----PILEAFGNSRTTKNHNSSRFGKFLKIEFRSSD-----MKIDGASIETYL-LEKSRISHRPDVNNLSYHIFYYLVMGASKEER----------------------------------------ERLGLD---NDPS----------KYRYLDASTSVIESFKKQSNGG-------------SGGGSGN----------NDLSESLQLVKQSLESMS----IAKEQC-DDIFLTLAAILHLG-NIEFEVDQ------TENEQT-SGFSKISEQKASVKKSLSMVSKLLGYPEQVFKQTLLNRNLKGGGRG------SVYCRPMEVYQSEQTRDALSKALYVRLFASI---------------------------VEKINVKFIQNTGS------KDLQGGYSSKRNNLFIGVLDIFGFENLS------SNSLDQLLINFTNEKLQQQ-FNLNVFENEQKDYLQEGIP--WSTSN-FIDN-KECIELFEKK---------------------------------SY----GLLSLLDDECMMP----------------KGSEVTLLEKYNKQYHNTN-------QYYQRTLAKG-------------TLGIKHFA--GDVTYQTDGWLE-KNRDSIPTEVEQLLSASS-----------------NNLIKSLFNLK------------------ELNKSNDNNSNNNNSNNNSSSSSSSQSTASITAKASPPRERFNSGSGSGTTSPLNLSGSSSP----------------------LSGSGS-----------------------------------------------------------------YSIIGGNSNSNSNNNNSSNNKKSQSVSVAGQFI-----------------------EQLNKLISTIN--STSVHYIRCIKPNVTMDCN-----------------------------NFNNSHVLSQLRNVGVLNTV----KVRKMGYSYRRDFIQFYSRYNC--ILNSLNIKINLTNINHSNLCKEILENVNSQYKNNNNNKNNNNQIVKIT------------TNSKPTFQIGKTKIF--------ISDELYIYLEKKRY---*
Gg FSk -IEDMAM-MTHLH-EPAVLYNLKERYAA-WMIYTYSGLFCVTVNPYKWLP-VYNPK----------------VVLAYR--GKK------------RQEAPPHIFSISDNAYQFMLTDR---------ENQSILITGESGAGKTVNTKRVIQYFATIAASGEK----------------------------------------------------------------------------------------------------------------------------------------KKEEQ-SG-------------------KMQGTLEDQIIS--AN-----PLLEAFGNAKTVRNDNSSRFGKFIRIHFGAT------GKLASADIETYL-LEKSRVTF-QLPAERSYHIFYQIMSNKKPEL-----------------------------------------IDMLLI--TTNPY----------DYHYVSEG----------------------------EITVPS----------IDDQEELMATDSAIDILG----FSADEK-TAIYKLTGAVMHYG-NLKFKQK-------QRE-----EQAEPDGT--E--VADKAAYLMG-LNSAELLKALCYPRVGVGN--------EAVTKGETVSEVHNSVGALAKAVYEKMFLWM---------------------------VIRINQQLDTK---------QPR---------QYFIGVLDIAGFEIFD------FNSFEQLCINFTNEKLQQF-FNHHMFVLEQEEYKKEGIE--WEFID-FGMDLAACIELIE-----------------------------------KPM---GIFSILEEECMFP----------------KATDTSFKNKLYDEHL-GK-----SNNFQKP-KPAK--------GKAEAHFSLVHYA--GTVDYNISGWLE-KNKDPLNETVIGLYQKSS-----------------VKTLALLFATYGG------------------EAE-G------G-GGKKG--------------------------------------------------------------------------------------------------------------------------------------------------------GKKKGSSFQTVSALFR-----------------------ENLNKLMANLR--STHPHFVRCIIPNETKTPG-----------------------------AMEHELVLHQLRCNGVLEGI----RICRKGFPSRVLYADFKQRYR---VLNAS----AIPEGQ--F----------------MDSKKASEKLLGGG----------DVDH--TQYAFGHTKVF--------FKAGL-LGLLEEMRD--*
Gg FSkE -IEDMAM-MTHLH-EPAVLYNLKERYAA-WMIYTYSGLFCVTVNPYKWLP-VYNPE----------------VVLAYR--GKK------------RQEAPPHIFSISDNAYQFMLTDR---------ENQSILITGESGAGKTVNTKRVIQYFATIAATGDK----------------------------------------------------------------------------------------------------------------------------------------KKEEQPAG-------------------KMQGTLEDQIIS--AN-----PLLEAFGNAKTVRNDNSSRFGKFIRIHFGAT------GKLASADIETYL-LEKSRVTF-QLKAERSYHIFYQIMSNKKPEL-----------------------------------------IEMLLI--TTNPY----------DYQYVSQG----------------------------EITVPS----------INDQEELMATDSAIDILG----FTPDEK-TAIYKLTGAVMHYG-NLKFKQK-------QRE-----EQAEPGGT--E--VADKAAYLMG-LNSADLLKALCYPRVKVGN--------EYVTKGQTVQQVYNSVGALAKSVFEKMFLWM---------------------------VVRINQQLDTK---------QPR---------QYFIGVLDIAGFEIFD------FNSLEQLCINFTNEKLQQF-FNHHMFVLEQEEYKKEGIE--WEFID-FGMDLAACIELIE-----------------------------------KPM---GIFSILEEECMFP----------------KATDTSFKNKLYDQHL-GK-----SNNFQKP-KPGK--------GKLEAHFSLVHYA--GTVDYNITGWLE-KNKDPLNETVVGLYQKSS-----------------LKTLALLFASVGG----------------A-EAESG------A-GGKKG--------------------------------------------------------------------------------------------------------------------------------------------------------GKKKGSSFQTVSALFR-----------------------ENLNKLMSNLR--STHPHFVRCLIPNETKTPG-----------------------------AMEHELVLHQLRCNGVLEGI----RICRKGFPIRILYADFKQRYK---VLNAS----AIPEGQ--F----------------IDSKKASEKLLGSI----------DVDH--TQYKFGHTKVF--------FKAGL-LGLLEEMRD--*
Hs Peri -IEDMAM-MTHLH-EPGVLYNLKERYAA-WMIYTYSGLFCVTVNPYKWLP-VYKPE----------------VVAAYR--GKK------------RQEAPPHIFSISDNAYQFMLTDR---------ENQSILITGESGAGKTVNTKRVIQYFATIAVTGEK----------------------------------------------------------------------------------------------------------------------------------------KKDES--G-------------------KMQGTLEDQIIS--AN-----PLLEAFGNAKTVRNDNSSRFGKFIRIHFGTT------GKLASADIETYL-LEKSRVTF-QLKAERSYHIFYQITSNKKPDL-----------------------------------------IEMLLI--TTNPY----------DYAFVSQG----------------------------EITVPS----------IDDQEELMATDSAIDILG----FTPEEK-VSIYKLTGAVMHYG-NMKFKQK-------QRE-----EQAEPDGT--E--VADKAAYLQS-LNSADLLKALCYPRVKVGN--------EYVTKGQTVQQVYNAVGALAKAVYEKMFLWM---------------------------VTRINQQLDTK---------QPR---------QYFIGVLDIAGFEIFD------FNSLEQLCINFTNEKLQQF-FNHHMFVLEQEEYKKEGIE--WTFID-FGMDLAACIELIE-----------------------------------KPL---GIFSILEEECMFP----------------KATDTSFKNKLYDQHL-GK-----SANFQKP-KVVK--------GKAEAHFSLIHYA--GTVDYNITGWLD-KNKDPLNDTVVGLYQKSA-----------------MKTLASLFSTYAS----------------A-EAD--------S-SAKKG--------------------------------------------------------------------------------------------------------------------------------------------------------AKKKGSSFQTVSALFR-----------------------ENLNKLMTNLR--STHPHFVRCIIPNETKTPG-----------------------------AMEHELVLHQLRCNGVLEGI----RICRKGFPSRILYGDFKQRYK---VLNAS----AIPEGQ--F----------------IDSKKASEKLLASI----------DIDH--TQYKFGHTKVF--------FKAGL-LGLLEEMRD--*
Hs FSkE -IEDMAM-LTHLN-EPAVLYNLKDRYTS-WMIYTYSGLFCVTVNPYKWLP-VYNPE----------------VVEGYR--GKK------------RQEAPPHIFSISDNAYQFMLTDR---------ENQSILITGESGAGKTVNTKRVIQYFATIAATGDL----------------------------------------------------------------------------------------------------------------------------------------AKKKD--S-------------------KMKGTLEDQIIS--AN-----PLLEAFGNAKTVRNDNSSRFGKFIRIHFGTT------GKLASADIETYL-LEKSRVTF-QLKAERSYHIFYQILSNKKPEL-----------------------------------------IELLLI--TTNPY----------DYPFISQG----------------------------EILVAS----------IDDREELLATDSAIDILG----FTPEEK-SGLYKLTGAVMHYG-NMKFKQK-------QRE-----EQAEPDGT--E--VADKTAYLMG-LNSSDLLKALCFPRVKVGN--------EYVTKGQTVDQVHHAVNALSKSVYEKLFLWM---------------------------VTRINQQLDTK---------LPR---------QHFIGVLDIAGFEIFE------YNSLEQLCINFTNEKLQQF-FNHHMFVLEQEEYKKEGIE--WTFID-FGMDLAACIELIE-----------------------------------KPM---GIFSILEEECMFP----------------KATDTSFKNKLYDQHL-GK-----SNNFQKP-KVVK--------GRAEAHFSLIHYA--GTVDYSVSGWLE-KNKDPLNETVVGLYQKSS-----------------NRLLAHLYATFAT----------------A-DAD--------S-GKKKV--------------------------------------------------------------------------------------------------------------------------------------------------------AKKKGSSFQTVSALFR-----------------------ENLNKLMSNLR--TTHPHFVRCIIPNETKTPG-----------------------------AMEHSLVLHQLRCNGVLEGI----RICRKGFPNRILYGDFKQRYR---VLNAS----AILEGQ--F----------------IDSKKACEKLLASI----------DIDH--TQYKFGHTKVF--------FKAGL-LGTLEEMRD--*
Rn FSkE -IEDMAM-LTHLN-EPAVLYNLKDRYTS-WMIYTYSGLFCVTVNPYKWLP-VYTPE----------------VVDGYR--GKK------------RQEAPPHIFSISDNAYQFMLTDR---------ENQSILITGESGAGKTVNTKRVIQYFATIAATGDL----------------------------------------------------------------------------------------------------------------------------------------AKKKD--S-------------------KMKGTLEDQIIS--AN-----PLLEAFGNAKTVRNDNSSRFGKFIRIHFGTT------GKLASADIETYL-LEKSRVTF-QLKAERSYHIFYQILSNKKPEL-----------------------------------------IELLLI--TTNPY----------DYPFISQG----------------------------EILVAS----------IDDREELLATDSAIDILG----FTPEEK-SGLYKLTGAVMHYG-NMKFKQK-------QRE-----EQAEPDGT--E--VADKTAYLMG-LNSSDLLKALCFPRVKVGN--------EYVTKGQTVDQVHHAVNALSKSVYEKLFLWM---------------------------VTRINQQLDTK---------LPR---------QHFIGVLDIAGFEIFE------YNSLEQLCINFTNEKLQQF-FNHHMFVLEQEEYKKEGIE--WTFID-FGMDLAACIELIE-----------------------------------KPM---GIFSILEEECMFP----------------KATDTSFKNKLYDQHL-GK-----SNNFQKP-KVVK--------GKAEAHFSLIHYA--GTVDYSVSGWLE-KNKDPLNETVVGLYQKSS-----------------NRLLAHLYATFAT----------------T-DAD--------G-GKKKV--------------------------------------------------------------------------------------------------------------------------------------------------------AKKKGSSFQTVSALFR-----------------------ENLNKLMSNLR--TTHPHFVRCIIPNETKTPG-----------------------------AMEHSLVLHQLRCNGVLEGI----RICRKGFPNRILYGDFKQRYR---VLNAS----AIPEGQ--F----------------IDSKKACEKLLASI----------DIDH--TQYKFGHTKVF--------FKAGL-LGTLEEMRD--*
Rn CaA -IEDMAM-LTFLH-EPAVLYNLKERYAA-WMIYTYSGLFCVTVNPYKWLP-VYNAE----------------VVAAYR--GKK------------RSEAPPHIFSISDNAYQYMLTDR---------ENQSILITGESGAGKTVNTKRVIQYFASIAAIGDR----------------------------------------------------------------------------------------------------------------------------------------SKKDNP-N-------------------ANKGTLEDQIIQ--AN-----PALEAFGNAKTVRNDNSSRFGKFIRIHFGAT------GKLASADIETYL-LEKSRVIF-QLKAERNYHIFYQILSNKKPEL-----------------------------------------LDMLLV--TNNPY----------DYAFVSQG----------------------------EVSVAS----------IDDSEELLATDSAFDVLG----FTAEEK-AGVYKLTGAIMHYG-NMKFKQK-------QRE-----EQAEPDGT--E--DADKSAYLMG-LNSADLLKGLCHPRVKVGN--------EYVTKGQSVQQVYYSIGALAKSVYEKMFNWM---------------------------VTRINATLETK---------QPR---------QYFIGVLDIAGFEIFD------FNSFEQLCINFTNEKLQQF-FNHHMFVLEQEEYKKEGIE--WEFID-FGMDLQACIDLIE-----------------------------------KPM---GIMSILEEECMFP----------------KATDMTFKAKLYDNHL-GK-----SNNFQKP-RNVK--------GKQEAHFSLVHYA--GTVDYNILGWLE-KNKDPLNETVVGLYQKSS-----------------LKLMATLFSTYAS----------------A-DTGD-------S-GKGKG--------------------------------------------------------------------------------------------------------------------------------------------------------GKKKGSSFQTVSALHR-----------------------ENLNKLMTNLR--TTHPHFVRCIIPNERKAPG-----------------------------VMDNPLVMHQLRCNGVLEGI----RICRKGFPNRILYGDFRQRYR---ILNPA----AIPEGQ--F----------------IDSGKGAEKLLGSL----------DIDH--NQYKFGHTKVF--------FKAGL-LGLLEEMRD--*
Ma CaA -IEDMAM-LTFLH-EPAVLYNLKERYAA-WMIYTYSGLFCVTVNPYKWLP-VYNAE----------------VVAAYR--GKK------------RSEAPAHIFSISDNAYQYMLTDR---------ENQSILITGESGAGKTVNTKRVIQYFASIAAIGDR----------------------------------------------------------------------------------------------------------------------------------------SKKDNP-N-------------------ANKGTLEDQIIQ--AN-----PALEAFGNAKTVRNDNSSRFGKFIRIHFGAT------GKLASADIETYL-LEKSRVIF-QLKAERNYHIFYQILSNKKPEL-----------------------------------------LDMLLV--TNNPY----------DYAFVSQG----------------------------EVSVAS----------IDDSEELLATDSAFDVLG----FTAEEK-AGVYKLTGAIMHYG-NMKFKQK-------QRE-----EQAEPDGT--E--DADKSAYLMG-LNSADLLKGLCHPRVKVGN--------EYVTKGQSVQQVYYSIGALGKSVYEKMFNWM---------------------------VTRINATLETK---------QPR---------QYFIGVLDIAGFEIFD------FNSFEQLCINFTNEKLQQF-FNHHMFVLEQEEYKKEGIE--WEFID-FGMDLQACIDLIE-----------------------------------KPM---GIMSILEEECMFP----------------KATDMTFKAKLYDNHL-GK-----SNNFQKP-RNVK--------GKQEAHFSLVHYA--GTVDYNILGWLE-KNKDPLNETVVGLYQKSS-----------------LKLMATLFSTYAS----------------A-DAGD-------S-GKGKG--------------------------------------------------------------------------------------------------------------------------------------------------------GKKKGSSFQTVSALHR-----------------------ENLNKLMTNLR--TTHPHFVRCIIPNERKAPG-----------------------------VMDNPLVMHQLRCNGVLEGI----RICRKGFPNRILYGDFRQRYR---ILNPA----AIPEGQ--F----------------IDSRKGAEKLLSSL----------DIDH--NQYKFGHTKVF--------FKAGL-LGLLEEMRD--*
Mm CaA -IEDMAM-LTFLH-EPAVLYNLKERYAA-WMIYTYSGLFCVTVNPYKWLP-VYNAE----------------VVAAYR--GKK------------RSEAPPHIFSISDNAYQYMLTDR---------ENQSILITGESGAGKTVNTKRVIQYFASIAAIGDR----------------------------------------------------------------------------------------------------------------------------------------SKKENP-N-------------------ANKGTLEDQIIQ--AN-----PALEAFGNAKTVRNDNSSRFGKFIRIHFGAT------GKLASADIETYL-LEKSRVIF-QLKAERNYHIFYQILSNKKPEL-----------------------------------------LDMLLV--TNNPY----------DYAFVSQG----------------------------EVSVAS----------IDDSEELLATDSAFDVLS----FTAEEK-AGVYKLTGAIMHYG-NMKFKQK-------QRE-----EQAEPDGT--E--DADKSAYLMG-LNSADLLKGLCHPRVKVGN--------EYVTKGQSVQQVYYSIGALAKSVYEKMFNWM---------------------------VTRINATLETK---------QPR---------QYFIGVLDIAGFEIFD------FNSFEQLCINFTNEKLQQF-FNHHMFVLEQEEYKKEGIE--WEFID-FGMDLQACIDLIE-----------------------------------KPM---GIMSILEEECMFP----------------KAADMTFKAKLYDNHL-GK-----SNNFQKP-RNVK--------GKQEAHFSLVHYA--GTVDYNIMGWLE-KNKDPLNETVVGLYQKSS-----------------LKLMATLFSTYAS----------------A-DTGD-------S-GKGKG--------------------------------------------------------------------------------------------------------------------------------------------------------GKKKGSSFQTVSALHR-----------------------ENLNKLMTNLK--TTHPHFVRCIIPNERKAPG-----------------------------VMDNPLVMHQLRCNGVLEGI----RICRKGFPNRILYGDFRQRYR---ILNPA----AIPEGQ--F----------------IDSRKGAEKLLGSL----------DIDH--NQYKFGHTKVF--------FKAGL-LGLLEEMRD--*
Hs CaA -IEDMAM-LTFLH-EPAVLFNLKERYAA-WMIYTYSGLFCVTVNPYKWLP-VYNAE----------------VVAAYR--GKK------------RSEAPPHIFSISDNAYQYMLTDR---------ENQSILITGESGAGKTVNTKRVIQYFASIAAIGDR----------------------------------------------------------------------------------------------------------------------------------------GKKDNA-N-------------------ANKGTLEDQIIQ--AN-----PALEAFGNAKTVRNDNSSRFGKFIRIHFGAT------GKLASADIETYL-LEKSRVIF-QLKAERNYHIFYQILSNKKPEL-----------------------------------------LDMLLV--TNNPY----------DYAFVSQG----------------------------EVSVAS----------IDDSEELMATDSAFDVLG----FTSEEK-AGVYKLTGAIMHYG-NMKFKQK-------QRE-----EQAEPDGT--E--DADKSAYLMG-LNSADLLKGLCHPRVKVGN--------EYVTKGQSVQQVYYSIGALAKAVYEKMFNWM---------------------------VTRINATLETK---------QPR---------QYFIGVLDIAGFEIFD------FNSFEQLCINFTNEKLQQF-FNHHMFVLEQEEYKKEGIE--WTFID-FGMDLQACIDLIE-----------------------------------KPM---GIMSILEEECMFP----------------KATDMTFKAKLYDNHL-GK-----SNNFQKP-RNIK--------GKPEAHFSLIHYA--GTVDYNILGWLE-KNKDPLNETVVGLYQKSS-----------------LKLMATLFSSYAT----------------A-DTGD-------S-GKSKG--------------------------------------------------------------------------------------------------------------------------------------------------------GKKKGSSFQTVSALHR-----------------------ENLNKLMTNLR--TTHPHFVRCIIPNERKAPG-----------------------------VMDNPLVMHQLRCNGVLEGI----RICRKGFPNRILYGDFRQRYR---ILNPV----AIPEGQ--F----------------IDSRKGAEKLLSSL----------DIDH--NQYKFGHTKVF--------FKAGL-LGLLEEMRD--*
Rn CaB -IEDMAM-LTFLH-EPAVLYNLKERYAS-WMIYTYSGLFCVTVNPYKWLP-VYNAQ----------------VVAAYR--GKK------------RSEAPPHIFSISDNAYQYMLTDR---------ENQSILITGESGAGKTVNTKRVIQYFAVIAAIGDR----------------------------------------------------------------------------------------------------------------------------------------SKKDQ--T-------------------PGKGTLEDQIIQ--AN-----PALEAFGNAKTVRNDNSSRFGKFIRIHFGAT------GKLASADIETYL-LEKSRVIF-QLKAERDYHIFYQILSNKKPEL-----------------------------------------LDMLLI--TNNPY----------DYAFFSQG----------------------------ETTVAS----------IDDSEEHMATDSAFDVLG----FTPEEK-NSIYKLTGAIMHFG-NMKFKQK-------QRE-----EQAEPDGT--E--EADKSAYLMG-LNSADLLKGLCHPRVKVGN--------EYVTKGQNVQQVAYAIGALAKSVYEKMFNWM---------------------------VTRINATLETK---------QPR---------QYFIGVLDIAGFEIFD------FNSFEQLCINFTNEKLQQF-FNHHMFVLEQEEYKKEGIE--WTFID-FGMDLQACIDLIE-----------------------------------KPM---GIMSILEEECMFP----------------KATDMTFKAKLYDNHL-GK-----SNNFQKP-RNIK--------GKQEAHFSLIHYA--GTVDYNILGWLQ-KNKDPLNETVVGLYQKSS-----------------LKLLSNLFANYAG----------------A-DAP--------V-DKGKG--------------------------------------------------------------------------------------------------------------------------------------------------------KAKKGSSFQTVSALHR-----------------------ENLNKLMTNLR--STHPHFVRCIIPNETKSPG-----------------------------VMDNPLVMHQLRCNGVLEGI----RICRKGFPNRILYGDFRQRYR---ILNPA----AIPEGQ--F----------------IDSRKGAEKLLGSL----------DIDH--NQYKFGHTKVF--------FKAGL-LGLLEEMRD--*
Ma CaB -IEDMAM-LTFLH-EPAVLYNLKDGYAS-WMIYTYSGLFCVTVNPYKWLP-VYNAE----------------VVAAYR--GKK------------RSEAPAHIFSISDNAYQYMLTDR---------ENQSILITGESGAGKTVNTKRVIQYFAVIAAIGDR----------------------------------------------------------------------------------------------------------------------------------------SKKDQ--T-------------------PGKGTLEDQIIQ--AN-----PALEAFGNAKTVRNDNSSRFGKFIRIHFGAT------GKLASADIETYL-LEKSRVIF-QLKAERDYHIFYQILSNKKPEL-----------------------------------------LDMLLI--TNNPY----------DYAFIPQG----------------------------ETTVAS----------IDDSEELMATDSAFDVLG----FTSEEK-NSIYKLTGAIMHFG-NMKFKQK-------QRE-----EQADRDGT--E--EEDKSAYLMG-LNSADLLKGMCHPRVKVGN--------EYVTKGQNVQQVSYAIGALAKSVYEKMFNWM---------------------------VTRINATLETK---------QPR---------QYFIGVLDIAGFEIFD------FNSFEQLCINFTNEKLQQF-FNHHMFVLEQEEYKKEGIE--WTFID-FGMDLQACIDLIE-----------------------------------KPM---RIMSILEEECMFP----------------KATDMTFKAKLYDNHL-GK-----SNNFQKP-RNVK--------GKQEAHFSLVHYA--GTVDYNILGWLQ-KNKDPLNETVVGLYQKSS-----------------LKLLSNLFANYAG----------------A-DAP--------V-DKGKG--------------------------------------------------------------------------------------------------------------------------------------------------------KAKKGSSFQTVSVLHR-----------------------ENLNKLMTNLR--STHPHFVRCIIPNETKSPG-----------------------------VMDNPLVMHQLRCNGVLEGI----RICRKGFPNRILYGDFRQRYR---ILNPA----AIPEGQ--F----------------IDSRKGAEKLLSSL----------DIDH--NQYKFGHTKVF--------FKAGL-LGLLEEMRD--*
Hs CaB -IEDMAM-LTFLH-EPAVLYNLKERYGS-WMIYTYSGLFCVTVNPYKWLP-VYTPE----------------VVAAYR--GKK------------RSEAPPHIFSISDNAYQYMLTDR---------ENQSILITGESGAGKTVNTKRVIQYFAVIAAIGDR----------------------------------------------------------------------------------------------------------------------------------------SKKDQ--S-------------------PGKGTLEDQIIQ--AN-----PALEAFGNAKTVRNDNSSRFGKFIRIHFGAT------GKLASADIETYL-LEKSRVIF-QLKAERDYHIFYQILSNKKPEL-----------------------------------------LDMLLI--TNNPY----------DYAFISQG----------------------------ETTVAS----------IDDAEELMATDNAFDVLG----FTSEEK-NSMYKLTGAIMHFG-NMKFKLK-------QRE-----EQAEPDGT--E--EADKSAYLMG-LNSADLLKGLCHPRVKVGN--------EYVTKGQNVQQVIYATGALAKAVYERMFNWM---------------------------VTRINATLETK---------QPR---------QYFIGVLDIAGFEIFD------FNSFEQLCINFTNEKLQQF-FNHHMFVLEQEEYKKEGIE--WTFID-FGMDLQACIDLIE-----------------------------------KPM---GIMSILEEECMFP----------------KATDMTFKAKLFDNHL-GK-----SANFQKP-RNIK--------GKPEAHFSLIHYA--GIVDYNIIGWLQ-KNKDPLNETVVGLYQKSS-----------------LKLLSTLFANYAG----------------A-DAP--------I-EKGKG--------------------------------------------------------------------------------------------------------------------------------------------------------KAKKGSSFQTVSALHR-----------------------ENLNKLMTNLR--STHPHFVRLYHPNETKSPG-----------------------------VMDNPLVMHQLRCNGVLEGI----RICRKGFPNRILYGDFRQRYR---ILNPA----AIPEGQ--F----------------IDSRKGAEKLLSSL----------DIDH--NQYKFGHTKVF--------FKAGL-LGLLEEMRD--*
Ai II -LEDMAN-MTYLN-EASVLYNLRSRYTS-GLIYTYSGLFCIAVNPYRRLP-IYTDS----------------VIAKYR--GKR------------KTEIPPHLFSVADNAYQNMVTDR---------ENQSCLITGESGAGKTENTKKVIMYLAKVACAVKK----------------------------------------------------------------------------------------------------------------------------------------KDEEAS-D-------------------KKEGSLEDQIIQ--AN-----PVLEAYGNAKTTRNNNSSRFGKFIRIHFGPT------GKIAGADIETYL-LEKSRVTY-QQSAERNYHIFYQICSNAIPEL-----------------------------------------NDVMLV--TPDSG----------LYSFINQG----------------------------CLTVDN----------IDDVEEFKLCDEAFDILG----FTKEEK-QSMFKCTASILHMG-EMKFKQR-------PRE-----EQAESDGT--A--EAEKVAFLCG-INAGDLLKALLKPKVKVGT--------EMVTKGQNMNQVVNSVGALAKSLYDRMFNWL---------------------------VRRVNKTLDTK---------AKR---------NYYIGVLDIAGFEIFD------FNSFEQLCINYTNERLQQF-FNHHMFILEQEEYKKEGIA--WEFID-FGMDLQMCIDLIE-----------------------------------KPM---GILSILEEECMFP----------------KADDKSFQDKLYQNHM-GK-----NRMFTKPGKPTRP-------NQGPAHFELHHYA--GNVPYSITGWLE-KNKDPINENVVALLGASK-----------------EPLVAELFKAPEE----------------P-AGG------------GKK--------------------------------------------------------------------------------------------------------------------------------------------------------KKGKSSAFQTISAVHR-----------------------ESLNKLMKNLY--STHPHFVRCIIPNELKQPG-----------------------------LVDAELVLHQLQCNGVLEGI----RICRKGFPSRLIYSEFKQRYS---ILAPN----AIPQG---F----------------VDGKTVSEKILAGL----------QMDP--AEYRLGTTKVF--------FKAGV-LGNLEEMRD--*
Sm II -IEDMAN-LTHLN-DASVLENLRARYYR-QLIYTYSGLFCVAVNPYKRFP-IYTEQ----------------VALKYK--GKR------------RGEMPPHIFSISDNAYHNMLQDR---------ENQSILITGESGAGKTENTKKVISYFAVVAAASKK----------------------------------------------------------------------------------------------------------------------------------------EDDDSS----------------------KKGTLEDQIVQ--AN-----PVLEAYGNAKTTRNNNSSRFGKFIRIHFGTT------GKIAGADIEHYL-LEKSRVVS-QMKGERNYHIFYQLLSTYGSKY-----------------------------------------HDKLLV--QTDPA----------LYSFINQG----------------------------ELTIDG----------VDDSEEMKLCDEAFEVLG----FNDDEK-LSLFKCTTSICNMG-EMKFKQR-------PRE-----EQAEADGT--A--EAEKVAFLLG-VNAKDLLTSFLKPKVKVGT--------EFVTKGQNLNQVTYAVSALAKSLYNRMFGWL---------------------------VARVNKTLDTK---------VKR---------QFFIGVLDIAGFEIFT------ENGFEQICINYTNERLQQF-FNHHMFVLEQEEYKREKIQ--WTFID-FGMDLQACIDLIE-----------------------------------KPM---GILSILEEECIVP----------------KASDQTFLSKLYDNHL-GK-----SPNFTKP-KPPKP-------GHVEAHFELHHYA--GSVPYTITGWLE-KNKDPLNDSVVALLGDSK-----------------DPLVSNLFTPVVG----------------E-PG------------------------------------------------------------------------------------------------------------------------------------------------------------------------KKTKGGSFLTVTYMHR-----------------------ESLNKLMKNLQ--STSPSFIRCIVPNEFKQPG-----------------------------VIDAHLVLHQLHCNGVLEGI----RICRKGFPNRMIYSEFKQRYS---ILAPN----VIPDG---F----------------VDGRQVTEKILEAT----------QLDK--NLYQCGNTKVF--------FKAGT-LAHLEDLRD--*
Dm II -AEDMSN-LTYLN-DASVLHNLRQRYYN-KLIYTYSGLFCVAINPYKRYP-VYTNR----------------CAKMYR--GKR------------RNEVPPHIFAISDGAYVDMLTNH---------VNQSMLITGESGAGKTENTKKVIAYFATVGASKKT----------------------------------------------------------------------------------------------------------------------------------------DEAAK-----------------------SKGSLEDQVVQ--TN-----PVLEAFGNAKTVRNDNSSRFGKFIRIHFGPT------GKLAGADIETYL-LEKARVIS-QQSLERCYHIFYQIMSGSVPGV-----------------------------------------KEMCFL--SDNIY----------DYYNVSQG----------------------------KVTVPN----------MDDGEEFQLADQAFDILG----FTKQEK-EDVYRITAAVMHMG-GMKFKQR-------GRE-----EQAEQDGE--E--EGGRVSKLFG-CDTAELYKNLLKPRIKVGN--------EFVTQGRNVQQVTNSIGALCKGVFDRLFKWL---------------------------VKKCNETLDTQ---------QKR---------QHFIGVLDIAGFEIFE------YNGFEQLCINFTNEKLQQF-FNHHMFVLEQEEYKREGID--WAFID-FGMDLLACIDLIE-----------------------------------KPM---GILSILEEESMFP----------------KATDQTFSEKLTNTHL-GK-----SAPFQKP-KPPKP-------GQQAAHFAIAHYA--GCVSYNITGWLE-KNKDPLNDTVVDQFKKSQ-----------------NKLLIEIFADHAG----------------Q-SGGG-------E-QAKGG--------------------------------------------------------------------------------------------------------------------------------------------------------RGKKGGGFATVSSAYK-----------------------EQLNSLMTTLR--STQPHFVRCIIPNEMKQPG-----------------------------VVDAHLVMHQLTCNGVLEGI----RICRKGFPNRMMYPDFKMRYQ---ILNPA----GIVG----V----------------DDPKKCGSIILEST----------ALDP--DMYRIGHTKVF--------FRAGV-LGQMEEFRD--*
Ce IIB -TEDMSN-LSFLN-DASVLHNLRSRYAA-MLIYTYSGLFCVVINPYKRLP-IYTDS----------------CARMFM--GKR------------KTEMPPHLFAVSDEAYRNMLQDH---------ENQSMLITGESGAGKTENTKKVICYFAAVGASQQEGG--------------------------------------------------------------------------------------------------------------------------------------AEVDP--N-------------------KKKVTLEDQIVQ--TN-----PVLEAFGNAKTVRNNNSSRFGKFIRIHFNKH------GRLASCDIEHYL-LEKSRVIR-QAPGERCYHIFYQIYSDFRPEL-----------------------------------------KKELLL--DLPIK----------DYWFVAQA----------------------------ELIIDG----------IDDVEEFQLTDEAFDILN----FSAVEK-QDCYRLMSAHMHMG-NMKFKQR-------PRE-----EQAEPDGT--V--EAEKASNMYG-IGCEEFLKALTKPRVKVGT--------EWVSKGQNCEQVNWAVGAMAKGLYSRVFNWL---------------------------VKKCNLTLDQKG--------IDR---------DYFIGVLDIAGFEIFD------FNSFEQLWINFVNEKLQQF-FNHHMFVLEQEEYAREGIQ--WVFID-FGLDLQACIELIE-----------------------------------KPL---GIISMLDEECIVP----------------KATDLTLASKLVDQHL-GK-----HPNFEKP-KPPKG-------KQGEAHFAMRHYA--GTVRYNCLNWLE-KNKDPLNDTVVSAMKQSKG----------------NDLLVEIWQDYTT----------------QEEAAAK------A-KEGGGGG-----------------------------------------------------------------------------------------------------------------------------------------------------KKKGKSGSFMTVSMLYR-----------------------ESLNNLMTMLN--KTHPHFIRCIIPNEKKQSG-----------------------------MIDAALVLNQLTCNGVLEGI----RICRKGFPNRTLHPDFVQRYA---ILAAK----EAKS----D----------------DDKKKCAEAIMSKLVNDG------SLSE--EMFRIGLTKVF--------FKAGV-LAHLEDIRD--*
Ce IID -TEDMSN-LTFLN-DASVLWNLRSRYAA-MLIYTYSGLFCVVINPYKRLP-IYTDS----------------VARMFM--GKR------------RTEMPPHLFAVSDQAYRYMLQDH---------ENQSMLITGESGAGKTENTKKVICYFATVGASQK-----------------------------------------------------------------------------------------------------------------------------------------AALKE--G-------------------EKEVTLEDQIVQ--TN-----PVLEAFGNAKTVRNNNSSRFGKFIRIHFNKH------GTLASCDIEHYL-LEKSRVIR-QAPGERCYHIFYQIYSDFKPQL-----------------------------------------RDELLL--NHPIS----------NYWFVAQA----------------------------ELLIDG----------IDDTEEFQLTDEAFDVLK----FSPTEK-MDCYRLMSAHMHMG-NMKFKQR-------PRE-----EQAEPDGQ--V--EAERACNMYG-IDVVQFLKALVSPRVKVGT--------EWVSKGQNVDQVHWAIGAMAKGLYARVFHWL---------------------------VKKCNLTLDQKG--------IDR---------DYFIGVLDIAGFEIFD------FNSFEQLWINFVNEKLQQF-FNHHMFVLEQEEYAREGIQ--WTFID-FGLDLQACIELIE-----------------------------------KPL---GIISMLDEECIVP----------------KATDMTLAQKLTDQHL-GK-----HPNFEKP-KPPKG-------KQGEAHLAMRHYA--GTVRYNVLNWLE-KNKDPLNDTVVSVMKASKK----------------NDLLVEIWQDYTT----------------QEEAAAA------A-KAGGG-------------------------------------------------------------------------------------------------------------------------------------------------------RKGGKSGSFMTVSMMYR-----------------------ESLNKLMTMLH--KTHPHFIRCIIPIEKKQSG-----------------------------MIDAALVLNQLTCNGVLEGI----RICRKGFPNRTQHPDFVQRYA---ILAAK----EAKS----S----------------DDMKTCAGAILQALINQK------QLND--EQFRIGHTKVF--------FKAGV-VAHIEDLRD--*
Ov II -TEDMSN-LTFLN-DASVLYNLRSRYSA-MLIYTYSGLFCVVINPYKRLP-IYTNS----------------VATMYM--GKR------------RTEMPPHLFAVSDEAYRNMLVDH---------ENQSMLITGESGAGKTENTKKVIAYFAVVGASQN-----------------------------------------------------------------------------------------------------------------------------------------KGQDQ--G-------------------EKKVTLEDQIVQ--TN-----PVLEAFGNAKTVRNNNSSRFGKFIRIHFSKQ------GKVASCDIEHYL-LEKSRVIR-QAPGERCYHIFYQVFSDFNPTL-----------------------------------------KKDLLL--DQPLK----------NYYFVAQA----------------------------ELTIDG----------VNDKEEHQLTDEAFDILN----FSPEEK-MNCYRLVAAIMHMG-CMKFKQR-------PRE-----EQAEPDGT--D--EADKASNMYG-IDTEEFLKALTKPRVKVGT--------EWVSKGQNVDQVTWDVGAMANLLYDRIFKWL---------------------------VTKCNKTLDQKG--------LTR---------DYFIGVLDIAGFEIFD------FNSFEQLWINFVNEKLQQF-FNHHMFVLEQEEYEREGIQ--WTFID-FGLDLQACIELIE-----------------------------------KPM---GIISMLDEECIVP----------------KATDLTLAQKLVDTHL-GK-----HPNFEKP-KPPKG-------KQSEAHFAMKHYA--GTVRYNVMNWLE-KNKDPLNDTVVSVMKQSKA----------------NDLLVEIWKDYTT----------------QEESAAA------K-DGGGG-------------------------------------------------------------------------------------------------------------------------------------------------------KKKGKSGSFLTVSMMYR-----------------------ESLNSLMSMLN--MTHPHFIRCIIPNHNKTSG-----------------------------LLHRRMVLNQLTCNGVLEGI----RICRKGFPNRNLHADFKQRYA---VLAAK----EAKS----E----------------DDPKKCAEVMLSKLVNDG------ALTE--ENFRLGKTKVF--------FKAGV-LAHLEDQRD--*
Bm II -TEDMSN-LTFLN-DASVLYNLRSRYSS-MLIYTYSGLFCVVINPYKRLP-IYTDS----------------VATMYM--GKR------------RTEMPPHLFAVSDEAYRNMLVDH---------ENQSMLITGESGAGKTENTKKVIAYFAVVGASQN-----------------------------------------------------------------------------------------------------------------------------------------K--NQ--G-------------------EKKVTLEDQIVQ--TN-----PVLEAFGNAKTVRNNNSSRFGKFIRIHFSRQ------GKVASCDIEHYL-LEKSRVIR-QAPGERCYHIFYQIFSEFNPTL-----------------------------------------KKELQL--DQPLK----------NYYFVAQA----------------------------ELTIDG----------VNDKEEHQLTDEAFDILN----FSPEEK-MNCYRLVAAIMHMG-CMKFKQR-------PRE-----EQAEPDGT--D--EAEKASAMYG-IDTEEFLKALTKPRVKVGT--------EWVSKGQNVDQVTWAVGAMAKGLYARIFKWL---------------------------VNKCNKTLDQKG--------ISR---------DYFIGVLDIAGFEIFD------FNSFEQLWINFVNEKLQQF-FNHHMFVLEQEEYEREGIQ--WTFID-FGLDLQACIELIE-----------------------------------KPM---GIISMLDEECIVP----------------KATDLTLAQKLVDNHL-GK-----HPNFEKP-KPPKG-------KQSERHFAMKHYA--GTVRYNVMNWLE-KNKDPLNDTVVSTMKASKT----------------NDLLVEIWQDYTT----------------QEERAAA------K-DGGGG-------------------------------------------------------------------------------------------------------------------------------------------------------KKKGKSGSFLTVSMMYR-----------------------ESLNSLMSMLN--MTHPHFIRCIIPNEKKTSG-----------------------------LLDAALVLNQLTCNGALEGI----RICRKGFPNRNLHADFKQRYA---VLAAK----EAKS----E----------------DDPKKSAEVMLSKLVNDG------ALTE--ENFRLGKTKVF--------FKAGV-LAHLEDLRD--*
Ce IIC -TEDMSN-LTFLN-DASVLYNLKARYAA-MLIYTYSGLFCVVINPYKRLP-IYTES----------------VARMFM--GKR------------RTEMPPHLFAVSDEAYRNMLQNH---------ENQSMLITGESGAGKTENTKKVISYFAAVGAAQQETFGAK-------KAA-------------------------------------------------------------------------------------------------------------------------TEEDK--N-------------------KKKVTLEDQIVQ--TN-----PVLEAFGNAKTVRNNNSSRFGKFIRIHFSKQ------GRVASCDIEHYL-LEKSRVIR-QAPGERSYHIFYQVFSDYLPNL-----------------------------------------KKDLLL--NKPVK----------DYWFIAQA----------------------------ELIIDG----------INDKEEHQLTDEAFDILK----FTPTEK-MECYRLVAAMMHMG-NMKFKQR-------PRE-----EQAEPDGT--D--DAERAAKCFG-IDSEEFLKALTRPRVKVGN--------EWVNKGQKIEQVNWAVGAMAKGLYSRIFNWL---------------------------VKKCNQTLDQKG--------ISR---------DHFIGVLDIAGFEIFD------FNSFEQLWINFVNEKLQQF-FNHHMFVLEQEEYAREGIQ--WTFID-FGLDLQACIELIE-----------------------------------KPL---GIIAMLDEECIVP----------------KATDLTLAQKLIDQHL-GK-----HPNFEKP-KPPKG-------KQAEAHFAMRHYA--GTVRYNCLNWLE-KNKDPLNDTVVTVMKASKE----------------HALIVEVWQDYTT----------------QEEAAAA------A-AKGTAGA-----------------------------------------------------------------------------------------------------------------------------------------------------KKKGKSGSFMTVSMLYR-----------------------ESLNKLMTMLH--STHPHFIRCIIPNEKKASG-----------------------------VIDAGLVLNQLTCNGVLEGI----RICRKGFPNRTLHPDFVQRYA---LLAAD----ESIIG---K----------------TDAKKGSALMLARLVKEK------KLEE--ENFRVGLTKVF--------FKAGI-VAHLEDLRD--*
Ce F58G4.1 -TEDMAN-LTFLN-DASVLHNLRQRYYS-MMIYTYSGLFCVVINPYKRLP-IYSES----------------VCQMYL--GKR------------RNEMPPHLFAVSDEAYRNMTNDR---------ENQSMLITGESGAGKTENTKKVISYFAMVGASQQSNK--------------------------------------------------------------------------------------------------------------------------------------KKSKK--D-------------------KAQVSLEDQIVQ--TN-----PVLEAFGNAKTVRNNNSSRFGKFIRIHFNTG------GKVAGADIEHYL-LEKSRVIK-QAPGERSYHIFYQIYSDAVKGL-----------------------------------------REKLFL--TRPIK----------EYTFVSQA----------------------------EVTIDG----------VDDKEEMLITDEAFDIMK----FTATEK-SELFAITAGIMHMG-ELKFKQR-------PRE-----EQAELEEG--K--EGELACKLYC-VESEKFINALLKPRVKVGT--------EWVNKGQNLDQVNWAVGALAKALFARMFSWL---------------------------IRRCNKTLDAQD--------LSR---------DFFIGVLDIAGFEIFD------LNSFEQLWINFVNEKLQQF-FNHHMFVLEQEEYKREGIQ--WEFID-FGLDLQACIELIE-----------------------------------KPL---GIVSMLDEECIVP----------------KASDLTLASKLNDQHL-GK-----HPNFQKP-RPPKG-------KQAEAHLAIVHYA--GTVRYNVKGWLE-KNKDPLNDTAVTVLKANKG----------------NQLMADLWADYAT----------------QEDVAAA------A-KDGKKAVG----------------------------------------------------------------------------------------------------------------------------------------------------KKKGKSASFMTVSMMYR-----------------------ESLNKLMHMLH--QTHPHFIRCIIPNELKKAG-----------------------------MIDANLVLNQLTCNGVLEGI----RICRKGFPNRMPFLDFKQRYA---VLAAD----AAKA----G----------------KDPKDAGEKISAALIKDG------SLKQ--EEFQCGLTKVF--------FKAGV-LAHLEELRD--*
Ce IIA -TEDMAN-LTFLN-EASVLGNLKDRYKD-LMIYTYSGLFCVVINPYKRLP-IYSES----------------VIKHFM--GKR------------RNEMPPHLFAVSDEAYRNMVQDK---------ENQSMLITGESGAGKTENTKKVISYFAIVGATQAASG--------------------------------------------------------------------------------------------------------------------------------------KEAKD--G-------------------KKGGTLEEQIVQ--TN-----PVLEAFGNAKTVRNNNSSRFGKFIRTHFSGS------GKLAGGDIEHYL-LEKSRVVR-QAPGERCYHIFYQIMSGNDPSL-----------------------------------------RGKLKL--SNDIT----------YYHFCSQA----------------------------ELTIEG----------MDDKEEMRLTQEAFDIMG----FEDNET-MDLYRSTAGIMHMG-EMKFKQR-------PRE-----EQAEPDGE--E--DALNAAAMLG-IQAEEFLKALTKPRVRVGT--------EWVNKGQNLEQVNWAVSGLAKAIYARMFKWI---------------------------ITRCNKTLDAKE--------IER---------KHFIGVLDIAGFEIFD------LNSFEQLWINFVNERLQQF-FNHHMFVLEQEEYKREGIA--WTFID-FGLDLQACIELIE-----------------------------------KPL---GIISILDEECIVP----------------KATDMTYAQKLLDQHL-GK-----HPNFQKP-KPPKG-------KQGDAHFAIVHYA--GTVRYNATNFLE-KNKDPLNDTAVALLKHSTD----------------NSLMLDIWQDYQT----------------QEEAAEA------A-KAGQTAG-----------------------------------------------------------------------------------------------------------------------------------------------------GKRGKSSSFATVSMIYR-----------------------ESLNNLMNMLY--QTHPHFIRCIIPNEKKASG-----------------------------VIDSALVLNQLTCNGVLEGI----RICRKGFPNRMLYPDFKHRYA---ILAAD----AAKE---------------------SDPKKASVGILDKISVDG------NLTD--EEFKVGETKIF--------FKAGV-LAKLEDLRD--*
Ce F45G2.2 -TEDMSN-LTFLN-EASVLHNLRQRYYS-MMIYTYSGLFCVFINPYKMLP-IYTDS----------------VASMYV--NKR------------RAEMPPHLFAVSDEAFRNMMSDK---------ENQSMLITGESGAGKTENTKKVIAYFAMIGSGNK--------------------------------------------------------------------------------------------------------------------------------------------D---Q-------------------KSESSLENQVVQ--AN-----PAIEAFGNGATTRNYNSSRYGKFIRIHFDRK------GKLVGGDIEHYL-LEKSRVIK-QAPGERSYHIFYQIMT--QKAL-----------------------------------------RERYGL--SDNIR----------DYKFVSQA----------------------------EITVPG----------MNDTEEWQITDGAFNVMG----FSEREK-DDLYKLCSAIMHIG-NSTFKQK-------PRD-----EQAEVDDM--T--SPTAACKLFG-INTDQFLNALTRPRIKVGM--------EWVNKGQNVQQVDWAVGALSKAIYARMFNWL---------------------------IKRVNKTLQANS--------DEM---------VYYIGVLDIAGFEIFD------RNSFEQLWINFVNEKLQQF-FNHHMFVLEQEEYQREGIE--WTFID-FGLDLQSCIELIE-----------------------------------KPL---GIVSMLDEECIVP----------------KASDMTYVDKLLTQHL-GK-----HPNFQKA-KPPKG-------KQAEAHFSIMHYA--GTVRYNAEQWLD-KNKDPLNDSAVAILKTSDK----------------EGVLYQLWEEYQT----------------DVDREES------E-KRGKAQA-----------------------------------------------------------------------------------------------------------------------------------------------------KKKGKSASFLTVSTMYR-----------------------ESLTSLMTMLH--TTHPHFIRCIIPNEKKTSG-----------------------------LIDAPLVLNQLTCNGVLEGI----RICRKGFPNRMMFADFRFRYA---ILAAD----EASD---------------------KDAAKASKAMLRKLSKNN------QLNV--DTFKVGTTKFR--------LDIPM-REHSVN-----*
Gg smII -VEDMAE-LTCLN-EASVLHNLRERYFS-GLIYTYSGLFCVVINPYKQLP-IYSEK----------------IIDMYK--GKK------------RHEMPPHIYAIADTAYRSMLQDR---------EDQSILCTGESGAGKTENTKKVIQYLAVVASSHKG----------------------------------------------------------------------------------------------------------------------------------------KRTPASL----------------KVHLFPYGELEKQLLQ--AN-----PILEAFGNAKTVKNDNSSRFGKFIRINFDVT------GYIVGANIETYL-LEKSRAIR-QAKDERTFHIFYYLIAGASEQM-----------------------------------------RNDLLL--EG-FN----------NYTFLSNG----------------------------HVPIPA----------QQDDEMFQETLEAMTIMG----FTEEEQ-TSILRVVSSVLQLG-NIVFKKE-------RNT-----DQASMPDN--T--AAQKVCHLMG-INVTDFTRSILTPRIKVGR--------DVVQKAQTKEQADFAIEALAKAKFERLFRWI---------------------------LTRVNKALDKTK--------RQG---------ASFLGILDIAGFEIFE------INSFEQLCINYTNEKLQQL-FNHTMFILEQEEYQREGIE--WNFID-FGLDLQPCIELIE-----------------------------------RPTNPPGVLALLDEECWFP----------------KATDTSFVEKLIQEQ--GN-----HAKFQKS-KQLK----------DKTEFCILHYA--GKVTYNASAWLT-KNMDPLNDNVTSLLNQSS-----------------DKFVADLWKDVDR----------------IVGLDQM------AKMTESSLPS----------------------------------------------------------------------------------------------------------------------------------------------------ASKTKKGMFRTVGQLYK-----------------------EQLTKLMTTLR--NTNPNFVRCIIPNHEKRAG-----------------------------KLDAHLVLEQLRCNGVLEGI----RICRQGFPNRIVFQEFRQRYE---ILAAN----AIPKG---F----------------MDGKQACILMIKAL----------ELDP--NLYRIGQSKIF--------FRTGV-LAHLEEERD--*
Oc smII -VEDMAE-LTCLN-EASVLHNLRERYFS-GLIYTYSGLFCVVVNPYKQLP-IYSEK----------------IVDMYK--GKK------------RHEMPPHIYAIADTAYRSMLQDR---------EDQSILCTGESGAGKTENTKKVIQYLAVVASSHKG----------------------------------------------------------------------------------------------------------------------------------------KKDTS-----------------------ITGELEKQLLQ--AN-----PILEAFGNAKTVKNDNSSRFGKFIRINFDVT------GYIVGANIETYL-LEKSRAIR-QAREERTFHIFYYLIAGAKEKM-----------------------------------------RNDLLL--EG-FN----------NYTFLSNG----------------------------FVPIPA----------AQDDEMFQEKVEAMSIMG----FSEEEQ-LSVLKVVSSVLQLG-NIVFKKE-------RNT-----DQASMPDN--T--AAQKVCHLMG-INVTDFTRSILTPRIKVGR--------DVVQKAQTKEQADFAVEALAKATYERLFRWI---------------------------LSRVNKALDKTH--------RQG---------ASFLGILDIAGFEIFE------VNSFEQLCINYTNEKLQQL-FNHTMFILEQEEYQREGIE--WNFID-FGLDLQPCIELIE-----------------------------------RPNNPPGVLALLDEECWFP----------------KATDKSFVEKLCTEQ--GN-----HPKFQKP-KQLK----------DKTEFSIIHYA--GKVDYNASAWLT-KNMDPLNDNVTSLLNASS-----------------DKFVADLWKDVDR----------------IVGLDQM------AKMTESSLPS----------------------------------------------------------------------------------------------------------------------------------------------------ASKTKKGMFRTVGQLYK-----------------------EQLGKLMTTLR--NTTPNFVRCIIPNHEKRSG-----------------------------KLDAFLVLEQLRCNGVLEGI----RICRQGFPNRIVFQEFRQRYE---ILAAN----AIPKG---F----------------MDGKQACILMIKAL----------ELDP--NLYRIGQSKIF--------FRTGV-LAHLEEERD--*
Gg nmII -VEDMAE-LTCLN-EASVLHNLKERYYS-GLIYTYSGLFCVVINPYKNLP-IYSEE----------------IVEMYK--GKK------------RHEMPPHIYAITDTAYRSMMQDR---------EDQSILCTGESGAGKTENTKKVIQYLAHVASSHKS----------------------------------------------------------------------------------------------------------------------------------------KKDQ--------------------------GELERQLLQ--AN-----PILEAFGNAKTVKNDNSSRFGKFIRINFDVN------GYIVGANIETYL-LEKSRAIR-QAKEERTFHIFYYLLSGAGEHL-----------------------------------------KTDLLL--EP-YN----------KYRFLSNG----------------------------HVTIPG----------QQDKDMFQETMEAMRIMG----IPDEEQ-IGLLKVISGVLQLG-NIVFKKE-------RNT-----DQASMPDN--T--AAQKVSHLLG-INVTDFTRGILTPRIKVGR--------DYVQKAQTKEQADFAIEALAKATYEQMFRWL---------------------------VMRINKALDKTK--------RQG---------ASFIGILDIAGFEIFE------LNSFEQLCINYTNEKLQQL-FNHTMFILEQEEYQNEGIE--WNFID-FGLDLQPCIDLIE-----------------------------------KPAGPPGILALLDEECWFP----------------KATDKSFVEKVVQEQ--GT-----HPKFQKP-KQLK----------DKADFCIIHYA--GKVDYKADEWLM-KNMDPLNDNIATLLHQSS-----------------DKFVSELWKDVDR----------------IVGLDQV------AGMSETALPG----------------------------------------------------------------------------------------------------------------------------------------------------AFKTRKGMFRTVGQLYK-----------------------EQLAKLMATLR--NTNPNFVRCIIPNHEKKAG-----------------------------KLDPHLVLDQLRCNGVLEGI----RICRQGFPNRVVFQEFRQRYE---ILTPN----AIPKG---F----------------MDGKQACVLMIKAL----------ELDS--NLYRIGQSKVF--------FRAGV-LAHLEEERD--*
Hs nmIIA -VEDMAE-LTCLN-EASVLHNLKERYYS-GLIYTYSGLFCVVINPYKNLP-IYSEE----------------IVEMYK--GKK------------RHEMPPHIYAITDTAYRSMMQDR---------EDQSILCTGESGAGKTENTKKVIQYLAYVASSHKS----------------------------------------------------------------------------------------------------------------------------------------KKDQ--------------------------GELERQLLQ--AN-----PILEAFGNAKTVKNDNSSRFGKFIRINFDVN------GYIVGANIETYL-LEKSRAIR-QAKEERTFHIFYYLLSGAGEHL-----------------------------------------KTDLLL--EP-YN----------KYRFLSNG----------------------------HVTIPG----------QQDKDMFQETMEAMRIMG----IPEEEQ-MGLLRVISGVLQLG-NIVFKKE-------RNT-----DQASMPDN--T--AAQKVSHLLG-INVTDFTRGILTPRIKVGR--------DYVQKAQTKEQADFAIEALAKATYERMFRWL---------------------------VLRINKALDKTK--------RQG---------ASFIGILDIAGFEIFD------LNSFEQLCINYTNEKLQQL-FNHTMFILEQEEYQREGIE--WNFID-FGLDLQPCIDLIE-----------------------------------KPAGPPGILALLDEECWFP----------------KATDKSFVEKVMQEQ--GT-----HPKFQKP-KQLK----------DKADFCIIHYA--GKVDYKADEWLM-KNMDPLNDNIATLLHQSS-----------------DKFVSELWKDVDR----------------IIGLDQV------AGMSETALPG----------------------------------------------------------------------------------------------------------------------------------------------------AFKTRKGMFRTVGQLYK-----------------------EQLAKLMATLR--NTNPNFVRCIIPNHEKKAG-----------------------------KLDPHLVLDQLRCNGVLEGI----RICRQGFPNRVVFQEFRQRYE---ILTPN----SIPKG---F----------------MDGKQACVLMIKAL----------ELDS--NLYRIGQSKVF--------FRAGV-LAHLEEERD--*
Rn neurII -VEDMAE-LTCLN-EASVLHNLKERYYS-GLIYTYSGLFCVVINPYKNLP-IYSEE----------------IVEMYK--GKK------------RHEMPPHIYAITDTAYRSMMQDR---------EDQSILCTGESGAGKTENTKKVIQYLAHVASSHKS----------------------------------------------------------------------------------------------------------------------------------------KKDQ--------------------------GELERQLLQ--AN-----PILEAFGNAKTVKNDNSSRFGKFIRINFDVN------GYIVGANIETYL-LEKSRAIR-QAKEERTFHIFYYLLSGAGEHL-----------------------------------------KTDLLL--EP-YG----------KYRFLSNG----------------------------HVTIPG----------QQDKDMFQETMEAMRIMG----IPDEEQ-IGLLKVISGVLQLG-NIVFKKE-------RNT-----DQASMPDN--T--AAQKVSHLLG-INVTDFTRGILTPRIKVGR--------DYVQKAQTKEQADFAIEALAKATYEQMFRWL---------------------------VMRINKALDKTK--------RQG---------ASFIGILDIAGFEIFE------LNSFEQLCINYTNEKLQQL-FNHTMFIE-QEEYQREGIE--WNFID-FGLDLQPCIDLIE-----------------------------------RPANPPGVLALLDEECWFP----------------KATDKTFVEKLVQEQ--GT-----HSKFQKP-RQLK----------DKADFCIIHYA--GKVDYKGDEWLM-KNMDPLNDNVATLLHQSS-----------------DKFVAELWKDVDR----------------IVGLDQV------TGITETAFGS----------------------------------------------------------------------------------------------------------------------------------------------------AYKTKKGMFRTVGQLYK-----------------------ESLTKLMATLR--NTNPNFVRCIIPNHEKRAG-----------------------------KLDPHLVLDQLRCNGVLEGI----RICRQGFPNRIVFQEFRQRYE---ILTPN----AIPKG---F----------------MDGKQACERMIRAL----------ELDP--NLYRIGQSKIF--------FRAGV-LAHLEEERD--*
Hs nmIIB -VEDMAE-LTCLN-EASVLHNLKDRYYS-GLIYTYSGLFCVVINPYKNLP-IYSEN----------------IIEMYR--GKK------------RHEMPPHIYAISESAYRCMLQDR---------EDQSILCTGESGAGKTENTKKVIQYLAHVASSHKG----------------------------------------------------------------------------------------------------------------------------------------RKDHNIP-----------------------GELERQLLQ--AN-----PILESFGNAKTVKNDNSSRFGKFIRINFDVT------GYIVGANIETYL-LEKSRAVR-QAKDERTFHIFYQLLSGAGEHL-----------------------------------------KSDLLL--EG-FN----------NYRFLSNG----------------------------YIPIPG----------QQDKDNFQETMEAMHIMG----FSHEEI-LSMLKVVSSVLQFG-NISFKKE-------RNT-----DQASMPEN--T--VAQKLCHLLG-MNVMEFTRAILTPRIKVGR--------DYVQKAQTKEQADFAVEALAKATYERLFRWL---------------------------VHRINKALDRTK--------RQG---------ASFIGILDIAGFEIFE------LNSFEQLCINYTNEKLQQL-FNHTMFILEQEEYQREGIE--WNFID-FGLDLQPCIDLIE-----------------------------------RPANPPGVLALLDEECWFP----------------KATDKTFVEKLVQEQ--GS-----HSKFQKP-RQLK----------DKADFCIIHYA--GKVDYKADEWLM-KNMDPLNDNVATLLHQSS-----------------DRFVAELWKDVDR----------------IVGLDQV------TGMTETAFGS----------------------------------------------------------------------------------------------------------------------------------------------------AYKTKKGMFRTVGQLYK-----------------------ESLTKLMATLR--NTNPNFVRCIIPNHEKRAG-----------------------------KLDPHLVLDQLRCNGVLEGI----RICRQGFPNRIVFQEFRQRYE---ILTPN----AIPKG---F----------------MDGKQACERMIRAL----------ELDP--NLYRIGQSKIF--------FRAGV-LAHLEEERD--*
Xl nmII -VEDMAE-LTCLN-EASVLHNLKDRYYS-GLIYTYSGLFCVVINPYKNLP-IYSEN----------------IIEMYR--GKK------------RHEMPPHIYAISESAYRCMLQDR---------EDQSILCTGESGAGKTENTKKVIQYLAHVASSHKG----------------------------------------------------------------------------------------------------------------------------------------KKDHTIPTESPKAIKH-------QSGSLLYGELERQLLQ--AN-----PILESFGNAKTVKNDNSSRFGKFIRINFDVT------GYIVGANIETYL-LEKSRAVR-QAKDERTFHIFYQLLAGSGEHL-----------------------------------------KSDLLL--DG-FN----------NYRFVSNG----------------------------YIPIPG----------QQDKDNFQETMEAMHIMG----FSHEEI-LSMLKVVSSVLQFG-NIVFKKE-------RNT-----DQASMPEN--T--AAQKLCHLLG-LNIMEFTRAILTPRIKVGR--------DYVQKAQTKEQADFAVEALRKATYERLFRWL---------------------------VYRINKALDRTK--------RQG---------ASFIGILDIAGFEIFE------LNSFEQLCINYTNEKLQQL-FNHTMFILEQEEYQREGIE--WNFID-FGLDLQPCIDLIE-----------------------------------RPANSPGVLALLDEECWFP----------------KATDKTFVDKLVQEQ--GT-----HSKFQKP-RQLK----------DKADFCIIHYA--GRVDYKADEWLL-KNMDPLNDNVATLLHQSS-----------------DKFVSELWKDVDR----------------IVGLDQV------AGMAETAFGA----------------------------------------------------------------------------------------------------------------------------------------------------AYKTKKGMFRTVGQLYK-----------------------ESLAKLMATLR--NTNPNFVRCIIPNHEKRAG-----------------------------KLDPHLVLDQLRCNGVLEGI----RICRQGFPNRIVFQEFRQRYE---ILTPN----SIPRG---F----------------MDGKQACERMIRSL----------ELDP--NLYRIGQSKIF--------FRAGV-LAHLEEERD--*
Dm nmII -VEDMAE-LTCLN-EASVLHNIKDRYYS-GLIYTYSGLFCVVVNPYKKLP-IYTEK----------------IMERYK--GIK------------RHEVPPHVFAITDSAYRNMLGDR---------EDQSILCTGESGAGKTENTKKVIQFLAYVAASKPK----------------------------------------------------------------------------------------------------------------------------------------GSGAVPHP------------------AVLIGELEQQLLQ--AN-----PILEAFGNAKTVKNDNSSRFGKFIRINFDAS------GFISGANIETYL-LEKSRAIR-QAKDERTFHIFYQLLAGATPEQ-----------------------------------------REKFIL--DD-VK----------SYAFLSNG----------------------------SLPVPG----------VDDYAEFQATVKSMNIMG----MTSEDF-NSIFRIVSAVLLFG-SMKFRQE-------RNN-----DQATLPDN--T--VAQKIAHLLG-LSVTDMTRAFLTPRIKVGR--------DFVTKAQTKEQVEFAVEAIAKACYERMFKWL---------------------------VNRINRSLDRTK--------RQG---------ASFIGILDMAGFEIFE------LNSFEQLCINYTNEKLQQL-FNHTMFILEQEEYQREGIE--WKFID-FGLDLQPTIDLID-----------------------------------KPG---GIMALLDEECWFP----------------KATDKTFVDKLVSAH--SM-----HPKFMKT--DFR----------GVADFAIVHYA--GRVDYSAAKWLM-KNMDPLNENIVSLLQGSQ-----------------DPFVVNIWKDAE-----------------IVGMAQQ------A-LTDTQFG------------------------------------------------------------------------------------------------------------------------------------------------------ARTRKGMFRTVSHLYK-----------------------EQLAKLMDTLR--NTNPNFVRCIIPNHEKRAG-----------------------------KIDAPLVLDQLRCNGVLEGI----RICRQGFPNRIPFQEFRQRYE---LLTPN----VIPKG---F----------------MDGKKACEKMIQAL----------ELDS--NLYRVGQSKIF--------FRAGV-LAHLEEERD--*
Ce NMY1 -IEDMSE-LTYLN-EASVLHNLKDRYYS-SLIYTYSGLFCVVINPYKKLP-IYSED----------------LIEEFK--GKK------------RHEMPPHIFAIADTAYRSMLQER---------EDQSILCTGESGAGKTENTKKVIQYLAHVAGATRN----------------------------------------------------------------------------------------------------------------------------------------KSLNAAAQQN----------------IVQKGELEHQLLQ--AN-----PILEAFGNSKTVKNDNSSRFGKFIRINFDMS------GYISGANIEFYL-LEKSRVLR-QAQDERSFHIFYQILRGCSAKE-----------------------------------------KSEYLL--EG-VD----------NYRFLVNR----------------------------GITLPN----------VDDVQEFHSTINSMRIMG----FADDEI-SSIMRVVSAVLLLG-NLEFTQE-------KKS-----DQAMLQDD--R--VIQKVCHLLG-LPVIELQKAFLRPRIKVGR--------EFVNKAQNQEQAEFAVEAIAKASYERLFKWL---------------------------VTRINKSLDRTH--------RQG---------ASFIGILDIAGFEIFD------INSFEQICINYTNEKLQQL-FNNTMFILEQEEYQREGIE--WDFID-FGLDLQPTIDLIE-----------------------------------KPM---GVLALLDEECLFP----------------KANDKSFVEKLQKTH--NK-----HPKFIVP--DMR----------SKSHFAVVHYA--GRVDYSADQWLM-KNMDPLNENVVGLMQNST-----------------DPFVAGIWKDAE-----------------FAGICAA------E-MNETAFG------------------------------------------------------------------------------------------------------------------------------------------------------MRSRKGMFRTVSQLHK-----------------------EQLTKLMTTLR--NTSPHFVRCIIPNHEKKSG-----------------------------KINSNLVLEQLRCNGVLEGI----RICRQGFPNRVPFQEFRHRYE---ILTPD----VIPKN---F----------------IDGKESVRKMITAL----------DIDT--NLYRIGQSKVF--------FRTGV-LAHLEEERD--*
Ce NMY2 -CEDMSM-LTCLN-EASVLHNLKQRYFS-NLYYTYSGLFCVVINPYKRIP-IYTDT----------------IAEQFK--CKK------------RKEMPPHIFAVADEAYRSMLQER---------DDQSILCTGESGAGKTENTKKVIQYLAYVANRSMV----------------------------------------------------------------------------------------------------------------------------------------KNRKTSVDLDTSTN-------------RIMGQLEEQLLQ--AN-----PILEAFGNSKTVKNDNSSRFGKFIRVHFDST------GCISGANIEFYL-LEKSRVLK-QAPNERSFHIFYQLLKGLSKVQ-----------------------------------------REHYLL--EDSLS----------KYKFVSNG----------------------------DSKLAG----------VDDGAEMKETLNAMSIMG----LNDEEI-GGILRVVSAVMLFG-NLEFSHEN------KNN-----DQAVLLND--A--VAQKIASLLG-VNVTELMRAFLKPKIKVQR--------DLVHRAQSVDQVNFSVGAIAKASYERLFRWL---------------------------VHRLNKSLDRTR--------QQS---------VSFIGILDIAGFEIFE------TNSFEQLCINYTNEKLQQL-FNNTMFVREQQEYLDEGLE--WKFLD-FGLNLQPTIDLID-----------------------------------KPM---GIMSTLDDVCLFP----------------QGNDQSFVQRLNNTH--SQ-----HPKYVVP--EIR----------SRSDFAVVHYA--GRVDYQSEGWRV-KNMDPLNENVIDVLKTSK-----------------ESLIVDMWKDIAD----------------VCSLSAA------DSTSDTGVFG----------------------------------------------------------------------------------------------------------------------------------------------------SRVPKKGMFRTVSQLYK-----------------------EQLARLMSTLN--NTNPHFVRCIIPNHEKKHG-----------------------------VLNAHLVLDQLRCNGVLEGI----RICRQGFPTRLPFQEFRQRYEK--LLAPD----VNPAG---F----------------MDGKNAVYRIVQYL----------EVDA--NLFRIGQSKIF--------FRSGV-IAEFEEMRD--*
Dd II -VEDMSE-LSYLN-EPAVFHNLRVRYNQ-DLIYTYSGLFLVAVNPFKRIP-IYTQE----------------MVDIFK--GRR------------RNEVAPHIFAISDVAYRSMLDDR---------QNQSLLITGESGAGKTENTKKVIQYLASVAGRNQAN-------------------------------------------------------------------------------------------------------------------------------------------------------------------GSGVLEQQILQ--AN-----PILEAFGNAKTTRNNNSSRFGKFIEIQFNNA------GFISGASIQSYL-LEKSRVVF-QSETERNYHIFYQLLAGATAEE-----------------------------------------KKALHL--AG-PE----------SFNYLNQS---------------------------GYVDIKG----------VSDSEEFKITRQAMDIVG----FSQEEQ-MSIFKIIAGILHLG-NIKFEKG--------AG-----EGAVLKDK--T--ALNAASTVFG-VNPSVLEKALMEPRILAGR--------DLVAQHLNVEKSSSSRDALVKALYGRLFLWL---------------------------VKKINNVLCQE---------RK----------AYFIGVLDISGFEIFK------VNSFEQLCINYTNEKLQQF-FNHHMFKLEQEEYLKEKIN--WTFID-FGLDSQATIDLIDG---------------------------------RQPP---GILALLDEQSVFP----------------NATDNTLITKLHSHFS-KK-----NAKYEEPRFSKT-------------EFGVTHYA--GQVMYEIQDWLE-KNKDPLQQDLELCFK-DSS----------------DNVVTKLFNDPN-----------------IAS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------RAKKGANFITVAAQYK-----------------------EQLASLMATLE--TTNPHFVRCIIPNNKQLPA-----------------------------KLEDKVVLDQLRCNGVLEGI----RITRKGFPNRIIYADFVKRYY---LLAPN----VPRD----A----------------EDSQKATDAVLKHLN----------IDP--EQYRFGITKIF--------FRAGQ-LARIEEARE--*
Ac II -VEDMGE-LGYLN-EPAVLHNLKKRYDA-DLFHTYSGLFLVVVNPYKRLP-VYTPE----------------IIDIYR--GRQ------------RDKVAPHIFAISDAAYRAMLNTR---------QNQSMLITGESGAGKTENTKKVIQYLTAIAGRAEG----------------------------------------------------------------------------------------------------------------------------------------------------------------------GLLEQQLLE--FN-----PILEAFGNAKTTKNNNSSRFGKFIELQFNAG------GQITGANTFIYL-LEKSRVTA-QGAGERNFHIFYQILSKAMPEEL----------------------------------------KQKLKL--TK-PE----------DYFFLNQN---------------------------ACYTVDD----------MDDAKEFDHMLKAFDILN----INEEER-LAIFQTISAILHLG-NLPFIDV--------NS-----ETAGLKDE--V--ELNIAAELLG-VSAAGLKAGLLSPRIKAGN--------EWVTRALNKPKAMASRDALCKALFGRLFLWI---------------------------VQKINRILSHK---------DKT---------ALWIGVLDISGFEIFQ------HNSFEQLCINYTNEKLQQF-FNHHMFTLEQQEYEREKID--WTFVD-YGMDSQDCIDLIE----------------------------------KKPM---GILPLLDEQTVFP----------------DADDTSFTKKLFQTHE-N------HRNFRRPRFDAN-------------NFKIVHYA--GEVEYQTSAWLE-KNRDPLEDDLSNLCK-KSS----------------VRFVTGLFDEDL-----------------MPSFKAAPAEEEKAAAGGSRNRST---------------------------------------------------------------------------------------------------------------------------------------------------GRGKGGAQFITVAFQYK-----------------------EQLAHLMSMLS--STAPHFIRCIIPNLGKKPG-----------------------------VVSDQLVLDQLKCNGVLEGI----RIARKGWPNRLKYDEFLKRYF---LLKPG----ATPT----S----------------PSTKDAVKDLIEHLIAKE----PTKVNK--DEVRFGVTKIF--------FRSGQ-LAAIEELRE--*
Eh II -VDDMSQ-LTHLS-EATVLYNLRIRYME-DIIHTYSGLFCVVINPYKFFP-IYTPF----------------IVSKYQ--GRR------------REDVAPHVYAIADGAYRAMLDPASKF------RNQSILITGESGAGKTENTKRVIQFLAMTAGQSKKAG------------------------------------------------------------------------------------------------------------------------------------------------------------------QLGELEEQLID--LN-----PMLEAFGNAKTVKNNNSSRFGKFIEIQFSNG------GKIVGCIMSSYL-LEKSRVVY-QAREDRNYHIFYQLLAGATAQQ-----------------------------------------KSEMHL--DR-PE----------SYKLIYQNK-----------------------KSPQELNVEY----------MDDAEEFKNTIKAMRTMN----ITDDEQ-NQIFKIVAGMLHLG-NVEYSQG--------R------DGAELANP--E--TFRKAAELFG-VDAESLRKAIIQPKIKAGL--------EIIERHLSKEEAEFNTTATLKAIYHRLFVFI---------------------------VNKVNEVMGKA---------G-----------AHSIGILDIAGFEIFR------ENSFEQLCINLTNEKLQQF-FNNHMFNLEQLEYQNEGIP--WTHQN-FGDDLQPVIDLIES---------------------------------KIPA---GILAMLDEQSFVA----------------SGSDENFHANICNTFG-RG-----HPRFRKPRIGGDG----------VYEFDILHYA--GTVTYNAKDWVK-KNRDPLERDIQQVFIGKDS----------------SSLISRLFRITEG----------------IAG------------SSGDDMGTG---------------------------------------------------------------------------------------------------------------------------------------------------KGSSKAAKFLTVGSNHK-----------------------AQLEELMRKLK--MTNPHFIRCILPNTQKKQR-----------------------------YFVDSTVLKQLRCNGVLEGI----RITRMGYPNRMIYSEFLKRYY---FLGDK----INRR----A----------------SDEKATASTLMRQIIEKYKKDGQPRAKE--GDYRFCKTKIF--------FRVGI-LAEIEEVRE--*
Sc MyoI IIA -VENMSE-LTHLN-EPSVLYNLEKRYDC-DLIYTYSGLFLVAINPYHNLN-LYSED----------------HINLYH--NKHNRLSKSRLDENSHEKLPPHIFAIAEEAYENLLSEG---------KDQSILVTGESGAGKTENTKKILQYLASITSGSPS----------------------------------------------------------------------------------------------------------------------------------------NIAPVSGS-------------------SIVESFEMKILQ--SN-----PILESFGNAQTVRNNNSSRFGKFIKIEFNEH------GMINGAHIEWYL-LEKSRIVH-QNSKERNYHIFYQLLSGLDDSEL----------------------------------------KNLRLK--SRNVK----------DYKILSNS---------------------------NQDIIPG----------INDVENFKELLSALNIIG----FSKDQI-RWIFQVVAIILLIG-NIEFVSD--------RA-----EQASFKN------DVSAICSNLG-VDEKDFQTAILRPRSKAGK--------EWVSQSKNSQQAKFILNALSRNLYERLFGYI---------------------------VDMINKNLDHG---------SAT---------LNYIGLLDIAGFEIFE------NNSFEQLCINYTNEKLQQF-FNNHMFVLEQSEYLKENIQ--WDYID-YGKDLQLTIDLIES---------------------------------KGPP--TGVLPLLDEEAVLP----------------KSTDESFYSKLISTWD-QN-----SSKFKRS--RLK------------NGFILKHYA--GDVEYTVEGWLS-KNKDPLNDNLLSLLSSSQ-----------------NDIISKLFQPEGE----------------KSSSAG------VEANISNQE--V---------------------------------------------------------------------------------------------------------------------------------------------------KKSARTSTFKTTSSRHR-----------------------EQQITLLNQLA--STHPHFVRCIIPNNVKKVK-----------------------------TFNRRLILDQLRCNGVLEGI----RLAREGYPNRIAFQEFFQRYR---ILYPE----NSTTTT--FSSKLK-----------ASTKQNCEFLLTSL----------QLDT--KVYKIGNTKLF--------FKAGV-LADLEKQKD--*
Ce Y11D7A.14 --EDLCT-LTQPN-AATVLNALKIRYTS-NVIHTFCGLFCVVINPWRNIP-IYSDE----------------VKQLYQ--LQN--------------DLPPHVYSVAQNAFHGILKGG---------RNQSILITGESGAGKTENTKKIIDFILSSSVSNN------------------------------------------------------------------------------------------------------------------------------------------------------------------------TIGDCVVT--SG-----VLLEAMGNARTTHNSNSSRFGKFIRIEFDEN------SKLIGAKIECYL-LEKSRVVF-QSDGDRNFHIFYQMLSNYFDNPH----------------------------------------KSFLKL--SKKVN----------EYKYLRND-------------------------------DSM----------IDDAETAKMTDEAFTRIG----LSEEEK-IWIFQILSAVLWIG-DIKFGER-------SGL-----DVSFVESM--Q--EVDNIAELLE-MKSSKLVDALTQPTIKVHD--------KLIRKNQNLAKTLSSASAMAKILYERLFGWI---------------------------VKRCNDAFSVDD--------TESTCRL-----SRFIAVLDIAGFEIIE------KNSFEQFCINYTNEKLQQF-FNHFMFAKEQSDYLEEGIK--WTQVN-FANHLQPTIDLIE-----------------------------------KPM---GILSFLEEECVVP----------------NGSEKSLLEKLCSNLS-N------DSSFKKS-KQTQK-------CSTIRHFYVQHYA--GEVHYNIDGWLD-KNRDNVETSVLDILSQST-----------------HPLLKLLFPPVPV----------------N-NLK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------TRRGTITNSTVSFLYK-----------------------NQLQCLLDTLN--SSSAHFIRCVVSNYEKLPG-----------------------------KIDAPLVLAQLKCNGVLEGI----RICREGYPSRLSHSEFIERYSL--LMKNK----EQSKG--------------------ASEKEKCTLICQDA----------QVRK--ERYAVGKTKLF--------CKVGV-ISELETKRN--*
Ss VI -VEDNCS-LMYLN-EATLLHNIKVRYSK-DRIYTYVANILIAVNPYFDIPKIYSSE----------------TIKSYQ--GKS------------LGTMPPHVFAIADKAFRDMKV---------LKLSQSIIVSGESGAGKTENTKFVLRYLTESYG------------------------------------------------------------------------------------------------------------------------------------------TGQ------------------------------DIDDRIVE--AN-----PLLEAFGNAKTVRNNNSSRFGKFVEIHFNEK------SSVVGGFVSHYL-LEKSRICV-QGKEERNYHIFYRLCAGASED-----------------------------------------IRERLH---LSSPD----------NFRYLNR-----------GCTRYFANKETDKQILQNRKSPEYLKAGSLKDPLLDDHGDFIRMCTAMKKIG----LDDEEK-LDLFRVVAGVLHLG-NIDFEEAG------STS-----GGCNLKNK--STQALEYCAEKLLGLDQDDLRVSLTTRVMLTTAGG---AKGTVIKVPLKVEQANNARDALAKTVYSHLFDHV---------------------------VNRVNQCFPFE---------TSS----------YFIGVLDIAGFEYF------EHNSFEQFCINYCNEKLQQF-FNERILKEEQELYQKEGLG--VNEVH-YVDN-QDCIDLIEA----------------------------------RL---VGILDILDEENRLP----------------QPSDQHFTSAGHQK--HKD-----HFRLSIPRKSKLA--IHR-NIAYDEGFIIRHFA--GAVCYETTQFVE-KNNDALHMSLESLICES-----------------RDKFIRELFESST--------------NNNKDTKQKAG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------KL-SFISVGNKFK-----------------------TQLNLLLDKLR--STGASFIRCIKPNLKMTSH-----------------------------HFEGAQILSQLQCSGMVSVL----DLMQGGFPSRASFHEVYNMYK---KSLPD----KL------AR--L-------------DPRLFCKALFKALG---------LNE---IDYKFGLTKVF--------FRPGK-FAEFDQIMK--*
Hs VI -VEDNCS-LMYLN-EATLLHNIKVRYSK-DRIYTYVANILIAVNPYFDIPKIYSSE----------------AIKSYQ--GKS------------LGTRPPHVFAIADKAFRDMKV---------LKMSQSIIVSGESGAGKTENTKFVLRYLTESYG------------------------------------------------------------------------------------------------------------------------------------------TGQ------------------------------DIDDRIVE--AN-----PLLEAFGNAKTVRNNNSSRFGKFVEIHFNEK------SSVVGGFVSHYL-LEKSRICV-QGKEERNYHIFYRLCAGASED-----------------------------------------IREKLH---LSSPD----------NFRYLNR-----------GCTRYFANKETDKQILQNRKSPEYLKAGSMKDPLLHDHGDFIKMCTALKKIG----LDDEEK-LDLFRVFPGVLHLG-NIDFEEAG------NTS-----GGCSLNNK--SAQSLEYCAE-LLGLDRYDLQVLLTTRVMLTTAGG---TRGTVIKVPLIVEQANHARDALAKTVYSHLFDHV---------------------------VNIVNQCFPFE---------PSS----------YFIGVLDIAGFEYF------EHNSFEQFCINYCNEKLQQF-FNERILKEEQELYQKEGLG--VNEVH-YVDN-QDCIDLIEA----------------------------------KL---VGILDILDEENRLP----------------QPSDQHFTSAVHQK--HKD-----HFRLTIPRKSKLA--VHR-NIRDDEGFIIRHFA--GAVCYETTQFVE-KNNDALHMSLESLICES-----------------RDKFIRELFESST--------------NNNKDTKQKAG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------KL-SFISVGNKFK-----------------------TQLNLLLDKLR--STGASFIRCIKPNLKMTSH-----------------------------HFEGAQILSQLQCSGMVSVL----DLMQGGYPSRASFHELYNMYK---KYMPD----KL------AR--L-------------DPRLFCKALFKALG---------LNE---NDYKFGLTKVF--------FRPGK-FAEFDQIMKS-*
Mm Waltzer VI -VEDNCS-LMYLN-EATLLHNVKVRYSK-DRIYTYVANILIAVNPYFDIPKIYSSD----------------TIKSYQ--GKS------------LGTMPPHVFGIADKAFRDMKV---------LKMSQSIIVSGESGAGKTENTKFGSKIPDRILW------------------------------------------------------------------------------------------------------------------------------------------TGQ------------------------------DIDDRIVE--AN-----PLLEAFGNAKTVRNNNSSRFGKFVEIHFNEK------SSVVGGFVSHYL-LEKSRICV-QGKEERNHHIFYRLCAGASED-----------------------------------------IREKLH---LSSPD----------NFRYLNR-----------GCTRFFANKETDKQILQNRKSPEYVKAGSLEGSSIRRPWRFYQDVHSHEKNW----FGMMKKNFDLFRVVAGVLHLG-NIDLEEAG------STS-----GGCNLKNK--SAPSLEYCAE-LLGLDQDDLRVSLTTRVMLTTAGG---TKGTVIKVPLKVEQANNARDALAKTVYSHLFDHV---------------------------VNRVNQCFPFE---------TSS----------YFIGVLDIAGFEYF------EHNSFEQFCINYCNEKLQQF-FNERILKEEQELYQKEGLG--VNEVH-YVDN-QDCIELIEV----------------------------------KL---VGILDILDEENRLP----------------QPSDQHFTSVVHQK--HKD-----HFRLTIPRKSKLA--VHR-NLRDDEGFIIRQLCR-GRVLRRQPQYGGGKNNDALHMSLESLICES-----------------RDKFIRALFESST--------------NNSKDTKQKAG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------KL-SFISVGNKFK-----------------------TQLNLLLDKLR--STGASFIRCIKPNLKMASH-----------------------------HFEGAQILSQLQCSGMVSVL----DLMQGGFPSRASFHELYNMYK---KYMPE----KL------PR--L-------------DPRLFCKPLFKALG---------LNE---VDYKFGLTQVF--------FRPGK-FAEFDQI----*
Ms VIB -VDDNCS-LMYLN-EATLLNNVRVRYSK-DHIYTYVANILIAVNPYYDIPKLYGPD----------------SIKSYR--GKS------------LGTLPPHVFAIADKAYRDMKV---------LKMSQSIIVSGESGAGKTENTKFVLRYLTTTYG------------------------------------------------------------------------------------------------------------------------------------------SGQ------------------------------DIDERIVE--AN-----PLLEAFGNAKTVRNNNSSRFGKFVEIHFDEK------NAVVGGFVSHYL-LEKSRICM-QSNDERNYHIFYRLCAGASED-----------------------------------------IKKKLH---LDSPD----------SFRYLNR-----------GCTRYFASKDSDKQIMQNRKSPEHLKVGALKDLLLDDQGDFNRMCVAMKKIG----LDDTEK-LDLFRVVAGVLHLG-NIDFEETG------SSS-----GGCVLKNQ--SGQTLEYCAD-LLGLDQDDLRVSLTTRIMLTTAGG---AKGTVIKVPLKVEQANNARDALAKAVYSRLFDHV---------------------------VKRVNQCFPFE---------TSS----------NFIGVLDIAGFEYF------EHNSFEQFCINYCNEKLQQF-FNERILKEEQELYQREGLG--VNEVH-YVDN-QDCIDLVEV----------------------------------KL---VGVLDILDEENRLP----------------QPSDQHFALAVHNK--HKD-----HFRLTVPRKSKLT--IHR-NLRDDEGFIIRHFA--GAVCYETCRFVE-KNNDALHMSLESLVCES-----------------KDKFVRELFENS---------------NTTKDSKQKAG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------KL-GFISVGNKFK-----------------------TQLNLLLEKLR--STGSSFIRCVKPNLKMVSH-----------------------------QFEGALILSQLQCSGMVSVL----DLMQGGFPSRASFHELYNMYK---QYMPD----KL------TR--L-------------NPRLFCKALFKALG---------LND---SDFKFGLTRVF--------FRPGK-FAEFDQIMRS*
Ms VIA -VEDNCS-LMYLN-EATLLNNVRVRYSK-DKIYTFVANILIAVNPYYDIPKLYSPE----------------TIKQYR--GRS------------LGTLPPHVYAIADKAYRDMKV---------LKMSQSIIVSGESGAGKTENTKFVLRYLTTSYG------------------------------------------------------------------------------------------------------------------------------------------TGQ------------------------------DIDERIVE--AN-----PLLEAFGNAKTVRNNNSSRFGKFVEIHFNEK------NAVVGGFVSHYL-LEKSRICR-QSSEERNYHIFYRLCAGATED-----------------------------------------IRQKFH---LSSPD----------TFRYLNR-----------GCTRFYASKDTDKQILQNRKSPEHMKSGPLKDPLLDDRGDFNRMSVAMKKIG----LDDTEK-LDLFRGVAGVLHLG-NIDFEEAG------STS-----GGCAIKNQ--SIQTLEHCAE-LLGLEEGDLRVSLTTRVMLTTAGG---AKGTLIKVPLKVEQANNSRDALAKAVYSRLFDHV---------------------------VTRVNQCFPFD---------SSA----------NFIGVLDIAGFEYF------EHNSFEQFCINYCNEKLQQF-FNERILKEEQELYQREGLG--VNEVH-YVDN-QDCIDLVEA----------------------------------KL---VGILDILDEENRLP----------------QPTDQHFTDTVHNK--HKN-----HFRLTIPRKSKLA--VHR-NVRDDEGFIIRHFA--GAVCYETTNFVE-KNNDALHMSLECLVSES-----------------KDRFVRELFENS---------------NNSKDVKQKPE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------KL-SFISVGNKFK-----------------------TQLNILLEQARC-STGSSFIRCIKPNLKMVSH-----------------------------QFEGAQILSQLQCSGMVSVL----DLMQGGFPSRAPFHELYNMYQ---KYMPP----KP------TR--L-------------DPCLFCKALFKALG---------LNE---NDYKFGLTIVF--------FRPGK-FAEFDHIMKS*
Dm 95F VI -HDDNCE-LMLLN-EATFLDNLKTRYYK-DKIYTYVANILIAVNPYREIKELYAPD----------------TIKKYN--GRS------------LGELPPHVFAIADKAIRDMRV---------YKLSQSIIVSGESGAGKTESTKYLLKYLCYSHD------------------------------------------------------------------------------------------------------------------------------------------SAG------------------------------PIETKILD--AN-----PVLEAFGNAKTTRNNNSSRFGKFIEVHYDAK------CQMVGGYISHYL-LEKSRICT-QSAEERNYHVFYMLLAGAPQQ-----------------------------------------LRDKLS---LGKPD----------DYRYLS------------GCTQYFANAKTEQLIPGSQKSKNHQQKGPLKDPIIDDYQHFHNLDKALGRLG----LSDTEK-LGIYSLVAAVLHLG-NIAFEEIP------DDVR----GGCQVSEA--SEQSLTITSG-LLGVDQTELRTALVSRVMQSKGGG---FKGTVIMVPLKIYEASNARDALAKAIYSRLFDRI---------------------------VGLINQSIPFQ---------ASN----------FYIGVLDIAGFEYF------TVNSFEQFCINYCNEKLQKF-FNDNILKNEQELYKREGLN--VPEIT-FTDN-QDIIELIEA----------------------------------KS---NGIFTLLDEESKLP----------------KPSYSHFTAEVHKS--WAN-----HYRLGLPRSSRLK--AHR-TLRDEEGFLVRHFA--GAVCYNTEQFIE-KNNDALHASLEGLVQEC-----------------DNPLLQTLFPSG-------------------SSTSVRG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------KL-NFISVGSKFK-----------------------TQLGELMEKLE--QNGTNFIRCIKPNSKMIDR-----------------------------QFEGSLALAQLKCSGTISVL----ELMEHGYPSRVLFADLYSMYK---SVLPP----EL------VS--L-------------PARTFCEAMFQSLN---------LSA---KDFKFGITKVF--------FRPGK-FVEFDRIMR--*
Ce hum3 -VEDNCA-LVHLN-EATLLNNCRLRYAN-GKIYTYVANILISINPYQLIDGLYSPE----------------TIKEYR--GKS------------LGQMEPHIFAIADKAYREMRR---------IKTSQSIIVSGESGAGKTESQKAVLKYLCENWG------------------------------------------------------------------------------------------------------------------------------------------TDAG-----------------------------PIQQRLLE--TN-----PILEAFGNAKTLRNNNSSRFGKFVQIHFSDN------GTVAGGFVSHYL-LETSRVCR-QAAGERNYHIFYQLIAGSSPD-----------------------------------------LYKKLR---LAPAS----------SFNYLKH-----------GATLFFVNSKSSLKTDASRFSETN---SSVSDSIISDIDDFAKLERALALSG----VSDDEK-MFIWSTVAGILHLG-NIEFEENA------SDSR----GGCMITSG--TENSLMAAAE-LLGLEPEEMKLGLCARIMQTTKGG---VKGTLIRVPLKAHEASAGRDALAKAIYSKLFDWL---------------------------VAQINKSIPFE---------KST----------GYIGVLDVAGFEYF------AVNSFEQFCINFCNEKLQHF-FNERILKQEQEMYEAEGLN--IQKIE-FTDN-LDCIELFEK----------------------------------KA---SGLFDLLDEEAKLP----------------RATFQHFTQRAHES--NKN-----HFRLDAPRKSKVK--SHR-EMRDDEGLLIRHYA--GTVCYETRYFVE-KNNDQLHNSLEMLIEQS-----------------SFPLVVSLFTSEA--------------TG---AVKTGG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------RL-KAVSVGAKFK-----------------------SQLSSLLDKLN--NTGTHFVRCVKPNSQMKAW-----------------------------HFDGSAILGQLQCAGMASVL----RLMQEGFPSRTSFADLYAMYE---KNLPP----SL------AR--L-------------DPRLFSKCLFHALG---------LDQ---NDFQFGNTKVF--------FTAGK-FAEFDQMMK--*
Mm shaker VII ---------------------------------TYTGSILVAVNPYQ-LLSIYSPE----------------HIRQYT--NKK------------IGEMPPHIFAIADNCYFNMKR---------NNRDQCCIIRGESGAGKTESTKLILQFLAAIS---------------------------------------------------------------------------------------------------------------------------------------------GQ---------------------------HSWIEQQVLE--AT-----PILEAFGNAKTIRNDNSSRFGKYIDIHFNKR------GAIEGAKIEQYL-LEKSRVCR-QAPDERNYHVFYCMLEGMNEE-----------------------------------------EKKKLG---LGQAA----------DYNYLAMG-----------N----------------CITCEG----------RVDSQEYANIRSAMKVLM----FTDTEN-WEISKLLAAILHMG-NLQYEAR-------TFEN---LDACEVLFS--P--SLATAASLL-EVNPPDLMSCLTSRTLITRG--------ETVSTPLSREQALDVRDAFVKGIYGRLFVWI---------------------------VEKINAAIYKP---------PPLEVKN----SRRSIGLLDIFGFENF------TVNSFEQLCINFANEHLQQF-FVRHVFKLEQEEYDLESID--WLHIE-FTDN-QEALDMIAN----------------------------------RR---MNVISLIDEESKFP----------------KGTDATMLHKLNSQ--HKL-----NANYVPPKNSHET------------QFGINHFA--GVVYYESQGFLE-KNRDTLHGDIIQLVHSS-----------------RNKFVKQIFQAD----------------VAMGAET--------------------------------------------------------------------------------------------------------------------------------------------------------------------------RK-RSPTLSSQFK-----------------------RSLELLMRTLG--ACQPFFVRCIKPNEFKKPM-----------------------------LFDRHLCVRQLRYSGMMETI----RIRHAGYPIRYSFVEFVERYR---VLLPG----VKP-----AYKQ--------------GDLRGTCQRMAEAVL--------GTH---DDWQIGKTKIF--------LKDHH-DMLLEVERD--*
Hs UsherIb VIIa -VEDMIR-LGDLN-EAGILRNLLIRYRD-HLIYTYTGSILVAVNPYQ-LLSIYSPE----------------HIRQYT--NKK------------IGEMPPHIFAIADNCYFNMKR---------NSRDQCCIISGESGAGKTESTKLILQFLAAIS---------------------------------------------------------------------------------------------------------------------------------------------GQ---------------------------HSWIEQQVLE--AT-----PILEAFGNAKTIRNDNSSRFGKYIDIHFNKR------GAIEGAKIEQYL-LEKSRVCR-QALDERNYHVFYCMLEGMSED-----------------------------------------QKKKLG---LGQAS----------DYNYLAMG-----------N----------------CITCEG----------RVDSQEYANIRSAMKVLM----FTDTEN-WEISKLLAAILHLG-NLQYEAR-------TFEN---LDACEVLFS--P--SLATAASLL-EVNPPDLMSCLTSRTLITRG--------ETVSTPLSREQALDVRDAFVKGIYGRLFVWI---------------------------VDKINAAIYKP---------PSQDVKN----SRRSIGLLDIFGFENF------AVNSFEQLCINFANEHLQQF-FVRHVFKLEQEEYDLESID--WLHIE-FTDN-QDALDMIAN----------------------------------KP---MNIISLIDEESKFP----------------KGTDTTMLHKLNSQ--HKL-----NANYIPPKNNHET------------QFGINHFA--GIVYYETQGFLE-KNRDTLHGDIIQLVHSS-----------------RNKFIKQIFQAD----------------VAMGAET--------------------------------------------------------------------------------------------------------------------------------------------------------------------------RK-RSPTLSSQFK-----------------------RSLELLMRTLG--ACQPFFVRCIKPNEFKKPM-----------------------------LFDRHLCVRQLRYSGMMETI----RIRRAGYPIRYSFVEFVERYR---VLLPG----VKP-----AYKQ--------------GDLRGTCQRMAEAVL--------GTH---DDWQIGKTKIF--------LKDHH-DMLLEVERD--*
Ss VIIa -MEDMIQHLGDLN-EAGILRNLLIRYRD-HLIYTYTGSILVAVNPYQ-LLSIYSPE----------------HIRQYT--NKK------------IGEMPPHIFAIADNCYFNMKR---------NSRDQCCIISGESGAGKTESTKLILQFLAAIS---------------------------------------------------------------------------------------------------------------------------------------------GQ---------------------------HSWIEQQVLE--AT-----PILEAFGNAKTIRNDNSSRFGKYIDIHFNKR------GAIEGARIEQYL-LEKSRVCR-QAPDERNYHVFYCMLEGMSEE-----------------------------------------QKKKLG---LGQAT----------DYNYLAMG-----------N----------------CITCEG----------REDSQEYANIRSAMKVLM----FTDTEN-WEISKLLAAILHLG-NLQYKDR-------TFEN---LDACEVLFS--T--ALATAASLL-EVNPPDLMNCLTSRTLITRG--------ETVSTPLSREQALDVRDAFVKGIYGRLFVWI---------------------------VDKINAAIYKP---------PSQEVKN----PRRSIGLLDIFGFENF------AVNSFEQLCINFANEHLQQF-FVRHVFKLEQEEYDLESID--WLHIE-FTDN-QDALDMIAN----------------------------------KP---MNIISLIDEESKFP----------------KGTDTTMLHKLNSQ--HRL-----NSNYIPPKYNHET------------QFGINHFA--GVVYYESQG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------*
Dm 35B VII -VEDMIS-LGDLH-EAGILRNLLIRYKE-NLIYTYTGSILVAVNPYQ-ILPIYTGD----------------QIKLYK--ERK------------IGELPPHIFAIGDNAYAHMKR---------YRQDQCIVISGESGAGKTESTKLILQYLAAIS---------------------------------------------------------------------------------------------------------------------------------------------GK---------------------------HSWIEQQILE--AN-----PILEAFGNAKTIRNDNSSRFGKYIDIHFSAN------GVIEGAKIEQYL-LEKSRIVS-QNHSERNYHVFYCILAGLSAD-----------------------------------------EKSRLD---LGMAA----------DYKYLTGG-----------N----------------SITCEG----------RDDAAEFSDIRSAMKVLL----FSDQEI-WEIIKLLAALLHCG-NIKYKAT-------VVDN---LDATEIPEH--I--NVERVAGLL-GLPIQPLIDALTRRTLFAHG--------ETVVSTLSRDQSVDVRDAFVKGIYGRMFVHI---------------------------VRKINTAIFKP---------RG--T------SRNAIGVLDIFGFENF------DQNSFEQFCINYANENLQQF-FVQHIFKLEQEEYNHEAIN--WQHIE-FVDN-QDALDLIAI----------------------------------KQ---LNIMALIDEEARFP----------------KGTDQTMLAKLHKT--HGS-----HKNYLKPKSDINT------------SFGLNHFA--GVVFYDTRGFLD-KNRDTFSPDLLHLVSQS-----------------TNKFLRQIFAQD----------------IEMGAET--------------------------------------------------------------------------------------------------------------------------------------------------------------------------RK-RTPTLSTQFR-----------------------KSLDALMKTLS--SCQPFFIRCIKPNELKKPM-----------------------------MFDRGLCCRQLRYSGMMETI----RIRRAGYPIRHGFREFVERYR---FLIPG----VPP-----AHR---------------TDCQAATSRICAVVL--------G-K---SDYQLGHTKVF--------LKDAH-DLFLEQERD--*
Ce HUM6 -VEDMCQ-LGDFH-ESAILRNLFIRYRE-KLIYAYTGSILIAVNPYM-DIAIYTAD----------------EIRMYK--RKR------------IGELPPHIFAIADNAYTNMRR---------EKKNQSVIISGESGAGKTESTKLVLQFLATIS---------------------------------------------------------------------------------------------------------------------------------------------GQ---------------------------HSWIEQQVLE--AN-----PVLEAFGNAKTIRNDNSSRFGKYIDVHFNES------GSIEGAKIEQYL-LEKSRIVT-QSENERNYHIFYCLLAGLSRE-----------------------------------------EKSELE---LGTAA----------DYYYLIQG-----------K----------------TLTAEG----------RDDAADLAEIRSAMRVLM----INEQEI-GSIFKLLASLLHIG-NIRFRQN-------TNDN---MESVDVADP--S--TLVRIAKLL-QLHEQNLLDAITTKSLVTRE--------ERVISRLNGQQAVDARDALAKAIYGKLFIHI---------------------------VRRVNDAIYKP---------SQ--S------RRTSIGILDIFGFENF------ESNSFEQLCINFANETLQQF-FVHHVFKMEQKEYDEEHIN--WRHIK-FVDN-QATVDLIAQ----------------------------------RP---LNILSLIDEESIFP----------------KGTDKTMLLKLHST--HGR-----NELYLQPKSELQR------------AFGVTHFA--GNVFYNTRGFLE-KNRDSFSADLSVLISSS-----------------KMPFLARLFD-D----------------IEYDTSS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------RK-K-VTVGNQFR-----------------------RSLEQLMSQLT--QTHPFFIRCIKPNEMKRAL-----------------------------VMDRDLVLRQLRYSGMMETI----KIRRSGYPIRHDYYPFVFRYR---VLVSS----IQG-----PVNR--------------IDLHDAAKKICHMIL--------GTN---ADYQLGKTKVF--------LKDKH-DLVLEQ-----*
Dd myoI -VEDMIT-LPILT-EESLLLNLKMRYKK-KEIYTYTGSILVAVNPYE-ILPIYTAD----------------IVKSYF--AKS------------RNLMLPHIFAVSDAAFTNMIE---------EGKNQSIIISGESGAGKTESTKLIIQYLAART---------------------------------------------------------------------------------------------------------------------------------------------NR---------------------------HSQVEQMIVE--SS-----PILEAFGNAKTIRNNNSSRFGKFIEIQFNRE------GHISGARIINYL-LEKSRISH-QASSERNYHIFYQLLAGASDE-----------------------------------------LKEKLK---LGEPE----------DYHYLSQS-----------G----------------CIRIEN----------INDVEDFEHVKYAMNVLG----LPEDKQ-FTIFSIVSAVLHIG-NLKFEKSE------KTQG---AEGSEVSNK--D--TLKIIAQLL-SVDPVKLETCLTIRHVLIRG--------QNFVIPLKVNEAEDTRDSLAKALYGNVFNWL---------------------------VVFINSKIHKP---------QK--N-------STFIGVLDIFGFENF------KKNSFEQFCINFANEKLQQH-FNQHIFKLEQEEYEKEKIN--WSKIV-YNDN-QECLDLIEK----------------------------------RP---LGILSLLDEESRFP----------------QATDLTYLDKLHTN--HEK-----HPYYEKPRRSKN-------------TFVVKHYA--GEVHYDTQGFLD-KNKDTVSDDLSSLLQGS-----------------KSKFIIELFTPP----------------REEGDDSDKG----------R------------------------------------------------------------------------------------------------------------------------------------------------------------EK-KKTTAGQTFK-----------------------TQLQSLINILS--STQPHYVRCIKPNTTKEPA-----------------------------VYDRELIQAQLRYAGMMETI----RIRKLGYPIRHTHKEFRDRYL---ILDYR----ARS-----TDHK--------------QTCAGLINLLSGTGG--------LER---DEWQLGNTKVF--------IRDHQ-YLKLEELRK--*
Bt X -VDDMAT-LTELH-GGAIMHNLYQRYKR-NQIYTYIGSIIASVNPYKTITGLYSRD----------------AVDRYS--RCH------------LGELPPHVFAIANECYRCLWK---------RHDNQCVLISGESGAGKTESTKLILKFLSAIS---------------------------------------------------------------------------------------------------------------------------------------------QQSVDLSS------------------KEKTSSVEQAILE--SS-----PIMEAFGNAKTVYNNNSSRFGKFVQLNIGQK------GNIQGGRIVDYL-LEKNRVVR-QNPGERNYHIFYALLAGLGHE-----------------------------------------EREEFY---LSVPE----------NYHYLNQS-----------G----------------CVTDRT----------ISDQESFREVIMAMEVMQ----FSKEEV-REVLRLLAGILHLG-NIEFITAG------G---------AQVSFK--T--ALGRSAELL-GLDPAQLTDALTQRSMFLRG--------EEILTPLNVQQAADSRDSLAMALYARCFEWV---------------------------IKKINSRIKGK---------DDFKS----------IGILDIFGFENF------EVNHFEQFNINYANEKLQEY-FNKHIFSLEQLEYSREGLV--WEDID-WIDN-GECLDLIEK----------------------------------K----LGLLALINEESHFP----------------QATDSTLLEKLHNQ--HAN-----NHFYVKPRVAVN-------------NFGVKHYA--GEVQYDVRGILE-KNRDTFRDDLLNLLRES-----------------RFDFIYDLFEHV----------------SSRNNQDTLK-------CGS-------------------------------------------------------------------------------------------------------------------------------------------------------------KH-RRPTVSSQFK-----------------------DSLHSLMATLS--ASNPFFVRCIKPNMQKMPD-----------------------------QFDQAVVVNQLRYSGMLETV----RIRKAGYAVRRPFQDFYKRYK---VLMR-----NVA-----LPE----------------DIRGKCTALLQLYD--------ASN---SEWQLGKTKVF--------LRESL-EQKLEKRQE--*
Mm X -VDDMAS-LAELH-GVAIMYNLFQRYKR-NQIYTYIGSIIASVNPYQPIAGLYERA----------------TMEEYS--RCH------------LGELPPHIFAIANECYRCLWK---------RHDNQCVLISGESGAGKTESTKLILKFLSVIS---------------------------------------------------------------------------------------------------------------------------------------------QQTLDLGL------------------QEKTSSVEQAILQ--SS-----PIMEAFGNAKTVYNNNSSRFGKFVQLNICQQ------GNIQGGRIVDYL-LEKNRVVR-RIPGERNYHIFYALLAGLDQE-----------------------------------------EREEFY---LSLPE----------NYHYLNQS-----------G----------------CTEDKT----------ISDQESFRQVITAMEVMQ----FSKEEV-REVLRLLAGILHLG-NIEFITAG------G---------AQIPFK--T--ALGRSADLL-GLDPTQLTDALTQRSMILRG--------EEILTPLSVQQAVDSRDSLAMALYARCFEWV---------------------------IKKINSRIKGK---------DDFKS----------IGILDIFGFENF------EVNHFEQFNINYANEKLQEY-FNKHIFSLEQLEYSREGLV--WEDID-WIDN-GECLDLIEK----------------------------------K----LRLLALINEESHFP----------------QATDSTLLEKLHSQ--HAN-----NHFYVKPRVAVN-------------NFGVKHYA--GEVQYDVRGILE-KNRDTFRDDLLNLLRES-----------------RFDFIYDLFEHV----------------SSRNNQDTLK-------CGS-------------------------------------------------------------------------------------------------------------------------------------------------------------KH-RRPTVSSQFK-----------------------DSLHSLMATLS--SSNPFFVRCIKPNTQKMPD-----------------------------QFDQVVVLNQLRYSGMLETV----RIRKAGYAVRRPFQDFYKRYK---VLMR-----NLA-----LPD----------------DIRGKCTVLLQVYD--------ASN---SEWQLGKTKVF--------LRESL-EQKLEKRRE--*
Mm XV -VEDMTQ-LEDLQ-ETTVLANLKTRFER-NLIYTYIGSILVSVNPYR-MFAIYGPE----------------QVQQYS--GRA------------LGENPPHLFAIANLAFAKMLD---------AKQNQCVIISGESGSGKTEATKLILRCLAAMN---------------------------------------------------------------------------------------------------------------------------------------------QR------------------------RDVMQQI----LE--AT-----PLLEAFGNAKTVRNDNSSRFGKFVEIFLEG-------GVICGAITSQYL-LEKSRIVF-QAKNERNYHIFYELLAGLPAQ-----------------------------------------LRQAFS---LQEAE----------TYYYLNQG-----------G----------------NCEIAG----------KSDADDFRRLLAAMEVLG----FTSEDQ-DSIFRILASILHLG-NVYFEKHE------TD-A---QEVASVVSA--R--EIQAVAELL-QVSPEGLQKAITFKVTETIR--------EKIFTPLTVESAVDARDAIAKVLYALLFGWL---------------------------ITRVNALVSPK---------QDTLS----------IAILDIYGFEDL------SFNSFEQLCINYANENLQYL-FNKIVFQEEQEEYIREQMD--WREIA-FADN-QPCINLISL----------------------------------KP---YGILRILDDQCCFP----------------QATDHTFLQKCHYH--HGA-----NPLYSKPKMPLP-------------EFTIKHYA--GKVTYQVHKFLD-KNHDQVRQDVLDLFVHS-----------------RTRVVAHLFSSH----------------AAQTAPPRLG-------KSSS--------------------------------------------------------------------------------------------------------------------------------IT------------------R-------LY-KAHTVAAKFQ-----------------------QSLLDLVEKME--RCNPLFVRCLKPNHKKEPG-----------------------------LFEPDVMMAQLRYSGVLETV----RIRKEGFPVRLPFQVFIDRYR---CLVAL----KLN-----VPA----------------DGDMCVSLLSRLCT--------VTP---DMYRVGISKLF--------LKEHL-HQLLESMRE--*
Hs XV -VEDMTQ-LEDLQ-ETTVLSNLKIRFER-NLIYTYIGSILVSVNPYQ-MFGIYGPE----------------QVQQYN--GRA------------LGENPPHLFAVANLAFAKMLD---------AKQNQCIIISGESGSGKTEATKLILRYLAAMN---------------------------------------------------------------------------------------------------------------------------------------------QK------------------------REVMQQIK--ILE--AT-----PLLESFGNAKTVRNDNSSRFGKFVEIFLEG-------GVISGAITSQYL-LEKSRIVF-QAKNERNYHIFYELLAGLPAQ-----------------------------------------LRQAFS---LQEAE----------TYYYLNQG-----------G----------------NCEIAG----------KSDADDFRRLLAAMEVLG----FSSEDQ-DSIFRILASILHLG-NVYFEKYE------TD-A---QEVASVVSA--R--EIQAVAELL-QISPEGLQKAITFKVTETMR--------EKIFTPLTVESAVDARDAIAKVLYALLFSWL---------------------------ITRVNALVSPR---------QDTLS----------IAILDIYGFEDL------SFNSFEQLCINYANENLQYL-FNKIVFQEEQEEYIREQID--WQEIT-FADN-QPRINLISL----------------------------------KP---YGILRILDDQCCFP----------------QATDHTFLQKCHYH--HGA-----NPLYSKPKMPLP-------------EFTIKHYA--GKVTYQVHKFLD-KNHDQVRQDVLDLFVRS-----------------RTRVVAHLFSSH----------------APQAAPQRLG-------KSSS--------------------------------------------------------------------------------------------------------------------------------VT------------------R-------LY-KAHTVAAKFQ-----------------------QSLLDLVEKME--RCNPLFMRCLKPNHKKEPG-----------------------------LFEPDVVMAQLRYSGVLETV----RIRKEGFPVRLPFQGFIDRYC---CLVAL----KHD-----LPA----------------NGDMCVSVLSRLCK--------VMP---NMYRVGVSKLF--------LKEHL-YQLLESMRE--*
Rn myrV IX -FDDLCN-LPELN-EANLLQSLKLRFVQ-QKIYTYAGSILVAINPFK-FLPIYNPK----------------YVKMYE--NQQ------------LGKLEPHVFALADVAYYTMLR---------KHVNQCIVISGESGSGKTQSTNFLIHCLTALS---------------------------------------------------------------------------------------------------------------------------------------------QKG-------------------------YASGVERTILG--AG-----PVLEAFGNAKTAHNNNSSRFGKFIQVNYLES------GIVRGAVVEKYL-LEKSRLVS-QEKDERNYHVFYYLLLGVSEE-----------------------------------------ERQEFQ---LKQPQ----------DYFYLNQHN---------LN------------------IEDG----------EDLKHDFERLQQAMEMVG----FLPATK-KQIFSVLSAILYLG-NVTYKKRA-------TGR---DEGLEVGPP--E--VLDTLSQLL-KVKRETLVEVLTKRKTITVN--------DKLILPYSLSEAITARDSMAKSLYSALFDWI---------------------------VLRINHALLNK---------KDMEEAV----SCLSIGVLDIFGFEDF------ERNSFEQFCINYANEQLQYY-FTQHIFKLEQEEYQGEGIS--WHNID-YTDN-VGCIHLISK----------------------------------KP---TGLFYLLDEESNFP----------------HATSHTLLAKFKQQ--HED-----NKYFLGTPVLEP-------------AFIIQHFA--GRVKYQIKDFRE-KNMDYMRPDIVALLRGSDSSYVRQLIGMDPVAVFRWAVLRAAIRAM----------------AVLREAGRLRA-----ERAEKAEAG--------------VSSPVTRSHVEELPR---------------------GANTPSEKLYRDLHNQIIKSLKGLPWQGEDPR--RLLQ---------SLSRLQKPRTFFLKSKGIKQKQIIPKNLLDSKSLRLIISMTLHDRTTKSLLHLHKKK-KPPSISAQFQ-----------------------TSLNKLLEALG--KAEPFFIRCIRSNAEKKEL-----------------------------CFDDELVLQQLRYTGMLETV----RIRRSGYSAKYTFQDFTEQFQ---VLLP------KD-----VQP----------------CREAIAALLE-KLQ--------VDR---QNYQIGKTKVF--------LKETE-RQALQERLHGE*
Mm 9b -FDDLCN-LPELT-EANLLQNLKLRFMQ-QKIYTYAGSILVAINPFK-FLPIYNPK----------------YVKMYE--NQQ------------LGKLEPHVFALADVAYYAMLR---------KHVNQCIVISGESGSGKTQSTNFLIHCLTALS---------------------------------------------------------------------------------------------------------------------------------------------QKG-------------------------YASGVERTILG--AG-----PVLEAFGNAKTAHNNNSSRFGKFIQVNYLEN------GIVRGAVVEKYL-LEKSRLVS-QEKDERNYHVFYYLLLGVSEE-----------------------------------------ERLEFQ---LKQPQ----------DYFYLNQHN---------LN------------------IEDG----------EDLKHDFERLQQAMEMVG----FLPATK-KQIFSVLSAILYLG-NVTYKKRA-------TGR---DEGLEVGPP--E--VLDTLSQLL-KVKRETLVEVLTKRKTVTVN--------DKLILPYSLSEAITARDSMAKSLYSALFDWI---------------------------VLRINHALLNK---------KDMEEAV----SCLSIGVLDIFGFEDF------ERNSFEQFCINYANEQLQYY-FTQHIFKLEQEEYQGEGIS--WHNID-YTDN-VGCIHLISK----------------------------------KP---TGLFYLLDEESNFP----------------HATSHTLLAKFKQQ--HED-----NKYFLGTPVLEP-------------AFIIQHFA--GRVKYQIKDFRE-KNMDYMRPDIVALLRGSDSSYVRQLIGMDPVAVFRWAVLRAAIRAM----------------AVLREAGRLRA-----ERAEKAAG---------------ISSPATRSHMEELPR---------------------GASTPSEKLYRDLHNQIIKSLKGLPWQGEDPR--RLLQ---------SLSLLQKPRTSFLKSKGIKQKQIIPKNLLDSKSLRLIISMTLHDRTTKSLLHLHKKK-KPPSISAQFQ-----------------------TSLNKLLEALG--KAEPFFIRCIRSNAEKKEL-----------------------------CFDDELVLQQLRYTGMLETV----RIRRSGYSAKYTFQDFTEQFQ---VLLP------KD-----VQP----------------CREAIAALLE-KLQ--------VDR---QNYQIGKTKVF--------LKETE-RQTLQEKLH--*
Hs IXa -FDDLCS-LPDLN-EKTLLENLRDRFKH-EKIYTYVGSILIVINPFK-FLPIYNPK----------------YVKMYD--NHQ------------LGKPEPHIYAVADVAYHAMLQ---------RKKNQCIVISGESGSGKTQSTNFLIHHLTALS---------------------------------------------------------------------------------------------------------------------------------------------QKG-------------------------FASGVEQIILG--AG-----PVLEAFGNAKTAHNNNSSRFGKFIQVNYQET------GTVLGAYVEKYL-LEKSRLVY-QEHNERNYHVFYYLLAGASED-----------------------------------------ERSAFH---LKQPE----------EYHYLNQIT---------KKPLRQSWDDYCYDSEPDCFTVEG----------EDLRHDFERLQLAMEMVG----FLPKTR-RQIFSLLSAILHLG-NICYKKKT-------Y-R---DDSIDICNP--E--VLPIVSELL-EVKEEMLFEALVTRKTVTVG--------EKLILPYKLAEAVTVRNSMAKSLYSALFDWI---------------------------VFRINHALLNS---------KDLEHNT----KTLSIGVLDIFGFEDY------ENNSFEQFCINFANERLQHY-FNQHIFKLEQEEYRTEGIS--WHNID-YIDN-TCCINLISK----------------------------------KP---TGLLHLLDEESNFP----------------QATNQTLLDKFKHQ--HED-----NSYIEFPAVMEP-------------AFIIKHYA--GKVKYGVKDFRE-KNTDHMRPDIVALLRSSKNAFISGMIGIDPVAVFRWAILRAFFRAM----------------VAFREAGKRNI-----HRKTGHDDTAPCAILKSMDSFSFLQHPVHQRSLEILQRCKEEKYSITRKNPRTPLSDLQGMNALNEKNQHDTFDIAWNGRTGIRQSRLSSG-TSLLDKDGIFANSTSSKLLERAHGILTRNKNFKSKPALPKHLLEVNSLKHLTRLTLQDRITKSLLHLHKKK-KPPSISAQFQ-----------------------ASLSKLMETLG--QAEPYFVKCIRSNAEKLPL-----------------------------RFSDVLVLRQLRYTGMLETV----QIRQSGYSSKYSFQDFVSHFH---VLLP------RN-----IIP----------------SKFNIQDFFR-KIN--------LNP---DNYQVGKTMVF--------LKEQE-RQHLQDLLH--*
Rn myr7 -FDDLCS-LPDLN-EKTLLENLRNRFKH-EKIYTYVGSILIAINPFK-FLPIYNPK----------------YVKMYD--NHQ------------LGKLEPHIYAVADVAYHAMLQ---------RKKNQCIVISGESGSGKTQSTNFLIHHLTALS---------------------------------------------------------------------------------------------------------------------------------------------QKG-------------------------FASGVEQIILG--AG-----PVLEAFGNAKTAHNNNSSRFGKFIQVNYQET------GTVLGAYVEKYL-LEKSRLVY-QEHNERNYHVFYYLLAGASEE-----------------------------------------ERLAFH---LKQPE----------EYHFLNQIT---------KKPLRQSWDDYCYDSEPDCFTVEG----------EDLRHDFERLQLAMEMVG----FLPKTR-RQIFSLLSAILHLG-NISYKKKT-------Y-R---DDSIDICNP--E--VLPIVSELL-EVKEEMLFEALVTRKTVTVG--------EKLILPYKLAEAVTVRNSMAKSLYSALFDWI---------------------------VFRINHALLNS---------KDLEKDT----KTLSIGVLDIFGFEDY------ENNSFEQFCINFANERLQHY-FNQHIFKLEQEEYRTEGIS--WHNID-YIDN-TCCINLISK----------------------------------KP---TGLLHLLDEESNFP----------------QATNQTLLDKFKHQ--HEE-----NSYIEFPAVMEP-------------AFIIKHYA--GKVKYGVKDFRE-KNTDHMRPDIVALLRSSRNAFVSGMTGIDPVAVFRWAVLRAFFRAV----------------VAFREAGKRHI-----QRKSGHDDTTPCTILKSMDSFSFLQHPVHQRSLEILQRCKEEKYSITRKNPRTPLSDLQGMNTLNEKNQHDTFDIAWNVRTGIRQSRLPTNNTSLLDKDGIFANSASSKLLERAHGILTRNKNFRSKPVLPKHLLEVNSLKHLTRLTLQDRITKSLLHLHKKK-KPPSISAQFQ-----------------------VSLSKLMETLD--QAEPYFVKCIRSNAEKLPL-----------------------------RFSDALVLRQLRYTGMLETV----RIRQSGYSSKYSFQDFVSHFH---VLLP------QH-----IIP----------------SKFNIQDFFR-KIN--------INP---DNYQVGKTMVF--------LKEHE-RQHLQDLLH--*
Ce HUM7 -YADLCN-LPELT-EQTLLDNLRERFAN-GHIYTYIGPILVAVNPFC-FFPIYNPK----------------YARLYFQ-SKR------------LGSLPPHIFAIADVCYHNMLR---------IKENQCVVISGESGSGKTESTNHLMSHLISLS---------------------------------------------------------------------------------------------------------------------------------------------QKGS------------------------TGCSTEQTLLS--AG-----PVLEAFGNAVTLTNNNSSRFGKFIKINYREN------GMVSGANVEIYL-LEKSRIIF-QTKGERNYHVFYYLLEGADEE-----------------------------------------ERKKYF---LLKPH----------DYKYLNQN-----------EP----------------FALEG----------VNERNEFDRLRHAMSSVG----FCAKTQ-QTIFGIISAVLLLG-NITYIKRH------GYHS---DESGYIENE--E--VVDLVANLL-HIKTDTLMQALTMKRHVMKT--------ETVVLRYSVSEATNTRDAMAKCIYNSLFHYI---------------------------VLRINQALLK----------KDFSAG-----KGYYIGILDIFGFEDVGS----QCNSFEQLCINYANEKLQSY-FNQHIFQFEQEEYLKEGIS--WTNIE-YTDN-TECVQLFQ----------------------------------------------------------------------------------------N-----NEYYETPQKKEP-------------AFIVAHYA--GKVKYQITGFRE-KNKDLMRQDVLNALKSSTSSVMKTLLGIDPVAVHRWNVLRSVFRAM----------------NAFKQSTRKLQ-----KKSAGHLR-------------------VMDSIVTSPRR---------------------GSDS---------------ALSAFLRGELRCEVPDFCD---------TS-MFNTIRNQARRTPAGKSD----DKMSLLKSLQILKEAIGGRRLAK----------KPSSVSKQFE-----------------------YSLTRLMSTLA--NATPYFIRCIKSNNDKIAN-----------------------------HFDDNIILRQLRYTGMLETV----RIRRAGYSVRIEYPSFVQQYR---ILLR------NG-----RDS----------------TVDDVKEYIHSHAS--------IDN---DNIQYGTNKIF--------MRDAE-KLILDDHLH--*
Dd IA -VEDLIM-LTEVS-ESSLHENLKIRYKE-GLIYTSIGPVLVSMNPYKQLG-IYGND----------------QINLYK--GKH------------EFEIPPHIYSIADKAYRALRS---------EGENQCIIISGESGAGKTEASKYIMQYIASIT----------------------------------------------------------------------------------------------------------------------------------------G----SST-------------------------EVERVKKTIL--ESN-----PLLEAFGNGKTLRNNNSSRFGKYMEIQFNLG------GDPEGGKITNYL-LEKSRVIN-QTQGERNFHIFYQLLKGHQGK-----------------------------------------KTYNL---LSPDQ------------YHYLTRNAS--------NGW---------------FSLPDG----------IDDQIGFKQTKNAMKVVG----IDEPLQ-KKSFATLSAILLLG-NLSFNKSA------SGNG------SVISDK--K--LANTIASLM-GVDAIVLESSLVSRQISTGQGA----RISTYSVPQTVEQAMYARDAFAKATYSKLFDFI---------------------------VRKINQSIEVK---------TIG----------KVIGVLDIYGFEIF------ENNSFEQFCINYVNETLQQI-FIDLTLKTEQEEYVQEGIT--WIPVQ-YINN-KACVDLIEK----------------------------------KP---IGILSLLDEECLFP----------------EGNDQTMIDKLNKH--FSN-----HTHYSKVERQKNS--Q----------FIINHYA--GKVFYNIDGFLD-KNRDTLFNDLVTLATSS-----------------SCSLLVEIFK---------------------YVPPLEVD-------PEQEKKNRDKFSKNGFANNA-----------------------------------------------------------------------------------------------------------------------------------AKTFIPTDKK-SPITAGFQFK-----------------------NQVTSLLKSLY--SCSPHYVRCIKPNSNMRAL-----------------------------EWDQSKCAEQVAYLGSFENL----LVRRAGYCYRQTFSKFMRRYY---MIGKS----TWP----KWSG---------------DAEKGVNLLMGELT---------QEINIKEEVQYGKTKIF--------IRNPQPLFLLEDKRN--*
Dd IE -VPDFVL-LNQIT-ENAFIDNLTMRHKS-DNIYTYIGDVVISRNPFKNLN-IYKES----------------DIKAYN--GRY------------KYEMPPHIYALANDAYRSMRQ---------SQENQCVIISGESGAGKTEASKKIMQFLTFVS----------------------------------------------------------------------------------------------------------------------------------------SN---QSP-------------------------NGERISKMLIRFQSN-----PLLEAFGNAKTLRNDNSSRFGKYMEMQFNAV------GSPIGGKITNYL-LEKSRVVG-RTQGERSFHIFYQMLKGLSQS-----------------------------------------KLNELG--LTPNAP----------AYEYLKK-----------SGC---------------FDVST-----------IDDSGEFKIIVKAMETLG----LKESDQ-NSIWRILAAILHIG-NITFAEAA------EQRT--GTTTVKVSDT--K--SLAAAASCL-KTDQQSLSIALCYRSISTGVGK----RCSVISVPMDCNQAAYSRDALAKALYERLFNWL---------------------------VSKINTLSIVH---------REG----------TVIGILDIYGFEVF------QNNSFEQLNINFCNEKLQQL-FIELTLKSEQEEY--KGIE--WKNIE-YFN--KPICELIEK----------------------------------KP---IGLISLLDEACLIA----------------KSTDQTFLDSICKQ--FEK-----NPHLQSYVVSKDR--SN-----GDTCFRLKHYA--GDVTYDVRGFLD-KNKDTLFGDLISSMQSS-----------------SDPLVQGLFP---------------------PTR------------PEDS-----------------------------------------------------------------------------------------------------------------------------------------------------------KK-RPETAGSQFR-----------------------NAMNALITTLL--ACSPHYVRCIKSNDNKQAG-----------------------------VIDEDRDRHQVRYLGLLENV----RVRRAGFAGRIEYTRFYNRYK---MLCKK----TWP----SFNG---------------TAKQATELILQQHN---------ID---KEEIRMGKTKVF--------IRIPRTLFYFEEKRE--*
Bt IC -VEDLVL-LEPLE-QESLIRNLQLRYEK-KEIYTYIGNVLVSVNPYQQLP-IYDLE----------------FVAKYR--DYT------------FYELKPHIYALANMAYQSLRD---------RDRDQCILITGESGAGKTEASKLVMSYVAAVC----------------------------------------------------------------------------------------------------------------------------------------GK---GE--------------------------QVNSVKEQLLQ--SN-----PVLEAFGNAKTIRNNNSSRFGKYMDIEFDFK------GFPLGGVITNYL-LEKSRVVK-QLEGERNFHIFYQLLAGADAQ-----------------------------------------LLKALK--LERDTG----------GYAYLNP-------------D---------------TSRVDG----------MDDDANFKVLQSAMTVIG----FSDEEI-RQVLEVAALVLKLG-NVELINEF------QANG---VPASGIRDG--R--GVQEIGELV-GLNSVELERALCSRTMETAK--------EKVVTTLNVIQAQYARDALAKNIYSRLFNWL---------------------------VNRINESIKVG---------TGEKR--------KVMGVLDIYGFEIL------EDNSFEQFVINYCNEKLQQV-FIEMTLKEEQEEYKREGIP--WVKVE-YFDN-GIICNLIEH----------------------------------NQ---RGILAMLDEECLRPG---------------VVSDSTFLAKLNQL--FSK-----HSHYESKVTQNAQ--RQYDHSMGLSCFRICHYA--GKVTYNVNSFID-KNNDLLFRDLSQAMWKA-----------------RHPLLRSLFP---------------------EGDPKQ---------ASL-------------------------------------------------------------------------------------------------------------------------------------------------------------K-RPPTAGAQFK-----------------------SSVTTLMKNLY--SKNPNYIRCIKPNEHQQRG-----------------------------HFSFELVSVQAQYLGLLENV----RVRRAGYAYRQAYGSFLERYR---LLSRS----TWP----RWNG---------------GDQEGVEKVLGELS---------MSS---EELAFGKTKIF--------IRSPKTLFYLEEQRR--*
Gg Bb -VGDLVM-LDPLS-EESLLRTLQERFSR-GEIYTYIGEVVISVNPYKPLP-IYTPE----------------KVEEYH--NCN------------FFAVKPHIYAIADDAYRSLRD---------RDRDQCILITGESGAGKTEASKLVMSYVAAVS----------------------------------------------------------------------------------------------------------------------------------------SK---GE--------------------------EVDKVKEQLLQ--SN-----PVLEAFGNAKTIRNDNSSRFGKYMDVEFDFK------GDPLGGVISNYL-LEKSRIVR-HVKGERNFHIFYQLLAGGSAQ-----------------------------------------LLQQLK--LRPDCS----------HYGYLNH-------------E---------------KSVLPG----------MDDAANFRAMQDAMAIIG----FAPAEV-TALLEVTAVVLKLG-NVKLSSCF------QASG---MEASSITEP--R--ELQEISQLI-GLDPSTLEQALCSRTVKVRD--------ESVLTALSVSQGYYGRDALAKNIYSRLFDWL---------------------------VNRINTSIQVK---------PGKQR--------KVMGVLDIYGFEIF------QDNGFEQFIINYCNEKLQQI-FILMTLKEEQEEYVREGIQ--WTPVE-FFDN-SIICDLIEN----------------------------------SK---VGILAMLDEECLRPG---------------TVNEDTFITKLNQI--FAS-----HKRYESKETLNAK--HVTDVSLPLRCFRIHHYA--GKVTYNVTGFIE-KNNDLLFRDLSQAMWAA-----------------RHTLLRSLFP---------------------EGDPQR---------PSL-------------------------------------------------------------------------------------------------------------------------------------------------------------K-LPPTTGSQFK-----------------------ASVATLMKNLY--SKNPNYIRCIKPNDTKTAM-----------------------------LFTPDLVLAQVRYLGLMENV----RVRRAGYAFRQLYQPFLERYK---MLSRK----TWP----RWTG---------------GDREGAEVLLAELK---------FPP---EELAYGHTKIF--------IRSPRTLFDLEKRRQ--*
Mm Brain IB -VGDMVL-LEPLN-EETFIDNLKKRFDH-NERYTYIGSVVISVNPYRSLP-IYSPE----------------KVEDYR--NRN------------FYELSPHIFALSDEAYRSLRD---------QDKDQCILITGESGAGKTEASKLVMSYVAAVC----------------------------------------------------------------------------------------------------------------------------------------GK---GA--------------------------EVNQVKEQLLQ--SN-----PVLEAFGNAKTVRNDNSSRFGKYMDIEFDFK------GDPLGGVISNYL-LEKSRVVK-QPRGERNFHVFYQLLSGASEE-----------------------------------------LLYKLK--LERDFS----------RYNYLSL-------------D---------------SAKVNG----------VDDAANFRTVRNAMQYVG----FLDHEA-EAVLEVVAAVLKLG-NIEFKPES------RVNG---LDESKIKDK--N--ELKEICELT-SIDQVVLERAFSFRTVEAKQ--------EKVSTTLNVAQAYYARDALAKNLYSRLFSWL---------------------------VNRINESIKAQ---------TKVRK--------KVMGVLDIYGFEIF------EDNSFEQFIINYCNEKLQQI-FIELTLKEEQEEYIREDIE--WTHID-YFNN-AIICDLIEN----------------------------------NT---NGILAMLDEECLRPG---------------TVTDETFLEKLNQV--CAT-----HQHFESRMSKCSR--FLNDTTLPHSCFRIQHYA--GKVLYQVEGFVD-KNNDLLYRDLSQAMWKA-----------------GHSLIKSLFP---------------------EGNPAK---------VNL-------------------------------------------------------------------------------------------------------------------------------------------------------------K-RPPTRSSQFK-----------------------ASVATLMRNLG--TKNPNYIRCIKPNDKKAAH-----------------------------IFNESLVCHQIRYLGLLENV----RVRRAGYAFRQAYEPCLERYK---MLCKQ----TWP----HWKG---------------PARSGVEVLFNELE---------IPV---EEHSFGRSKIF--------IRNPRTLFQLEDLRK--*
Rn MyrI IA -VGDTVL-LEPLN-EETFIDNLKKRFDH-NEIYTYIGSVVISVNPYRSLP-IYSPE----------------KVEDYR--NRN------------FYELSPHIFALSDEAYRSLRD---------QDKDQCILITGESGAGKTEASKLVMSYVAAVC----------------------------------------------------------------------------------------------------------------------------------------GK---GA--------------------------EVNQVKEQLLQ--ST-----PVLEAFGNAKTVRNDNSSRFGKYMDIEFDFK------GDPLGGVISNYL-LEKSRVVK-QPRGERNFHVFYQLLSGASEE-----------------------------------------LLHKLK--LERDFS----------RYNYLSL-------------D---------------SAKVNG----------VDDAANFRTVRNAMQIVG----FSDPEA-ESVLEVVAAVLKLG-NIEFKPES------RMNG---LDESKIKDK--N--ELKEICELT-SIDQVVLERAFSFRTVEAKQ--------EKVSTTLNVAQAYYARDALAKNLYSRLFSWL---------------------------VNRINESIKAQ---------TKVRK--------KVMGVLDIYGFEIF------EDNSFEQFIINYCNEKLQQI-FIELTLKEEQEEYIREDIE--WTHID-YFNN-AIICDLIEN----------------------------------NT---NGILAMLDEECLRPG---------------TVTDETFLEKLNQV--CAT-----HQHFESRMSKCSR--FLNDTTLPHSCFRIQHYA--GKVLYQVEGFVD-KNNDLLYRDLSQAMWKA-----------------GHALIKSLFP---------------------EGNPAK---------VNL-------------------------------------------------------------------------------------------------------------------------------------------------------------K-RPPTAGSQFK-----------------------ASVATLMKNLQ--TKNPNYIRCIKPNDKKAAH-----------------------------IFSESLVCHQIRYLGLLENV----RVRRAGYAFRQAYEPCLERYK---MLCKQ----TWP----HWKG---------------PARSGVEVLFNELE---------IPV---EEYSFGRSKIF--------IRNPRTLFQLEDLRKQR*
Mm IA -VGDMVL-LEPLN-EETFIDNLKKRFDH-NEIYTYIGSVVISVNPYRSLP-IYSPE----------------KVEDYR--NRN------------FYELSPHIFALSDEAYRSLRD---------QDKDQCILITGESGAGKTEASKLVMSYVAAVC----------------------------------------------------------------------------------------------------------------------------------------GK---GA--------------------------EVNQVKEQLLQ--SN-----PVLEAFGNAKTVRNDNSSRFGKYMDIEFDFK------GDPLGGVISNYL-LEKSRVVK-QPRGERNFHVFYQLLSGASEE-----------------------------------------LLYKLK--LERDFS----------RYNYLSL-------------D---------------SAKVNG----------VDDAANFRTVRNAMQIVG----FLDHEA-EAVLEVVAAVLKLG-NIEFKPES------RVNG---LDESKIKDK--I--ELNEKFASRPASVKVVLERAFSFRTVEAKR--------EKVSTTLNVAQAYYARDALAKNLYSRLFSWL---------------------------VNRINESIKAQ---------TKVRK--------KVMGVLDIYGFEIF------EDNSFEQFIINYCNEKLQQI-FIELTLKEEQEEYIREDIE--WTHID-YFNN-AIICDLIEN----------------------------------NT---NGILAMLDEECLRPG---------------TVTDETFLEKLNQV--CAT-----HQHFESRMSKCSR--FLNDTTLPHSCFRIQHYA--GKVLYQVEGFVD-KNNDLLYRDLSQAMWKA-----------------DHSLIKSLFP---------------------EGNPAK---------VNL-------------------------------------------------------------------------------------------------------------------------------------------------------------K-RPPTAGSQFK-----------------------ASVATLMRNLQ--TKNPNYIRCIKPNDKKAAH-----------------------------IFNESLVCHQIRYLGLLENV----RVRRAGYAFRQAYEPCLERYK---MLCKQ----TWP----HWKG---------------PARSGVEVLFNELE---------IPV---EEHSFGRSKIF--------IRNPRTLFQLEDLRKQR*
Rn Myr2 IB -VQDFVL-LENFTSEAAFIENLRRRFRE-NLIYTYIGPVLVSVNPYRDLQ-IYTRQ----------------HMERYR--GVS------------FYEVPPHLFAVADTVYRALRT---------ERRDQAVMISGESGAGKTEATKRLLQFYAETC----------------------------------------------------------------------------------------------------------------------------------------PA---PE--------------------------RGGAVRDRLLQ--SN-----PVLEAFGNAKTLRNDNSSRFGKYMDVQFDFK------GAPVGGHILSYL-LEKSRVVH-QNHGERNFHVFYQLLEGGEEE-----------------------------------------ALRRLG--LERNPQ----------SYLYLVK------------GQ---------------CAKVSS----------INDKSDWKVVRKALSVID----FTEDEV-EDLLSIVASVLHLG-NIHFAADE------DSN-------AQVTTE--N--QLKYLTRLL-GVEGTTLREALTHRKIIAKG--------EELLSPLNLEQAAYARDALAKAVYSRTFTWL---------------------------VRKINRSLASK---------DAESPSWR---STTVLGLLDIYGFEVF------QHNSFEQFCINYCNEKLQQL-FIELTLKSEQEEYEAEGIA--WEPVQ-YFNN-KIICDLVEE----------------------------------KF---KGIISILDEECLRPG---------------EATDLTFLEKLEDT--IKH-----HPHFLTHKLADQK--TR--KSLDRGEFRLLHYA--GEVTYSVTGFLD-KNNDLLFRNLKETMCSS-----------------TNPIMAQCFD---------------------KSELS-----------DK-------------------------------------------------------------------------------------------------------------------------------------------------------------K-RPETVATQFK-----------------------MSLLQLVEILR--SKEPAYIRCIKPNDAKQPG-----------------------------RFDEVLIRHQVKYLGLMENL----RVRRAGFAYRRKYEAFLQRYK---SLCPE----TWP----VWTG---------------RPQDGVAVLVRHLG---------YKP---EEYKMGRTKIF--------IRFPKTLFATEDSLE--*
Mm Ibeta -VQDFVL-LENFTSEAAFIENLRGGFRE-NLIYTYIGPVLVSVNPYRDLQ-IYRRK----------------HMERYR--GVS------------FYEVPPHLFAVADTVYRALRT---------ERRDQAVMISGESGAGKTEATKRLLQFYAETC----------------------------------------------------------------------------------------------------------------------------------------PA---PE--------------------------RGGAVRDRLLQ--SN-----PVLEAFGNAKTLRNDNSSRFGKYMDVQFDFK------GAPVGGHILSYL-LEKSRVVH-QNHGERNFHVFYQLLEGGEEE-----------------------------------------TLRRLG--LERNPQ----------SYLYLVK------------GQ---------------CAKVSS----------INDKSDWKVMRKALSVID----FTEDEV-EDLLSIVASVLHLG-NIHFAADE------DSN-------AQVTTE--N--QLKYLTRLL-GVEGTTLREALTHRKIIAKG--------EELLSPLNLEQAAYARDALAKAVYSRTFTWL---------------------------VRKINRSLASK---------DAESPSWR---STTVLGLLDIYGFEVF------QHNSFEQFCINYCNEKLQQL-FIELTLKSEQEEYEAEGIA--WEPVQ-YFNN-KIICDLVEE----------------------------------KF---KGIISILDEECLRPG---------------EATDLTFLEKLEDT--VKP-----HPHFLTHKLADQK--TR--KSLDRGEFRLLHYA--GEVTYSVTGFLD-KNNDLLFRNLKETMCSS-----------------MNPIMAQCFD---------------------KSELS-----------DK-------------------------------------------------------------------------------------------------------------------------------------------------------------K-RPETVATQFK-----------------------MSLLQLVEILR--SKEPAYIRCIKPNDAKQPG-----------------------------RFDEVLIRHQVKYLGLMENL----RVRRAGFAYRRKYEAFLQRYK---SLCPE----TWP----MWAG---------------RPQDGVAVLVRHLG---------YKP---EEYKMGRTKIF--------IRFPKTLFATEDSL---*
Hs Ib -VQDFVL-LENFTSEAAFIENLRRRFRE-NLIYTYIGPVLVSVNPYRDLQ-IYSRQ----------------HMERYR--GVS------------FYEVPPHLFAVADTVYRALRT---------ERRDQAVMISGESGAGKTEATKKLLQFYAETC----------------------------------------------------------------------------------------------------------------------------------------PA---PQ--------------------------RGGAVRDRLLQ--SN-----PVLEAFGNAKTLRNDNSSRFGKYMDVQFDFK------GAPVGGHILSYL-LEKSRVVH-QNHGERNFHIFYQLLEGGEEE-----------------------------------------TLRRLG--LERNPQ----------SYLYLVK------------GQ---------------CAKVSS----------INDKSDWKVVRKALTVID----FTEDEV-EDLLSIVASVLHLG-NIHFAANE------DSN-------AQVTTE--N--QLKYLTRLL-SVEGSTLREALTHRKIIAKG--------EELLSPLNLEQAAYARNALAKAVYSRTFTWL---------------------------VGKINRSLASK---------DVESPSWR---STTVLGLLDIYGFEVF------QHNSFEQFCINYCNEKLQQL-FIELPLKSEQEEYEAEGIA--WEPVQ-YFNN-KIICDLVEE----------------------------------KF---KGIISILDEECLRPG---------------EATDLTFLEKLEDT--VKH-----HPHFLTHKLADQR--TR--KSLGRGEFRLLHYA--GEVTYSVTGFLD-KNNDLLFRNLKETMCSS-----------------KNPIMSQCFD---------------------RSELS-----------DK-------------------------------------------------------------------------------------------------------------------------------------------------------------K-RPETVATQFK-----------------------MSLLQLVEILQ--SKEPAYVRCIKPNDAKQPG-----------------------------RFDEVLIRHQVKYLGLLENL----RVRRAGFAYRRKYEAFLQRYK---SLCPE----TWP----TWAG---------------RPQDGVAVLVRHLG---------YKP---EEYKMGRTKIF--------IRFPKTLFATEDAL---*
Bt Adren IA -VQDFVL-LENFTSEAAFIENLRRRFRE-NLIYTYIGPVLVSVNPYRDLQ-IYSRQ----------------HMERYR--GVS------------FYEVPPHLFAVADTVYRALRT---------ERGDQAVMISGESGAGKTEATKRLLQFYAETC----------------------------------------------------------------------------------------------------------------------------------------PA---PE--------------------------RGGAVRDRLLQ--SN-----PVLEAFGNAKTLRNDNSSRFGKYMDVQFDFK------GAPVGGHILSYL-LEKSRVVH-QNHGERNFHIFYQLLEGGEEE-----------------------------------------TLRRLG--LERNPQ----------SYLYLVK------------GQ---------------CAKVSS----------INDKSDWKVVRKALTVID----FTEDEV-EDLLSIVASVLHLG-NTHFAADE------ESN-------AQVTTE--N--QLKYLTRLL-GVEGSTLREALTHRKIIAKG--------EELLSPLNLEQAAYARDALAKAVYSRTFTWL---------------------------VAKINRSLASK---------DAESPSWR---STTVLGLLGIYGFEVF------QHNSFEQFCINYCNEKLQQL-FIELTLKSEQEEYEAEGIA--WEPVQ-YFNN-KIICDLVEE----------------------------------KF---KGIISILDEECLRPG---------------EATDLTFLEKLEDT--IKQ-----HPHFLTHKLADQR--TR--KSLDRGEFRLLHYA--GEVTYNVTGFLD-KNNDLLFRNLKETMCSS-----------------ENPILGQCFD---------------------RSELS-----------SK-------------------------------------------------------------------------------------------------------------------------------------------------------------K-RPETVATQFK-----------------------MSLLELVEILK--SKEPAYVRCIKPNDSKQPG-----------------------------RFDEVLIRHQVKYLGLMENL----RVRRAGFAYRRKYEAFLQRYK---SLCPE----TWP----TWTG---------------RRQDGVTVLVRHLG---------YKP---EEYKMGRTKIF--------IRFPKTLFATEDALE--*
Bt IB -VQDFVL-LENFTSEAAFIENLRRRFRE-NLIYTYIGPVLVSVNPYRDLQ-IYSRQ----------------HMERYR--GVS------------FYEVPPHLFAVADTVYRALRT---------ERRDQAVMISGESGAGKTEATKRLLQFYAETC----------------------------------------------------------------------------------------------------------------------------------------P